Compounds > fluorodeoxyuridylate
Page last updated: 2024-09-21

fluorodeoxyuridylate

Description

Fluorodeoxyuridylate: 5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8642
CHEMBL ID886
CHEBI ID2129
SCHEMBL ID6107
MeSH IDM0008627

Synonyms (37)

Synonym
[(2r,3s,5r)-5-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
f-dump
5-fluoro-2'-deoxy-5'-monophosphateuridine
5fdump
UFP ,
5-fluoro-2'-deoxyuridine-5'-monophosphate
C04242
5-fluorodeoxyuridine monophosphate
DB03761 ,
fluorodeoxyuridylate
fdump
5'-uridylic acid, 2'-deoxy-5-fluoro-
134-46-3
chebi:2129 ,
5-fluoro-2-deoxyuridine monophosphate (fdump)
CHEMBL886 ,
[(2r,3s,5r)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
2'-deoxy-5-fluorouridine 5'-(dihydrogen phosphate)
phosphoric acid mono-[5-(5-fluoro-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester
bdbm50022238
5-fluoro-2''-deoxyuridine-5''-monophosphate
phosphoric acid mono-[(2r,3s,5r)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester
(r)-5-fluoro-1-((4s,5r)-4-hydroxy-5-methylphosphate-tetrahydro-furan-2-yl)-1h-pyrimidine-2,4-dione
unii-7cj707h131
7cj707h131 ,
SCHEMBL6107
DTXSID60158450
fosifloxuridine
uridine, 2'-deoxy-5-fluoro-, 5'-(dihydrogen phosphate)
5-fluoro-2'-deoxyuridine 5'-phosphate
18453-22-0
5-fluoro-dump
5-fluoro-2'-deoxy-ump
Q27105559
PD059482
2 inverted exclamation mark -deoxy-5-fluorouridine 5 inverted exclamation mark -phosphate triethylammonium
F90253

Drug Classes (1)

ClassDescription
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

fluorodeoxyuridylate is involved in 1 pathway(s), involving a total of 0 unique proteins and 15 unique compounds

PathwayProteinsCompounds
Fluoropyrimidine activity015

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidylate synthase Escherichia coliKi0.01000.00300.06870.1500AID220356
Thymidylate synthaseLacticaseibacillus caseiKi4.97600.01001.65509.3900AID1134942; AID1147592; AID1147594
Thymidylate synthaseHomo sapiens (human)Ki0.01400.00010.34353.0000AID709346
Thymidylate synthaseMus musculus (house mouse)IC50 (µMol)2.51680.00041.322610.0000AID212496; AID212498; AID212499; AID212635
Thymidylate synthaseMus musculus (house mouse)Ki0.02000.00341.73759.3000AID211086; AID211087; AID228251; AID228252
Delta-type opioid receptorRattus norvegicus (Norway rat)Ki0.01400.00000.60689.2330AID1134942
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki0.01400.00000.38458.6000AID1134942
Kappa-type opioid receptorRattus norvegicus (Norway rat)Ki0.01400.00000.18683.9500AID1134942
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidylate synthaseLacticaseibacillus caseiKd0.00500.00000.00500.0100AID1147597; AID1147598
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidylate synthaseMus musculus (house mouse)Ki'0.00530.00180.04470.1840AID211088; AID211090; AID228253; AID228254
Thymidylate synthaseMus musculus (house mouse)Ki''0.03130.01400.30181.4600AID211236; AID211238; AID228255; AID228256
Thymidylate kinaseMycobacterium tuberculosis H37RvKm420.00004.50004.50004.5000AID211051; AID211056
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (21)

Processvia Protein(s)Taxonomy
dTMP biosynthetic processThymidylate synthaseHomo sapiens (human)
dTTP biosynthetic processThymidylate synthaseHomo sapiens (human)
circadian rhythmThymidylate synthaseHomo sapiens (human)
response to xenobiotic stimulusThymidylate synthaseHomo sapiens (human)
response to toxic substanceThymidylate synthaseHomo sapiens (human)
negative regulation of translationThymidylate synthaseHomo sapiens (human)
uracil metabolic processThymidylate synthaseHomo sapiens (human)
methylationThymidylate synthaseHomo sapiens (human)
response to progesteroneThymidylate synthaseHomo sapiens (human)
response to vitamin AThymidylate synthaseHomo sapiens (human)
response to cytokineThymidylate synthaseHomo sapiens (human)
tetrahydrofolate interconversionThymidylate synthaseHomo sapiens (human)
response to ethanolThymidylate synthaseHomo sapiens (human)
response to organophosphorusThymidylate synthaseHomo sapiens (human)
developmental growthThymidylate synthaseHomo sapiens (human)
cartilage developmentThymidylate synthaseHomo sapiens (human)
response to glucocorticoidThymidylate synthaseHomo sapiens (human)
response to folic acidThymidylate synthaseHomo sapiens (human)
intestinal epithelial cell maturationThymidylate synthaseHomo sapiens (human)
DNA biosynthetic processThymidylate synthaseHomo sapiens (human)
liver regenerationThymidylate synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
mRNA regulatory element binding translation repressor activityThymidylate synthaseHomo sapiens (human)
thymidylate synthase activityThymidylate synthaseHomo sapiens (human)
folic acid bindingThymidylate synthaseHomo sapiens (human)
protein homodimerization activityThymidylate synthaseHomo sapiens (human)
sequence-specific mRNA bindingThymidylate synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
nucleusThymidylate synthaseHomo sapiens (human)
cytoplasmThymidylate synthaseHomo sapiens (human)
mitochondrionThymidylate synthaseHomo sapiens (human)
mitochondrial inner membraneThymidylate synthaseHomo sapiens (human)
mitochondrial matrixThymidylate synthaseHomo sapiens (human)
cytosolThymidylate synthaseHomo sapiens (human)
mitochondrionThymidylate synthaseHomo sapiens (human)
cytosolThymidylate synthaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (93)

