5-(2-iodovinyl)-2'-deoxyuridine profile

ID Source	ID
PubMed CID	6440124
PubMed CID	6438371
CHEMBL ID	223205
SCHEMBL ID	1626547
SCHEMBL ID	1626550
MeSH ID	M0096083

Synonym
1-((2r,4s,5r)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-((e)-2-iodo-vinyl)-1-h-pyrimidine-2,4-dione
(e)-5-(2-iodovinyl)-durd
ivdu
1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-[(e)-2-iodovinyl]pyrimidine-2,4-dione
uridine, 2'-deoxy-5-(2-iodoethenyl)-, (e)-
uridine, 2'-deoxy-5-(2-iodovinyl)-, (e)-
brn 0758154
(e)-5-(2-iodovinyl)deoxyuridine
(e)-2'-deoxy-5-(2-iodovinyl)uridine
(e)-5-(2-iodovinyl)-2'-deoxyuridine
CHEMBL223205
unii-4wlk8jc9ar
69304-48-9
e-5-(2-iodovinyl)-2'-deoxyuridine
4wlk8jc9ar ,
SCHEMBL1626547
SCHEMBL1626550
DTXSID70219364
Q27260602
5-(2-iodovinyl)-2'-deoxyuridine
e-5-(2-iodovinyl)-durd
uridine, 2'-deoxy-5-(2-iodoethenyl)-
1-[(4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-[(z)-2-iodoethenyl]pyrimidine-2,4-dione
87727-68-2

