Compounds > 6-phosphonylmethoxyethoxy-2,4-diaminopyrimidine
Page last updated: 2024-12-08

6-phosphonylmethoxyethoxy-2,4-diaminopyrimidine

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Cross-References

ID SourceID
PubMed CID493045
CHEMBL ID298845
SCHEMBL ID1032922
MeSH IDM0591525

Synonyms (9)

Synonym
pmeo-dapym
pmeo-dapy
2-(2,6-diaminopyrimidin-4-yl)oxyethoxymethylphosphonic acid
phosphonic acid, [[2-[(2,6-diamino-4-pyrimidinyl)oxy]ethoxy]methyl]-
CHEMBL298845
429676-19-7
SCHEMBL1032922
DTXSID70333231
6-[2-(phosphonomethoxy)ethoxy]-2,4-diaminopyrimidine

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
" These mt-QSARs offer also a good opportunity to construct drug-drug Complex Networks (CNs) that can be used to explore large and complex drug-viral species databases."( Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (118)

Assay IDTitleYearJournalArticle
AID324765Antiviral activity against Simian virus 40 PML1 EK in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID1462036Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID374204Cytotoxicity against human PHK assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID322825Inhibition of wild type HBV replication in Huh7 cells2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID65703Inhibition of Herpes simplex virus-2 (G strain) induced cytopathicity in E6SM cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID1462032Antiviral activity against Herpes simplex virus 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID1462056Antiviral activity against Influenza A virus (H1N1) infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID45994Cytotoxicity against CEM (human lymphoblastic leukemia) cells in vitro.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID1383903Potency index, ratio of tenofovir EC50 to compound EC50 for antiviral activity against HSV2018European journal of medicinal chemistry, Apr-25, Volume: 150Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
AID374195Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID322840Antiviral activity against Lamivudine -adenofir-resistant HBV with reverse transcriptase V173L/L180M/A181V/M204V mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID1462031Antiviral activity against wild type Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID324764Antiviral activity against Simian virus 40 A2895 in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID322848Fold resistance, ratio of Lamivudine -adenofir-resistant with HBV reverse transcriptase V173L/L180M/A181V/M204V mutant to wildtype HBV genotype E2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID3059Antiviral activity against 07/1 strain of VZV in HEL (human erythroleukemia) cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID43371In vitro cytotoxicity against CCRF-CEM T lymphoblastoid cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID322826Effect on cell viability in human Huh7 cells2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID322847Fold resistance, ratio of Lamivudine -adenofir-resistant HBV with reverse transcriptase V173L/L180M/A181V mutant to wildtype HBV genotype E2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID43365Inhibitory activity against CCRF-CEM cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID1462041Antiviral activity against Vesicular stomatitis virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID1462038Antiviral activity against Vaccinia virus Lederle infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID374196Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML1 infected in HEL299 cells2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID322845Fold resistance, ratio of lamivudine-resistant HBV with reverse transcriptase L180M/A181V mutant to wild-type HBV genotype E2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID95008Antiviral activity against KOS strain of HSV-1 in E6SM cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID1462050Selectivity index, ratio of CC50 for HEL cells to EC50 for wild type Herpes simplex virus 1 KOS infected in HEL cells2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID10054Antiviral activity against AD169 strain of cytomegalovirus (CMV) in HEL (human erythroleukemia) cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID83255Antiviral activity against HIV-2 (ROD) in CEM (human leukemia) cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID322842Antiviral activity against lamivudine-adenofir-resistant HBV with reverse transcriptase V173L/L180M/A181V/N236T mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID324766Antiviral activity against Simian virus 40 PML2 DAR in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID322841Antiviral activity against Lamivudine -adenofir-resistant HBV with reverse transcriptase V173L/L180M/A181V/M204V/N236T mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID374194Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID322844Fold resistance, ratio of lamivudine-resistant HBV with reverse transcriptase L180M/M204V mutant to wild-type HBV genotype E2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID324761Selectivity index, ratio of CC50 for mouse UC1B cells to EC50 of Murine polyomavirus PTA2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID1462051Selectivity index, ratio of CC50 for HEL cells to EC50 for Herpes simplex virus 2 G infected in HEL cells2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID1383901Antiviral activity against HBV2018European journal of medicinal chemistry, Apr-25, Volume: 150Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
