Compounds > carbodine
Page last updated: 2024-12-07

carbodine

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Description

carbodine: RN given refers to (R-(1alpha,2beta,3beta,4alpha))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID459903
CHEMBL ID1089302
SCHEMBL ID3333453
MeSH IDM0103522

Synonyms (12)

Synonym
c-cyd
4-amino-1-[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidin-2-one
2(1h)-pyrimidinone, 4-amino-1-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-, (2:1),(1alpha,2beta,3beta, 4alpha)-(+/-)-
carbodine
c-arc-c
(-)-carbodine
CHEMBL1089302
(+/-)-carbodine
SCHEMBL3333453
HY-128718
CS-0099817
AKOS040732711
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (66)

Assay IDTitleYearJournalArticle
AID474542Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza A virus California/07/2009 /H1N1 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474345Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza A virus Hong Kong/213/2003/H5N1 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474328Antiviral activity against Influenza A virus Gull/PA/4175/83/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID230734Ratio of the VR of the C-cytosine nucleoside to the VR of ribavirin1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID474327Antiviral activity against Influenza A virus Duck/MN/1525/81/H5N1 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474540Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus California/07/2009 /H1N12010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474341Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus Gull/PA/4175/83/H5N12010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474331Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474359Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474340Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza A virus Duck/MN/1525/81/H5N1 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID217907Compound was tested for its potency against Herpes Simplex Virus-1 (HF strain) in vero cells (african green monkey kidney cells)1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID474551Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza B virus Malaysia/2506/2004 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID70069Compound was tested for its potency against Herpes Simplex Virus-1(HF strain) in human epidermoid carcinoma cells1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID474358Antiviral activity against Influenza A virus Wisconsin/67/2005/H3N2 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474325Antiviral activity against Influenza A virus Duck/MN/1525/81/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474547Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza A virus Wisconsin/67/2005/H3N2 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474351Antiviral activity against Influenza A virus California/07/2009 /H1N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474338Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus Duck/MN/1525/81/H5N12010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID218209Compound was tested for antiviral activity against Herpes Simplex Virus-1(HF strain) in vero cells (african green monkey kidney cells)1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID199255Compound was tested for its potency against influenza virus (A2) in RhMK cells1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID474544Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza A virus Solomon Islands/03/2006/H1N1 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474330Antiviral activity against Influenza A virus Gull/PA/4175/83/H5N1 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID105974Compound was tested for antiviral activity against influenza virus (Ao) in MDCK cells1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID85703In vitro antiviral activity in secondary cultures of rabbit kidney cells infected with HSV type 1 strain HF1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID474357Antiviral activity against Influenza A virus Wisconsin/67/2005/H3N2 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474549Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza B virus Malaysia/2506/20042010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474339Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza A virus Duck/MN/1525/81/H5N1 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474347Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus Vietnam/1203/ 2004H/H5N12010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474344Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus Hong Kong/213/2003/H5N12010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474361Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474342Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza A virus Gull/PA/4175/83/H5N1 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474329Antiviral activity against Influenza A virus Gull/PA/4175/83/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474356Antiviral activity against Influenza A virus Wisconsin/67/2005/H3N2 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474546Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus Wisconsin/67/2005/H3N22010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474545Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza A virus Solomon Islands/03/2006/H1N1 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474348Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza A virus Vietnam/1203/ 2004H/H5N1 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474541Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza A virus California/07/2009 /H1N1 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID218210Compound was tested for antiviral activity against Herpes Simplex Virus-2(HF strain) in vero cells (african green monkey kidney cells)1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID84756In vitro antiviral activity in secondary cultures of rabbit kidney cells infected with HSV type 2 strain MS1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID84609Concentration required to inhibit HSV type 2 strain MS induced cytopathogenic affects by 50%1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID474360Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID70070Compound was tested for its antiviral activity against Herpes Simplex Virus-1(HF strain) in human epidermoid carcinoma cells (H.Ep.