idoxuridine has been researched along with Colorectal Neoplasms in 23 studies
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate hypoxia measured by pimonidazole binding, glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CA-IX) expression, proliferation, and vascularity in liver metastases of colorectal cancer and to compare GLUT1 and CA-IX expression in corresponding primary tumors." | 3.73 | Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer. ( Heerschap, A; Kaanders, JH; Lok, J; Peeters, WJ; Punt, CJ; Rijken, PF; Ruers, TJ; van der Kogel, AJ; van Laarhoven, HW; Wiering, B, 2006) |
| "Multiple studies have shown that leucovorin-fluorouracil regimens are modestly superior to fluorouracil alone in the treatment of advanced colorectal cancer." | 3.69 | Biochemical modulation in the treatment of advanced cancer: a study of combined leucovorin, fluorouracil, and iododeoxyuridine. ( DeLap, RJ; Marshall, JL; Richmond, E, 1996) |
| "Seven patients with colorectal adenocarcinoma and one with squamous cell carcinoma of anorectal region were infused preoperatively with iododeoxyuridine (IUdR) and bromodeoxyuridine (BrdU) in sequence (100 mg/m2 x 1 hr each with 1-hr interval in between) to label S-phase cells." | 3.68 | Cell cycle parameters and DNA ploidy in colorectal carcinomas. ( Bokhari, J; Hyams, D; Khan, S; Raza, A; Sheikh, Y; Yousuf, N, 1991) |
| " Low dose and either continuous infusion or repetitive dosing of leucovorin, as well as the effect of treatment sequence and intervals between drugs, require additional investigation." | 2.39 | Preclinical and clinical aspects of biomodulation of 5-fluorouracil. ( Allegra, CJ; Grogan, L; Sotos, GA, 1994) |
| "Methoxyamine not only was able to increase IdUrd cytotoxicity but also increased the incorporation of IdUrd into DNA of HCT116 human colon cancer cells leading to greater radiosensitization." | 1.32 | Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization. ( Hwang, HS; Kinsella, TJ; Radivoyevitch, T; Reddy, G; Schupp, JE; Session, NN; Taverna, P; Zarling, DA, 2003) |
| "The prognosis of colorectal cancer has not significantly changed during the last 30 years." | 1.30 | Systematic heterogeneity and prognostic significance of cell proliferation in colorectal cancer. ( Bergström, C; Oberg, A; Palmqvist, R; Rutegård, JN; Stenling, R; Zackrisson, B, 1998) |
| "Ten patients with colorectal cancer were injected intratumorally with [125I]UdR) (0." | 1.29 | Tumor targeting in vivo and metabolic fate of 5-[iodine-125]iodo-2'-deoxyuridine following intratumoral injection in patients with colorectal cancer. ( Baranowska-Kortylewicz, J; Cei, A; Collecchi, P; Di Luca, L; Di Sacco, S; Di Stefano, R; Ferdeghini, EM; Mariani, G; Van den Abbeele, AD; Viacava, P, 1993) |
| " This paper describes a new approach, based upon pharmacokinetic clearance of radioactivity from the tumor, with which to quantify the fraction of [125I]IUdR incorporated within the DNA of tumor cells." | 1.29 | Pharmacokinetics and dosimetry of iodine-125-IUdR in the treatment of colorectal cancer metastatic to liver. ( Daghighian, F; Finn, R; Humm, JL; Izzo, J; Kemeny, N; Larson, SM; Macapinlac, HA; Zhang, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 17 (73.91) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gurkan-Cavusoglu, E | 1 |
| Schupp, JE | 3 |
| Kinsella, TJ | 5 |
| Loparo, KA | 1 |
| Taverna, P | 1 |
| Hwang, HS | 1 |
