Substance | Relationship Strength | Studies | Trials | Classes | Roles |
3-aminobenzamide [no description available] | 1.98 | 1 | 0 | benzamides; substituted aniline | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
thymidine [no description available] | 5.46 | 21 | 0 | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite |
idoxuridine [no description available] | 4.86 | 11 | 0 | organoiodine compound; pyrimidine 2'-deoxyribonucleoside | antiviral drug; DNA synthesis inhibitor |
uridine [no description available] | 2.66 | 3 | 0 | uridines | drug metabolite; fundamental metabolite; human metabolite |
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors. | 3.06 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | antimetabolite; antineoplastic agent |
cytidine [no description available] | 1.96 | 1 | 0 | cytidines | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
cytarabine [no description available] | 3.06 | 1 | 0 | beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside | antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent |
trifluridine Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis. | 2.38 | 2 | 0 | nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside | antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor |
phenyl isocyanate [no description available] | 1.98 | 1 | 0 | benzenes; isocyanates | allergen; hapten |
fluorodeoxyuridylate Fluorodeoxyuridylate: 5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine. | 2.01 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside 5'-monophosphate | |
5-fluorouridine [no description available] | 2.01 | 1 | 0 | organofluorine compound; uridines | mutagen |
thymidine monophosphate Thymidine Monophosphate: 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.. dTMP : The neutral species of thymidine 5'-monophosphate (2'-deoxythymidine 5'-monophosphate). | 2.01 | 1 | 0 | thymidine 5'-monophosphate | fundamental metabolite |
deoxycytidine [no description available] | 2.66 | 3 | 0 | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
deoxyuridine [no description available] | 2.89 | 4 | 0 | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
2-chloroethyl isocyanate [no description available] | 1.96 | 1 | 0 | | |
stavudine Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase | 2.66 | 3 | 0 | dihydrofuran; nucleoside analogue; organic molecular entity | antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor |
doxifluridine doxifluridine : A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. | 2.01 | 1 | 0 | organofluorine compound; pyrimidine 5'-deoxyribonucleoside | antimetabolite; antineoplastic agent; prodrug |
vidarabine adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. | 3.06 | 1 | 0 | beta-D-arabinoside; purine nucleoside | antineoplastic agent; bacterial metabolite; nucleoside antibiotic |
zalcitabine Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase. | 1.97 | 1 | 0 | pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor |
alovudine [no description available] | 2.01 | 1 | 0 | pyrimidine 2',3'-dideoxyribonucleoside | |
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. | 2.67 | 3 | 0 | azide; pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor |
ribavirin Rebetron: Rebetron is tradename | 3.06 | 1 | 0 | 1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide | anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor |
fiacitabine fiacitabine: anti-herpes virus agent which also inhibits growth of certain human tumor cell lines in vitro. | 3.06 | 1 | 0 | | |
3'-azido-2',3'-dideoxyuridine [no description available] | 2.37 | 2 | 0 | | |
2',3'-dideoxycytidinene 2',3'-dideoxycytidinene: 2',3'-unsaturated derivative of 2',3'-dideoxycytidine; potent inhibitor of HTLV-III in vitro; structure given in first source | 1.97 | 1 | 0 | | |
thymidine 5'-triphosphate thymidine 5'-triphosphate: RN given refers to parent cpd. dTTP : A thymidine phosphate having a triphosphate group at the 5'-position. | 2.89 | 4 | 0 | pyrimidine 2'-deoxyribonucleoside 5'-triphosphate; thymidine phosphate | Escherichia coli metabolite; mouse metabolite |
