| ID Source | ID |
|---|---|
| PubMed CID | 451374 |
| CHEMBL ID | 1791029 |
| SCHEMBL ID | 15643018 |
| MeSH ID | M0570444 |
| Synonym |
|---|
| 84472-89-9 |
| cs-91 |
| azddcyd |
| 3'-azido-2',3'-dideoxycytidine |
| 4-amino-1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one |
| 3'-azido-ddc |
| cytidine, 3'-azido-2',3'-dideoxy- |
| 3'-n3-ddc |
| 4-amino-1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| CHEMBL1791029 |
| nsc 382318 |
| 3'-azido-2'-deoxy-d-cytidine |
| cytidine,3'-azido-2',3'-dideoxy- |
| YIEFKLOVIROQIL-SHYZEUOFSA-N |
| DTXSID10233443 |
| SCHEMBL15643018 |
| 2',3'-dideoxy-3'-azidocytidine |
| 1-((2r,4s,5s)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-imino-3,4-dihydropyrimidin-2(1h)-one |
| mfcd00880598 |
| BS-42381 |
| 4-amino-1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID81438 | Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells. | 1988 | Journal of medicinal chemistry, Oct, Volume: 31, Issue:10 | Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. |
| AID104310 | Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6 | Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides. |
| AID235875 | Ratio of CD50 to ED50 rvaluated for inhibition of HIV replication in MT-4 cells | 1988 | Journal of medicinal chemistry, Oct, Volume: 31, Issue:10 | Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. |
| AID106768 | Cytotoxic dose required to reduce the viability of normal uninfected MT-4 cells by 50% | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6 | Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides. |
| AID210869 | Inhibitory activity against thymidine kinase (TK) from L1210 cells | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12 | Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides. |
| AID154965 | Antiviral activity against HIV I strain (LAV) in human peripheral blood mononuclear (PBM) cells; Range is 0.66 - 1.19 | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells. |
| AID152642 | Cytotoxic effect in uninfected human peripheral blood mononuclear (PBM) cells | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3 | Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells. |
| AID125177 | In vitro inhibitory activity against Moloney murine leukemia virus (M-MULV) replication, a mammalian T-lymphotropic retrovirus | 1987 | Journal of medicinal chemistry, Feb, Volume: 30, Issue:2 | Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses. |
| AID56582 | Inhibitory activity against deoxycytidine kinase from L1210 cells | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12 | Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides. |
| AID81069 | Cytotoxic dose required to reduce the viability of normal uninfected MT-4 cells. | 1988 | Journal of medicinal chemistry, Oct, Volume: 31, Issue:10 | Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. |
| AID98047 | In vitro inhibition against replication of L1210 murine cells; inactive | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12 | Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides. |
| AID235704 | Selectivity index of CD50 to ED50 of MT-4 cells | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6 | Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides. |
| AID98521 | Ability to effect the replication of L1210 cells in vitro; IN-Inactive | 1983 | Journal of medicinal chemistry, Apr, Volume: 26, Issue:4 | Synthesis and antineoplastic activity of 3'-azido and 3'-amino analogues of pyrimidine deoxyribonucleoside. |
| AID201886 | In vitro inhibition against replication of Sarcoma-80 cells; inactive | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12 | Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides. |
| AID81411 | Inhibition of HIV-1 replication in human peripheral blood mononuclear cells. | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides. Journal of medicinal chemistry, Volume: 33, Issue: 6 | 1990 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |