idoxuridine has been researched along with Astrocytoma, Grade IV in 26 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to evaluate the effect of resveratrol on cytogenetic damages of iododeoxyuridine (IUdR) and x-ray megavoltage radiation (6 MV) in spheroid model of U87MG glioblastoma cancer cell line using clonogenic and alkaline comet assay." | 7.81 | Role of resveratrol on the cytotoxic effects and DNA damages of iododeoxyuridine and megavoltage radiation in spheroid culture of U87MG glioblastoma cell line. ( Firouzi, F; Khoei, S; Mirzaei, HR, 2015) |
| ") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma." | 7.72 | Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004) |
| "The purpose of this study was to evaluate the effect of resveratrol on cytogenetic damages of iododeoxyuridine (IUdR) and x-ray megavoltage radiation (6 MV) in spheroid model of U87MG glioblastoma cancer cell line using clonogenic and alkaline comet assay." | 3.81 | Role of resveratrol on the cytotoxic effects and DNA damages of iododeoxyuridine and megavoltage radiation in spheroid culture of U87MG glioblastoma cell line. ( Firouzi, F; Khoei, S; Mirzaei, HR, 2015) |
| ") injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma." | 3.72 | Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts. ( Adamer, F; Buchegger, F; de Tribolet, N; Delaloye, AB; Dupertuis, YM; Grannavel, C; Kosinski, M; Mach, JP; Schaffland, AO, 2004) |
| "Twenty-one patients had Grade 3 (anaplastic astrocytoma) tumors and 18 patients had Grade 4 (glioblastoma multiforme)." | 2.67 | National Cancer Institute (phase II) study of high-grade glioma treated with accelerated hyperfractionated radiation and iododeoxyuridine: results in anaplastic astrocytoma. ( Cook, JA; Epstein, AH; Goffman, TE; Herscher, LL; Kinsella, TJ; Mitchell, JB; Oldfield, EH; Smith, J; Steinberg, SM; Sullivan, FJ, 1994) |
| " The purpose of this study is to measure the effect of different drug dosing schedules on tumor radiosensitization and therapeutic index in human glioblastoma xenografts." | 1.33 | Schedule-dependent drug effects of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as an in vivo radiosensitizer in U251 human glioblastoma xenografts. ( Kinsella, TJ; Radivoyevitch, T; Schupp, JE; Seo, Y; Yan, T, 2005) |
| "To facilitate cell kinetics studies of brain tumors labeled with thymidine analogs, we developed a new method to identify nuclei labeled sequentially with bromodeoxyuridine (BUdR) and iododeoxyuridine (IUdR) by double staining with immunogold-silver and alkaline phosphatase." | 1.29 | Immunohistochemical double staining with immunogold-silver and alkaline phosphatase to identify nuclear markers of cellular proliferation. ( Davis, RL; Hoshino, T; Ito, S; Shibuya, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 11 (42.31) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rezaie, P | 1 |
| Khoei, S | 2 |
| Khoee, S | 1 |
| Shirvalilou, S | 1 |
| Mahdavi, SR | 1 |
| Firouzi, F | 1 |
| Mirzaei, HR | 1 |
| Frum, RA | 1 |
| Khondker, ZS | 1 |
| Kaufman, DG | 1 |
| Jang, SJ | 1 |
| Kang, JH | 1 |
| Kim, KI | 1 |
| Lee, TS | 1 |
| Lee, YJ | 1 |
| Lee, KC | 1 |
| Woo, KS | 1 |
| Chung, WS | 1 |
| Kwon, HC | 1 |
| Ryu, CJ | 1 |
| Choi, TH | 1 |
| Choi, CW | 1 |
| Lim, SM | 1 |
| Cheon, GJ | 1 |
| Buchegger, F | 7 |
| Vieira, JM | 1 |
| Blaeuenstein, P | 1 |
| Dupertuis, YM | 7 |
| Schaffland, AO | 3 |
| Grannavel, C | 2 |
| de Tribolet, N | 5 |
| Slosman, DO | 3 |
| Bischof Delaloye, A | 2 |
| Pichard, C | 3 |
| Adamer, F | 1 |
| Kosinski, M | 1 |
| Mach, JP | 2 |
| Delaloye, AB | 2 |
| Seo, Y | 1 |
| Yan, T | 1 |