AID374203Cytotoxicity against HEL299 cells assessed as minimum cytotoxic concentration required for alteration in cell morphology after 4 days by microscopy2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID1462052Selectivity index, ratio of CC50 for HEL cells to EC50 for thymidine kinase-deficient ACV-resistant Herpes simplex virus 1 KOS infected in HEL cells2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID55965Antiviral activity against Davis strain of cytomegalovirus (CMV) in HEL (human erythroleukemia) cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID1462035Antiviral activity against wild type thymidine kinase-deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as inhibition of virus-induced plaque formation2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID324759Cytotoxicity against mouse UC1B cells2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID1462039Cytotoxicity against HEL cells assessed as alteration of cell morphology by microscopic analysis2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID322837Antiviral activity against lamivudine-resistant HBV with reverse transcriptase L180M/A181V mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID44141Inhibition of moloney sarcoma virus (MSV) induced cytopathicity in C3H/3T3 embryo fibroblast cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID1462045Antiviral activity against Reovirus-1 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID324767Cytotoxicity against african green monkey BSC1 cells2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID1462040Cytotoxicity against HEL cells assessed as reduction in cell growth after 3 days by coulter counter method2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID322835Antiviral activity against wild type HBV genotype E assessed as inhibition of replication2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID1462048Antiviral activity against Feline coronavirus infected in CRFK cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID82134Antiviral activity against HIV-1 (IIIB) in CEM (human leukemia) cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID405412Antiviral activity against PERV infected in human 293T cells assessed as inhibition of proximal DNA synthesis after 24 hrs by RT-PCR2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
AID322839Antiviral activity against lamivudine-adenofir-resistant HBV with reverse transcriptase V173L/L180M/A181V mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID324763Selectivity index, ratio of CC50 for mouse UC1B cells to EC50 of Murine polyomavirus LID12007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID392512Antiviral activity against Herpes simplex virus 22009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID82695Inhibition of Thymidine kinase deficient (TK-) Varicella-Zoster virus (VZV) YS/R strain induced cytopathicity in HEL cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID322831Fold resistance, ratio of EC50 for adenofir-resistant HBV with reverse transcriptase N236T mutant to EC50 for wild-type HBV2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID374193Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID1462054Selectivity index, ratio of CC50 for HEL cells to EC50 for wild type thymidine kinase-deficient Varicella-Zoster virus 07-1 infected in HEL cells2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID322827Antiviral activity against wild type HBV assessed as inhibition of replication2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID82696Inhibition of Varicella-Zoster virus (VZV) OKA strain induced cytopathicity in HEL cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID324770Selectivity index, ratio of CC50 for african green monkey BSC1 cells ot EC50 for Simian virus 40 PML2 DAR2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID1462058Antiviral activity against influenza B virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID46194Inhibition of Human immunodeficiency virus (HIV) -1 III B strain induced cytopathicity in CEM cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID95246In vitro cytotoxicity against murine L929 cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID374202Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML14 infected in human PHK2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID322833Fold resistance, ratio of EC50 for lamivudine-adefovir-resistant HBV with reverse transcriptase L180M/M204V/N236T mutant to EC50 for wild-type HBV2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID96479Inhibitory activity against L1210 cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID65704Inhibition of thymidine kinase deficient Herpes simplex virus-1 VMW 1837 strain induced cytopathicity in E6SM cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID324756Antiviral activity against Murine polyomavirus PTA in mouse UC1B cells assessed as reduction of virus-induced cytopathogenicity2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID87607In vitro cytotoxicity against human cervix carcinoma HeLa S3 cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID46195Inhibition of Human immunodeficiency virus (HIV)-2 ROD strain induced cytopathicity in CEM cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID94721In vitro cytotoxicity against L1210 mouse leukemia cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID1462034Antiviral activity against wild type thymidine kinase expressing Varicella-Zoster virus Oka infected in HEL cells assessed as inhibition of virus-induced plaque formation2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID322846Fold resistance, ratio of lamivudine-resistant HBV with reverse transcriptase V173L/L180/M204V mutant to wild-type HBV genotype H2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID65702Inhibition of Herpes simplex virus-1, KOS strain induced cytopathicity in E6SM cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID1462033Antiviral activity against thymidine kinase-deficient ACV-resistant Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID374201Selectivity index, ratio of CC50 for human PHK to EC50 for Camelpox virus CML1 infected in human PHK2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID1383890Antiviral activity against HIV12018European journal of medicinal chemistry, Apr-25, Volume: 150Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
