Compounds > ic9564
Page last updated: 2024-12-08

ic9564

Description

IC9564: betulinic acid derivative; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID463615
CHEMBL ID137752
SCHEMBL ID14369573
MeSH IDM0377792

Synonyms (11)

Synonym
ic-9564
heptanoic acid, 3-hydroxy-4-[[8-[[(3.beta.)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino]-1-oxooctyl]amino]-6-methyl-, (3r,4s)-
174847-98-4
(3r,4s)-4-[8-[[(1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-9-hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carbonyl]amino]octanoylamino]-3-hydroxy-6-methyl-heptanoic acid
ic9564
CHEMBL137752
(3r,4s)-4-[8-[[(1r,3as,5ar,5br,7ar,9s,11ar,11br,13ar,13br)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carbonyl]amino]octanoylamino]-3-hydroxy-6-methylheptanoic acid
(3r,4s)-n'-(n-3beta-hydroxylup-20(29)-en-28-oyl)-8-aminooctanoyl)-4-amino-3-hydroxy-6-methylheptanoic acid
heptanoic acid, 3-hydroxy-4-((8-(((3beta)-3-hydroxy-28-oxolup-20(29)-en-28-yl)amino)-1-oxooctyl)amino)-6-methyl-, (r-(r*,s*))-
ic 9564
SCHEMBL14369573

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
" These mt-QSARs offer also a good opportunity to construct drug-drug Complex Networks (CNs) that can be used to explore large and complex drug-viral species databases."( Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID427785Antiviral activity against HIV1 ZM197M.PB7 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID492516Antiviral activity against HIV1 by fusion assay2010Journal of natural products, Mar-26, Volume: 73, Issue:3
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
AID350159Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as p24 antigen level after 4 days by ELISA2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.
AID427781Antiviral activity against HIV1 WITO4160.33 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID683336Antiviral activity against HIV1 in human TZM-bl cells assessed as viral infectivity by luciferase assay2012European journal of medicinal chemistry, Oct, Volume: 56Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding.
AID427601Antiviral activity against HIV1 Q769.d22 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427791Cytotoxicity against human TZM-bl cells at 15 uM after 2 days by trypan blue exclusion assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427799Inhibition of V3-speciifc monoclonal antibody 2G12 binding to HIV1 3B gp120 by ELISA-based competitive binding assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427801Inhibition of V3-speciifc monoclonal antibody 2G12 binding to HIV1 Ba-L gp120 by ELISA-based competitive binding assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID439732Ratio of IC50 for HIV2 KR X3 infected in human TZM-b1 cells to IC50 for HIV1 NL4-3 infected in human TZM-b1 cells2009Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.
AID1706899Anti-HIV-1 activity against HIV1 NL4-3 infected in human HeLa expressing CD4/CCR5/beta-gal assessed as inhibition of syncytium formation incubated for 2 days by MAGI assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Triterpenoid-Mediated Inhibition of Virus-Host Interaction: Is Now the Time for Discovering Viral Entry/Release Inhibitors from Nature?
AID1873271Antiviral activity against HIV-1 NL4-3(X4) infected in human TZM-bl cells assessed as reduction in viral replication2022Bioorganic & medicinal chemistry letters, 08-01, Volume: 69Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds.
AID427605Antiviral activity against HIV1 HXB2 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID621520Inhibition of human 20S proteasome chymotrypsin-like activity using Suc-Leu-Leu-Val-Tyr-AMC fluorogenic substrate by fluorimetry2011Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19
New betulinic acid derivatives as potent proteasome inhibitors.
AID427788Antiviral activity against HIV1 ZM109F.PB4 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427786Antiviral activity against HIV1 ZM214M.PL15 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427604Antiviral activity against HIV1 NL4-3 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427784Antiviral activity against HIV1 Du422.1 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427599Antiviral activity against HIV1 Q168.a2 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID439729Cytotoxicity against human TZM-b1 cells after 2 days2009Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.