| Schupp, JE | 1 |
| Radivoyevitch, T | 1 |
| Kinsella, TJ | 6 |
| Perillo-Adamer, F | 1 |
| Genton, CS | 1 |
| Sullivan, FJ | 1 |
| Herscher, LL | 1 |
| Cook, JA | 1 |
| Smith, J | 1 |
| Steinberg, SM | 3 |
| Epstein, AH | 1 |
| Oldfield, EH | 2 |
| Goffman, TE | 2 |
| Mitchell, JB | 3 |
| Shibuya, M | 1 |
| Ito, S | 1 |
| Davis, RL | 1 |
| Hoshino, T | 1 |
| Vokes, EE | 1 |
| Dolan, ME | 1 |
| Krishnasamy, S | 1 |
| Mick, R | 1 |
| Ratain, MJ | 1 |
| Berezin, F | 1 |
| Brachman, D | 1 |
| Whitman, G | 1 |
| Schilsky, RL | 1 |
| Charette, J | 1 |
| Urtasun, RC | 2 |
| Cosmatos, D | 1 |
| DelRowe, J | 1 |
| Lester, S | 1 |
| Wasserman, T | 1 |
| Fulton, DS | 2 |
| Farnan, N | 1 |
| DelRowe, JD | 1 |
| Lester, SG | 1 |
| Phillips, TL | 1 |
| Neshasteh-Riz, A | 1 |
| Angerson, WJ | 1 |
| Reeves, JR | 1 |
| Smith, G | 1 |
| Rampling, R | 1 |
| Mairs, RJ | 1 |
| Williams, JA | 1 |
| Yuan, X | 1 |
| Dillehay, LE | 1 |
| Shastri, VR | 1 |
| Brem, H | 1 |
| Williams, JR | 1 |
| Xiao, WH | 2 |
| Mermillod, B | 1 |
| Sun, LQ | 1 |
| Vazquez, M | 1 |
| Dachowski, LJ | 1 |
| Bobo, H | 1 |
| Cook, J | 1 |
| Katz, D | 3 |
| Smith, R | 1 |
| Glatstein, E | 3 |
| Miller, MA | 1 |
| Bokhari, SA | 1 |
| Qadir, K | 1 |
| Raza, A | 1 |
| Goodman, JH | 1 |
| Gahbauer, RA | 1 |
| Kanellitsas, C | 1 |
| Clendenon, NR | 1 |
| Laster, BH | 1 |
| Fairchild, RG | 1 |
| Jackson, D | 1 |
| Kinsella, T | 1 |
| Rowland, J | 3 |
| Wright, D | 3 |
| Main, D | 1 |
| Collins, J | 2 |
| Kornblith, P | 1 |
| Klecker, R | 1 |
| Glastein, E | 1 |
| Russo, A | 1 |
| Collins, JM | 1 |
6 trials available for idoxuridine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
National Cancer Institute (phase II) study of high-grade glioma treated with accelerated hyperfractionated radiation and iododeoxyuridine: results in anaplastic astrocytoma.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Humans; | 1994 |
5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chemotherapy, Adjuvant; Dr | 1993 |
Iododeoxyuridine (IUdR) combined with radiation in the treatment of malignant glioma: a comparison of short versus long intravenous dose schedules (RTOG 86-12).
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Drug Administratio | 1993 |
Survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: final report of RTOG 86-12, Phase I-II study.
Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Glioblastoma; Humans; Idoxuridine; Middle Aged; | 1996 |
Long-term follow-up on National Cancer Institute Phase I/II study of glioblastoma multiforme treated with iododeoxyuridine and hyperfractionated irradiation.
Topics: Adult; Aged; Brain Neoplasms; Drug Evaluation; Follow-Up Studies; Glioblastoma; Humans; Idoxuridine; | 1992 |
Halogenated pyrimidines as radiosensitizers in the treatment of glioblastoma multiforme.
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Drug Evaluation; Female; Glioblastoma; Humans; Idox | 1987 |
20 other studies available for idoxuridine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Evaluation of combined effect of hyperthermia and ionizing radiation on cytotoxic damages induced by IUdR-loaded PCL-PEG-coated magnetic nanoparticles in spheroid culture of U87MG glioblastoma cell line.
Topics: Biological Transport; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Drug Carriers | 2018 |
Role of resveratrol on the cytotoxic effects and DNA damages of iododeoxyuridine and megavoltage radiation in spheroid culture of U87MG glioblastoma cell line.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; Dose-Re | 2015 |
Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cells.
