5-hydroxy-2'-deoxyuridine: a major oxidation product of 2'-deoxycytidine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 96622 |
| CHEMBL ID | 223557 |
| SCHEMBL ID | 530100 |
| MeSH ID | M0200128 |
| Synonym |
|---|
| 5-hydroxy-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1h-pyrimidine-2,4-dione |
| 5-hydroxy-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione |
| 5168-36-5 |
| CHEMBL223557 |
| 5-hydroxy-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| 2'-deoxy-5-hydroxyuridine |
| uridine, 2'-deoxy-5-hydroxy- |
| 5-hydroxy-2'-deoxyuridine |
| oh-5-du |
| nsc 82265 |
| SCHEMBL530100 |
| UIJSURSVLVISBO-UBKIQSJTSA-N |
| 5-hydroxy-1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione |
| HY-130801 |
| 5-hydroxy-2-deoxyuridine |
| mfcd00057414 |
| 5-ohdu |
| CS-0114103 |
| MS-23451 |
| A930124 |
| STARBLD0009508 |
| PD157353 |
| AKOS040744150 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1135597 | Antiviral activity against Herpes simplex virus 1 KOS infected in primary rabbit kidney cells assessed as inhibition of virus-induced cytopathogenicity | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | 5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine. |
| AID458877 | Cytotoxicity against human MT4 cells by MTT assay | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | 5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity. |
| AID280941 | Cytotoxicity against mouse L1210/0 cells after 48 hrs | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7 | Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set. |
| AID458874 | Antiviral activity against HIV1 LAI in human CEM-SS cells assessed as RT activity after 5 days by single passage assay | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | 5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity. |
| AID458876 | Antiviral activity against HIV1 3B in human MT4 cells assessed as RT activity after 5 days by single passage assay | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | 5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity. |
| AID1135595 | Antiviral activity against Vaccinia virus infected in primary rabbit kidney cells assessed as inhibition of virus-induced cytopathogenicity | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | 5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine. |
| AID1135596 | Antiviral activity against Vaccinia virus infected in human skin fibroblasts primed with interferon and superinduced with cyclohexamide and actinomycin D assessed as inhibition of virus-induced cytopathogenicity | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | 5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine. |
| AID458875 | Cytotoxicity against human CEM-SS cells by MTT assay | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 | 5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity. |
| AID1135598 | Antiviral activity against Herpes simplex virus 1 KOS infected in human skin fibroblasts primed with interferon and superinduced with cyclohexamide and actinomycin D assessed as inhibition of virus-induced cytopathogenicity | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | 5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||