AID427776Antiviral activity against HIV1 QH0515.1 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427606Antiviral activity against HIV1 5768.4 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID392513Antiviral activity against HIV12009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID81086Anti HIV-1 activity against the virus NL4-3 using fusion assay2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.
AID427797Inhibition of V3-speciifc monoclonal antibody 447-52D binding to HIV1 3B gp120 by ELISA-based competitive binding assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID439728Antiviral activity against HIV2 KR X3 infected in human TZM-b1 cells assessed as reduction in luciferase activity after 2 days by luciferase reporter gene assay2009Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.
AID427603Antiviral activity against HIV1 Q842.d12 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427789Antiviral activity against HIV1 CAP.2.00.G3 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427803Inhibition of HIV1 3B gp120/CD4 complex binding to CCR5 expressing HOS cells at 5 mg/ml after 1 hr by competitive binding assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427783Antiviral activity against HIV1 Du151.2 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID271062Cytotoxicity against COS-TZM fused cells2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.
AID439727Antiviral activity against HIV1 NL4-3 infected in human TZM-b1 cells assessed as reduction in luciferase activity after 2 days by luciferase reporter gene assay2009Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.
AID350163Therapeutic index, ratio of CC50 for human MT4 cells to EC50 for HIV1 NL4-32009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.
AID427778Antiviral activity against HIV1 TRO.11 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427600Antiviral activity against HIV1 Q461.e2 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427796Ratio of inhibition of HIV1 NH4-3 envelope glycoprotein 120-mediated membrane fusion to inhibition of HIV1 (isolate YU2) envelope glycoprotein 120-mediated membrane fusion2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427602Antiviral activity against HIV1 Q259.d2.17 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427787Antiviral activity against HIV1 ZM55F.PB28a infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID1873270Antiviral activity against HIV-1 YU2 (R4) infected in human TZM-bl cells assessed as reduction in viral replication2022Bioorganic & medicinal chemistry letters, 08-01, Volume: 69Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds.
AID427777Antiviral activity against HIV1 SS1196.1 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID271061Inhibition of membrane fusion between HIV1 NL4-3 envelope gene expressing COS cells and TZM cells2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.
AID427790Antiviral activity against HIV1 CAP244.2.00.D3 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427800Inhibition of V3-speciifc monoclonal antibody 447-52 binding to HIV1 Ba-L gp120 by ELISA-based competitive binding assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID1873272Antiviral activity against HIV-1 89.6 infected in human TZM-bl cells assessed as reduction in viral replication2022Bioorganic & medicinal chemistry letters, 08-01, Volume: 69Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds.
AID492515Antiviral activity against HIV1 by MAGI assay2010Journal of natural products, Mar-26, Volume: 73, Issue:3
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
AID81085Anti HIV-1 activity against the virus NL4-3 using MAGI assay2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.
AID1873273Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability by CellTitre-Glo assay2022Bioorganic & medicinal chemistry letters, 08-01, Volume: 69Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds.
AID427792Cytotoxicity against human TZM-bl cells after 2 days by trypan blue exclusion assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427607Antiviral activity against HIV1 6535.3 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427780Antiviral activity against HIV1 REJO4541.67 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427798Inhibition of V3-speciifc monoclonal antibody 39F binding to HIV1 3B gp120 by ELISA-based competitive binding assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID350162Cytotoxicity against human MT4 cells by XTT assay2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.
AID427779Antiviral activity against HIV1 RHPA4259.7 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID1873274Selectivity index, ratio of CC50 for human TZM-bl cells to IC50 for IC50 for antiviral activity against HIV-1 89.6 infected in human TZM-bl cells2022Bioorganic & medicinal chemistry letters, 08-01, Volume: 69Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds.
