Compounds > cyclopropavir
Page last updated: 2024-10-15

cyclopropavir

Description

cyclopropavir: cyclopropavir is the (Z)-isomer; has antiviral activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135409256
CHEMBL ID265948
SCHEMBL ID1335812
SCHEMBL ID22412801
MeSH IDM0479488

Synonyms (37)

Synonym
cyclopropavir
2-amino-9-(2,2-bis-hydroxymethyl-cyclopropylidenemethyl)-1,9-dihydro-purin-6-one
zsm-i-62
cpv ,
2-amino-9-[(z)-[2,2-bis(hydroxymethyl)cyclopropylidene]methyl]-1h-purin-6-one
mbx400
zsm-i62
mbx-400
CHEMBL265948 ,
zsm-162
zsm-i 62
filociclovir
2-amino-9-[(z)-[2,2-bis(hydroxymethyl)cyclopropylidene]methyl]-3h-purin-6-one
bdbm50330328
2-amino-9-[2,2-bis-hydroxymethyl-cycloprop-(z)-ylidenemethyl]-1,9-dihydro-purin-6-one
(z)-9-((2,2-bis(hydroxymethyl)cyclopropylidene)methyl)-2-amino-1h-purin-6(9h)-one
(z)-2-amino-9-((2,2-bis(hydroxymethyl)cyclopropylidene)methyl)-1h-purin-6(9h)-one
SCHEMBL1335812
mbx 400
eao0td9b13 ,
632325-71-4
filociclovir [usan:inn]
9-((2,2-bis(hydroxymethyl)cyclopropylidene)methyl)guanine
(z)-9-((2,2-bis-(hydroxymethyl)cyclopropylidene)methyl)guanine
unii-eao0td9b13
zdm-i-62
filociclovir [inn]
filociclovir [usan]
filociclovir [who-dd]
filociclovir (usan/inn)
D10632
DTXSID10212612
DB12438
Q27277076
SCHEMBL22412801
2-amino-9-{[(1z)-2,2-bis(hydroxymethyl)cyclopropylidene]methyl}-6,9-dihydro-1h-purin-6-one
AKOS040741584

Research Excerpts

Overview

Cyclopropavir is a guanine nucleoside analog active against human and murine cytomegaloviruses in cell culture. It is efficacious in mice by oral administration.

ExcerptReference
"Cyclopropavir (CPV) is a guanine nucleoside analog active against human and murine cytomegaloviruses in cell culture and efficacious in mice by oral administration."( Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
Coen, DM; Drach, JC; Gentry, BG; Kamil, JP; Zemlicka, J, 2010)
"Cyclopropavir (CPV) is a promising antiviral drug against human cytomegalovirus (HCMV). "( Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase.
Bowlin, TL; Chen, H; Coen, DM; Gentry, BG; Li, C; Zemlicka, J, 2016)

Compound-Compound Interactions

ExcerptReference
" These mt-QSARs offer also a good opportunity to construct drug-drug Complex Networks (CNs) that can be used to explore large and complex drug-viral species databases."( Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E, 2009)

Bioavailability

ExcerptReference
" Pharmacokinetic studies in mice established that the oral bioavailability of valcyclopropavir was 95%."( L-valine ester of cyclopropavir: a new antiviral prodrug.
Bowlin, TL; Drach, JC; Prichard, MN; Wu, Z; Yanachkov, I; Yanachkova, M; Zemlicka, J, 2009)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Serine/threonine protein kinase UL97Human herpesvirus 5 strain AD169Ki0.00300.00300.00300.0030AID533772
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (89)

