Page last updated: 2024-09-28

Mediastinal Cyst

Cysts of one of the parts of the mediastinum: the superior part, containing the trachea, esophagus, thoracic duct and thymus organs; the inferior middle part, containing the pericardium; the inferior anterior part containing some lymph nodes; and the inferior posterior part, containing the thoracic duct and esophagus.

Synonyms(5)

Synonym
Tracheal Cyst
Thymic Cyst
Mediastinal Cyst
Pericardial Cyst
Thoracic Cyst

Research Excerpts

Overview

ExcerptReference
"The pericardial cysts are uncommon disease and it originated in the mesenchymal tissue during fetal life."( Fujinami, T; Morozumi, K; Shinmura, I; Suganuma, T; Yoshida, A, 1989)
"Thymic cysts are commonly absent or inconspicuous in untreated, gonadectomized or hypophysectomized male and female hamsters prior to 450 days of age."( Kirkman, H; Kirkman-Liff, B, 1985)
"Pericardial cysts are rare."( Maisch, B, 2013)

Treatment

ExcerptReference
"The authors report a mediastinal cyst treated by aspiration and ethanol sclerosis, which were performed under ultrasonographic guidance."( Chadda, DJ; Kedar, RP; Malde, HM, 1993)

Research

Studies (80)

TimeframeStudies, This Condition (%)All Conditions %
pre-199024 (30.00)23.3326
1990's18 (22.50)12.5806
2000's16 (20.00)18.1394
2010's20 (25.00)28.8240
2020's2 (2.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetic acid0low10
iodine0low10
1-anilino-8-naphthalenesulfonate0low10
albendazole0low70
dapi0low10
furosemide0low20
mebendazole0low10
neostigmine0low10
pamidronate0low20
prednisolone0low10
thyroxine0low10
prednisone0low10
triiodothyronine0low10
oxacillin0low10
ambenonium chloride0low10
framycetin0low10
limestone0low10
technetium0low40
barium sulfate0low80
trolamine salicylate0low10
calcium oxalate0low10
fluorodeoxyglucose f180low20
dihydrorhodamine 1230low10
deoxyglucose0low10
imatinib mesylate0low10
diethylstilbestrol0low10
bromochloroacetic acid0low60
picibanil0low10
barium0low20
gadolinium dtpa0low10
rifamycins0low10
technetium tc 99m sestamibi0low10
ro13-99040low20
sodium pertechnetate tc 99m0low40
cardiovascular agents0low10
oxytetracycline, anhydrous0low10
rome0low10
lewis x antigen0low30

