5'-amino-5-iodo-2',5'-dideoxyuridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	124317
CHEMBL ID	1790057
SCHEMBL ID	1045657
MeSH ID	M0075959

Synonyms (16)

Synonym
1-[(2r,4s,5r)-5-(aminomethyl)-4-hydroxy-tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione
1-((2r,4s,5r)-5-aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-5-iodo-2,4(1h,3h)-pyrimidinedione
5'-nh2-iddurd
aiddu
5'-amino-2',5'-dideoxy-5-iodouridine
aidu
uridine, 5'-amino-2',5'-dideoxy-5-iodo-
aidurd
56045-73-9
CHEMBL1790057
5'-amino-5-iodo-2',5'-dideoxyuridine
5-iodo-5'-amino-2',5'-dideoxyuridine
SCHEMBL1045657
1-((2r,4s,5r)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1h,3h)-dione
1-(5-amino-2,5-dideoxypentofuranosyl)-4-hydroxy-5-iodopyrimidin-2(1h)-one
DTXSID90971417

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID1145769	Cytotoxicity against mouse Sarcoma 180 cells assessed as cell viability at 200 uM after 18 to 24 hrs relative to control	1976	Journal of medicinal chemistry, Apr, Volume: 19, Issue:4	Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1131483	Antiviral activity against HSV1 CL101 infected in African green monkey Vero cells assessed as plaque forming unit at 200 uM after 40 hrs relative to control	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID1136031	Cytotoxicity against mouse L1210 cells at 400 uM after 1 day	1979	Journal of medicinal chemistry, Oct, Volume: 22, Issue:10	Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1145908	Cytotoxicity against African green monkey Vero cells after 3 days by haemocytometer analysis	1976	Journal of medicinal chemistry, Jul, Volume: 19, Issue:7	Synthesis and biological activities of 5-trifluoromethyl-5'-azido-2',5'-dideoxyuridine and 5-trifluoromethyl-5'-amino-2',5'-dideoxyuridine.
AID1136032	Antiviral activity against HSV1	1979	Journal of medicinal chemistry, Oct, Volume: 22, Issue:10	Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1145770	Antiviral activity against Herpes simplex virus 1 infected in African green monkey Vero cells assessed as viral titer at 200 uM after 40 hrs by plaque formation assay relative to control	1976	Journal of medicinal chemistry, Apr, Volume: 19, Issue:4	Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1145767	Cytotoxicity against mouse Sarcoma 180 cells assessed as cell viability at 400 uM after 18 to 24 hrs relative to control	1976	Journal of medicinal chemistry, Apr, Volume: 19, Issue:4	Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1136033	Inhibition of Herpesvirus 1 pyrimidine 2'-deoxyribonucleoside kinase by double reciprocal plot analysis in presence of thymidine	1979	Journal of medicinal chemistry, Oct, Volume: 22, Issue:10	Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1136030	Cytotoxicity against mouse S180 cells at 400 uM after 1 day	1979	Journal of medicinal chemistry, Oct, Volume: 22, Issue:10	Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1131497	Cytotoxicity against mouse S180 cells at 200 uM after 18 to 42 hrs relative to control	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID1131490	Cytotoxicity against African green monkey Vero cells at 200 uM after 3 days by haemocytometry	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID85425	Antiviral activity against herpes simplex virus type I was measured at 200 uM concentration.	1980	Journal of medicinal chemistry, Feb, Volume: 23, Issue:2	Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID162825	Kinetic inhibition constant against herpes simplex virus type I pyrimidine deoxyribonucleoside kinase was measured	1980	Journal of medicinal chemistry, Feb, Volume: 23, Issue:2	Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID1145766	Cytotoxicity against African green monkey Vero cells assessed as inhibition of replication	1976	Journal of medicinal chemistry, Apr, Volume: 19, Issue:4	Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1145765	Antiviral activity against Herpes simplex virus 1 infected in African green monkey Vero cells assessed as viral titer at 400 uM after 40 hrs by plaque formation assay relative to control	1976	Journal of medicinal chemistry, Apr, Volume: 19, Issue:4	Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	21 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.36 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.36)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (9.52%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (90.48%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	3.05	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
thymidine [no description available]	5.17	9	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
floxuridine Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.. floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.	1.95	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; radiosensitizing agent
idoxuridine [no description available]	5.82	18	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	4.26	3	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
cytarabine [no description available]	3.97	2	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
trifluridine Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.	1.95	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor
deoxycytidine [no description available]	1.95	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
deoxyuridine [no description available]	3.05	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
arabinofuranosyluracil [no description available]	1.95	1	N-glycosyl compound	metabolite
vidarabine adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.	3.46	2	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic
ribavirin Rebetron: Rebetron is tradename	3.97	2	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
fiacitabine fiacitabine: anti-herpes virus agent which also inhibits growth of certain human tumor cell lines in vitro.	3.97	2
thymine arabinoside thymine arabinoside: selectively inhibits replication of herpes simplex virus	3.46	2	N-glycosyl compound
ibacitabine ibacitabine: antiherpetic agent	1.95	1	pyrimidine 2'-deoxyribonucleoside
5'-amino-2',5'-dideoxythymidine 5'-amino-5'-deoxythymidine: RN given refers to parent cpd	3.97	4
edoxudin [no description available]	3.05	1	pyrimidine 2'-deoxyribonucleoside
5-hydroxymethyl-2'-deoxyuridine [no description available]	1.95	1	pyrimidine 2'-deoxyribonucleoside
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	1.96	1
9-(2,3-dihydroxypropyl)adenine [no description available]	3.05	1
brivudine brivudine: anti-herpes agent	4.26	3
cyclouridine cyclouridine: structure given in third source	1.95	1
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	4.26	3	2-aminopurines; oxopurine	antimetabolite; antiviral drug
guanine [no description available]	3.46	2	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	1.95	1
Sarcoma 180 An experimental sarcoma of mice.	3.05	5
Leukemia L 1210 [description not available]	2.65	3
B Virus Infection [description not available]	2.87	1
Viral Diseases [description not available]	2.87	1
Virus Diseases A general term for diseases caused by viruses.	2.87	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.96	1
Gingivostomatitis, Herpetic [description not available]	2.36	2
Stomatitis, Herpetic Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.	2.36	2
Herpes Simplex Virus Infection [description not available]	6.96	1
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	6.96	1
Cold Sore [description not available]	1.95	1
Herpes Labialis Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)	1.95	1
Cell Transformation, Viral An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.	1.95	1

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