Assay IDTitleYearJournalArticle
AID350201Antiviral activity against Epstein-Barr virus infected in human Akata cells by DNA hybridization assay2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID665768Antiviral activity against HHV-8 infected in human BCBL1 cells assessed as reduction in viral DNA after 7 days by qPCR analysis2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID419654Cytotoxicity against HFF by visual cytotoxicity assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID246170Effective concentration required to inhibit herpes simplex virus 1 in BSC-1 cells in ELISA2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID246179Effective concentration required to inhibit varicella zoster virus replication in HFF cells2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID520606Selectivity index, ratio of CC50 for human WI38 cells to EC50 for BK polyomavirus ATCC VR8372008Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
Anti-BK virus activity of nucleoside analogs.
AID106147In vitro cytotoxic concentration required to inhibit murine cytomegalovirus (MCMV) replication in MEF cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID419661Antiviral activity against Herpes simplex virus type 1 in african green monkey BSC1 cells by ELISA2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID419652Cytotoxicity against HFF by neutral red uptake assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID350198Cytotoxicity against HFF cells by plaque reduction assay2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID350212Antiviral activity against cyclopropavir-resistant Human cytomegalovirus isolate 2696r with phosphotransferase UL97 mutation by plaque reduction assay2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID392512Antiviral activity against Herpes simplex virus 22009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID533772Inhibition of Human cytomegalovirus pUL97 assessed as inhibition of phosphorylation of 100 to 1000 uM cyclopropavir2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
AID245893Cytotoxic concentration to inhibit replication in daudi cells2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID665759Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID419651Cytotoxicity against MEF2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID245945Cytotoxic concentration against murine cytomegalovirus infected MEF cells2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID81923In vitro effective concentration required to inhibit varicella zoster virus (VZV) replication in HFF cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID350200Cytotoxicity against HFF cells by neutral red uptake assay2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID665765Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID350199Antiviral activity against Human cytomegalovirus AD169 infected in human foreskin fibroblast cells assessed as inhibition of virus-induced cytopathic effect2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID246381Effective concentration for antiviral activity against AD169 strain of human cytomegalovirus in plaque reduction assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID246292Effective concentration required to inhibit herpes simplex virus 2 in vero cells in plaque reduction assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID520604Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis2008Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
Anti-BK virus activity of nucleoside analogs.
AID246330Effective concentration required to inhibit herpes simplex virus 1 in HFF cells in cytopathic effect (CPE) assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID419666Antiviral activity against Varicella zoster virus in HFF assessed as inhibition of virus-induced cytopathic effect2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID245994Cytotoxic concentration against AD169 strain of human cytomegalovirus infected HFF cells of human (by neutral red uptake)2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID533774Antiviral activity against Murine cytomegalovirus infected in severe combined immunodeficient mouse assessed as reduction in viral load2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
AID665763Antiviral activity against EBV Akata infected in human Akata cells assessed as reduction in viral DNA after 72 hrs by hybridization assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID533770Activity of Human cytomegalovirus pUL972010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
AID392508Antiviral activity against Epstein-Barr virus2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID79097In vitro effective concentration required to inhibit Epstein-Barr virus (EBV) replication in H-1 cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID665761Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID665767Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID246382Effective concentration for antiviral activity against towne strain of human cytomegalovirus in plaque reduction assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID350202Cytotoxicity against human Akata cells2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID665762Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID654449Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in kidney at 10 mg/kg, po relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.
AID326204Selectivity index, ratio of EC50 for Epstein-Barr virus to CC50 for human akata cells2008Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.
AID246458Effective concentration required to inhibit Epstein-barr virus replication in daudi cells in viral capsid immunofluorescence ELISA2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID2994In vitro cytotoxic concentration required to inhibit hepatitisB virus (HBV) replication in 2.2.15 cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID350213Antiviral activity against Human cytomegalovirus E8 with phosphotransferase UL97 two point mutation by plaque reduction assay2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID55955In vitro cytotoxic concentration required to inhibit Epstein-Barr virus (EBV) replication in Daudi cells2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID533775Antiviral activity against Human cytomegalovirus infected in severe combined immunodeficient mouse with human fetal tissue implanted assessed as reduction in viral replication2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
