Compounds > 9-(4-hydroxybutyl)guanine
Page last updated: 2024-10-15

9-(4-hydroxybutyl)guanine

Cross-References

ID SourceID
PubMed CID135433410
CHEMBL ID258513
SCHEMBL ID571645
SCHEMBL ID14595281
MeSH IDM0117247

Synonyms (18)

Synonym
2-amino-9-(4-hydroxybutyl)hydropurin-6-one
2-amino-9-(4-hydroxybutyl)-1h-purin-6-one
6h-purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxybutyl)-
2-amino-9-(4-hydroxybutyl)-1,9-dihydro-6h-purin-6-one
inchi=1/c9h13n5o2/c10-9-12-7-6(8(16)13-9)11-5-14(7)3-1-2-4-15/h5,15h,1-4h2,(h3,10,12,13,16
bdbm21868
9-(4-hydroxybutyl)guanine
2-amino-9-(4-hydroxybutyl)-6,9-dihydro-3h-purin-6-one
chembl258513 ,
23169-37-1
SCHEMBL571645
DVQJDXCYEPGOCF-UHFFFAOYSA-N
9-hydroxybutylguanine
SCHEMBL14595281
DTXSID90177750
2-amino-9-(4-hydroxybutyl)-6,9-dihydro-1h-purin-6-one
famciclovir impurity 2
2-amino-9-(4-hydroxybutyl)-1h-purin-6(9h)-one

Pharmacokinetics

ExcerptReference
" The extremely short half-life in plasma and the high clearance of 9-(4-hydroxybutyl)guanine as compared with those of (R)-9-(3,4-dihydroxybutyl)guanine probably made 9-(4-hydroxybutyl)guanine inefficacious when given intraperitoneally or orally to mice infected with herpesvirus."( Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.
Aoki, FY; Datema, R; Ericson, AC; Johansson, NG; Larsson, A; Oberg, B; Yisak, WA, 1985)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidine kinase Macacine alphaherpesvirus 1IC50 (µMol)177.00000.15002.57504.2000AID326127
Thymidine kinase, cytosolicHomo sapiens (human)Ki2.06000.09001.52137.0000AID210697
Thymidine kinaseHuman alphaherpesvirus 1 strain SC16IC50 (µMol)60.00000.10001.84917.9433AID241897
Thymidine kinase Human alphaherpesvirus 2IC50 (µMol)160.00000.10000.84621.6000AID241898
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (6)