| Radivoyevitch, T | 1 |
| Session, NN | 1 |
| Reddy, G | 1 |
| Zarling, DA | 1 |
| van Laarhoven, HW | 1 |
| Kaanders, JH | 1 |
| Lok, J | 1 |
| Peeters, WJ | 1 |
| Rijken, PF | 1 |
| Wiering, B | 1 |
| Ruers, TJ | 1 |
| Punt, CJ | 1 |
| Heerschap, A | 1 |
| van der Kogel, AJ | 1 |
| Yan, T | 1 |
| Seo, Y | 1 |
| Zeng, X | 1 |
| Desai, AB | 1 |
| Sotos, GA | 1 |
| Grogan, L | 1 |
| Allegra, CJ | 1 |
| Perez, LA | 1 |
| Dombkowski, D | 1 |
| Efird, J | 1 |
| Preffer, F | 1 |
| Suit, HD | 1 |
| Wilson, MS | 3 |
| Anderson, E | 1 |
| Bell, JC | 1 |
| Pearson, JM | 1 |
| Haboubi, NY | 1 |
| James, RD | 3 |
| Schofield, PF | 3 |
| Mariani, G | 3 |
| Cei, A | 1 |
| Collecchi, P | 1 |
| Baranowska-Kortylewicz, J | 3 |
| Van den Abbeele, AD | 1 |
| Di Luca, L | 3 |
| Di Stefano, R | 2 |
| Viacava, P | 1 |
| Ferdeghini, EM | 1 |
| Di Sacco, S | 3 |
| West, CM | 2 |
| Wilson, GD | 2 |
| Roberts, SA | 2 |
| Volterrani, D | 1 |
| Buralli, S | 2 |
| Bonora, D | 2 |
| Matteucci, F | 1 |
| Ricci, S | 2 |
| Bellina, CR | 1 |
| Falcone, A | 2 |
| Salvadori, PA | 1 |
| Mosca, F | 1 |
| Adelstein, SJ | 2 |
| Kassis, AI | 2 |
| Daghighian, F | 2 |
| Humm, JL | 1 |
| Macapinlac, HA | 2 |
| Zhang, J | 2 |
| Izzo, J | 1 |
| Finn, R | 2 |
| Kemeny, N | 2 |
| Larson, SM | 2 |
| Humm, J | 1 |
| Squire, O | 1 |
| Bonini, R | 1 |
| Palmqvist, R | 1 |
| Oberg, A | 1 |
| Bergström, C | 1 |
| Rutegård, JN | 1 |
| Zackrisson, B | 1 |
| Stenling, R | 1 |
| Marshall, JL | 1 |
| Richmond, E | 1 |
| DeLap, RJ | 1 |
| Thakur, ML | 1 |
| Li, J | 1 |
| Kim, SM | 1 |
| Zhang, JJ | 1 |
| Andrews, D | 1 |
| Lawrence, TS | 1 |
| Davis, MA | 1 |
| Maybaum, J | 2 |
| Mukhopadhyay, SK | 1 |
| Stetson, PL | 2 |
| Normolle, DP | 1 |
| McKeever, PE | 1 |
| Ensminger, WD | 2 |
| Burton, EC | 1 |
| Shelton, DA | 1 |
| Jing, HW | 1 |
| Dusenbury, CE | 1 |
| Yousuf, N | 1 |
| Khan, S | 1 |
| Sheikh, Y | 1 |
| Hyams, D | 1 |
| Bokhari, J | 1 |
| Raza, A | 1 |
| Chang, AE | 1 |
| Collins, JM | 1 |
| Speth, PA | 1 |
| Smith, R | 1 |
| Rowland, JB | 1 |
| Walton, L | 1 |
| Begley, MG | 1 |
| Glatstein, E | 1 |
| Sakamoto, S | 1 |
| Kawachi, Y | 1 |
| Tsukada, K | 1 |
| Mishima, Y | 1 |
| Okamoto, R | 1 |
1 review available for idoxuridine and Colorectal Neoplasms
| Article | Year |
|---|---|
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neopla | 1994 |
1 trial available for idoxuridine and Colorectal Neoplasms
| Article | Year |
|---|---|
Pilot clinical trial of 5-[125I]iodo-2'-deoxyuridine in the treatment of colorectal cancer metastatic to the liver.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Hepatic Artery; Humans; Ido | 1996 |
21 other studies available for idoxuridine and Colorectal Neoplasms
| Article | Year |
|---|---|
Quantitative analysis of the effects of iododeoxyuridine and ionising radiation treatment on the cell cycle dynamics of DNA mismatch repair deficient human colorectal cancer cells.
Topics: Cell Cycle; Colorectal Neoplasms; DNA Mismatch Repair; HCT116 Cells; Humans; Idoxuridine; Models, Bi | 2013 |
Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization.
Topics: Animals; CHO Cells; Colorectal Neoplasms; Cricetinae; DNA; DNA Damage; DNA Repair; DNA-Binding Prote | 2003 |
Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Carbonic Anhydrases; Cell Hypoxia; Cell Proliferation; Colorectal Ne | 2006 |
Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence.