Assay ID	Title	Year	Journal	Article
AID91297	Inhibitory concentration of the drug against the cytopathic effect for E-377 strain of herpes simplex virus-1 (HSV-1) in human HFF cells	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17 ISSN: 0022-2623	Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
AID91307	Concentration of the drug required to reduce the uptake of neural red stain by uninfected cell monolayers (HFF)	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17 ISSN: 0022-2623	Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
AID91306	Concentration of the drug required to reduce the proliferation of human foreskin fibroblast cells	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17 ISSN: 0022-2623	Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
AID87509	Minimum inhibitory concentration (MIC) required to reduce HSV-1 strain (F) induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID146667	Minimum inhibitory concentration (MIC) required to inhibit proliferation of Novikoff rat hepatoma	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID87830	Minimum inhibitory concentration (MIC) required to reduce HSV-2 strain G induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID216193	Dose to inhibit plaque formation in vero cells infected with herpes simplex virus type-1 (HSV-1,strainJLJ) was determined	1990	Journal of medicinal chemistry, Feb, Volume: 33, Issue:2 ISSN: 0022-2623	Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
AID87510	Minimum inhibitory concentration (MIC) required to reduce HSV-1 strain McIntyre induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID144640	Inhibition constant was determined for the facilitated transport of [3N]-thymidine by murine erythrocyte NBMPR-sensitive nucleoside transporter.	1990	Journal of medicinal chemistry, Feb, Volume: 33, Issue:2 ISSN: 0022-2623	Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
AID91295	Inhibitory concentration of the drug against the cytopathic effect for AD169 strain of epstein barr virus-2 (HCMV) in human HFF cells	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17 ISSN: 0022-2623	Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
AID165905	Inhibitory concentration of the drug against the antigen production against P3HR-1 strain of epstein barr virus-2 (EBV) in Raji cells; ND is Not Determined	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17 ISSN: 0022-2623	Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
AID87639	Minimum inhibitory concentration (MIC) required to reduce thymidine kinase deficient HSV-1 induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID93932	Minimum inhibitory concentration (MIC) required to inhibit proliferation of murine leukemia L1210 (wild type)	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID222316	Minimum inhibitory concentration (MIC) required to inhibit proliferation of human lymphoblast Raji	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID91301	Inhibitory concentration of the drug against the cytopathic effect for ellen strain of varicella zoster virus-2 (VZV-2) in human HFF cells	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17 ISSN: 0022-2623	Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
AID85249	Inhibitory activity against HSV-1	2003	Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 ISSN: 0022-2623	Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
AID87511	Minimum inhibitory concentration (MIC) required to reduce Herpes simplex virus (HSV-1) KOS strain induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID91299	Inhibitory concentration of the drug against the cytopathic effect for MS strain of herpes simplex virus-2 (HSV-2) in human HFF cells	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17 ISSN: 0022-2623	Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
AID93930	Minimum inhibitory concentration (MIC) required to inhibit proliferation of murine leukemia L1210 (TK-)	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID280941	Cytotoxicity against mouse L1210/0 cells after 48 hrs	2007	Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7 ISSN: 0022-2623	Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
AID216379	Minimum inhibitory concentration (MIC) required to reduce vesicular stomatis virus induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID87829	Minimum inhibitory concentration (MIC) required to reduce HSV-2 strain (Lyons) induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID217835	Minimum inhibitory concentration (MIC) required to reduce vaccinia virus induced cytopathogenicity in primary rabbit kidney cell cultures	1985	Journal of medicinal chemistry, May, Volume: 28, Issue:5 ISSN: 0022-2623	Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID85250	Inhibitory activity against HSV-2	2003	Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 ISSN: 0022-2623	Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
AID229018	Inhibitory activity against vaccinia virus	2003	Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6 ISSN: 0022-2623	Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	23 (69.70)	18.7374
1990's	5 (15.15)	18.2507
2000's	4 (12.12)	29.6817
2010's	1 (3.03)	24.3611
2020's	0 (0.00)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	34 (100.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	pre-1990	1990's	2000's
fluorouracil	2	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic	1990	2007	25.5	low	0	1	1
thymidine	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite	2003	2003	21.0	low	0	0	1
floxuridine	2	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; radiosensitizing agent	2003	2007	19.0	low	0	0	2
idoxuridine	3	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor	1985	2007	25.7	low	1	0	2
bromodeoxyuridine	1	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent	2007	2007	17.0	low	0	0	1
cytarabine	1	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent	2007	2007	17.0	low	0	0	1
trifluridine	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor	2007	2007	17.0	low	0	0	1
isosorbide dinitrate	1	glucitol derivative; nitrate ester	nitric oxide donor; vasodilator agent	2003	2003	21.0	low	0	0	1
deoxyuridine	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1990	1990	34.0	low	0	1	0
adefovir	1	6-aminopurines; ether; phosphonic acids	antiviral drug; DNA synthesis inhibitor; drug metabolite; HIV-1 reverse transcriptase inhibitor; nephrotoxic agent	2007	2007	17.0	low	0	0	1
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine	1			2007	2007	17.0	low	0	0	1
thymine arabinoside	1	N-glycosyl compound		2007	2007	17.0	low	0	0	1
edoxudin	2	pyrimidine 2'-deoxyribonucleoside		1993	2007	24.0	low	0	1	1
n-(2-(hydroxyethoxy)methyl)-5-methyluracil	1			2007	2007	17.0	low	0	0	1
5-fluoro-1-((2-hydroxyethoxy)methyl)uracil	1			2007	2007	17.0	medium	0	0	1
5-hydroxymethyl-2'-deoxyuridine	1	pyrimidine 2'-deoxyribonucleoside		2007	2007	17.0	medium	0	0	1
msh release-inhibiting hormone	1	oligopeptide		2007	2007	17.0	low	0	0	1
5-hydroxy-2'-deoxyuridine	1			2007	2007	17.0	medium	0	0	1
5-formyl-2'-deoxyuridine	1			2007	2007	17.0	low	0	0	1
5-nitro-2'-deoxyuridine	1			2007	2007	17.0	medium	0	0	1
5-vinyl-2'-deoxyuridine	1			2007	2007	17.0	low	0	0	1
5-propyl-2'-deoxyuridine	1			2007	2007	17.0	medium	0	0	1
adenosine-5'-carboxaldehyde	1	adenosines		2007	2007	17.0	high	0	0	1
brivudine	2			1990	2007	25.5	low	0	1	1
carbocyclic 5-iodo-2'-deoxyuridine	1			1985	1985	39.0	high	1	0	0
melphalan	1	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent	1990	1990	34.0	low	0	1	0
5-ethynyl-2'-deoxyuridine	1			2007	2007	17.0	low	0	0	1
5-cyano-2'-deoxyuridine	1			2007	2007	17.0	medium	0	0	1
5-(2-chloroethyl)-2'-deoxyuridine	1	pyrimidine 2'-deoxyribonucleoside		1990	1990	34.0	low	0	1	0
acyclovir	3	2-aminopurines; oxopurine	antimetabolite; antiviral drug	1990	2007	27.3	low	0	2	1
ganciclovir	1	2-aminopurines; oxopurine	antiinfective agent; antiviral drug	1993	1993	31.0	low	0	1	0
9-((2-phosphonylmethoxy)ethyl)guanine	1	phosphoethanolamine		2007	2007	17.0	low	0	0	1