Processvia Protein(s)Taxonomy
nucleobase-containing compound metabolic processThymidine kinase, cytosolicHomo sapiens (human)
deoxyribonucleoside monophosphate biosynthetic processThymidine kinase, cytosolicHomo sapiens (human)
thymidine metabolic processThymidine kinase, cytosolicHomo sapiens (human)
thymidine biosynthetic processThymidine kinase, cytosolicHomo sapiens (human)
protein homotetramerizationThymidine kinase, cytosolicHomo sapiens (human)
DNA synthesis involved in mitotic DNA replicationThymidine kinase, cytosolicHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
thymidine kinase activityThymidine kinase, cytosolicHomo sapiens (human)
protein bindingThymidine kinase, cytosolicHomo sapiens (human)
ATP bindingThymidine kinase, cytosolicHomo sapiens (human)
zinc ion bindingThymidine kinase, cytosolicHomo sapiens (human)
identical protein bindingThymidine kinase, cytosolicHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
nucleusThymidine kinase, cytosolicHomo sapiens (human)
cytosolThymidine kinase, cytosolicHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID241897Inhibitory concentration against herpes simplex virus type 1 thymidine kinase2005Journal of medicinal chemistry, Jun-02, Volume: 48, Issue:11
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.
AID1572733Antiviral activity against Varicella-zoster virus Oka harboring thymidine kinase infected in HEL cells assessed as reduction in virus plaque formation2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID326131Activity of Herpes B virus recombinant thymidine kinase at 100 uM2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID86827Percentage of diphosphates (DP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID1572740Cytostatic activity against human NCI-H460 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1572729Antiviral activity against herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID326127Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID1572730Antiviral activity against herpes simplex virus 2 G infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID241898Inhibitory concentration against herpes simplex virus type 2 thymidine kinase2005Journal of medicinal chemistry, Jun-02, Volume: 48, Issue:11
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.
AID164770Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)1994Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.
AID87443Percentage of triphosphates (TP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID1572736Antiviral activity against Human cytomegalovirus Davis assessed as reduction in virus-induced cytopathogenicity by microscopic analysis2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID53487Inhibition of DNA polymerase1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID1572739Cytostatic activity against human HAP1 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID87640Antiviral activity against HSV-1 cell line (concentration required to prevent viral cytopathic effect in half of primary rabbit kidney cell cultures)1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID87302Percentage of monophosphates (MP) formed in the first step of staggered assay compound was incubated with HSV-1 thymidine kinase for 4 hr1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID1572735Antiviral activity against Human cytomegalovirus AD169 assessed as reduction in virus-induced cytopathogenicity by microscopic analysis2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID90940Antiviral activity against HCMV was determined; No inhibition1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation.
AID53466Inhibition of DNA polymerase1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID1572738Cytostatic activity against human Capan1 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID230017Ratio of Ki values for guanine and related hypoxanthines in PNP inhibition assay1994Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.
AID87834Antiviral activity against HSV-2 cell line (concentration required to prevent viral cytopathic effect in half of primary rabbit kidney cell cultures)1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID1572737Cytostatic activity against human hTERT-RPE1 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1572731Antiviral activity against thymidine kinase deficient and aciclovir resistant herpes simplex virus 1 KOS infected in HEL cells assessed as reduction in virus-induced cytopathogenicity by microscopic analysis2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1572741Cytostatic activity against human DND41 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID210697Binding affinity towards HSV-1 thymidine kinase was determined1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID82116Antiviral activity against HIV-1 was determined; No inhibition1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation.
AID1572732Cytotoxicity against HEL cells assessed as effect on cell morphology at 0.32 to 200 uM by microscopic analysis2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID87303Percentage of monophosphates (MP) in the second step of staggered assay mixture from step 1 was incubated with GMP kinase and crude extract of HSV-1 infected HeLa cells over night1988Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds.
AID1572734Antiviral activity against thymidine kinase deficient Varicella-zoster virus 07-1 infected in HEL cells assessed as reduction in virus plaque formation2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1572743Cytostatic activity against human K562 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1572744Cytostatic activity against human Z138 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1572742Cytostatic activity against human HL60 cells2019Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
AID1798138Thymidine Kinase Inhibition Assay from Article 10.1021/jm049059x: \\Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.\\2005Journal of medicinal chemistry, Jun-02, Volume: 48, Issue:11
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (33.33)18.7374
1990's4 (33.33)18.2507
2000's2 (16.67)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
foscarnet
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.		2.4320carboxylic acid;
one-carbon compound;
phosphonic acids		antiviral drug;
geroprotector;
HIV-1 reverse transcriptase inhibitor;
sodium-dependent Pi-transporter inhibitor
thymidine
[no description available]		2.0310pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
idoxuridine
[no description available]		2.0310organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
trifluridine
Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.		2.0310nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor
butylhydroxybutylnitrosamine
Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.		1.9810nitrosamine;
primary alcohol		carcinogenic agent
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		2.0310beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		2.0610pseudohalide anionmitochondrial respiratory-chain inhibitor
etoposide
[no description available]		2.2110beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
staurosporine
[no description available]		2.2110indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
adefovir
adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.		1.97106-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.		2.4920phosphonic acids;
pyrimidone		anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent
edoxudin
[no description available]		2.0310pyrimidine 2'-deoxyribonucleoside
9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
[no description available]		1.9710
9-(2,3-dihydroxypropyl)adenine, (s)-isomer
[no description available]		1.9710
o(6)-n-butylguanine
[no description available]		1.9810
docetaxel anhydrous
Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.		2.2110secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
5-propyl-2'-deoxyuridine
5-propyl-2'-deoxyuridine: RN given refers to parent cpd		2.0310
brivudine
brivudine: anti-herpes agent		2.4920
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		3.691002-aminopurines;
oxopurine		antimetabolite;
antiviral drug
guanine
[no description available]		2.39202-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanosine
ribonucleoside : Any nucleoside where the sugar component is D-ribose.		1.9710guanosines;
purines D-ribonucleoside		fundamental metabolite
hypoxanthine
[no description available]		1.9810nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
ganciclovir
[no description available]		2.92402-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
penciclovir
penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.		2.92402-aminopurines;
propane-1,3-diols		antiviral drug
8-amino-9-benzylguanine
8-amino-9-benzylguanine: structure given in first source		1.9810
buciclovir
buciclovir: structure given in first source		2.6630
peldesine
peldesine: potent inhibitor of human CCRF-CEM T-cell proliferation; structure given in first source		1.9810
n(2)-phenylguanine
[no description available]		1.9810
8-aminoguanine
[no description available]		1.9810
n(2)-(3-trifluoromethylphenyl)guanine
[no description available]		2.4120
9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine
9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine: structure given in first source		1.9710
adenallene
adenallene: structure given in first source; inhibits replication and cytopathic effects of HIV in vitro		1.9710
9-deaza-9-(3-thienylmethyl)guanine
[no description available]		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Necrotizing Encephalitis, Herpetic
[description not available]		02.0210
Eye Infections, Viral
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.		02.0210
Encephalitis, Herpes Simplex
An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)		02.0210
Genital Herpes
[description not available]		02.2110
Herpes Simplex Virus Infection
[description not available]		02.6830
Herpes Genitalis
Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.		02.2110
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		02.6830
Furrow Keratitis
[description not available]		01.9610
Bladder Cancer
[description not available]		01.9810
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		01.9810
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		01.9710