Assay IDTitleYearJournalArticle
AID165909Cytostatic activity against proliferation of Raji/TK cells (deoxythymidine kinase deficient Raji cells)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID212663Compound was evaluated for the inhibition of L1210 Thymidylate synthase1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID18726Apparent rate constant Kon for inactivation of dTMP synthase.1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.
AID1304932Drug uptake in Sprague-Dawley rat liver S9 fraction treated with (S)-Isopropyl 2-(((R)-(((2R,3S,5R)-5-(5-fluoro-2,4-dioxo 3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)((2-methylbenzyl)oxy)phosphoryl)amino)propanoate at 20 ug/mL pre2016Journal of medicinal chemistry, 04-28, Volume: 59, Issue:8
Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.
AID85714Antiviral activity against Herpes Simplex Virus-1 (McIntyre)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID230651Ki/Km values of L1210/0 dTMP synthase for the compound was determined.1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
AID212635Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID211051Affinity towards thymidine monophosphate kinase (TMPKmt) in Mycobacterium tuberculosis2003Bioorganic & medicinal chemistry letters, Sep-15, Volume: 13, Issue:18
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
AID96658Dose inhibiting L1210/0 murine leukemia cell proliferation by 50% in presence of 5 ug/mL of dThd.1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
AID211054Kinetic parameter Vm of thymidine monophosphate kinase (TMPKmt) in Mycobacterium tuberculosis was determined2003Bioorganic & medicinal chemistry letters, Sep-15, Volume: 13, Issue:18
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
AID96642Cytostatic activity against proliferation of L1210/0 cells (murine leukemia L1210 cells)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID229760Ratio of ID50 upon addition of dThd to the ID50 upon addition of dUrd against the L1210/0 cell proliferation.1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
AID1134942Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by radioisotope assay1979Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase.
AID87506Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain F1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID87508Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain McIntyre1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID220363Binding of 0.1 mM [14C]5,10-CH2-H4 folate to 2.5 nmol dTMP synthetase from Lactobacillus casei1981Journal of medicinal chemistry, Dec, Volume: 24, Issue:12
Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase.
AID87507Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain KOS.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID211240The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID87828Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain Lyons1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID232972Ratio of Concentration of intact versus pearmeabilized of above1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID211241The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of L1210 Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID221339Evaluation for antitumor activity against human lymphoblast Raji cells1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID1147598Binding affinity to amethopterin-resistant Lactobacillus casei thymidylate synthetase in presence of cofactor not permitting covalent bond formation1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.
AID704506Ratio of IC50 for human CEM cells expressing human ENT1 transporter in presence of dipyridamole to IC50 for human CEM cells expressing human ENT1 transporter2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
AID211056Compound was tested for binding affinity against Mycobacterium tuberculosis thymidine monophosphate kinase2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
AID216408Antiviral activity against vesicular stomatitis virus1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID87826Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain 196.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID228255Compound was tested for time-dependent slow-binding inhibition (K) of thymidylate synthase from L1210-P cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID228416Compound was tested for time-dependent 1 (k2) inhibition of thymidylate synthase from L1210-R cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID1147597Binding affinity to amethopterin-resistant Lactobacillus casei thymidylate synthetase in presence of cofactor permitting covalent bond formation1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.
AID211238The reaction rate(Ki'') of compound was measured for inactivation of L1210 Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID23991Half-life period of [6-3H]3''-FFdUMP from its ternary complex with dTMP synthetase.1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.
AID220356Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Interaction of 1-(5-phospho-beta-D-arabinofuranosyl)-5-substituted-uracils with thymidylate synthetase: mechanism-based inhibition by 1-(5-phospho-beta-D-arabinosyl)-5-fluorouracil.
AID98529Evaluation of antitumor activity against mutant murine leukemia L1210 cells1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID217995Antiviral activity against vaccinia virus1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID228256Compound was tested for time-dependent slow-binding inhibition (K) of thymidylate synthase from L1210-R cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID704505Ratio of IC50 for human CEM cells expressing human ENT1 transporter in presence of NBMPR to IC50 for human CEM cells expressing human ENT1 transporter2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
AID96655Dose inhibiting L1210/0 murine leukemia cell proliferation by 50%1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
AID96656Dose inhibiting L1210/0 murine leukemia cell proliferation by 50% in presence of 125 ug/mL of dUrd.1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
AID228258Compound was tested for time-dependent 1 (k2') inhibition of thymidylate synthase from L1210-R cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID85713Antiviral activity against Herpes Simplex Virus-1 (KOS)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID220371In vitro competitive inhibition of cleavage of substrate dUMP phosphorylase.1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.
AID1321552Inhibition of Mycobacterium tuberculosis ThyX at 100 uM preincubated with enzyme followed by [5-3H]dUMP substrate addition measured after 30 mins in presence of 5,10-methylenetetrahydrofolate,NADPH and FAD by liquid scintillation counting2016Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase.
AID704507Ratio of IC50 for ENT1 transporter-deficient human CEM cells to IC50 for human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