AID322850Fold resistance, ratio of Lamivudine -adenofir-resistant with HBV reverse transcriptase V173L/L180M/A181V/N236T mutant to wildtype HBV genotype E2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID374198Antiviral activity against Camelpox virus CML1 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID1462046Antiviral activity against Sindbis virus infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID324755Antiviral activity against Murine polyomavirus MN/RDE Toronto in mouse UC1B cells assessed as reduction of virus-induced cytopathogenicity2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID147626Antiviral activity against OKA strain of VZV in HEL (human erythroleukemia) cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID322828Antiviral activity against adenofir-resistant HBV with reverse transcriptase N236T mutant assessed as inhibition of replication2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID142453Antiviral activity against murine sarcoma virus2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID322830Antiviral activity against lamivudine-adefovir-resistant HBV with reverse transcriptase L180M/M204V/N236T mutant assessed as inhibition of replication2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID322834Antiviral activity against wild type HBV genotype H assessed as inhibition of replication2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID322843Antiviral activity against entecavir-resistant HBV with reverse transcriptase L180M/S202G/M204V mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID322851Fold resistance, ratio of entecavir-resistant HBV with reverse transcriptase L180M/S202G/M204V mutant to wild-type HBV genotype H2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID392511Antiviral activity against Herpes simplex virus 12009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID1462037Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID72410Antiviral activity against vaccinia virus in HEL (human erythroleukemia) cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID82523Inhibitory activity against HEL cell proliferation2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID324757Antiviral activity against Murine polyomavirus 2PTA2 in mouse UC1B cells assessed as reduction of virus-induced cytopathogenicity2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID322832Fold resistance, ratio of EC50 for lamivudine-resistant HBV with reverse transcriptase L180M/M204V mutant to EC50 for wild-type HBV2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID324768Selectivity index, ratio of CC50 for african green monkey BSC1 cells ot EC50 for Simian virus 40 A28952007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID324769Selectivity index, ratio of CC50 for african green monkey BSC1 cells ot EC50 for Simian virus 40 PML1 EK2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID1462047Antiviral activity against Punta Toro virus infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID324762Selectivity index, ratio of CC50 for mouse UC1B cells to EC50 of Murine polyomavirus 2PTA22007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID72409Antiviral activity against G strain of HSV-2 in E6SM cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
AID82697Inhibition of Varicella-Zoster virus (VZV) YS strain induced cytopathicity in HEL cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID1462043Antiviral activity against Respiratory syncytial virus A strain long infected in human HeLA cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID324760Selectivity index, ratio of CC50 for mouse UC1B cells to EC50 of Murine polyomavirus MN/RDE Toronto2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID99816Inhibitory activity against L929 cells2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID322838Antiviral activity against lamivudine-resistant HBV with reverse transcriptase V173L/L180/M204V mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID322829Antiviral activity against lamivudine-resistant HBV with reverse transcriptase L180M/M204V mutant assessed as inhibition of replication2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID322836Antiviral activity against lamivudine-resistant HBV with reverse transcriptase L180M/M204V mutant2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
AID374199Antiviral activity against Camelpox virus CML14 infected in human PHK assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID1383902Antiviral activity against HSV2018European journal of medicinal chemistry, Apr-25, Volume: 150Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
AID374197Selectivity index, ratio of CC50 for HEL299 cells to EC50 for Camelpox virus CML14 infected in HEL299 cells2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID1462053Selectivity index, ratio of CC50 for HEL cells to EC50 for wild type thymidine kinase expressing Varicella-Zoster virus Oka infected in HEL cells2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID1462044Antiviral activity against Parainfluenza virus 3 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID1462057Antiviral activity against Influenza A virus H3N2 infected in HEL cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID82694Inhibition of Thymidine kinase deficient (TK-) Varicella-Zoster virus (VZV) 07/1 strain induced cytopathicity n HEL cell line2002Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