AID427782Antiviral activity against HIV1 Du123.6 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427598Antiviral activity against HIV1 Q23.71 infected in human TZM-b1 cells assessed as inhibition of viral infection after 2 days postinfection by luciferase reporter gene assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
AID427802Inhibition of HIV1 Ba-L gp120/CD4 complex binding to CCR5 expressing HOS cells at 5 mg/ml after 1 hr by competitive binding assay2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (64.29)29.6817
2010's3 (21.43)24.3611
2020's2 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.73 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.44 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amantadine
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source		2.0510adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
buspirone
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.. buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.		2.0510azaspiro compound;
N-alkylpiperazine;
N-arylpiperazine;
organic heteropolycyclic compound;
piperidones;
pyrimidines		anxiolytic drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
sedative;
serotonergic agonist
foscarnet
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.		2.0510carboxylic acid;
one-carbon compound;
phosphonic acids		antiviral drug;
geroprotector;
HIV-1 reverse transcriptase inhibitor;
sodium-dependent Pi-transporter inhibitor
nevirapine
Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.. nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.		2.0510cyclopropanes;
dipyridodiazepine		antiviral drug;
HIV-1 reverse transcriptase inhibitor
olomoucine
olomoucine: inhibits protein P34CDC2. olomoucine : A 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor.		2.05102,6-diaminopurines;
ethanolamines		EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
delavirdine
Delavirdine: A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.. delavirdine : The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.		2.0510aminopyridine;
indolecarboxamide;
N-acylpiperazine;
sulfonamide		antiviral drug;
HIV-1 reverse transcriptase inhibitor
idoxuridine
[no description available]		2.0510organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		2.0110amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		3.1510alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
benzohydroxamic acid
[no description available]		2.0510
oleanolic acid
[no description available]		3.3510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		3.1510furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
n-hydroxyphthalimide
N-hydroxyphthalimide: causes contact dermititis		2.0510
toyocamycin
Toyocamycin: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.. toyocamycin : An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.		2.0510antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
nitrile;
ribonucleoside		antimetabolite;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite
thiocholchicine
thiocholchicine: RN refers to (S)-isomer		3.1510
stavudine
Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase		2.0510dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
acetylpyruvic acid
acetylpyruvic acid: structure. acetylpyruvic acid : A dioxo monocarboxylic acid that is pentanoic acid carrying two oxo groups at positions 2 and 4.		2.0510beta-diketone;
dioxo monocarboxylic acid		bacterial metabolite
helenalin
helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure. helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.		3.1510cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		2.0510pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		4.3960azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
etoposide
[no description available]		3.1510beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
ribavirin
Rebetron: Rebetron is tradename		2.05101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
fialuridine
[no description available]		2.0510
adefovir
adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.		2.05106-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.		2.0510phosphonic acids;
pyrimidone		anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent
lamivudine
[no description available]		2.0510monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
zanamivir
Zanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.		2.0510guanidinesantiviral agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
adefovir dipivoxil
bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine: structure given in first source. adefovir pivoxil : An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.		2.05106-aminopurines;