AID99522In vitro percent inhibition at 10 e-8 M against L5178Y cell growth after 72 hr (replicate flasks inoculated with 10 e5 cells were treated with the nucleotide)1980Journal of medicinal chemistry, Nov, Volume: 23, Issue:11
Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates.
AID704508Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of NBMPR2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
AID1147592Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometric analysis in presence of CH2-H4-folate1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.
AID211088The reaction rate(Ki') of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID17052Apparent rate constant Koff for inactivation of dTMP synthase.1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.
AID96659Dose inhibiting L1210/Br-dUrd murine leukemia cell proliferation by 50%1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
AID704510Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
AID709346Inhibition of human thymidylate synthase expressed in Escherichia coli incubated for 1 hr by spectrophotometry2012Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
AID212496Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID1147594Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence of CH2-H4-folate1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.
AID98532Evaluation of cytostatic activity by using antitumor assays against murine leukemia L1210 cells1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID229757Ratio of ID50 for L1210/0 cell growth and ID50 for L1210/BdUrd cell growth.1984Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
AID216539Evaluation of antiviral activity against Vesicular stomatitis virus.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID218132Evaluation of antiviral activity against Vaccinia virus1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID84761Antiviral activity against Herpes Simplex Virus-2(G)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID228252Time-independent inhibition of thymidylate synthase from parenteral L1210 cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID211245The time dependent reaction (k2'(1/min)) of compound was measured for inactivation of L1210 Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID98737In vitro cytotoxicity of compounds were determined on murine leukemia cell line (L1210).1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID43713In vitro cytotoxicity of compounds were determined on Inhibition of human leukemia cell line(CCRF-CEM). 1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID220992Evaluation of antitumor activity against thymidine kinase deficient Raji cell line1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID211236The reaction rate(Ki'') of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID96643Cytostatic activity against proliferation of L1210/BdU cells (deoxythymidine kinase deficient L1210 cells)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID233941Ratio between Ki of L1210-P enzyme and Michaelis-Menten constant (kM)2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID228254Compound was tested for time-dependent slow-binding inhibition (K') of thymidylate synthase from L1210-R cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID680603TP_TRANSPORTER: transport into inside-out membrane vesicles in membrane vesicle from MRP8-2-expressing LLC-PK1 cells2003The Journal of biological chemistry, Aug-08, Volume: 278, Issue:32
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.
AID211811Compound was tested for its inhibition against Thymidylate synthase up to concentration of 1 mM; IA means inactive1980Journal of medicinal chemistry, Nov, Volume: 23, Issue:11
Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates.
AID84760Antiviral activity against Herpes Simplex Virus-2(196)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID1123575Inhibition of Lactobacillus casei thymidylate synthetase using dUMP as substrate without pre-incubation with enzyme at 1.2 X 10'-7 M relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid.
AID704509Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of dipyridamole2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
AID228251Time-independent inhibition of thymidylate synthase from FdUrd-resistant L1210 cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID211244The time dependent reaction (k2'(1/min)) of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID99399Inhibitory activity against Lactobacillus casei MTX-resistant1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
AID211057Enzyme Kinetic constant was determined in the presence of Mycobacterium tuberculosis thymidine monophosphate kinase2002Bioorganic & medicinal chemistry letters, Oct-07, Volume: 12, Issue:19
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
AID228253Compound was tested for time-dependent slow-binding inhibition (K') of thymidylate synthase from L1210-P cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID704511Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting2011Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
AID212499Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID228257Compound was tested for time-dependent 1 (k2') inhibition of thymidylate synthase from L1210-P cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID211086Apparent Ki value was measured by competitive inhibition of Thymidylate Synthases from Ehrlich Carcinoma cells of mouse1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID87827Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain G1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID165908Cytostatic activity against proliferation of Raji/0 cells (human lymphoblast Raji cells)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID211087Apparent Ki value was measured by competitive inhibition of Thymidylate Synthases from L1210 cells of mouse1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID84762Antiviral activity against Herpes Simplex Virus-2(Lyons)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID211090The reaction rate(Ki') of compound was measured for inactivation of L1210 Thymidylate Synthases1993Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID233942Ratio between Ki of L1210-R enzyme and Michaelis-Menten constant (kM)2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID99823In vitro cytotoxicity of compounds were determined on mouse fibroblast (L929 TK-).1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID85712Antiviral activity against Herpes Simplex Virus-1 (F)1986Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
AID212498Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells.1996Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
AID99514Comparative inhibition of L5178Y cell growth in vitro (concentration required for 50% inhibition)1980Journal of medicinal chemistry, Nov, Volume: 23, Issue:11
Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates.