AID665760Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID81921In vitro effective concentration required to inhibit AD169 strain of human cytomegalovirus (HCMV) replication in HFF cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID665769Cytotoxicity against human BCBL1 cells after 7 days by Cell-Titer Glo assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID419658Antiviral activity against cyclopropavir-resistant Human cytomegalovirus 2696r expressing most of UL97 phosphotransferase sequence deleted mutant by plaque reduction assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID419653Antiviral activity against Murine cytomegalovirus in MEF by plaque reduction assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID326202Antiviral activity against Epstein-Barr virus infected in human akata cells2008Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.
AID245999Cytotoxic concentration against towne strain of human cytomegalovirus infected HFF cells of human (visual cytotoxicity); range=100-2002005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID419663Cytotoxicity against human replicating KB cells2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID665757Antiviral activity against HHV-6A infected in human HSB2 cells assessed as reduction in viral DNA after 7 days by hybridization assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID246331Effective concentration required to inhibit herpes simplex virus 2 in HFF cells in cytopathic effect (CPE) assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID665764Cytotoxicity against human Akata cells after 7 days by Cell-Titer Glo assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID654448Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in spleen at 10 mg/kg, po relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.
AID533773Antiviral activity against Human cytomegalovirus2010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
AID2999In vitro effective concentration required to inhibit hepatitisB virus (HBV) replication in 2.2.15 cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID246291Effective concentration required to inhibit herpes simplex virus 1 in vero cells in plaque reduction assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID419664Antiviral activity against Herpes simplex virus type 1 in HFF assessed as inhibition of virus-induced cytopathic effect2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID81922In vitro effective concentration required to inhibit towne strain of human cytomegalovirus (HCMV) replication in HFF cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID326203Cytotoxicity against human akata cells by DNA hybridization assay2008Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.
AID654447Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in lung at 10 mg/kg, po relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.
AID533771Ratio of Kcat to Km for Human cytomegalovirus pUL972010Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
AID350211Antiviral activity against Hepatitis C virus2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID81919In vitro cytotoxic concentration required to inhibit towne strain of human cytomegalovirus (HCMV) replication in HFF cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID419650Cytotoxicity against human Akata cells2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID246366Effective concentration required to inhibit hepatitis B virus replication in 2.2.15 cells in DNA hybridization assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID350210Antiviral activity against Hepatitis B virus2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID81918In vitro cytotoxic concentration required to inhibit AD169 strain of human cytomegalovirus (HCMV) replication in HFF cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID665758Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID419656Antiviral activity against Human cytomegalovirus Towne in HFF by plaque reduction assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID245916Cytotoxic concentration to inhibit replication in H-1 cells (in CEM cells)2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID106149In vitro effective concentration required to inhibit murine cytomegalovirus (MCMV) replication in MEF cell line2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID419657Antiviral activity against Human cytomegalovirus Towne expressing wild type UL97 phosphotransferase by plaque reduction assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID520605Cytotoxicity against human WI38 cells by neutral red assay2008Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
Anti-BK virus activity of nucleoside analogs.
AID665766Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay2012Bioorganic & medicinal chemistry, Jun-15, Volume: 20, Issue:12
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
AID654446Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in liver at 10 mg/kg, po relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.
AID246354Effective concentration required to inhibit Epstein-barr virus replication in H-1 cells in DNA hybridization assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID245942Cytotoxic concentration required to inhibit herpes simplex virus 1 infected BSC-1 cells2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID392537Antiviral activity against Varicella zoster virus2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID350197Antiviral activity against Human cytomegalovirus Towne infected in human foreskin fibroblast cells by plaque reduction assay2009Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.