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990

Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003

Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990

Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990

Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993

Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	pre-1990	1990's	2000's
thymidine	2	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite	1986	1987	37.5	low	2	0	0
floxuridine	2	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; radiosensitizing agent	1986	2004	29.0	low	1	0	1
idoxuridine	28	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor	1981	2010	35.6	high	22	3	3
bromodeoxyuridine	11	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent	1981	1987	39.6	medium	11	0	0
fluorodeoxyuridylate	1	pyrimidine 2'-deoxyribonucleoside 5'-monophosphate		1981	1981	43.0	low	1	0	0
cyclopentane	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent	1990	1990	34.0	low	0	1	0
deoxyuridine	4	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1981	1990	40.5	low	3	1	0
bromine	1	diatomic bromine		1984	1984	40.0	low	1	0	0
etoposide	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor	1988	1988	36.0	low	1	0	0
aminopterin	1	dicarboxylic acid	EC 1.5.1.3 (dihydrofolate reductase) inhibitor; mutagen	1986	1986	38.0	low	1	0	0
brivudine	10			1981	1987	39.8	medium	10	0	0
bromodeoxycytidine	1			1985	1985	39.0	low	1	0	0
1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-(2-iodovinyl)-2,4-(1h,3h)-pyrimidinedione	1			1990	1990	34.0	medium	0	1	0
5-(1-propenyl)-2'-deoxyuridine	1			1981	1981	43.0	medium	1	0	0
5-(2-iodovinyl)-1-(2'-fluoro-2'-deoxyuridine)	1			2004	2004	20.0	medium	0	0	1
i(3)so3-galactosylceramide	1	galactosylceramide sulfate; N-acyl-beta-D-galactosylsphingosine		1988	1988	36.0	low	1	0	0
phosphatidylcholines	1	1,2-diacyl-sn-glycero-3-phosphocholine		1988	1988	36.0	low	1	0	0
acyclovir	3	2-aminopurines; oxopurine	antimetabolite; antiviral drug	1985	1989	37.3	low	3	0	0
ganciclovir	1	2-aminopurines; oxopurine	antiinfective agent; antiviral drug	2010	2010	14.0	low	0	0	1