carbonate ester;
ether;
organic phosphonate		antiviral drug;
DNA synthesis inhibitor;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent;
prodrug
efavirenz
efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.		2.0510acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor
nelfinavir
Nelfinavir: A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.. nelfinavir : An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.		2.0510aryl sulfide;
benzamides;
organic heterobicyclic compound;
phenols;
secondary alcohol;
tertiary amino compound		antineoplastic agent;
HIV protease inhibitor
betulinic acid
[no description available]		4.2250hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
plerixafor
plerixafor: a bicyclam derivate, highly potent & selective inhibitor of HIV-1 & HIV-2. plerixafor : An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.		2.0410azacycloalkane;
azamacrocycle;
benzenes;
crown amine;
secondary amino compound;
tertiary amino compound		anti-HIV agent;
antineoplastic agent;
C-X-C chemokine receptor type 4 antagonist;
immunological adjuvant
amprenavir
[no description available]		2.0510carbamate ester;
sulfonamide;
tetrahydrofuryl ester		antiviral drug;
HIV protease inhibitor
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.0510acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
2-Oxo-4-phenylbutyric acid
[no description available]		2.0510benzenes
9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
[no description available]		2.0510
clevudine
[no description available]		2.0510
rpr 103611
RPR 103611: a statine derivative; structure given in first source		3.8220
suksdorfin
suksdorfin: from the fruit of Lomatium sukdorfi; structure given in first source		3.1510
heraclenol
heraclenol: isolated from the herb Huanghuaren		3.1510
echinocystic acid
[no description available]		3.3510triterpenoid
lopinavir
[no description available]		2.0510amphetamines;
dicarboxylic acid diamide		anticoronaviral agent;
antiviral drug;
HIV protease inhibitor
calpain inhibitor 2
calpain inhibitor 2: inhibits degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and some other cysteine proteinases		2.0610peptide
4-amino-5-bromo-7-(2-hydroxyethoxymethyl)pyrrolo(2,3-d)pyrimidine
4-amino-5-bromo-7-(2-hydroxyethoxymethyl)pyrrolo(2,3-d)pyrimidine: structure given in first source; 5-bromotubercidin in which the ribose is replaced by 2-hydroxyethoxymethyl		2.0510
npf-etoposide
NPF-etoposide: RN given refers to (5R-(5alpha,5abeta,8aalpha,9beta))-isomer; structure in first source		3.1510
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: prodrug for HPMPC; specific name and structure not given in first source		2.0510
gl 331
GL 331: structure in first source		3.1510
bcx 1812
[no description available]		2.05103-hydroxy monocarboxylic acid;
acetamides;
cyclopentanols;
guanidines		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
tak 779
[no description available]		2.0410
1-(benzenesulfonyl)indole
[no description available]		2.0510sulfonamide
11alpha,13-dihydrohelenalin
[no description available]		3.1510sesquiterpene lactone
(north)-methanocarbathymidine
(north)-methanocarbathymidine: also called NMCT. 1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)bicyclo[3.1.0]hexan-2-yl]thymine : A carbobicyclic compound that is bicyclo[3.1.0]hexane which is substituted at the 2-pro-S, 4-pro-S and 5-pro-R positions by thymin-1-yl, hydroxy, and hydroxymethyl groups, respectively.		2.0510C-glycosyl pyrimidine;
carbobicyclic compound;
primary alcohol;
pyrimidone;
secondary alcohol
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		2.05102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
brivudine
brivudine: anti-herpes agent		2.0510
gs 4071
GS 4071: The acid form.. oseltamivir acid : A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). An antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza.		2.0510acetate ester;
amino acid;
cyclohexenecarboxylic acid;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
marine xenobiotic metabolite
lamivudine triphosphate
[no description available]		2.0510
l 737126
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: structure given in first source; an inhibitor of HIV-1 reverse transcriptase		2.0510
bevirimat
bevirimat: an HIV inhibitor; disrupts late step in processing HIV Major Core Protein p24, preventing the capsid precursor p25 from being converted to mature capsid p24. bevirimat : A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.		4.9260dicarboxylic acid monoester;
monocarboxylic acid;
pentacyclic triterpenoid		HIV-1 maturation inhibitor;
metabolite
tenofovir
tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.		2.0510nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