AID419649Antiviral activity against Epstein-Barr virus in human Akata cells by DNA hybridization assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID419659Antiviral activity against drug-resistant Human cytomegalovirus E8 isolate expressing UL97 phosphotransferase with two point mutation in UL97 gene by plaque reduction assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID419668Antiviral activity against Human cytomegalovirus AD169 in HFF by plaque reduction assay2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
AID55958In vitro effective concentration required to inhibit Epstein-Barr virus (EBV) replication in Daudi cells2004Journal of medicinal chemistry, Jan-29, Volume: 47, Issue:3
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
AID246389Effective concentration for antiviral activity against AD169 strain of murine cytomegalovirus in plaque reduction assay2005Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
AID392511Antiviral activity against Herpes simplex virus 12009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID419665Antiviral activity against Herpes simplex virus type 2 in HFF assessed as inhibition of virus-induced cytopathic effect2009Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (44.00)29.6817
2010's14 (56.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (96.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		7.95106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cytosine
[no description available]		4.1140aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
amantadine
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source		2.0510adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
brl 42810
[no description available]		2.04102-aminopurines;
acetate ester		antiviral drug;
prodrug
foscarnet
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.		4.2850carboxylic acid;
one-carbon compound;
phosphonic acids		antiviral drug;
geroprotector;
HIV-1 reverse transcriptase inhibitor;
sodium-dependent Pi-transporter inhibitor
nevirapine
Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.. nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.		2.0510cyclopropanes;
dipyridodiazepine		antiviral drug;
HIV-1 reverse transcriptase inhibitor
olomoucine
olomoucine: inhibits protein P34CDC2. olomoucine : A 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor.		2.05102,6-diaminopurines;
ethanolamines		EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
delavirdine
Delavirdine: A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.. delavirdine : The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.		2.0510aminopyridine;
indolecarboxamide;
N-acylpiperazine;
sulfonamide		antiviral drug;
HIV-1 reverse transcriptase inhibitor
idoxuridine
[no description available]		2.0510organoiodine compound;
pyrimidine 2'-deoxyribonucleoside		antiviral drug;
DNA synthesis inhibitor
valine
Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.		7.0510L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
benzohydroxamic acid
[no description available]		2.0510
n-hydroxyphthalimide
N-hydroxyphthalimide: causes contact dermititis		2.0510
toyocamycin
Toyocamycin: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.. toyocamycin : An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.		2.0510antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
nitrile;
ribonucleoside		antimetabolite;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite
stavudine
Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase		2.4520dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
acetylpyruvic acid
acetylpyruvic acid: structure. acetylpyruvic acid : A dioxo monocarboxylic acid that is pentanoic acid carrying two oxo groups at positions 2 and 4.		2.0510beta-diketone;
dioxo monocarboxylic acid		bacterial metabolite
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		2.0510pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		2.9510diatomic bromine
2,6-diaminopurine
9H-purine-2,6-diamine : A member of the class of 2,6-diaminopurines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by amino groups.		2.07102,6-diaminopurines;
primary amino compound		antineoplastic agent
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		2.4520azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
ribavirin
Rebetron: Rebetron is tradename		2.05101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
fialuridine
[no description available]		2.0510
adefovir
adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.		2.45206-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.		4.4360phosphonic acids;
pyrimidone		anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent
lamivudine
[no description available]		2.7330monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
zanamivir
Zanamivir: A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.		2.0510guanidinesantiviral agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
adefovir dipivoxil
bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine: structure given in first source. adefovir pivoxil : An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.		2.45206-aminopurines;
carbonate ester;
ether;
organic phosphonate		antiviral drug;
DNA synthesis inhibitor;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent;
prodrug
efavirenz
efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.		2.0510acetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound		antiviral drug;
HIV-1 reverse transcriptase inhibitor
nelfinavir
Nelfinavir: A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.. nelfinavir : An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.		2.0510aryl sulfide;
benzamides;
organic heterobicyclic compound;
phenols;
secondary alcohol;
tertiary amino compound		antineoplastic agent;
HIV protease inhibitor
amprenavir
[no description available]		2.0510carbamate ester;
sulfonamide;
tetrahydrofuryl ester		antiviral drug;
HIV protease inhibitor
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.0510acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
o-(6)-methylguanine
O-(6)-methylguanine: structure. 6-O-methylguanine : A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.. methylguanine : A 2-aminopurine that is guanine bearing a single methyl substituent.		2.0710methylguaninemutagen