AID228415Compound was tested for time-dependent 1 (k2) inhibition of thymidylate synthase from L1210-P cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (334)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990155 (46.41)18.7374
1990's107 (32.04)18.2507
2000's43 (12.87)29.6817
2010's25 (7.49)24.3611
2020's4 (1.20)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (1.72%)5.53%
Reviews18 (5.17%)6.00%
Case Studies2 (0.57%)4.05%
Observational0 (0.00%)0.25%
Other322 (92.53%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
bromodeoxyuridylate[no description available]medium100
5-nitro-2'-deoxyuridine 5'-monophosphate[no description available]medium20
5-trifluoromethyl-2'-deoxyuridylic acid[no description available]medium50
5-iodo-2'-deoxyuridine 5'-monophosphate[no description available]medium90
5-chloro-2'-deoxyuridine 5'-triphosphate[no description available]medium30
thymidine monophosphate[no description available]medium170thymidine 5'-monophosphatefundamental metabolite
2'-deoxyuridylic acid[no description available]medium360deoxyuridine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate		Escherichia coli metabolite;
metabolite;
mouse metabolite
fluorouracil[no description available]medium1380nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
fluorouracil[no description available]medium1383nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
bromouracil[no description available]medium10nucleobase analogue;
pyrimidines		mutagen
5-fluorouridine[no description available]medium130organofluorine compound;
uridines		mutagen
5-chlorouracil[no description available]medium10organochlorine compound
5-iodouracil[no description available]medium10organoiodine compoundantimetabolite
brivudine[no description available]medium30
floxuridine[no description available]medium500nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
radiosensitizing agent
idoxuridine[no description available]medium30organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
bromodeoxyuridine[no description available]medium50pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
bromodeoxyuridine[no description available]medium51pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
trifluridine[no description available]medium30nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor
5-chloro-2'-deoxyuridine[no description available]medium20
5-(2-bromovinyl)-2'-deoxyuridylate[no description available]medium10
methotrexate[no description available]medium170dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
cytidine monophosphate[no description available]medium40cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
cytarabine[no description available]medium50beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
5-hydroxymethyl-2'-deoxyuridine[no description available]medium10pyrimidine 2'-deoxyribonucleoside
n-4-hydroxy-2'-deoxycytidylic acid[no description available]medium40
3'-azido-3'-deoxythymidine 5'phosphate[no description available]medium20
3'-amino-3'-deoxythymidine 5'-monophosphate[no description available]medium20
adefovir[no description available]medium106-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
thymidine[no description available]medium130pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
doxifluridine[no description available]medium60organofluorine compound;
pyrimidine 5'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
prodrug
alovudine[no description available]medium20pyrimidine 2',3'-dideoxyribonucleoside
zidovudine[no description available]medium30azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
thymine arabinoside[no description available]medium10N-glycosyl compound
5'-amino-2',5'-dideoxythymidine[no description available]medium10
edoxudin[no description available]medium20pyrimidine 2'-deoxyribonucleoside
3'-amino-2',3'-dideoxythymidine[no description available]medium10
2'-fluorothymidine[no description available]medium10
2-toluic acid[no description available]medium10methylbenzoic acidxenobiotic metabolite
2-methylhippuric acid[no description available]medium10N-acylglycinemetabolite
sorafenib[no description available]medium10(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
levoleucovorin[no description available]medium2915-formyltetrahydrofolic acidantineoplastic agent;
metabolite
deoxycytidine monophosphate[no description available]medium302'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate		Escherichia coli metabolite;
mouse metabolite
cyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
paclitaxel[no description available]medium10taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine[no description available]medium10N-substituted diamine;
pyridines;
tertiary amino compound		apoptosis inducer;
chelator;
copper chelator
uridine triphosphate[no description available]medium100pyrimidine ribonucleoside 5'-triphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
5-fluorouridine 5'-triphosphate[no description available]medium90
estrone sulfate[no description available]medium1017-oxo steroid;
steroid sulfate		human metabolite;
mouse metabolite
dehydroepiandrosterone sulfate[no description available]medium1017-oxo steroid;
steroid sulfate		EC 2.7.1.33 (pantothenate kinase) inhibitor;
human metabolite;
mouse metabolite
estrone[no description available]medium1017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
hydroxyurea[no description available]medium10one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
aphidicolin[no description available]medium10tetracyclic diterpenoidantimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite
cadaverine[no description available]medium10alkane-alpha,omega-diamineDaphnia magna metabolite;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite
monodansylcadaverine[no description available]medium10aminonaphthalene;
primary amino compound;
sulfonamide;
tertiary amino compound		EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor;
fluorochrome;
protective agent
cytidine[no description available]medium20cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
platinum[no description available]medium10elemental platinum;
nickel group element atom;
platinum group metal atom
fluorosulfonic acid[no description available]medium10sulfur oxoacidNMR solvent
5,10-methylenetetrahydrofolic acid[no description available]medium340benzamides;
methylenetetrahydrofolic acid
uridine monophosphate[no description available]medium30pyrimidine ribonucleoside 5'-monophosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
camptothecin[no description available]medium20delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
topotecan[no description available]medium10pyranoindolizinoquinolineantineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor
irinotecan[no description available]medium10carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug
calpain[no description available]medium10
plx4032[no description available]medium10aromatic ketone;
difluorobenzene;
monochlorobenzenes;
pyrrolopyridine;
sulfonamide		antineoplastic agent;
B-Raf inhibitor
