| Assay ID | Title | Year | Journal | Article |
|---|
| AID220366 | Compound was evaluated for average apparent binding constant (Kd ) using Scatchard analysis to dTMP synthetase enzyme from chick embryo | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
| AID24704 | Dissociation time from ternary complex using nitrocellulose binding assay incubating 5.0 uM of TMP synthetase enzyme from chick embryo and 0.15 nM of CH2-H4 folate | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
| AID220365 | Compound was evaluated for the dissociation of the radiolabeled N4-HOdCMP by competitive binding to the excess dTMP synthetase; Active | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
| AID233941 | Ratio between Ki of L1210-P enzyme and Michaelis-Menten constant (kM) | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID228254 | Compound was tested for time-dependent slow-binding inhibition (K') of thymidylate synthase from L1210-R cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID228258 | Compound was tested for time-dependent 1 (k2') inhibition of thymidylate synthase from L1210-R cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID233942 | Ratio between Ki of L1210-R enzyme and Michaelis-Menten constant (kM) | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID228256 | Compound was tested for time-dependent slow-binding inhibition (K) of thymidylate synthase from L1210-R cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID228251 | Time-independent inhibition of thymidylate synthase from FdUrd-resistant L1210 cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID24703 | Dissociation time from ternary complex using nitrocellulose binding assay by incubating the compound was evaluated at 100 fold excess along with 3.8 uM of TMP synthetase enzyme from chick embryo and 0.15 nM of CH2-H4 folate. | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
| AID228415 | Compound was tested for time-dependent 1 (k2) inhibition of thymidylate synthase from L1210-P cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID220364 | Compound (4.5 uM) was evaluated for the percent binding to the excess dTMP synthetase (3.9 uM and 7.8 uM sites) enzyme from chick embryo, 0.15 nM of CH2-H4 folate. This complex was incubated 25 degrees Celsius for 2 hours. | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
| AID228255 | Compound was tested for time-dependent slow-binding inhibition (K) of thymidylate synthase from L1210-P cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID228252 | Time-independent inhibition of thymidylate synthase from parenteral L1210 cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID228257 | Compound was tested for time-dependent 1 (k2') inhibition of thymidylate synthase from L1210-P cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID220369 | Compound was evaluated for time-dependent loss of activity with use of 15 nM of dTMP synthetase enzyme from chick embryo in the presence of 0.15 nM of CH2-H4 folate at about 20 seconds | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
| AID228416 | Compound was tested for time-dependent 1 (k2) inhibition of thymidylate synthase from L1210-R cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| AID220359 | The apparent association constant (Ki) with dTMP synthetase enzyme from chick embryo in the absence of CH2-H4 folate was evaluated | 1984 | Journal of medicinal chemistry, Oct, Volume: 27, Issue:10
| Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
| AID228253 | Compound was tested for time-dependent slow-binding inhibition (K') of thymidylate synthase from L1210-P cells | 2000 | Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
| 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |