Compounds > 3'-amino-2',3'-dideoxycytidine
Page last updated: 2024-09-23

3'-amino-2',3'-dideoxycytidine

Cross-References

ID SourceID
PubMed CID73515
CHEMBL ID1791179
SCHEMBL ID4117883
MeSH IDM0117413

Synonyms (14)

Synonym
cytidine, 3'-amino-2',3'-dideoxy-
nsc 365107
84472-90-2
4-amino-1-[(2r,4s,5s)-4-amino-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
3'-amino-2',3'-dideoxycytidine
4-amino-1-((2r,4s,5s)-4-amino-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one
A840798
CHEMBL1791179
AKOS015896790
LDQAHTVPOZCQNH-SHYZEUOFSA-N
SCHEMBL4117883
mfcd00870894
3-amino-2,3-dideoxycytidine
4-amino-1-[(2r,4s,5s)-4-amino-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one

Bioassays (26)

Assay IDTitleYearJournalArticle
AID93874Minimum inhibitory concentration against Klebsiella pneumoniae1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID201396Minimum inhibitory concentration against Salmonella typhi1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID120894Ratio of treated to that of control was determined in mice tested in vivo(on day 31)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antineoplastic activity of 3'-azido and 3'-amino analogues of pyrimidine deoxyribonucleoside.
AID98046In vitro inhibition against replication of L1210 murine cells1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides.
AID201885In vitro inhibition against replication of Sarcoma-80 cells1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides.
AID56582Inhibitory activity against deoxycytidine kinase from L1210 cells1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides.
AID98883Compound was tested for the inhibition of the transport of aminoisobutyric acid into L1210 cells at the 10 uM concentration after <20 min1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Synthesis and biological activity of several amino nucleoside-platinum(II) complexes.
AID207203In vitro minimum inhibitory concentration against Staphylococcus aureus1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID55275In vitro cytotoxicity against human D-38 cells.1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID98885Compound was tested for the inhibition of the transport of methionine into L1210 cells at the 10 uM concentration after <20 min1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Synthesis and biological activity of several amino nucleoside-platinum(II) complexes.
AID216569Minimum inhibitory concentration against Vibrio cholerae1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID210869Inhibitory activity against thymidine kinase (TK) from L1210 cells1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides.
AID98520Ability to effect the replication of L1210 cells in vitro1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antineoplastic activity of 3'-azido and 3'-amino analogues of pyrimidine deoxyribonucleoside.
AID94565in vitro cytotoxicity against mouse L cells.1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID67853Minimum inhibitory concentration against Enterobacter aerogenes1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID203189Minimum inhibitory concentration against Shigella flexneri1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID200872Minimum inhibitory concentration against Salmonella Typhimurium1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID50534Minimum inhibitory concentration against Citrobacter freundii1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID162934Minimum inhibitory concentration against Pseudomonas aeruginosa1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID199112Ability to effect the replication of S-180 cells in vitro1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antineoplastic activity of 3'-azido and 3'-amino analogues of pyrimidine deoxyribonucleoside.
AID69202Minimum inhibitory concentration against Escherichia coli1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID163407Minimum inhibitory concentration against Proteus vulgaris1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID31821In vitro antiviral activity against adeno virus using plaque reduction assay.1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID155775Minimum inhibitory concentration against Pasteurella multocida1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID203153Minimum inhibitory concentration against Serratia marcescens1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
AID162881Minimum inhibitory concentration against Proteus mirabilis1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (66.67)18.7374
1990's3 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
3'-amino-2',3'-dideoxythymidine[no description available]medium30
idoxuridine[no description available]medium10organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
deoxyuridine[no description available]medium10pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
zidovudine[no description available]medium10azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
3'-azido-2',3'-dideoxyuridine[no description available]medium20
3'-azido-2',3'-dideoxy-5-methylcytidine[no description available]medium10
3'-amino-2',3'-dideoxyuridine[no description available]medium30
3'-azido-2',3'-dideoxycytidine[no description available]medium20
deoxycytidine[no description available]medium20pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
zalcitabine[no description available]medium50pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
cytarabine[no description available]medium20beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
alpha-chymotrypsin[no description available]medium10
durapatite[no description available]medium10
aphidicolin[no description available]medium10tetracyclic diterpenoidantimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight0low10
Carcinoma, Ehrlich Tumor0low10
Ehrlich Ascites Tumor0low10
Leukemia L 12100low60
Leukemia L12100low60
Leukemia P3880low10
P388D(1) Leukemia0low10
Sarcoma 1800low20
Sarcoma 180, Crocker0low20
Sensitivity and Specificity0low10

Research Highlights

Safety/Toxicity (2)

ArticleYear
Ribo- and deoxyribonucleoside effect on 3'-amino-2',3'-dideoxycytidine-induced cytotoxicity in cultured L1210 cells.
Biochemical pharmacology, Aug-15, Volume: 32, Issue: 16		1983
The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3'-amino-2',3'-dideoxycytidine and cytosine arabinoside.
Cancer chemotherapy and pharmacology, Volume: 30, Issue: 2		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]