AID1462042Antiviral activity against Coxsackie virus B4 infected in human HeLA cells assessed as inhibition of virus-induced cytopathic effect2017Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
AID405582Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
AID324758Antiviral activity against Murine polyomavirus LID1 ATCC VR-252 in mouse UC1B cells assessed as reduction of virus-induced cytopathogenicity2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
AID374200Cytotoxicity against human PHK after 4 days by Z1 Coulter counting analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
AID322849Fold resistance, ratio of lamivudine -adenofir-resistant with HBV reverse transcriptase V173L/L180M/A181V/M204V/N236T mutant to wild-type HBV genotype E2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (77.78)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.00 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amantadine
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source		2.0510adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
foscarnet
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.		2.0510carboxylic acid;
one-carbon compound;
phosphonic acids		antiviral drug;
geroprotector;
HIV-1 reverse transcriptase inhibitor;
sodium-dependent Pi-transporter inhibitor
nevirapine
Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.. nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.		2.4420cyclopropanes;
dipyridodiazepine		antiviral drug;
HIV-1 reverse transcriptase inhibitor
olomoucine
olomoucine: inhibits protein P34CDC2. olomoucine : A 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor.		2.05102,6-diaminopurines;
ethanolamines		EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
delavirdine
Delavirdine: A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.. delavirdine : The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.		2.0510aminopyridine;
indolecarboxamide;
N-acylpiperazine;
sulfonamide		antiviral drug;
HIV-1 reverse transcriptase inhibitor
idoxuridine
[no description available]		2.0510organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
alizarin
[no description available]		3.2710dihydroxyanthraquinonechromophore;
dye;
plant metabolite
benzohydroxamic acid
[no description available]		2.0510
n-hydroxyphthalimide
N-hydroxyphthalimide: causes contact dermititis		2.0510
toyocamycin
Toyocamycin: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.. toyocamycin : An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.		2.0510antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
nitrile;
ribonucleoside		antimetabolite;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite
stavudine
Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase		2.4420dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
acetylpyruvic acid
acetylpyruvic acid: structure. acetylpyruvic acid : A dioxo monocarboxylic acid that is pentanoic acid carrying two oxo groups at positions 2 and 4.		2.0510beta-diketone;
dioxo monocarboxylic acid		bacterial metabolite
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		2.0510pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		3.8630azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
ribavirin
Rebetron: Rebetron is tradename		2.05101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
fialuridine
[no description available]		2.0510
adefovir
adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.		4.52706-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.		2.9740phosphonic acids;
pyrimidone		anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent
lamivudine
[no description available]		2.7330monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
zanamivir
Zanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.		2.0510guanidinesantiviral agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
adefovir dipivoxil
bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine: structure given in first source. adefovir pivoxil : An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.		2.44206-aminopurines;
carbonate ester;
ether;
organic phosphonate		antiviral drug;
DNA synthesis inhibitor;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent;
prodrug
efavirenz
efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.		2.0510acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor
nelfinavir
Nelfinavir: A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.. nelfinavir : An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.		2.0510aryl sulfide;
benzamides;
organic heterobicyclic compound;
phenols;
secondary alcohol;
tertiary amino compound		antineoplastic agent;
HIV protease inhibitor
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
[no description available]		2.4220
amprenavir
[no description available]		2.0510carbamate ester;
sulfonamide;
tetrahydrofuryl ester		antiviral drug;
HIV protease inhibitor
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.0510acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
stavudine triphosphate
stavudine triphosphate: shows termination substrate properties in DNA synthesis catalyzed by several different DNA polymerases; also abbreviated d4TTP		2.0310
2-Oxo-4-phenylbutyric acid
[no description available]		2.0510benzenes
zidovudine triphosphate
[no description available]		2.0310