oligonucleotides[no description available]medium20
thymine[no description available]medium30pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite
sb 218078[no description available]medium10indolocarbazole
carbene[no description available]medium10carbene;
methanediyl
dihydrofolate[no description available]medium30dihydrofolic acidsEscherichia coli metabolite;
mouse metabolite
folic acid[no description available]medium320folic acids;
N-acyl-amino acid		human metabolite;
mouse metabolite;
nutrient
5,6,7,8-tetrahydrofolic acid[no description available]medium40tetrahydrofolic acid
nadp[no description available]medium30
methane[no description available]medium10alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
quinazolines[no description available]medium170azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
carbogen[no description available]medium20
formic acid[no description available]medium10monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
fluorine[no description available]medium50diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
flucytosine[no description available]medium40aminopyrimidine;
nucleoside analogue;
organofluorine compound;
pyrimidine antifungal drug;
pyrimidone		prodrug
mercaptoethanol[no description available]medium20alkanethiol;
primary alcohol		geroprotector
5,10-methenyltetrahydrofolate[no description available]medium10methylenetetrahydrofolic acidEscherichia coli metabolite;
mouse metabolite
raltitrexed[no description available]medium60N-acyl-amino acid
thiophenes[no description available]medium60mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
palladium[no description available]medium10metal allergen;
nickel group element atom;
platinum group metal atom
deoxyuridine[no description available]medium140pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
phosphorus[no description available]medium20monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
guanine[no description available]medium102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
pemetrexed[no description available]medium10N-acyl-L-glutamic acid;
pyrrolopyrimidine		antimetabolite;
antineoplastic agent;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
EC 2.1.1.45 (thymidylate synthase) inhibitor;
EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
cysteine[no description available]medium50cysteiniumfundamental metabolite
glycosides[no description available]medium10
uridine diphosphate glucose[no description available]medium30UDP-D-glucosefundamental metabolite
uracil[no description available]medium90pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
uridine diphosphate n-acetylglucosamine[no description available]medium10
tretinoin[no description available]medium10retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
1-methyl-3-isobutylxanthine[no description available]medium103-isobutyl-1-methylxanthine
8-bromo cyclic adenosine monophosphate[no description available]medium103',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound		antidepressant;
protein kinase agonist
orotic acid[no description available]medium20pyrimidinemonocarboxylic acidEscherichia coli metabolite;
metabolite;
mouse metabolite
uridine[no description available]medium150uridinesdrug metabolite;
fundamental metabolite;
human metabolite
5-fluorouridine 5'-phosphate[no description available]medium20organofluorine compound;
pyrimidine ribonucleoside 5'-monophosphate		drug metabolite
arabinofuranosylcytosine triphosphate[no description available]medium10
5-(2-iodovinyl)-2'-deoxyuridine[no description available]medium10
5-(1-propenyl)-2'-deoxyuridine[no description available]medium10
metaperiodate[no description available]medium10iodine oxoacid
methylamine[no description available]medium10methylamines;
one-carbon compound;
primary aliphatic amine		mouse metabolite
metaperiodate[no description available]medium10iodine oxoanion;
monovalent inorganic anion
trichloroacetic acid[no description available]medium30monocarboxylic acid;
organochlorine compound		carcinogenic agent;
metabolite;
mouse metabolite
iodoacetamide[no description available]medium20
aspartic acid[no description available]medium40aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
phosphonoacetic acid[no description available]medium20monocarboxylic acid;
phosphonic acids		antiviral agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor
aminopterin[no description available]medium10dicarboxylic acidEC 1.5.1.3 (dihydrofolate reductase) inhibitor;
mutagen
arabinofuranosyluracil[no description available]medium10
vitamin b 12[no description available]medium10
homocysteine[no description available]medium10amino acid zwitterion;
homocysteine;
serine family amino acid		fundamental metabolite;
mouse metabolite
5-fluoro-2'-deoxycytidine[no description available]medium10
deoxycytidine[no description available]medium30pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
pyridoxine[no description available]medium10hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
penicillamine[no description available]medium10non-proteinogenic alpha-amino acid;
penicillamine		antirheumatic drug;
chelator;
copper chelator;
drug allergen
pyridoxal phosphate[no description available]medium30methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate		coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydrogen[no description available]medium10elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
2-deoxyribose 1-phosphate, (alpha-d-erythro)-isomer[no description available]medium202-deoxy-D-ribofuranose 1-phosphate
sodium dodecyl sulfate[no description available]medium10organic sodium saltdetergent;
protein denaturant
tegafur[no description available]medium70organohalogen compound;
pyrimidines
5-fluoropyrimidine[no description available]medium10
dipyridamole[no description available]medium20piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol		adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent
carboplatin[no description available]medium10
emitefur[no description available]medium10
ro 09-1390[no description available]medium10
oxonic acid[no description available]medium201,3,5-triazines;
monocarboxylic acid
s 1 (combination)[no description available]medium20
5-fluoroorotic acid[no description available]medium10
tyrosine[no description available]medium40amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
uftoral[no description available]medium10
histidine[no description available]medium20amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
1843u89[no description available]medium10
nolatrexed[no description available]medium30
1-methyluracil[no description available]medium10nucleobase analogue;
pyrimidone		metabolite
ethyl methanesulfonate[no description available]medium10methanesulfonate esteralkylating agent;
antineoplastic agent;
carcinogenic agent;
genotoxin;
mutagen;
teratogenic agent
nocodazole[no description available]medium10aromatic ketone;
benzimidazoles;
carbamate ester;
thiophenes		antimitotic;
antineoplastic agent;
microtubule-destabilising agent;
tubulin modulator
