Page last updated: 2024-12-07

5'-amino-5-iodo-2',5'-dideoxyuridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID124317
CHEMBL ID1790057
SCHEMBL ID1045657
MeSH IDM0075959

Synonyms (16)

Synonym
1-[(2r,4s,5r)-5-(aminomethyl)-4-hydroxy-tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione
1-((2r,4s,5r)-5-aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-5-iodo-2,4(1h,3h)-pyrimidinedione
5'-nh2-iddurd
aiddu
5'-amino-2',5'-dideoxy-5-iodouridine
aidu
uridine, 5'-amino-2',5'-dideoxy-5-iodo-
aidurd
56045-73-9
CHEMBL1790057
5'-amino-5-iodo-2',5'-dideoxyuridine
5-iodo-5'-amino-2',5'-dideoxyuridine
SCHEMBL1045657
1-((2r,4s,5r)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1h,3h)-dione
1-(5-amino-2,5-dideoxypentofuranosyl)-4-hydroxy-5-iodopyrimidin-2(1h)-one
DTXSID90971417
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1145769Cytotoxicity against mouse Sarcoma 180 cells assessed as cell viability at 200 uM after 18 to 24 hrs relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1131483Antiviral activity against HSV1 CL101 infected in African green monkey Vero cells assessed as plaque forming unit at 200 uM after 40 hrs relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID1136031Cytotoxicity against mouse L1210 cells at 400 uM after 1 day1979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1145908Cytotoxicity against African green monkey Vero cells after 3 days by haemocytometer analysis1976Journal of medicinal chemistry, Jul, Volume: 19, Issue:7
Synthesis and biological activities of 5-trifluoromethyl-5'-azido-2',5'-dideoxyuridine and 5-trifluoromethyl-5'-amino-2',5'-dideoxyuridine.
AID1136032Antiviral activity against HSV11979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1145770Antiviral activity against Herpes simplex virus 1 infected in African green monkey Vero cells assessed as viral titer at 200 uM after 40 hrs by plaque formation assay relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1145767Cytotoxicity against mouse Sarcoma 180 cells assessed as cell viability at 400 uM after 18 to 24 hrs relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1136033Inhibition of Herpesvirus 1 pyrimidine 2'-deoxyribonucleoside kinase by double reciprocal plot analysis in presence of thymidine1979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1136030Cytotoxicity against mouse S180 cells at 400 uM after 1 day1979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1131497Cytotoxicity against mouse S180 cells at 200 uM after 18 to 42 hrs relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID1131490Cytotoxicity against African green monkey Vero cells at 200 uM after 3 days by haemocytometry1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID85425Antiviral activity against herpes simplex virus type I was measured at 200 uM concentration.1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID162825Kinetic inhibition constant against herpes simplex virus type I pyrimidine deoxyribonucleoside kinase was measured1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID1145766Cytotoxicity against African green monkey Vero cells assessed as inhibition of replication1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1145765Antiviral activity against Herpes simplex virus 1 infected in African green monkey Vero cells assessed as viral titer at 400 uM after 40 hrs by plaque formation assay relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-199021 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.36 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (9.52%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (90.48%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]