9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
[no description available]		2.9440
9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine
9-(3-hydroxy-2-phosphonomethoxypropyl)-2,6-diaminopurine: RN refers to (S)-isomer		2.4420
4'-azidothymidine
4'-azidothymidine: inhibits HIV replication in human lymphocytes		2.0310
clevudine
[no description available]		2.0510
lopinavir
[no description available]		2.0510amphetamines;
dicarboxylic acid diamide		anticoronaviral agent;
antiviral drug;
HIV protease inhibitor
4-amino-5-bromo-7-(2-hydroxyethoxymethyl)pyrrolo(2,3-d)pyrimidine
4-amino-5-bromo-7-(2-hydroxyethoxymethyl)pyrrolo(2,3-d)pyrimidine: structure given in first source; 5-bromotubercidin in which the ribose is replaced by 2-hydroxyethoxymethyl		2.0510
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: prodrug for HPMPC; specific name and structure not given in first source		2.7330
bcx 1812
[no description available]		2.05103-hydroxy monocarboxylic acid;
acetamides;
cyclopentanols;
guanidines		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine
cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine: specific name and structure not given in first source		2.4420
1-(benzenesulfonyl)indole
[no description available]		2.0510sulfonamide
(north)-methanocarbathymidine
(north)-methanocarbathymidine: also called NMCT. 1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)bicyclo[3.1.0]hexan-2-yl]thymine : A carbobicyclic compound that is bicyclo[3.1.0]hexane which is substituted at the 2-pro-S, 4-pro-S and 5-pro-R positions by thymin-1-yl, hydroxy, and hydroxymethyl groups, respectively.		2.0510C-glycosyl pyrimidine;
carbobicyclic compound;
primary alcohol;
pyrimidone;
secondary alcohol
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		2.05102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
brivudine
brivudine: anti-herpes agent		2.4920
gs 4071
GS 4071: The acid form.. oseltamivir acid : A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). An antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza.		2.0510acetate ester;
amino acid;
cyclohexenecarboxylic acid;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
marine xenobiotic metabolite
kni-727
KNI-727: structure in first source		3.2710
lamivudine triphosphate
[no description available]		2.0510
l 737126
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: structure given in first source; an inhibitor of HIV-1 reverse transcriptase		2.0510
ic9564
IC9564: betulinic acid derivative; structure in first source		2.0510
tenofovir
tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.		4.2450nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
2,5,6-trichloro-1-(ribofuranosyl)benzimidazole
[no description available]		2.0510
gw 257406x
maribavir: has antiviral activity against human cytomegalovirus		2.0510
cmx 001
[no description available]		2.0510
favipiravir
favipiravir : A member of the class of pyrazines that is pyrazine substituted by aminocarbonyl, hydroxy and fluoro groups at positions 2, 3 and 6, respectively. It is an anti-viral agent that inhibits RNA-dependent RNA polymerase of several RNA viruses and is approved for the treatment of influenza in Japan.		2.0510hydroxypyrazine;
organofluorine compound;
primary carboxamide		anticoronaviral agent;
antiviral drug;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
4-phenyl-4-oxo-2-hydroxybuten-2-oic acid
2,4-dioxo-4-phenylbutanoic acid: structure in first source		2.0510
2-hydroxy-4h-isoquinoline-1,3-dione
2-hydroxy-4H-isoquinoline-1,3-dione: structure in first source		2.0510
benzoylacrylic acid
benzoylacrylic acid: structure in first source		2.0510
at 61
AT 61: a phenylpropenamide derivative; structure in first source		2.0510
2',3'-didehydro-3'-deoxy-4'-ethynylthymidine
2',3'-didehydro-3'-deoxy-4'-ethynylthymidine: a highly active anti-HIV agent; structure in first source		2.4420
vicriviroc
vicriviroc: structure in first source		2.0510(trifluoromethyl)benzenes
hcv 371
[no description available]		2.0510
bms 806
BMS 806: prevents entry of HIV into cells by binding HIV envelope protein gp120; no further info available 4/2002		2.0510
flutimide
flutimide: isolated from Delitschia confertaspora; selectively inhibits the transcriptase of influenza viruses; structure given		2.0510
a 315675
[no description available]		2.0510
rilpivirine
[no description available]		2.0510aminopyrimidine;
nitrile		EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor
bms 433771
[no description available]		2.0510
entecavir
entecavir (anhydrous) : Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.		2.03102-aminopurines;
oxopurine;
primary alcohol;
secondary alcohol		antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.49202-aminopurines;
oxopurine		antimetabolite;
antiviral drug
didanosine
Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.		3.5920purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
ganciclovir
[no description available]		2.49202-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
penciclovir
penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.		2.05102-aminopurines;
propane-1,3-diols		antiviral drug
cyclopropavir
cyclopropavir: cyclopropavir is the (Z)-isomer; has antiviral activity; structure in first source		2.0510
9-((2-phosphonylmethoxy)ethyl)guanine
9-((2-phosphonylmethoxy)ethyl)guanine: structure given in first source		2.0310phosphoethanolamine
ConditionIndicatedRelationship StrengthStudiesTrials
Chronic Hepatitis B
[description not available]		02.0310
Hepatitis B, Chronic
INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		02.0310
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		02.1510
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		03.0910