mimosine[no description available]medium10alpha-amino acid
hydroxyl radical[no description available]medium10oxygen hydride;
oxygen radical;
reactive oxygen species
dithionitrobenzoic acid[no description available]medium20nitrobenzoic acid;
organic disulfide		indicator
cladribine[no description available]medium10organochlorine compound;
purine 2'-deoxyribonucleoside		antineoplastic agent;
immunosuppressive agent
gemcitabine[no description available]medium10organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
cyclin d1[no description available]medium10
asparagine[no description available]medium10amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
5-ethyluracil[no description available]medium10
5-fluorodihydrouracil[no description available]medium10pyrimidone
proline[no description available]medium10amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
1,2-dimethylhydrazine[no description available]medium10hydrazinesalkylating agent;
carcinogenic agent
intrinsic factor[no description available]medium10
gimeracil[no description available]medium10organic molecular entity
n(4)-oleylcytosine arabinoside[no description available]medium10
picibanil[no description available]medium10penicillinate anion
pirenzepine[no description available]medium10pyridobenzodiazepineanti-ulcer drug;
antispasmodic drug;
muscarinic antagonist
telenzepine[no description available]medium10benzodiazepine
azides[no description available]medium20pseudohalide anionmitochondrial respiratory-chain inhibitor
arginine[no description available]medium20arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
adenosine[no description available]medium10adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
sepharose[no description available]medium20
cytosine[no description available]medium20aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
erythrosine[no description available]medium10
ethylmaleimide[no description available]medium20maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
3-methylcholanthrene[no description available]medium10ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
nickel[no description available]medium10metal allergen;
nickel group element atom		epitope;
micronutrient
semustine[no description available]medium10N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent
mitomycin[no description available]medium10mitomycinalkylating agent;
antineoplastic agent
phosphoribosyl pyrophosphate[no description available]medium205-O-phosphono-D-ribofuranosyl diphosphateEscherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite
brequinar[no description available]medium10biphenyls;
monocarboxylic acid;
monofluorobenzenes;
quinolinemonocarboxylic acid		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral agent;
EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor;
immunosuppressive agent;
pyrimidine synthesis inhibitor
cytidine triphosphate[no description available]medium10cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
hypoxanthine[no description available]medium10nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
deoxyuridine triphosphate[no description available]medium10deoxyuridine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate		Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite
potassium phosphate[no description available]medium10inorganic phosphate salt;
inorganic potassium salt
adenosine diphosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
ribose 1-phosphate[no description available]medium10D-ribose 1-phosphateEscherichia coli metabolite
7-hydroxymethotrexate[no description available]medium10folic acids
valine[no description available]medium10L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
adenosine monophosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
allopurinol[no description available]medium10nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
chlorpromazine[no description available]medium10organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
isomethyleugenol[no description available]medium10isomethyleugenol
deoxy-5-methylcytidylic acid[no description available]low002'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate
thymidine 5'-4-nitrophenyl phosphate[no description available]low00aryl phosphate;
C-nitro compound;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate
5-hydroxymethyldeoxycytidylic acid[no description available]low002'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome0low10
Abnormalities, Chromosomal0low10
Abnormalities, Chromosome0low10
Acute Myelogenous Leukemia0low20
Acute Myeloid Leukemia0low20
Acute Myeloid Leukemia with Maturation0low20
Acute Myeloid Leukemia without Maturation0low20
Acute Promyelocytic Leukemia0low10
Adenocarcinoma0low230
Adenocarcinoma, Basal Cell0low230
Adenocarcinoma, Granular Cell0low230
Adenocarcinoma, Oxyphilic0low230
Adenocarcinoma, Tubular0low230
Adenoma, Malignant0low230
Adult Optic Nerve Glioma0low10
AML M30low10
ANLL0low20
Anorexia0medium11
Ascites0low10
Astrocytoma, Malignant, Optic Nerve0low10
Autosome Abnormalities0low10
Benign Neoplasms0medium131
Bladder Cancer0low20
Bladder Neoplasms0low20
Bladder Tumors0low20
Body Weight0low50
Breast Cancer0medium101
Breast Carcinoma0medium101
Breast Neoplasms0medium101
Breast Tumors0medium101
Cancer0medium131
Cancer of Bladder0low20
Cancer of Breast0medium101
Cancer of Cecum0low10
Cancer of Colon0medium552
Cancer of ILEUM0low10
Cancer of Liver0low80
Cancer of Lung0medium61
Cancer of Ovary0low30
Cancer of Pancreas0medium51
Cancer of Prostate0low30
Cancer of Rectum0low60
Cancer of Sigmoid0low10
Cancer of Skin0low10
Cancer of Stomach0medium113
Cancer of Testis0low10
Cancer of the Bladder0low20
Cancer of the Breast0medium101
Cancer of the Cecum0low10
Cancer of the Colon0medium552
Cancer of the ILEUM0low10
Cancer of the Liver0low80
Cancer of the Lung0medium61
Cancer of the Ovary0low30
Cancer of the Pancreas0medium51
Cancer of the Prostate0low30
Cancer of the Rectum0low60
Cancer of the Sigmoid0low10
Cancer of the Skin0low10
Cancer of the Stomach0medium113
Cancer of the Testes0low10
Cancer of the Testis0low10
Cancer of the Uterus0low10
Cancer of Uterus0low10
Cancer, Cecal0low10
Cancer, Hepatocellular0low80
Cancer, Ileal0low10
Carcinoma0low50
Carcinoma 256, Walker0low40
Carcinoma, Anaplastic0low50
Carcinoma, Cribriform0low230
Carcinoma, Ehrlich Tumor0low90
Carcinoma, Epidermoid0low10
Carcinoma, Granular Cell0low230
Carcinoma, Hepatocellular0low30
Carcinoma, Non-Small Cell Lung0low20
Carcinoma, Non-Small-Cell Lung0low20
Carcinoma, Planocellular0low10
Carcinoma, Spindle-Cell0low50
Carcinoma, Squamous0low10
Carcinoma, Squamous Cell0low10
Carcinoma, Transitional Cell0low20
Carcinoma, Tubular0low230
Carcinoma, Undifferentiated0low50
Carcinomatosis0low50
Carcinosarcoma 256, Walker0low40
Cecal Cancer0low10
Cecal Neoplasms0low10
Cell Transformation, Neoplastic0low20
Childhood Optic Nerve Glioma0low10
Choriocarcinoma0low10
Chromosomal Aberrations0low10
Chromosome Aberrations0low10
Chromosome Abnormalities0low10
Colon Cancer0medium552
Colon Neoplasms0medium552
Colonic Cancer0medium552
