5-formyl-2'-deoxyuridine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 98561 |
| CHEMBL ID | 379296 |
| SCHEMBL ID | 337091 |
| MeSH ID | M0170574 |
| Synonym |
|---|
| 5-formyl-2'-deoxyuridine |
| uridine, 2'-deoxy-5-formyl- |
| ccris 6343 |
| nsc 148297 |
| 5-pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1-(2-deoxy-beta-d-ribofuranosyl)-2,4-dioxo- |
| 1,2,3,4-tetrahydro-1-(2-deoxy-beta-d-ribofuranosyl)-2,4-dioxo-5-pyrimidinecarboxaldehyde |
| 4494-26-2 |
| 5-pyrimidinecarboxaldehyde, 1-(2-deoxy-beta-d-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo- |
| 1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2,4-dioxo-pyrimidine-5-carbaldehyde |
| 1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidine-5-carbaldehyde |
| CHEMBL379296 |
| 2'-deoxy-5-formyluridine |
| 1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde |
| 5-formyldeoxyuridine |
| SCHEMBL337091 |
| AKOS022172827 |
| MVORBLZUGBSUNB-XLPZGREQSA-N |
| AC-32343 |
| mfcd01689820 |
| A872444 |
| 1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde;5-formyl-du |
| BS-18944 |
| CS-0452613 |
| 1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Thymidine phosphorylase | Homo sapiens (human) | Km | 125.0000 | 0.1600 | 0.1600 | 0.1600 | AID211066 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| mitochondrial genome maintenance | Thymidine phosphorylase | Homo sapiens (human) |
| angiogenesis | Thymidine phosphorylase | Homo sapiens (human) |
| pyrimidine nucleobase metabolic process | Thymidine phosphorylase | Homo sapiens (human) |
| pyrimidine nucleoside metabolic process | Thymidine phosphorylase | Homo sapiens (human) |
| chemotaxis | Thymidine phosphorylase | Homo sapiens (human) |
| signal transduction | Thymidine phosphorylase | Homo sapiens (human) |
| cell differentiation | Thymidine phosphorylase | Homo sapiens (human) |
| regulation of myelination | Thymidine phosphorylase | Homo sapiens (human) |
| dTMP catabolic process | Thymidine phosphorylase | Homo sapiens (human) |
| regulation of transmission of nerve impulse | Thymidine phosphorylase | Homo sapiens (human) |
| regulation of gastric motility | Thymidine phosphorylase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| 1,4-alpha-oligoglucan phosphorylase activity | Thymidine phosphorylase | Homo sapiens (human) |
| protein binding | Thymidine phosphorylase | Homo sapiens (human) |
| growth factor activity | Thymidine phosphorylase | Homo sapiens (human) |
| thymidine phosphorylase activity | Thymidine phosphorylase | Homo sapiens (human) |
| protein homodimerization activity | Thymidine phosphorylase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| cytosol | Thymidine phosphorylase | Homo sapiens (human) |
| cytosol | Thymidine phosphorylase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID211066 | Michaelis-Menten constant (Km) against horse liver thymidine phosphorylase | 1980 | Journal of medicinal chemistry, Aug, Volume: 23, Issue:8 | Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines. |
| AID270072 | Antileishmanial activity against Leishmania donovani LV9 promastigotes by MTT method | 2006 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19 | Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro. |
| AID156549 | Concentration required to reduce HSV-1 KOS virus induced cytogenicity in primary rabbit kidney (PRK); Range is 1-2 | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID270074 | Antiviral activity against cowpox virus | 2006 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19 | Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro. |
| AID156557 | Concentration required to reduce [Me-H]dThd incorporation into DNA in primary rabbit kidney (PRK) | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID270073 | Antiviral activity against vaccinia virus | 2006 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19 | Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro. |
| AID156547 | Concentration required to reduce HSV-1 F virus induced cytogenicity in primary rabbit kidney (PRK); Range is 1-2 | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID232840 | Ratio of Vmax to that of dThd (Vmax = 0.14) | 1980 | Journal of medicinal chemistry, Aug, Volume: 23, Issue:8 | Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines. |
| AID265923 | Antiviral activity against cowpox virus Brighton by plaque reduction in HFF cells | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity. |
| AID156697 | Minimum Cytotoxic concentration in primary rabbit kidney (PRK) | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID229758 | Ratio of ID50 for [Me-H]dThd to ID50 for [1,2-H]dUrd | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID156556 | Concentration required to reduce [1,2-H]dUrd incorporation into DNA in primary rabbit kidney (PRK) | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID156550 | Concentration required to reduce HSV-1 McIntyre virus induced cytogenicity in primary rabbit kidney (PRK) | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID156552 | Concentration required to reduce HSV-2 Lyons virus induced cytogenicity in primary rabbit kidney (PRK); Range is 2-4 | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID156683 | Concentration required to reduce virus HSV-2G induced cytogenicity in primary rabbit kidney (PRK); Range is 1-2 | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID156680 | Concentration required to reduce vaccinia virus induced cytogenicity in primary rabbit kidney (PRK); Range is 0.1-0.2 | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID265924 | Cytotoxicity against HFF cell line by neutral red toxicity assay | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity. |
| AID82318 | Growth inhibition against HL-60 after 72 hours incubation period | 1988 | Journal of medicinal chemistry, Aug, Volume: 31, Issue:8 | Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil. |
| AID265922 | Antiviral activity against cowpox virus Brighton measured as cytopathogenicity in HFF cells | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity. |
| AID265920 | Antiviral activity against vaccinia virus Copenhagen measured as cytopathogenicity in HFF cells | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity. |
| AID280941 | Cytotoxicity against mouse L1210/0 cells after 48 hrs | 2007 | Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7 | Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set. |
| AID156554 | Concentration required to reduce HV2 196 virus induced cytogenicity in primary rabbit kidney (PRK); Range is 1-4 | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. |
| AID265921 | Antiviral activity against vaccinia virus Copenhagen assessed as plaque reduction in HFF cells | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (9.76) | 18.7374 |
| 1990's | 6 (14.63) | 18.2507 |
| 2000's | 16 (39.02) | 29.6817 |
| 2010's | 13 (31.71) | 24.3611 |
| 2020's | 2 (4.88) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 44 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism. Toxicology letters, Feb-03, Volume: 119, Issue: 1 | 2001 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |