Compounds > 5'-amino-5-iodo-2',5'-dideoxyuridine
Page last updated: 2024-12-07

5'-amino-5-iodo-2',5'-dideoxyuridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID124317
CHEMBL ID1790057
SCHEMBL ID1045657
MeSH IDM0075959

Synonyms (16)

Synonym
1-[(2r,4s,5r)-5-(aminomethyl)-4-hydroxy-tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione
1-((2r,4s,5r)-5-aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-5-iodo-2,4(1h,3h)-pyrimidinedione
5'-nh2-iddurd
aiddu
5'-amino-2',5'-dideoxy-5-iodouridine
aidu
uridine, 5'-amino-2',5'-dideoxy-5-iodo-
aidurd
56045-73-9
CHEMBL1790057
5'-amino-5-iodo-2',5'-dideoxyuridine
5-iodo-5'-amino-2',5'-dideoxyuridine
SCHEMBL1045657
1-((2r,4s,5r)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1h,3h)-dione
1-(5-amino-2,5-dideoxypentofuranosyl)-4-hydroxy-5-iodopyrimidin-2(1h)-one
DTXSID90971417
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1145769Cytotoxicity against mouse Sarcoma 180 cells assessed as cell viability at 200 uM after 18 to 24 hrs relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1131483Antiviral activity against HSV1 CL101 infected in African green monkey Vero cells assessed as plaque forming unit at 200 uM after 40 hrs relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID1136031Cytotoxicity against mouse L1210 cells at 400 uM after 1 day1979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1145908Cytotoxicity against African green monkey Vero cells after 3 days by haemocytometer analysis1976Journal of medicinal chemistry, Jul, Volume: 19, Issue:7
Synthesis and biological activities of 5-trifluoromethyl-5'-azido-2',5'-dideoxyuridine and 5-trifluoromethyl-5'-amino-2',5'-dideoxyuridine.
AID1136032Antiviral activity against HSV11979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1145770Antiviral activity against Herpes simplex virus 1 infected in African green monkey Vero cells assessed as viral titer at 200 uM after 40 hrs by plaque formation assay relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1145767Cytotoxicity against mouse Sarcoma 180 cells assessed as cell viability at 400 uM after 18 to 24 hrs relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1136033Inhibition of Herpesvirus 1 pyrimidine 2'-deoxyribonucleoside kinase by double reciprocal plot analysis in presence of thymidine1979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1136030Cytotoxicity against mouse S180 cells at 400 uM after 1 day1979Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
AID1131497Cytotoxicity against mouse S180 cells at 200 uM after 18 to 42 hrs relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID1131490Cytotoxicity against African green monkey Vero cells at 200 uM after 3 days by haemocytometry1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID85425Antiviral activity against herpes simplex virus type I was measured at 200 uM concentration.1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID162825Kinetic inhibition constant against herpes simplex virus type I pyrimidine deoxyribonucleoside kinase was measured1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID1145766Cytotoxicity against African green monkey Vero cells assessed as inhibition of replication1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
AID1145765Antiviral activity against Herpes simplex virus 1 infected in African green monkey Vero cells assessed as viral titer at 400 uM after 40 hrs by plaque formation assay relative to control1976Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-199021 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.36 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (9.52%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (90.48%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		3.05106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
thymidine
[no description available]		5.1790pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
floxuridine
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.. floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.		1.9510nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
radiosensitizing agent
idoxuridine
[no description available]		5.82180organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.		4.2630pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
cytarabine
[no description available]		3.9720beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
trifluridine
Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.		1.9510nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor
deoxycytidine
[no description available]		1.9510pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
deoxyuridine
[no description available]		3.0510pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
arabinofuranosyluracil
[no description available]		1.9510N-glycosyl compoundmetabolite
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		3.4620beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
ribavirin
Rebetron: Rebetron is tradename		3.97201-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
fiacitabine
fiacitabine: anti-herpes virus agent which also inhibits growth of certain human tumor cell lines in vitro.		3.9720
thymine arabinoside
thymine arabinoside: selectively inhibits replication of herpes simplex virus		3.4620N-glycosyl compound
ibacitabine
ibacitabine: antiherpetic agent		1.9510pyrimidine 2'-deoxyribonucleoside
5'-amino-2',5'-dideoxythymidine
5'-amino-5'-deoxythymidine: RN given refers to parent cpd		3.9740
edoxudin
[no description available]		3.0510pyrimidine 2'-deoxyribonucleoside
5-hydroxymethyl-2'-deoxyuridine
[no description available]		1.9510pyrimidine 2'-deoxyribonucleoside
deoxyglucose
Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.		1.9610
9-(2,3-dihydroxypropyl)adenine
[no description available]		3.0510
brivudine
brivudine: anti-herpes agent		4.2630
cyclouridine
cyclouridine: structure given in third source		1.9510
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		4.26302-aminopurines;
oxopurine		antimetabolite;
antiviral drug
guanine
[no description available]		3.46202-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		01.9510
Sarcoma 180
An experimental sarcoma of mice.		03.0550
Leukemia L 1210
[description not available]		02.6530
B Virus Infection
[description not available]		02.8710
Viral Diseases
[description not available]		02.8710
Virus Diseases
A general term for diseases caused by viruses.		02.8710
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9610
Gingivostomatitis, Herpetic
[description not available]		02.3620
Stomatitis, Herpetic
Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.		02.3620
Herpes Simplex Virus Infection
[description not available]		06.9610
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		06.9610
Cold Sore
[description not available]		01.9510
Herpes Labialis
Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)		01.9510
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.		01.9510