Page last updated: 2024-10-15

isatoribine anhydrous

Cross-References

ID SourceID
PubMed CID135409474
CHEMBL ID2105116
SCHEMBL ID127980
SCHEMBL ID12592999
MeSH IDM0169584

Synonyms (37)

Synonym
satoribine
immunosine
ana-245
122970-40-5
5-amino-3-.beta.-d-ribofuranosylthiazolo[4,5]pyrimidine-2,7(3h,6h)-dione
7-thia-8-oxoguanosine
5-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6h-thiazolo[4,5-d]pyrimidine-2,7-dione
ana 245
isatoribine
ana245
5-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4h-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione
CHEMBL2105116
2dnt962h92 ,
isatoribine [usan:inn]
unii-2dnt962h92
7-deaza-7-thia-8-oxoguanosine
5-amino-3-ribofuranosylthiazolo(4,5-d)pyrimidine-2,7(3h,6h)-dione
7-tog
thiazolo(4,5-d)pyrimidine-2,7(3h,4h)-dione, 5-amino-3-beta-d-ribofuranosyl-
7-thio-8-oxoguanosine
DB04860
SCHEMBL127980
isatoribine anhydrous
5-amino-3-.beta.-d-ribofuranosylthiazolo(4,5-d)pyrimidine-2,7(3h,6h)-dione
isatoribine [inn]
TZYVRXZQAWPIAB-FCLHUMLKSA-N
5-amino-3-beta-d-ribofuranosylthiazolo[4,5-d]pyrimidine-2,7(6h)-dione
SCHEMBL12592999
DTXSID20924330
7-hydroxy-5-imino-3-pentofuranosyl-4,5-dihydro[1,3]thiazolo[4,5-d]pyrimidin-2(3h)-one
5-amino-3-|a-d-ribofuranosylthiazolo[4,5-d]pyrimidine-2,7(3h,4h)-dione
Q27095551
5-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6h-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione
BRD-K87535339-001-01-6
5-amino-3-d-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3h,6h)-dione
isatoribine free base
AKOS040745874

Dosage Studied

ExcerptReference
" However, dosing with masked oral prodrugs of TLR7 agonists, such as ANA-975, limits the adverse events associated with the activation of responsive gastrointestinal immune tissue."( Masked oral prodrugs of toll-like receptor 7 agonists: a new approach for the treatment of infectious disease.
Averett, D; Fletcher, S; Steffy, K, 2006
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (42)