2,5,6-trichloro-1-(ribofuranosyl)benzimidazole
[no description available]		2.0510
gw 257406x
maribavir: has antiviral activity against human cytomegalovirus		2.0510
cmx 001
[no description available]		2.0510
moronic acid
moronic acid: from root bark extract of Ozoroa mucronata; RN & N1 from 9th CI. moronic acid : A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group.		3.1510pentacyclic triterpenoidanti-HIV agent;
anti-HSV-1 agent;
metabolite
favipiravir
favipiravir : A member of the class of pyrazines that is pyrazine substituted by aminocarbonyl, hydroxy and fluoro groups at positions 2, 3 and 6, respectively. It is an anti-viral agent that inhibits RNA-dependent RNA polymerase of several RNA viruses and is approved for the treatment of influenza in Japan.		2.0510hydroxypyrazine;
organofluorine compound;
primary carboxamide		anticoronaviral agent;
antiviral drug;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
6-phosphonylmethoxyethoxy-2,4-diaminopyrimidine
[no description available]		2.0510
4-phenyl-4-oxo-2-hydroxybuten-2-oic acid
2,4-dioxo-4-phenylbutanoic acid: structure in first source		2.0510
2-hydroxy-4h-isoquinoline-1,3-dione
2-hydroxy-4H-isoquinoline-1,3-dione: structure in first source		2.0510
benzoylacrylic acid
benzoylacrylic acid: structure in first source		2.0510
at 61
AT 61: a phenylpropenamide derivative; structure in first source		2.0510
2',3'-didehydro-3'-deoxy-4'-ethynylthymidine
2',3'-didehydro-3'-deoxy-4'-ethynylthymidine: a highly active anti-HIV agent; structure in first source		2.0510
vicriviroc
vicriviroc: structure in first source		2.0510(trifluoromethyl)benzenes
hcv 371
[no description available]		2.0510
molephantinin
molephantinin: germacranolide from Elephantopus mollis; RN given refers to (3aR-(3aR*,4S*(E),6E,9Z,11S*,11aS*))-isomer; structure in first source		3.1510germacranolide
andrographolide
[no description available]		2.0710carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
bms 806
BMS 806: prevents entry of HIV into cells by binding HIV envelope protein gp120; no further info available 4/2002		2.4520
flutimide
flutimide: isolated from Delitschia confertaspora; selectively inhibits the transcriptase of influenza viruses; structure given		2.0510
a 315675
[no description available]		2.0510
rilpivirine
[no description available]		2.0510aminopyrimidine;
nitrile		EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor
daurichromenic acid
daurichromenic acid: structure in first source		3.1510
bms 433771
[no description available]		2.0510
desmosdumotin c
desmosdumotin C: an antitumor agent; structure in first source		3.1510olefinic compound
lactacystin
[no description available]		2.0610lactam;
S-substituted L-cysteine
oleanonic acid
oleanonic acid: structure in first source		3.3510
gomisin-g
[no description available]		3.1510
enfuvirtide
Enfuvirtide: A synthetic 36-amino acid peptide that corresponds to the heptad repeat sequence of HIV-1 gp41. It blocks HIV cell fusion and viral entry and is used with other anti-retrovirals for combination therapy of HIV INFECTIONS and AIDS.. enfuvirtide : A synthetic 36-amino acid peptide consisting of N-acetyltyrosyl, threonyl, seryl, leucyl, isoleucyl, histidyl, seryl, leucyl, isoleucyl, alpha-glutamyl, alpha-glutamyl, seryl, glutaminyl, asparaginyl, glutaminyl, glutaminyl, alpha-glutamyl, lysyl, asparaginyl, alpha-glutamyl, alpha-glutamyl, alpha-glutamyl, leucyl, leucyl, alpha-glutamyl, leucyl, alpha-aspartyl, lysyl, tryptophyl, alanyl, seryl, leucyl, tryptophyl, asparaginyl, tryptophyl, and phenylalaninamide residues joined in sequence. An HIV fusion inhibitor, it was the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection. It interferes with entry of HIV into cells by binding to the gp41 sub-unit of the viral envelope glycoprotein, so inhibiting fusion of viral and cellular membranes.		2.0410
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.05102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
didanosine
Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.		2.0510purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
ganciclovir
[no description available]		2.05102-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
penciclovir
penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.		2.05102-aminopurines;
propane-1,3-diols		antiviral drug
cyclopropavir
cyclopropavir: cyclopropavir is the (Z)-isomer; has antiviral activity; structure in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0610
Benign Neoplasms
[description not available]		02.0610
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0610
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