3'-azido-2',3'-dideoxy-5-bromouridine 3'-azido-2',3'-dideoxy-5-bromouridine: a potent, selective inhibitor of HIV replication; a weak competitive inhibitor of thymidylate kinase | 2.37 | 2 | 0 | | |
3'-azido-2',3'-dideoxy-5-methylcytidine 3'-azido-2',3'-dideoxy-5-methylcytidine: inhibits reproduction of AIDS virus in cultured cells | 2.37 | 2 | 0 | | |
thymine arabinoside thymine arabinoside: selectively inhibits replication of herpes simplex virus | 2.01 | 1 | 0 | N-glycosyl compound | |
ibacitabine ibacitabine: antiherpetic agent | 1.96 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | |
methylthymidine methylthymidine: RN given refers to N-3-methylthymidine | 1.96 | 1 | 0 | | |
2'-deoxyuridylic acid 2'-deoxyuridylic acid: RN given refers to parent cpd | 2.01 | 1 | 0 | deoxyuridine phosphate; pyrimidine 2'-deoxyribonucleoside 5'-monophosphate | Escherichia coli metabolite; metabolite; mouse metabolite |
2',3'-dideoxythymidine [no description available] | 2.89 | 4 | 0 | | |
2',3'-didehydro-2',3'-dideoxyuridine [no description available] | 2.37 | 2 | 0 | | |
2',3'-dideoxyuridine [no description available] | 2.37 | 2 | 0 | pyrimidine 2',3'-dideoxyribonucleoside | |
3'-azido-3'-deoxythymidine 5'phosphate 3'-azido-3'-deoxythymidine 5'phosphate: inhibits thymidylate kinase | 2.01 | 1 | 0 | | |
5-chloro-2'-deoxyuridine [no description available] | 1.98 | 1 | 0 | | |
edoxudin [no description available] | 2.01 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | |
4'-thiothymidine [no description available] | 2.04 | 1 | 0 | | |
bromodeoxyuridylate bromodeoxyuridylate: RN given refers to parent cpd | 2.01 | 1 | 0 | | |
cyanates Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N). | 2.38 | 2 | 0 | | |
3'-amino-2',3'-dideoxythymidine [no description available] | 3.36 | 7 | 0 | | |
5-amino-2'-deoxyuridine 5-amino-2'-deoxyuridine: structure in first source | 2.36 | 2 | 0 | | |
3'-amino-2',3'-dideoxyuridine 3'-amino-2',3'-dideoxyuridine: structure given in first source; a major metabolite of the antiviral agent, 3'-azido-2',3'-dideoxyuridine | 1.97 | 1 | 0 | | |
5'-amino-5-iodo-2',5'-dideoxyuridine [no description available] | 3.97 | 4 | 0 | | |
methotrexate [no description available] | 1.97 | 1 | 0 | dicarboxylic acid; monocarboxylic acid amide; pteridines | abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent |
2'-fluorothymidine [no description available] | 2.01 | 1 | 0 | | |
n(3)-ethylthymidine N(3)-ethylthymidine: structure given in first source | 1.95 | 1 | 0 | | |
3'-amino-3'-deoxythymidine 5'-monophosphate [no description available] | 2.01 | 1 | 0 | | |
5,6-dihydrothymidine 5,6-dihydrothymidine: RN given refers to cpd without isomeric designation. 5,6-dihydrothymidine : A pyrimidine 2'-deoxyribonucleoside having dihydrothymine as the nucleobase. | 1.96 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | Mycoplasma genitalium metabolite |
5-methyldeoxycytidine [no description available] | 1.96 | 1 | 0 | 2'-deoxycytidine | |
brivudine brivudine: anti-herpes agent | 3.06 | 1 | 0 | | |
5-iodo-2'-deoxyuridine 5'-monophosphate iododeoxyuridylate: RN given refers to parent cpd | 2.01 | 1 | 0 | | |
3'-azido-2',3'-dideoxycytidine [no description available] | 2.37 | 2 | 0 | | |
5-bromo-2',3'-dideoxyuridine 5-bromo-2',3'-dideoxyuridine: structure given in first source | 1.97 | 1 | 0 | | |
5-cyano-2'-deoxyuridine 5-cyano-2'-deoxyuridine: structure in first source | 1.95 | 1 | 0 | | |
sodium bicarbonate Sodium Bicarbonate: A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | 2.01 | 1 | 0 | one-carbon compound; organic sodium salt | antacid; food anticaking agent |
5-(1-propenyl)-2'-deoxyuridine 5-(1-propenyl)-2'-deoxyuridine: has anti-herpes activity; structure in first source | 1.96 | 1 | 0 | | |
4'-thiothymidine 4'-thiothymidine: RN & structure given in first source | 2.04 | 1 | 0 | | |
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. | 3.06 | 1 | 0 | 2-aminopurines; oxopurine | antimetabolite; antiviral drug |