Assay IDTitleYearJournalArticle
AID110461Ability to activate CBA/CaJ Mice spleen cells to proliferate in vitro by measuring new DNA synthesis in a [3H]thymidine incorporation assay at 0 mM1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID136825Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 100 mg/kg administration1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID202899Effect of compound on forest virus infection in mice, Mean survival time through 21 days at 100 mg/kg dose1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents.
AID136831Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 200 mg/kg administration.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID110579Ability to activate CBA/CaJ Mice spleen cells to proliferate in vitro by measuring new DNA synthesis in a [3H]thymidine incorporation assay at 0.20 mM1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID136357Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally in experiment 2; 11/12(92)1990Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.
AID1285200Antiviral activity against Semliki forest virus infected in mouse2016European journal of medicinal chemistry, May-04, Volume: 113Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery.
AID134275Compound was tested for mean survival time through 21 days after administration of 100 mg/kg, 24 and 18 hr prior to virus inoculation ( forest virus) in mice1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID136827Compound was tested for its activity against intraperitoneal administration.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID136829Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 150 mg/kg oral administration.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID220074In vivo effect on murine NK cell activity in isolated CBA/CaJ mice spleen cells and cytotoxicity measured against YAC-1 cells at a targetor ratio 50:11990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID134437Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally in experiment 21990Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.
AID134280Compound was tested for mean survival time through 21 days after oral administration of 150 mg/kg, 24 hr prior to virus inoculation ( forest virus) in mice1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID134438Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally in experiment 31990Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.
AID136833Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 50 mg/kg administration1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID134278Compound was tested for mean survival time through 21 days after intraperitoneal administration of 150 mg/kg, 24 hr prior to virus inoculation ( forest virus) in mice1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID220072In vivo effect on murine NK cell activity in isolated CBA/CaJ mice spleen cells and cytotoxicity measured against YAC-1 cells at a targetor ratio 100:11990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID202897Effect against semliki forest virus infection in mice at an ip dose of 100 mg/kg; 11/121990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID136832Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 25 mg/kg administration1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID136828Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 150 mg/kg intravenous administration.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID224755Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally in experiment 1; 9/12(75)1990Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.
AID202900Effect of compound on forest virus infection in mice, Mean survival time through 21 days at 200 mg/kg dose1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents.
AID202898Effect against semliki forest virus infection in mice at an ip dose of 200 mg/kg; 11/121990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID202903Effect of compound on forest virus infection in mice at the dose of 200 mg/kg; Tested over 12 mice1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents.
AID110578Ability to activate CBA/CaJ Mice spleen cells to proliferate in vitro by measuring new DNA synthesis in a [3H]thymidine incorporation assay at 0.05 mM1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID134281Compound was tested for mean survival time through 21 days after subcutaneous administration of 150 mg/kg, 24 hr prior to virus inoculation ( forest virus) in mice1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID202896Effect against semliki forest virus infection in mice at an ip dose of 200 mg/kg1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID134277Compound was tested for mean survival time through 21 days after administration of 25 mg/kg, 24 and 18 hr prior to virus inoculation ( forest virus) in mice1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID110577Ability to activate CBA/CaJ Mice spleen cells to proliferate in vitro by measuring new DNA synthesis in a [3H]thymidine incorporation assay at 0.01 mM1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID134276Compound was tested for mean survival time through 21 days after administration of 200 mg/kg, 24 and 18 hr prior to virus inoculation ( forest virus) in mice1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID136358Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally in experiment 3; 11/12(92)1990Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.
AID192094Compound at a dose 100 mg/kg was administered to rat and Percent survivors after coronavirus infection in suckling rats.1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
Modulation of leukocyte genetic expression by novel purine nucleoside analogues. A new approach to antitumor and antiviral agents.
AID202901Effect of compound on forest virus infection in mice at the dose of 100 mg/kg; Tested over 12 mice1990Journal of medicinal chemistry, Aug, Volume: 33, Issue:8
Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents.
AID134279Compound was tested for mean survival time through 21 days after intravenous administration of 150 mg/kg, 24 hr prior to virus inoculation ( forest virus) in mice1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID118548Mean survival time of mice that died; survivors lived through 21 days1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
Modulation of leukocyte genetic expression by novel purine nucleoside analogues. A new approach to antitumor and antiviral agents.
AID136826Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 100 mg/kg administration.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID202895Effect against semliki forest virus infection in mice at an ip dose of 100 mg/kg1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
AID1372795Antiviral activity against Semliki forest virus infected in Swiss Webster mouse assessed as mouse survival at 100 mg/kg, ip measured after 18 to 24 hrs2018Bioorganic & medicinal chemistry, 01-15, Volume: 26, Issue:2
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold.
AID136830Compound was tested for its activity against forest virus infection in mice, activity was determined by measuring the number of survived mice after 150 mg/kg subcutaneous administration.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system.
AID134436Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally in experiment 11990Journal of medicinal chemistry, Oct, Volume: 33, Issue:10
Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.
AID1372800Antiviral activity against Semliki forest virus infected in Swiss Webster mouse assessed as mean survival time at 100 mg/kg, ip2018Bioorganic & medicinal chemistry, 01-15, Volume: 26, Issue:2
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold.
AID110580Ability to activate CBA/CaJ Mice spleen cells to proliferate in vitro by measuring new DNA synthesis in a [3H]thymidine incorporation assay at 0.40 mM1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (8.00)18.7374
1990's16 (64.00)18.2507
2000's4 (16.00)29.6817
2010's3 (12.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (7.14%)5.53%
Reviews4 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (78.57%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]