2-Oxo-4-phenylbutyric acid
[no description available]		2.0510benzenes
9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
[no description available]		2.0510
clevudine
[no description available]		2.0510
methylenecyclopropane
methylenecyclopropane: structure in first source		3.1610
lopinavir
[no description available]		2.0510amphetamines;
dicarboxylic acid diamide		anticoronaviral agent;
antiviral drug;
HIV protease inhibitor
4-amino-5-bromo-7-(2-hydroxyethoxymethyl)pyrrolo(2,3-d)pyrimidine
4-amino-5-bromo-7-(2-hydroxyethoxymethyl)pyrrolo(2,3-d)pyrimidine: structure given in first source; 5-bromotubercidin in which the ribose is replaced by 2-hydroxyethoxymethyl		2.0510
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: prodrug for HPMPC; specific name and structure not given in first source		2.0510
2'-o-methylcytidine
[no description available]		2.0410methylcytidine
bcx 1812
[no description available]		2.05103-hydroxy monocarboxylic acid;
acetamides;
cyclopentanols;
guanidines		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		5.1950divalent inorganic anion;
phosphite ion
1-(benzenesulfonyl)indole
[no description available]		2.0510sulfonamide
(north)-methanocarbathymidine
(north)-methanocarbathymidine: also called NMCT. 1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)bicyclo[3.1.0]hexan-2-yl]thymine : A carbobicyclic compound that is bicyclo[3.1.0]hexane which is substituted at the 2-pro-S, 4-pro-S and 5-pro-R positions by thymin-1-yl, hydroxy, and hydroxymethyl groups, respectively.		2.0510C-glycosyl pyrimidine;
carbobicyclic compound;
primary alcohol;
pyrimidone;
secondary alcohol
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		2.05102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
brivudine
brivudine: anti-herpes agent		2.0510
gs 4071
GS 4071: The acid form.. oseltamivir acid : A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid which is substituted at positions 3, 4, and 5 by pentan-3-yloxy, acetamido, and amino groups, respectively (the 3R,4R,5S enantiomer). An antiviral drug, it is used as the corresponding ethyl ester prodrug, oseltamivir, to slow the spread of influenza.		2.0510acetate ester;
amino acid;
cyclohexenecarboxylic acid;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
marine xenobiotic metabolite
lamivudine triphosphate
[no description available]		2.0510
l 737126
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: structure given in first source; an inhibitor of HIV-1 reverse transcriptase		2.0510
ic9564
IC9564: betulinic acid derivative; structure in first source		2.0510
tenofovir
tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.		2.0510nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
2,5,6-trichloro-1-(ribofuranosyl)benzimidazole
[no description available]		2.0510
gw 257406x
maribavir: has antiviral activity against human cytomegalovirus		4.0950
cmx 001
[no description available]		2.4920
favipiravir
favipiravir : A member of the class of pyrazines that is pyrazine substituted by aminocarbonyl, hydroxy and fluoro groups at positions 2, 3 and 6, respectively. It is an anti-viral agent that inhibits RNA-dependent RNA polymerase of several RNA viruses and is approved for the treatment of influenza in Japan.		2.0510hydroxypyrazine;
organofluorine compound;
primary carboxamide		anticoronaviral agent;
antiviral drug;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
6-phosphonylmethoxyethoxy-2,4-diaminopyrimidine
[no description available]		2.0510
4-phenyl-4-oxo-2-hydroxybuten-2-oic acid
2,4-dioxo-4-phenylbutanoic acid: structure in first source		2.0510
2-hydroxy-4h-isoquinoline-1,3-dione
2-hydroxy-4H-isoquinoline-1,3-dione: structure in first source		2.0510
benzoylacrylic acid
benzoylacrylic acid: structure in first source		2.0510
at 61
AT 61: a phenylpropenamide derivative; structure in first source		2.0510
2',3'-didehydro-3'-deoxy-4'-ethynylthymidine
2',3'-didehydro-3'-deoxy-4'-ethynylthymidine: a highly active anti-HIV agent; structure in first source		2.0510
vicriviroc
vicriviroc: structure in first source		2.0510(trifluoromethyl)benzenes
hcv 371
[no description available]		2.0510
bms 806
BMS 806: prevents entry of HIV into cells by binding HIV envelope protein gp120; no further info available 4/2002		2.0510
flutimide
flutimide: isolated from Delitschia confertaspora; selectively inhibits the transcriptase of influenza viruses; structure given		2.0510
a 315675
[no description available]		2.0510
rilpivirine
[no description available]		2.0510aminopyrimidine;
nitrile		EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor
bms 433771
[no description available]		2.0510
aceclidine
[no description available]		2.0410
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		4.21602-aminopurines;
oxopurine		antimetabolite;
antiviral drug
guanine
[no description available]		12.661702-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
didanosine
Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.		2.4520purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
ganciclovir
[no description available]		6.81802-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
penciclovir
penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.		2.05102-aminopurines;
propane-1,3-diols		antiviral drug
valganciclovir
Valganciclovir: A ganciclovir prodrug and antiviral agent that is used to treat CYTOMEGALOVIRUS RETINITIS in patients with AIDS, and for the prevention of CYTOMEGALOVIRUS INFECTIONS in organ transplant recipients who have received an organ from a CMV-positive donor.. valganciclovir : The L-valinyl ester of ganciclovir, into which it is rapidly converted by intestinal and hepatic esterases. It is a synthetic analogue of 2'-deoxyguanosine.		3.5620L-valyl ester;
purines		antiviral drug;
prodrug
ConditionIndicatedRelationship StrengthStudiesTrials
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		07.13170
Cytomegalic Inclusion Disease
[description not available]		05.6260
Cytomegalovirus Infections
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.		010.6260