Bird Pox

A poxvirus infection of poultry and other birds characterized by the formation of wart-like nodules on the skin and diphtheritic necrotic masses (cankers) in the upper digestive and respiratory tracts.

Synonym
Bird Pox
Fowlpox
Variola Avium
Birdpox
Fowl Diphtheria
Epithelioma Contagiosum
Fowl Pox

Excerpt	Reference
"Cutaneous fowlpox is a disease of chickens and turkeys caused by the fowlpox virus (FWPV), characterized by the development of proliferative lesions and scabs on unfeathered areas."	( Bilic, I; Hess, M; Liebhart, D; Matos, M; Mitsch, P; Palmieri, N; Sommer, F; Tvarogová, J, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	14 (58.33)	23.3326
1990's	3 (12.50)	12.5806
2000's	3 (12.50)	18.1394
2010's	2 (8.33)	28.8240
2020's	2 (8.33)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	1
thymidine	low	2
idoxuridine	low	1
sucrose	low	1
cycloheximide	low	1
phencyclidine	low	1
acridines	low	1
nandrolone	low	1
spectinomycin	low	2
phenyl acetate	low	1
pyrimidine dimers	low	2
lincomycin	low	2
alpha-chymotrypsin	low	1
phosphorus	low	1
beta-escin	low	1
thimerosal	low	1
cyclic guanosine monophosphate-adenosine monophosphate	low	1
eye	low	2

Protein Targets (315)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Ferritin light chain	1	0	0	1
thioredoxin reductase	4	0	0	4
TDP1 protein	5	0	0	5
Microtubule-associated protein tau	2	0	0	2
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
alpha-galactosidase	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
flap endonuclease 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
DNA topoisomerase 2-alpha	0	0	0	1
Acetylcholinesterase	0	2	0	2
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
RAR-related orphan receptor gamma	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
estrogen nuclear receptor alpha	7	0	0	7
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Interferon regulatory factor 3	0	0	1	1
Stimulator of interferon genes protein	0	0	2	2
Stimulator of interferon genes protein	0	1	2	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
interleukin 8	1	0	0	1
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	2	0	0	2
ATAD5 protein, partial	1	0	0	1
Fumarate hydratase	2	0	0	2
USP1 protein, partial	2	0	0	2
PPM1D protein	1	0	0	1
GLI family zinc finger 3	3	0	0	3
AR protein	5	0	0	5
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	1	0	0	1
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	2	0	0	2
polyprotein	2	0	0	2
67.9K protein	3	0	0	3
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
RPL19A	0	0	1	1
IDH1	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
activating transcription factor 6	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	3	0	0	3
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
chromobox protein homolog 1	3	0	0	3
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
thyroid hormone receptor beta isoform 2	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
geminin	5	0	0	5
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	2	0	0	2
COUP transcription factor 2 isoform a	0	1	0	1
lethal factor (plasmid)	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Hexose transporter 1	0	1	0	1
Interferon beta	3	0	0	3
Cellular tumor antigen p53	2	0	0	2
Procathepsin L	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Glutamate receptor 2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Alpha-synuclein	2	0	0	2
Nuclear receptor ROR-gamma	1	0	0	1
Spike glycoprotein	0	0	1	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
GABA theta subunit	2	0	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	2
Thymidine kinase	0	2	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Vpr	1	0	0	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidine kinase	0	0	0	2
Albumin	0	1	1	2
Serum paraoxonase/arylesterase 1	0	1	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
glucocerebrosidase	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
Solute carrier family 22 member 1	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Androgen receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Muscarinic acetylcholine receptor M4	0	0	1	2
Delta-type opioid receptor	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Muscarinic acetylcholine receptor M5	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Bile salt export pump	0	1	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	3	1	4
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	2	1	3
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
pregnane X nuclear receptor	2	0	0	2
peripheral myelin protein 22	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Cruzipain	1	0	0	1
Luciferase	1	0	0	1
acetylcholinesterase	1	0	0	1
Nrf2	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
GLS protein	1	0	0	1
hypothetical protein, conserved	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
G	1	0	0	1
cytochrome P450 2D6	1	0	0	1
toll-like receptor 9	0	1	0	1
thyroid stimulating hormone receptor	1	0	0	1
caspase recruitment domain family, member 15	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	1	0	0	1
huntingtin isoform 2	1	0	0	1
neurotensin receptor type 1	0	0	1	1
mitogen-activated protein kinase 1	1	0	0	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
lamin isoform A-delta10	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Histamine H2 receptor	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
large T antigen	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(7)

Research Excerpts

Overview

Research

Studies (24)

Protein Targets (315)

Bird Pox

Synonyms(7)

Research Excerpts

Overview

Research

Studies (24)

Drugs Studied (23)

Protein Targets (315)