Topics: Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Cell Survival; Cellular Senescence; Colorectal Neop | 2006 |
Cell proliferation kinetics in human tumor xenografts measured with iododeoxyuridine labeling and flow cytometry: a study of heterogeneity and a comparison between different methods of calculation and other proliferation measurements.
Topics: Animals; Carcinoma, Squamous Cell; Cell Count; Cell Division; Colorectal Neoplasms; DNA, Neoplasm; F | 1995 |
An evaluation of five different methods for estimating proliferation in human colorectal adenocarcinomas.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Cell Division; Colorectal Neoplasms; Flow Cytometry; Humans; | 1994 |
Tumor targeting in vivo and metabolic fate of 5-[iodine-125]iodo-2'-deoxyuridine following intratumoral injection in patients with colorectal cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Autoradiography; Colorectal Neoplasms; Female; Humans; Idox | 1993 |
Intra-tumoral heterogeneity of tumour potential doubling times (Tpot) in colorectal cancer.
Topics: Adenocarcinoma; Biopsy; Cell Division; Colorectal Neoplasms; DNA, Neoplasm; Flow Cytometry; Humans; | 1993 |
An assessment of the reliability and reproducibility of measurement of potential doubling times (Tpot) in human colorectal cancers.
Topics: Adenocarcinoma; Cell Cycle; Cell Division; Colorectal Neoplasms; DNA, Neoplasm; Flow Cytometry; Huma | 1993 |
Correspondence re: J.A. Knol et al., Incorporation of 5-bromo-2-deoxyuridine into colorectal liver metastases and liver in patients receiving a 7-day hepatic arterial infusion. Cancer Res., 55: 3687-3691, 1995.
Topics: Bromodeoxyuridine; Colorectal Neoplasms; DNA, Neoplasm; Humans; Idoxuridine; Liver; Liver Neoplasms; | 1996 |
Tumor targeting by intra-arterial infusion of 5-[123I]iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer.
Topics: Aged; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Female; Hepatic Artery; Humans; Id | 1996 |
Pharmacokinetics and dosimetry of iodine-125-IUdR in the treatment of colorectal cancer metastatic to liver.
Topics: Bone Marrow; Colorectal Neoplasms; Hepatic Artery; Humans; Idoxuridine; Injections, Intra-Arterial; | 1996 |
Biochemical modulation by 5-fluorouracil and 1-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'deoxyuridine in patients with liver metastases from colorectal cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Feasibility Studies; Fluorouracil; Huma | 1996 |
Systematic heterogeneity and prognostic significance of cell proliferation in colorectal cancer.
Topics: Cecal Neoplasms; Cell Division; Colonic Neoplasms; Colorectal Neoplasms; Female; Flow Cytometry; Hum | 1998 |
Biochemical modulation in the treatment of advanced cancer: a study of combined leucovorin, fluorouracil, and iododeoxyuridine.
Topics: Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as | 1996 |
Targeting tumors with iodine-123 labeled deoxyuridine: distribution and DNA binding.
Topics: Animals; Chromatography, High Pressure Liquid; Colorectal Neoplasms; DNA, Neoplasm; Humans; Idoxurid | 1999 |
The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer.
Topics: Animals; Bromodeoxyuridine; Colorectal Neoplasms; DNA; DNA Damage; Female; Humans; Idoxuridine; Infa | 1992 |
Divergent patterns of incorporation of bromodeoxyuridine and iododeoxyuridine in human colorectal tumor cell lines.
Topics: Bromodeoxyuridine; Cell Division; Colorectal Neoplasms; DNA, Neoplasm; Floxuridine; Fluorouracil; Ga | 1991 |
Cell cycle parameters and DNA ploidy in colorectal carcinomas.
Topics: Adenocarcinoma; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Cycle; Colorectal Neoplasms; DNA; | 1991 |
A phase I study of intraarterial iododeoxyuridine in patients with colorectal liver metastases.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Combined Modality Therapy; DNA, Neoplasm; Drug Evaluati | 1989 |
[Clinical value of thymidine kinase activities in sera and tumor tissues of patients with colorectal cancer].
Topics: Biomarkers, Tumor; Colorectal Neoplasms; Humans; Idoxuridine; Iodine Radioisotopes; Neoplasm Staging | 1988 |