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	pre-1990	1990's	2000's
Astrocytoma, Grade IV	1	2010	2010	14.0	low	0	0	1
Benign Neoplasms	1	2004	2004	20.0	low	0	0	1
Benign Neoplasms, Brain	1	2010	2010	14.0	low	0	0	1
Brain Inflammation	6	1984	1988	37.3	medium	6	0	0
Brain Neoplasms	1	2010	2010	14.0	low	0	0	1
Cancer of Colon	1	2004	2004	20.0	low	0	0	1
Cell Transformation, Viral	3	1982	1986	39.7	low	3	0	0
Colonic Neoplasms	1	2004	2004	20.0	low	0	0	1
Encephalitis	6	1984	1988	37.3	medium	6	0	0
Experimental Mammary Neoplasms	4	1985	1995	36.2	low	3	1	0
Furrow Keratitis	1	1985	1985	39.0	low	1	0	0
Glioblastoma	1	2010	2010	14.0	low	0	0	1
Herpes Simplex	7	1984	1988	37.7	medium	7	0	0
Herpes Simplex Virus Infection	7	1984	1988	37.7	medium	7	0	0
Neoplasms	1	2004	2004	20.0	low	0	0	1
Cytomegalovirus	1	1993	1993	31.0	low	0	1	0
Herpes Simplex	1	1985	1985	39.0	low	1	0	0
Herpes Simplex Virus Infection	1	1985	1985	39.0	low	1	0	0
Leukemia L 1210	1	1990	1990	34.0	low	0	1	0
Leukemia P388	1	1990	1990	34.0	low	0	1	0

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma.
Cancer letters, , Nov-01, Volume: 297, Issue:1, 2010

Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk.
European journal of nuclear medicine and molecular imaging, , Volume: 31, Issue:3, 2004

Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
Journal of medicinal chemistry, , Aug-20, Volume: 36, Issue:17, 1993

Penetration of the blood-brain barrier by the antiviral drug (E)-5-(2-iodovinyl)-2'-deoxyuridine in a rat model of herpes encephalitis.
Drug design and delivery, , Volume: 3, Issue:1, 1988

Liposomes for targeted delivery of radioiodinated IVdU and 3-CH3-IVdU for non-invasive detection of herpes simplex virus encephalitis in mice.
Drug design and delivery, , Volume: 3, Issue:3, 1988

Specific neuro-radiological diagnosis of herpes encephalitis in an animal model.
Archives of virology, , Volume: 101, Issue:1-2, 1988

Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.
Antimicrobial agents and chemotherapy, , Volume: 29, Issue:2, 1986

Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by exchange labelling.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, , Volume: 37, Issue:4, 1986

Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-halovinyl)-2'-deoxyuridines.
The International journal of applied radiation and isotopes, , Volume: 35, Issue:11, 1984

Altered in vitro uptake of E-5-2-125iodovinyl-2'-deoxyuridine following administration of the antineoplastic agent etoposide.
Research in virology, , Volume: 140, Issue:1

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma.
Cancer letters, , Nov-01, Volume: 297, Issue:1, 2010

Specific neuro-radiological diagnosis of herpes encephalitis in an animal model.
Archives of virology, , Volume: 101, Issue:1-2, 1988

Penetration of the blood-brain barrier by the antiviral drug (E)-5-(2-iodovinyl)-2'-deoxyuridine in a rat model of herpes encephalitis.
Drug design and delivery, , Volume: 3, Issue:1, 1988

Liposomes for targeted delivery of radioiodinated IVdU and 3-CH3-IVdU for non-invasive detection of herpes simplex virus encephalitis in mice.
Drug design and delivery, , Volume: 3, Issue:3, 1988

Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.
Antimicrobial agents and chemotherapy, , Volume: 29, Issue:2, 1986

Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by exchange labelling.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, , Volume: 37, Issue:4, 1986

Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985

Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-halovinyl)-2'-deoxyuridines.
The International journal of applied radiation and isotopes, , Volume: 35, Issue:11, 1984

Quantitative uptake studies of 131I-labeled (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells in vitro.
Antimicrobial agents and chemotherapy, , Volume: 25, Issue:4, 1984

Altered in vitro uptake of E-5-2-125iodovinyl-2'-deoxyuridine following administration of the antineoplastic agent etoposide.
Research in virology, , Volume: 140, Issue:1

In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, , Volume: 60, Issue:1, 2004