Topics: Aphidicolin; Cell Line, Tumor; DNA; DNA Replication; Fibroblasts; Glioblastoma; Humans; Idoxuridine; | 2009 |
Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Rela | 2010 |
Preclinical Auger and gamma radiation dosimetry for fluorodeoxyuridine-enhanced tumour proliferation scintigraphy with [123I]iododeoxyuridine.
Topics: Animals; Body Burden; Computer Simulation; DNA, Neoplasm; Drug Evaluation, Preclinical; Drug Synergi | 2003 |
A balanced deoxyribonucleoside mixture increased the rate of DNA incorporation of 5-[125I]Iodo-2'-deoxyuridine in glioblastoma cells.
Topics: Cell Count; Cell Cycle; Deoxyribonucleosides; DNA; Flow Cytometry; Genes, p53; Glioblastoma; Humans; | 2003 |
Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts.
Topics: Animals; Brain Neoplasms; DNA; Floxuridine; Glioblastoma; Humans; Idoxuridine; Iodine Radioisotopes; | 2004 |
Schedule-dependent drug effects of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as an in vivo radiosensitizer in U251 human glioblastoma xenografts.
Topics: Administration, Oral; Animals; Area Under Curve; DNA, Neoplasm; Dose-Response Relationship, Drug; Dr | 2005 |
Short fluorodeoxyuridine exposure of different human glioblastoma lines induces high-level accumulation of S-phase cells that avidly incorporate 125I-iododeoxyuridine.
Topics: Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Floxuridine; Glioblastoma; Humans; I | 2006 |
Immunohistochemical double staining with immunogold-silver and alkaline phosphatase to identify nuclear markers of cellular proliferation.
Topics: Alkaline Phosphatase; Biomarkers; Brain Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Division; Cel | 1993 |
Comment on "survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: final report of RTOG 86-12, Phase I-II Study".
Topics: Glioblastoma; Humans; Idoxuridine; Radiation-Sensitizing Agents | 1996 |
Incorporation of iododeoxyuridine in multicellular glioma spheroids: implications for DNA-targeted radiotherapy using Auger electron emitters.
Topics: Antigens, Neoplasm; Antimetabolites; Brain Neoplasms; Glioblastoma; Humans; Idoxuridine; Ki-67 Antig | 1997 |
Synthetic, implantable polymers for local delivery of IUdR to experimental human malignant glioma.
Topics: Animals; Antimetabolites; Brain Neoplasms; Cell Division; Delayed-Action Preparations; Drug Carriers | 1998 |
Unlabelled iododeoxyuridine increases the cytotoxicity and incorporation of [1251]-iododeoxyuridine in two human glioblastoma cell lines.
Topics: Binding, Competitive; Cell Survival; DNA, Neoplasm; Glioblastoma; Humans; Idoxuridine; Iodine Radioi | 2000 |
Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine.
Topics: Animals; Brain Neoplasms; Cell Cycle; DNA, Neoplasm; Drug Synergism; Floxuridine; Glioblastoma; Huma | 2001 |
Unlabelled iododeoxyuridine increases the rate of uptake of [125I]iododeoxyuridine in human xenografted glioblastomas.
Topics: Animals; Cell Cycle; Disease Models, Animal; DNA, Neoplasm; Glioblastoma; Humans; Idoxuridine; In Vi | 2002 |
Simultaneous assessment of TGFB and cell cycle kinetics using IUdR/BrdU infusions in human neoplasms from plastic-embedded tissue.
Topics: Antibodies, Monoclonal; Biopsy; Bone Marrow; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Coloni | 1992 |
Theoretical basis and clinical methodology for stereotactic interstitial brain tumor irradiation using iododeoxyuridine as a radiation sensitizer and 145Sm as a brachytherapy source.
Topics: Brachytherapy; Brain Neoplasms; Glioblastoma; Humans; Idoxuridine; Radiation-Sensitizing Agents; Rad | 1990 |
Pharmacology and phase I/II study of continuous intravenous infusions of iododeoxyuridine and hyperfractionated radiotherapy in patients with glioblastoma multiforme.
Topics: Adult; Aged; Combined Modality Therapy; Drug Evaluation; Female; Follow-Up Studies; Glioblastoma; Hu | 1988 |
A phase I study of intravenous iododeoxyuridine as a clinical radiosensitizer.
Topics: Biopsy; Drug Evaluation; Duodenal Neoplasms; Glioblastoma; Humans; Idoxuridine; Liver Neoplasms; Rad | 1985 |