Colonic Neoplasms0medium552
Colorectal Cancer0low140
Colorectal Carcinoma0low140
Colorectal Neoplasms0low140
Colorectal Tumors0low140
Cytogenetic Aberrations0low10
Cytogenetic Abnormalities0low10
Diarrhea0low10
Disease Models, Animal0low10
Ehrlich Ascites Tumor0low90
EHS Tumor0low30
Epithelial Neoplasms, Malignant0low50
Epithelial Tumors, Malignant0low50
Epithelioma0low50
Experimental Hepatoma0low40
Experimental Hepatomas0low40
Experimental Leukemia0low20
Experimental Leukemias0low20
Experimental Liver Neoplasms0low40
Experimental Mammary Neoplasms0low40
Experimental Neoplasms0low150
Experimental Sarcoma0low30
Experimental Sarcomas0low30
Extravascular Hemolysis0low10
Gastric Cancer0medium113
Gastric Cancer, Familial Diffuse0medium113
Gastric Neoplasms0medium113
Germinoblastoma0low50
Glioma, Optic Nerve0low10
Glioma, Optic Nerve, Adult0low10
Glioma, Optic Nerve, Childhood0low10
Haemolysis0low10
Hemolysis0low10
Hepatic Cancer0low80
Hepatic Neoplasms0low80
Hepatoblastoma0low10
Hepatocellular Cancer0low80
Hepatocellular Carcinoma0low30
Hepatoma0low30
Hepatoma, Experimental0low40
Hepatoma, Morris0low40
Hepatoma, Novikoff0low40
Hepatomas, Experimental0low40
Hormone-Dependent Neoplasms0low10
Human Mammary Carcinoma0medium101
Ileal Cancer0low10
Ileal Neoplasms0low10
Intravascular Hemolysis0low10
Kaposi Sarcoma0low10
Kaposi's Sarcoma0low10
Koch's Disease0low10
Kochs Disease0low10
Leucocythaemia0low10
Leucocythemia0low10
Leukemia0low10
Leukemia L 12100low220
Leukemia L12100low220
Leukemia Model, Animal0low20
Leukemia P3880low40
Leukemia, Acute Monocytic0low10
Leukemia, Acute Myelogenous0low20
Leukemia, Acute Myeloid0low20
Leukemia, Acute Promyelocytic0low10
Leukemia, Experimental0low20
Leukemia, Lymphocytic0low30
Leukemia, Lymphoid0low30
Leukemia, Monoblastic, Acute0low10
Leukemia, Monocytic, Acute0low10
Leukemia, Myeloblastic, Acute0low20
Leukemia, Myelocytic, Acute0low20
Leukemia, Myelogenous, Acute0low20
Leukemia, Myeloid, Acute0low20
Leukemia, Myeloid, Acute, M10low20
Leukemia, Myeloid, Acute, M20low20
Leukemia, Myeloid, Acute, M30low10
Leukemia, Myeloid, Acute, M50low10
Leukemia, Myeloid, Schilling Type0low10
Leukemia, Myeloid, Schilling-Type0low10
Leukemia, Nonlymphoblastic, Acute0low20
Leukemia, Nonlymphocytic, Acute0low20
Leukemia, Progranulocytic0low10
Leukemia, Promyelocytic, Acute0low10
Leukemias, Experimental0low20
Liver Cancer0low80
Liver Cancer, Adult0low30
Liver Cell Carcinoma0low30
Liver Cell Carcinoma, Adult0low30
Liver Neoplasms0low80
Liver Neoplasms, Experimental0low40
Lung Cancer0medium61
Lung Neoplasms0medium61
Lymphocytic Leukemia0low30
Lymphoid Leukemia0low30
Lymphoma0low50
Lymphoma, Malignant0low50
M3 ANLL0low10
Malignancy0medium131
Malignant Astrocytoma, Optic Nerve0low10
Malignant Epithelial Neoplasms0low50
Malignant Melanoma0low20
Malignant Neoplasm of Breast0medium101
Malignant Neoplasms0medium131
Malignant Optic Nerve Astrocytoma0low10
Malignant Tumor of Breast0medium101
Malignant Tumor of Urinary Bladder0low20
Mammary Cancer0medium101
Mammary Carcinoma, Human0medium101
Mammary Neoplasm, Human0medium101
Mammary Neoplasms, Experimental0low40
Mammary Neoplasms, Human0medium101
Maxillary Neoplasms0low10
Melanoma0low20
Metastase0low20
Metastases, Neoplasm0low20
Metastasis0low20
Metastasis, Neoplasm0low20
Monoblastic Leukemia, Acute0low10
Monocytic Leukemia, Acute0low10
Multiple Idiopathic Pigmented Hemangiosarcoma0low10
Multiple Primary Neoplasms0low10
Multiple Primary Neoplasms, Synchronous0low10
Mycobacterium tuberculosis Infection0low10
Myeloblastic Leukemia, Acute0low20
Myelocytic Leukemia, Acute0low20
Myelogenous Leukemia, Acute0low20
Myeloid Leukemia, Acute0low20
Myeloid Leukemia, Acute, M10low20
Myeloid Leukemia, Acute, M20low20
Myeloid Leukemia, Acute, M30low10
Myeloid Leukemia, Acute, M50low10
Myeloid Leukemia, Schilling-Type0low10
Neoplasia0medium131
Neoplasm0medium131
Neoplasm Metastases0low20
Neoplasm Metastasis0low20
Neoplasms0medium131
Neoplasms, Benign0medium131
Neoplasms, Bladder0low20
Neoplasms, Breast0medium101
Neoplasms, Cecal0low10
Neoplasms, Colonic0medium552
Neoplasms, Colorectal0low140
Neoplasms, Experimental0low150
Neoplasms, Experimental Liver0low40
Neoplasms, Experimental Mammary0low40
Neoplasms, Gastric0medium113
Neoplasms, Hepatic0low80
Neoplasms, Hormone-Dependent0low10
Neoplasms, Liver0low80
Neoplasms, Lung0medium61
Neoplasms, Malignant Epithelial0low50
Neoplasms, Multiple Primary0low10
Neoplasms, Ovarian0low30
Neoplasms, Pancreatic0medium51
Neoplasms, Prostate0low30
Neoplasms, Prostatic0low30
Neoplasms, Pulmonary0medium61
Neoplasms, Rectal0low60
Neoplasms, Sigmoid0low10
Neoplasms, Skin0low10
Neoplasms, Stomach0medium113
Neoplasms, Synchronous0low10
Neoplasms, Synchronous Multiple Primary0low10
Neoplasms, Testicular0low10
Neoplasms, Testis0low10
Neoplasms, Uterine0low10
Neoplasms, Uterus0low10
Neoplastic Cell Transformation0low20
Neoplastic Transformation, Cell0low20
Non-Small Cell Lung Cancer0low20
Non-Small Cell Lung Carcinoma0low20
Non-Small-Cell Lung Carcinoma0low20
Nonlymphoblastic Leukemia, Acute0low20
Nonlymphocytic Leukemia, Acute0low20
Nonsmall Cell Lung Cancer0low20
Optic Glioma0low10
Optic Nerve Glioma0low10
Optic Nerve Glioma, Adult0low10
Optic Nerve Glioma, Childhood0low10
Optic Nerve, Malignant Astrocytoma0low10
Ovarian Cancer0low30
Ovarian Neoplasms0low30
Ovary Cancer0low30
Ovary Neoplasms0low30
P388D(1) Leukemia0low40
Pancreas Cancer0medium51
Pancreas Neoplasms0medium51
Pancreatic Cancer0medium51
Pancreatic Neoplasms0medium51
Pregnancy0low10
Progranulocytic Leukemia0low10
Promyelocytic Leukemia, Acute0low10
Prostate Cancer0low30
Prostate Neoplasms0low30
Prostatic Cancer0low30
Prostatic Neoplasms0low30
Pulmonary Cancer0medium61
Pulmonary Neoplasms0medium61
Rectal Cancer0low60
Rectal Neoplasms0low60
Rectal Tumors0low60
Rectum Cancer0low60
Rectum Neoplasms0low60
Reticulolymphosarcoma0low50
Sarcoma0low10
Sarcoma 1800medium21
Sarcoma 180, Crocker0medium21
Sarcoma, Engelbreth-Holm-Swarm0low30
Sarcoma, Epithelioid0low10
Sarcoma, Experimental0low30
Sarcoma, Germinoblastic0low50
Sarcoma, Jensen0low30
Sarcoma, Kaposi0low10
Sarcoma, Soft Tissue0low10
Sarcoma, Spindle Cell0low10
Sarcomas, Experimental0low30
Sensitivity and Specificity0low50
Sigmoid Cancer0low10
Sigmoid Colon Cancer0low10
Sigmoid Colon Neoplasms0low10
Sigmoid Neoplasms0low10
Sigmoidal Cancer0low10
Skin Cancer0low10
Skin Neoplasms0low10
Squamous Cell Carcinoma0low10
Stomach Cancer0medium113
Stomach Neoplasms0medium113
Synchronous Multiple Primary Neoplasms0low10
Synchronous Neoplasms0low10
Teratocarcinoma0low10
Testicular Cancer0low10
Testicular Neoplasm0low10
Testicular Neoplasms0low10
Testicular Tumor0low10
Testicular Tumors0low10
Testis Cancer0low10
Testis Neoplasms0low10
Transformation, Neoplastic Cell0low20
Tuberculosis0low10
Tumor of Rete Testis0low10
Tumorigenic Transformation0low20
Tumors0medium131
Tumors, Breast0medium101
Urinary Bladder Cancer0low20
Urinary Bladder Neoplasms0low20
Uterine Cancer0low10
Uterine Neoplasms0low10
Uterus Cancer0low10
Uterus Neoplasms0low10
Weight Loss0low10
Weight Reduction0low10

