carbocyclic inosine: anti-Leishmanial agent; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 135464871 |
| CHEMBL ID | 30714 |
| MeSH ID | M0138113 |
| Synonym |
|---|
| nsc-103529 |
| nsc103529 |
| 16975-94-3 |
| c-inosine |
| CHEMBL30714 |
| 3-(hydroxymethyl)-5-(6-hydroxy-9h-purin-9-yl)cyclopentane-1,2-diol |
| 9-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-3h-purin-6-one |
| carbocyclic inosine |
| DTXSID90937674 |
| 9-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-1h-purin-6-one |
Carbocyclic inosine is a potent inhibitor for the growth of the promastigote form of Leishmania tropica and Leishmania donovani.
| Excerpt | Reference |
|---|---|
| "Carbocyclic inosine is a potent inhibitor for the growth of the promastigote form of Leishmania tropica and Leishmania donovani. " | ( Anti-parasite activity of nucleoside analogues: the metabolism of carbocyclic inosine in promastigotes of Leishmania tropica and Leishmania donovani and its activity against amastigotes of Leishmania donovani in vitro. Aji, T; Fukukawa, K; Hiraoka, O; Ishii, A; Kimura, JY; Matsuda, A; Morishige, K; Satake, H; Ueda, T; Wataya, Y, 1986) |
| "Carbocyclic inosine is a potent inhibitor for the growth of the promastigote form of Leishmania tropica and Leishmania donovani. " | ( Carbocyclic inosine as a potent anti-leishmanial agent: the metabolism and selective cytotoxic effects of carbocyclic inosine in promastigotes of Leishmania tropica and Leishmania donovani. Hiraoka, O; Iguchi, S; Matsuda, A; Satake, H; Ueda, T; Wataya, Y, 1986) |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID85569 | Concentration required to inhibit HSV type 1 strain HF induced cytopathogenic affects by 50% | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11 | Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines. |
| AID217966 | In vitro for antiviral activity in secondary cultures of rabbit kidney cells infected with vaccinia virus | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11 | Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines. |
| AID85703 | In vitro antiviral activity in secondary cultures of rabbit kidney cells infected with HSV type 1 strain HF | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11 | Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines. |
| AID217834 | Concentration required to inhibit vaccinia virus induced cytopathogenic affects by 50% | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11 | Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||