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma.
Cancer letters, , Nov-01, Volume: 297, Issue:1, 2010

Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene.
Cell structure and function, , Volume: 11, Issue:3, 1986

Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Molecular pharmacology, , Volume: 28, Issue:6, 1985

Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells.
The Journal of biological chemistry, , Jan-25, Volume: 257, Issue:2, 1982

Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk.
European journal of nuclear medicine and molecular imaging, , Volume: 31, Issue:3, 2004

Specific neuro-radiological diagnosis of herpes encephalitis in an animal model.
Archives of virology, , Volume: 101, Issue:1-2, 1988

Penetration of the blood-brain barrier by the antiviral drug (E)-5-(2-iodovinyl)-2'-deoxyuridine in a rat model of herpes encephalitis.
Drug design and delivery, , Volume: 3, Issue:1, 1988

Liposomes for targeted delivery of radioiodinated IVdU and 3-CH3-IVdU for non-invasive detection of herpes simplex virus encephalitis in mice.
Drug design and delivery, , Volume: 3, Issue:3, 1988

Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by exchange labelling.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, , Volume: 37, Issue:4, 1986

Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.
Antimicrobial agents and chemotherapy, , Volume: 29, Issue:2, 1986

Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-halovinyl)-2'-deoxyuridines.
The International journal of applied radiation and isotopes, , Volume: 35, Issue:11, 1984

Altered in vitro uptake of E-5-2-125iodovinyl-2'-deoxyuridine following administration of the antineoplastic agent etoposide.
Research in virology, , Volume: 140, Issue:1

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma.
Cancer letters, , Nov-01, Volume: 297, Issue:1, 2010

Liposomes for targeted delivery of radioiodinated IVdU and 3-CH3-IVdU for non-invasive detection of herpes simplex virus encephalitis in mice.
Drug design and delivery, , Volume: 3, Issue:3, 1988

Penetration of the blood-brain barrier by the antiviral drug (E)-5-(2-iodovinyl)-2'-deoxyuridine in a rat model of herpes encephalitis.
Drug design and delivery, , Volume: 3, Issue:1, 1988

Specific neuro-radiological diagnosis of herpes encephalitis in an animal model.
Archives of virology, , Volume: 101, Issue:1-2, 1988

Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.
Antimicrobial agents and chemotherapy, , Volume: 29, Issue:2, 1986

Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by exchange labelling.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, , Volume: 37, Issue:4, 1986

Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985

Quantitative uptake studies of 131I-labeled (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells in vitro.
Antimicrobial agents and chemotherapy, , Volume: 25, Issue:4, 1984

Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-halovinyl)-2'-deoxyuridines.
The International journal of applied radiation and isotopes, , Volume: 35, Issue:11, 1984

Altered in vitro uptake of E-5-2-125iodovinyl-2'-deoxyuridine following administration of the antineoplastic agent etoposide.
Research in virology, , Volume: 140, Issue:1

Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.
Investigative ophthalmology & visual science, , Volume: 26, Issue:1, 1985

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990

Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Gene therapy, , Volume: 2, Issue:5, 1995

Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene.
Cell structure and function, , Volume: 11, Issue:3, 1986

Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Molecular pharmacology, , Volume: 28, Issue:6, 1985

Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
FEBS letters, , Jun-03, Volume: 185, Issue:1, 1985

In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, , Volume: 60, Issue:1, 2004

5-(2-iodovinyl)-2'-deoxyuridine

Description

Cross-References

Synonyms (24)

Bioassays (25)

Research

Studies (33)

Study Types

Pharmacokinetics (1)

5-(2-iodovinyl)-2'-deoxyuridine

Description

Cross-References

Synonyms (24)

Bioassays (25)

Research

Studies (33)

Study Types

Related Drugs (43)

Drugs Involved in Assays Together (32)

Drugs Researched Together (19)

Related Conditions (18)

Pharmacokinetics (1)