-2) measured as virus rating (VR).1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID85569Concentration required to inhibit HSV type 1 strain HF induced cytopathogenic affects by 50%1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID217966In vitro for antiviral activity in secondary cultures of rabbit kidney cells infected with vaccinia virus1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID474343Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza A virus Gull/PA/4175/83/H5N1 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474334Antiviral activity against Influenza A virus Vietnam/1203/ 2004H/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474335Antiviral activity against Influenza A virus Vietnam/1203/ 2004H/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474350Antiviral activity against Influenza A virus California/07/2009 /H1N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474349Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza A virus Vietnam/1203/ 2004H/H5N1 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474550Selectivity ratio of IC50 for MDCK cells to EC50 for Influenza B virus Malaysia/2506/2004 by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474548Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza A virus Wisconsin/67/2005/H3N2 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID105966Compound was tested for its potency against influenza virus (Ao) in MDCK cells1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID199256Compound was tested for its potency against influenza virus (A2) in RhMK cells1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID474354Antiviral activity against Influenza A virus Solomon Islands/03/2006/H1N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474352Antiviral activity against Influenza A virus California/07/2009 /H1N1 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474336Antiviral activity against Influenza A virus Vietnam/1203/ 2004H/H5N1 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474346Selectivity ratio of IC50 for MDCK cells to EC90 for Influenza A virus Hong Kong/213/2003/H5N1 by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474355Antiviral activity against Influenza A virus Solomon Islands/03/2006/H1N1 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474353Antiviral activity against Influenza A virus Solomon Islands/03/2006/H1N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474332Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474326Antiviral activity against Influenza A virus Duck/MN/1525/81/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474333Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells after 3 days by virus yield reduction assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474543Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus Solomon Islands/03/2006/H1N12010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID474337Cytotoxicity against MDCK cells after 3 days by neutral red dye uptake assay2010Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
AID217908Compound was tested for its potency against Herpes Simplex Virus-2(HF strain) in vero cells (african green monkey kidney cells)1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Carbocyclic analogues of 5-halocytosine nucleosides.
AID217834Concentration required to inhibit vaccinia virus induced cytopathogenic affects by 50%1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (35.29)18.7374
1990's4 (23.53)18.2507
2000's4 (23.53)29.6817
2010's3 (17.65)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		1.96106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		1.9710pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
flucytosine
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.. flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.		2.0810aminopyrimidine;
nucleoside analogue;
organofluorine compound;
pyrimidine antifungal drug;
pyrimidone		prodrug
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.4120nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
thymidine
[no description available]		1.9710pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
azauridine
Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.		1.9710N-glycosyl-1,2,4-triazineantimetabolite;
antineoplastic agent;
drug metabolite
idoxuridine
[no description available]		1.9610organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.		1.9610pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
cytidine
[no description available]		4.13160cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cytidine triphosphate
Cytidine Triphosphate: Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.		2.0410cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
tubercidin
Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.		2.6630antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite
cytarabine
[no description available]		2.3720beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
cyclopentanol
[no description available]		2.1110cyclopentanols
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.7730cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
thiazoles
[no description available]		2.39201,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
methylthioinosine
Methylthioinosine: 6-(Methylthio)-9-beta-D-ribofuranosylpurine. An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.		1.9610purine ribonucleoside;
thiopurine
deoxycytidine
[no description available]		2.3720pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
6-hydroxyadenosine
[no description available]		1.9610
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		2.3720beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
3-deazaadenosine
3-deazaadenosine: RN given refers to parent cpd.		1.9610
ribavirin
Rebetron: Rebetron is tradename		3.37701-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
3-deazaguanine
3-deazaguanine: structure		2.3820
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		2.3720adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
thiazolyl blue
thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.		2.3920organic bromide saltcolorimetric reagent;
dye
ibacitabine
ibacitabine: antiherpetic agent		1.9610pyrimidine 2'-deoxyribonucleoside
2-aminoadenosine
[no description available]		1.9610purine nucleoside
cyclopentenyl cytosine
cyclopentenyl cytosine: inhibits CTP synthetase; used in therapy of colonic neoplasms; structure given in first source; RN given refers to the (1R-(1alpha,4beta,5beta))-isomer		2.3720
neplanocin a
neplanocin A: neplanocins are antitumor antibiotics & carbocyclic analogs of purine nucleosides from Ampullarilla regularis A11079; see also neplanocin B, neplanocin C, neplanocin D & neplanocin F; structure in first source; a potent inhibitor of S-adenosylhomocysteine hydrolase		2.3720
6-chloropurine riboside
[no description available]		1.9610
9-(2,3-dihydroxypropyl)adenine
[no description available]		1.9610
6-methoxypurine arabinoside
[no description available]		1.9610
cyclopentenyluracil
cyclopentenyluracil: does not have antiviral acitivity in contrast to cyclopentenylcytosine; RN given refers to (1R-(1alpha,4beta,5beta)-isomer); RN for cpd without isomeric designation not avail 6/91		1.9710
bromodeoxycytidine
Bromodeoxycytidine: 5-Bromo-2'-deoxycytidine. Can be incorporated into DNA in the presence of DNA polymerase, replacing dCTP.		1.9610
ribose
ribopyranose : The pyranose form of ribose.		3.0750D-ribose;
ribopyranose
carbocyclic 3-deazaadenosine
carbocyclic 3-deazaadenosine: carboxylic analog of 3-deazaadenosine		2.3720
guanine
[no description available]		2.38202-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
pyrazofurin
pirazofurin : A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.		3.0750C-glycosyl compound;
pyrazoles		antimetabolite;
antimicrobial agent;
antineoplastic agent;
EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor
carbocyclic inosine
carbocyclic inosine: anti-Leishmanial agent; structure given in first source		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
[description not available]		02.1110
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.		07.1110
Encephalitis, Venezuelan Equine
[description not available]		02.0410
Infections, Orthomyxoviridae
[description not available]		01.9610
Orthomyxoviridae Infections
Virus diseases caused by the ORTHOMYXOVIRIDAE.		01.9610
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9810
Acute Myelogenous Leukemia
[description not available]		01.9610
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		01.9610