Research Highlights

Safety/Toxicity (12)

ArticleYear
Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells.
International journal of cancer, Nov-01, Volume: 131, Issue: 9		2012
Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment.
Acta oncologica (Stockholm, Sweden), Volume: 40, Issue: 5		2001
Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
The Journal of organic chemistry, Aug-24, Volume: 66, Issue: 17		2001
Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats.
Cancer chemotherapy and pharmacology, Volume: 46, Issue: 1		2000
Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
Nucleosides & nucleotides, Volume: 18, Issue: 8		1999
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
Oncology research, Volume: 9, Issue: 2		1997
Differentially potentiating effects by dipyridamole on cytotoxicity of 5-fluorouracil against three human maxillary cancer cell lines derived from a single tumor.
Anti-cancer drug design, Volume: 8, Issue: 4		1993
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Cancer research, Volume: 42, Issue: 9		1982
Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.
British journal of cancer, Volume: 60, Issue: 3		1989
Calcium leucovorin and 5-fluorouridine cytotoxicity.
Journal of the South Carolina Medical Association (1975), Volume: 86, Issue: 5		1990
In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines.
Cancer chemotherapy and pharmacology, Volume: 30, Issue: 6		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (1)

ArticleYear
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (3)

ArticleYear
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.
Journal of cancer research and clinical oncology, Volume: 125, Issue: 12		1999
18F-radiopharmacokinetics of [18F]-5-fluorouracil in a mouse bearing two colon tumors with a different 5-fluorouracil sensitivity: a study for a correlation with oncological results.
Nuclear medicine and biology, Volume: 23, Issue: 3		1996
Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.
British journal of cancer, Volume: 60, Issue: 3		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.
Journal of medicinal chemistry, 04-28, Volume: 59, Issue: 8		2016
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (6)

ArticleYear
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma.
Molecular cancer, 01-06, Volume: 20, Issue: 1		2021
Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
Antisense & nucleic acid drug development, Volume: 9, Issue: 5		1999
Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP): a strategy to introduce nucleotides into cells.
Journal of medicinal chemistry, Nov-11, Volume: 37, Issue: 23		1994
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Cancer, Mar-15, Volume: 45, Issue: 5 Suppl		1980
Synthesis and biological evaluation of neutral derivatives of 5-fluoro-2'-deoxyuridine 5'-phosphate.
Journal of medicinal chemistry, Volume: 26, Issue: 8		1983
Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo.
Cancer research, May-15, Volume: 49, Issue: 10		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]