Compounds > n(2)-(3-trifluoromethylphenyl)guanine
Page last updated: 2024-10-15

n(2)-(3-trifluoromethylphenyl)guanine

Cross-References

ID SourceID
PubMed CID135435057
CHEMBL ID405761
SCHEMBL ID8537131
MeSH IDM0179496

Synonyms (22)

Synonym
2-(3-(trifluoromethyl)anilino)-9h-purin-6-ol
2-[3-(trifluoromethyl)anilino]-9h-purin-6-ol
NCI60_029531
123994-68-3
n2-(m-trifluoromethylphenyl) guanine
2-[3-(trifluoromethyl)anilino]-1,9-dihydropurin-6-one
2-(3-trifluoromethyl-phenylamino)-1,9-dihydro-purin-6-one
nsc-682528
nsc682528
tmpg
CHEMBL405761 ,
bdbm50210810
n2-(3-trifluoromethylphenyl)guanine
2-[3-(trifluoromethyl)anilino]-3,7-dihydropurin-6-one
n(2)-(3-trifluoromethylphenyl)guanine
6h-purin-6-one, 1,7-dihydro-2-((3-(trifluoromethyl)phenyl)amino)-
SCHEMBL8537131
m-trifluoromethylphenylguanine
DTXSID00154178
2-{[3-(trifluoromethyl)phenyl]amino}-6,9-dihydro-1h-purin-6-one
2-[3-(trifluoromethyl)anilino]-1,7-dihydropurin-6-one
2-((3-(trifluoromethyl)phenyl)amino)-1h-purin-6(9h)-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidine kinase Macacine alphaherpesvirus 1IC50 (µMol)3.50000.15002.57504.2000AID326127
Thymidine kinaseHuman alphaherpesvirus 1 strain SC16IC50 (µMol)0.12570.10001.84917.9433AID210711; AID210716
Thymidine kinase Human alphaherpesvirus 2IC50 (µMol)0.10000.10000.84621.6000AID210714; AID210715
Thymidine kinaseHuman alphaherpesvirus 1 (Herpes simplex virus type 1)IC50 (µMol)0.15000.15004.81679.0000AID210696; AID210712
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID84399Inhibition against DNA-Dependent ATPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.
AID210696Inhibition of HSV-1 thymidine kinase, 1 uM [3H]thymidine and ATP as phosphate donor1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID210714Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
AID14665Plasma concentration at time-0 was measured in mice at 100 mg/kg after intraperitoneal administration with saline(pH=11.4) as vehicle1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID25177Half life in mice plasma was determined at 40 mg/kg after intravenous administration with saline(pH=11.4) as vehicle1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID210712Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 11990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
AID22429Volume of distribution in mice plasma was determined at 40 mg/kg after intravenous administration with saline(pH=11.4) as vehicle1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID210711Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
AID14667Plasma concentration at time-0 was measured in mice at 40 mg/kg after intravenous administration with saline(pH=11.4) as vehicle1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID210716Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 21990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
AID210715Inhibition of HSV-2 thymidine kinase, 2 uM [3H]thymidine and ATP as phosphate donor1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID25174Half life in mice plasma was determined at 100 mg/kg after intraperitoneal administration with saline(pH=11.4) as vehicle1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID326127Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (71.43)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
foscarnet
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.		2.0310carboxylic acid;
one-carbon compound;
phosphonic acids		antiviral drug;
geroprotector;
HIV-1 reverse transcriptase inhibitor;
sodium-dependent Pi-transporter inhibitor
thymidine
[no description available]		2.0310pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
idoxuridine
[no description available]		2.0310organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
trifluridine
Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.		2.0310nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		2.0310beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.		2.0310phosphonic acids;
pyrimidone		anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent
edoxudin
[no description available]		2.0310pyrimidine 2'-deoxyribonucleoside
5-propyl-2'-deoxyuridine
5-propyl-2'-deoxyuridine: RN given refers to parent cpd		2.0310
brivudine
brivudine: anti-herpes agent		2.0310
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		2.1510chalcogen;
nonmetal atom		macronutrient
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.41202-aminopurines;
oxopurine		antimetabolite;
antiviral drug
deoxyguanosine
[no description available]		1.9710purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanine
[no description available]		2.42202-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ganciclovir
[no description available]		2.03102-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
penciclovir
penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.		2.03102-aminopurines;
propane-1,3-diols		antiviral drug
n(2)-phenylguanine
[no description available]		2.940
9-(4-hydroxybutyl)guanine
[no description available]		2.4120
ConditionIndicatedRelationship StrengthStudiesTrials