Protein Targets (428)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase1001
thioredoxin reductase6006
USP1 protein, partial5005
TDP1 protein100010
vitamin D3 receptor isoform VDRA4004
importin subunit beta-1 isoform 12002
flap endonuclease 13003
serine/threonine-protein kinase PLK14004
snurportin-12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase eta isoform 13003
DNA polymerase iota isoform a (long)3003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin100010
DNA polymerase kappa isoform 13003
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0114
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G1001
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140202
estrogen nuclear receptor alpha120012
Free fatty acid receptor 30011
Free fatty acid receptor 20112
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0112
Fibrinogen C domain-containing protein 10101
Chain A, Beta-lactamase2002
Luciferase5005
glp-1 receptor, partial4004
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma9009
ATAD5 protein, partial2002
Fumarate hydratase2002
GLI family zinc finger 37007
AR protein100010
caspase 7, apoptosis-related cysteine protease1001
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor8008
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor6006
pregnane X nuclear receptor100010
polyprotein2002
67.9K protein2002
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-31001
IDH13003
euchromatic histone-lysine N-methyltransferase 26006
aryl hydrocarbon receptor9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
v-jun sarcoma virus 17 oncogene homolog (avian)8008
nuclear receptor subfamily 1, group I, member 23003
Histone H2A.x5005
cellular tumor antigen p53 isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 24004
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 28008
histone deacetylase 9 isoform 33003
heat shock protein beta-12002
mitogen-activated protein kinase 12002
Vif0001
peripheral myelin protein 224004
survival motor neuron protein isoform d3003
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 13003
lamin isoform A-delta107007
neuropeptide S receptor isoform A3003
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump0808
Interferon beta5005
Cellular tumor antigen p538008
Integrin beta-32002
Integrin alpha-IIb2002
Methionine aminopeptidase0202
Glutamate receptor 26006
Fatty-acid amide hydrolase 10202
Inositol monophosphatase 13003
Canalicular multispecific organic anion transporter 10606
ATPase family AAA domain-containing protein 54004
Ataxin-24004
acetylcholinesterase4004
cytochrome P450 family 3 subfamily A polypeptide 49009
cytochrome P450 2D63003
activating transcription factor 63003
aldehyde dehydrogenase 1 family, member A17007
thyroid stimulating hormone receptor4004
nuclear factor erythroid 2-related factor 2 isoform 1100010
Nuclear receptor ROR-gamma3003
Prothrombin 0101
Glandular kallikrein0101
Cell division protein FtsZ0012
Hsf1 protein0011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, Ferritin light chain2002
interleukin 81001
15-lipoxygenase, partial1001
GLS protein3003
Microtubule-associated protein tau2002
Smad31001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
thyroid stimulating hormone receptor1001
estrogen receptor 2 (ER beta)5005
regulator of G-protein signaling 43003
G3003
peroxisome proliferator-activated receptor delta3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
thyroid hormone receptor beta isoform a4004
potassium voltage-gated channel subfamily H member 2 isoform d1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 12002
cytochrome P450 3A4 isoform 11001
high affinity choline transporter 1 isoform a0101
lethal factor (plasmid)2002
Gamma-aminobutyric acid receptor subunit pi1113
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
5-hydroxytryptamine receptor 40202
Nuclear receptor subfamily 1 group I member 20112
Carbonic anhydrase 10203
Carbonic anhydrase 20203
HLA class I histocompatibility antigen, B alpha chain 3003
Estrogen receptor0415
Glucocorticoid receptor06213
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Glycine receptor subunit alpha-10606
Aldo-keto reductase family 1 member B10202
Beta-1 adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Polyunsaturated fatty acid 5-lipoxygenase0101
Adenosine receptor A30202
Muscarinic acetylcholine receptor M10202
Polyunsaturated fatty acid lipoxygenase ALOX150101
D(2) dopamine receptor0202
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-11113
Alpha-1B adrenergic receptor0202
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta1113
Gamma-aminobutyric acid receptor subunit gamma-21113
Alpha-2C adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit alpha-51113
Gamma-aminobutyric acid receptor subunit alpha-31113
Muscarinic acetylcholine receptor M30202
Glycine receptor subunit beta0606
Substance-K receptor0202
D(1A) dopamine receptor0202
Acetylcholinesterase0303
Glycine receptor subunit alpha-20606
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-11113
Gamma-aminobutyric acid receptor subunit alpha-21113
Sodium-dependent noradrenaline transporter 0202
Glycine receptor subunit alpha-30606
Thromboxane-A synthase 0101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-41113
Gamma-aminobutyric acid receptor subunit gamma-31113
Adenosine receptor A2a0202
Gamma-aminobutyric acid receptor subunit alpha-61113
Adenosine receptor A10404
Sodium-dependent serotonin transporter0202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Vasopressin V1a receptor0202
Alpha-synuclein1001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor2002
5-hydroxytryptamine receptor 60202
Spike glycoprotein4004
Estrogen-related receptor gamma0011
Gamma-aminobutyric acid receptor subunit alpha-11113
Gamma-aminobutyric acid receptor subunit beta-31113
Gamma-aminobutyric acid receptor subunit beta-21113
Disintegrin and metalloproteinase domain-containing protein 172002
Sodium-dependent dopamine transporter 0202
Aldehyde oxidase0101
TAR DNA-binding protein 431001
UDP-glucose 4-epimerase0101
GABA theta subunit1113
Inositol hexakisphosphate kinase 13003
Estrogen receptor beta0415
Gamma-aminobutyric acid receptor subunit epsilon1113
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Cysteinyl leukotriene receptor 10202
cytochrome P450 2C9, partial3003
Menin0011
Lecithin retinol acyltransferase0101
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Lethal factor0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
EWS/FLI fusion protein4004
thyrotropin-releasing hormone receptor1001
Solute carrier family 22 member 60101
Carbonic anhydrase 120102
Bile salt export pump0101
Albumin0112
Carbonic anhydrase 30101
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0202
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Serum paraoxonase/arylesterase 10202
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20202
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90102
Multidrug and toxin extrusion protein 10101
Carbonic anhydrase 130102
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
SMAD family member 22002
SMAD family member 32002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
serine/threonine-protein kinase mTOR isoform 11001
DNA repair protein RAD52 homolog isoform a0001
Tyrosine-protein kinase ABL10314
Cytochrome P450 3A40001
Cytochrome P450 2C80001
Mast/stem cell growth factor receptor Kit0112
Breakpoint cluster region protein0011
Platelet-derived growth factor receptor alpha0112
Cytochrome P450 3A50001
GALC protein1001
PPM1D protein1001
cytochrome P450 2C9 precursor1001
huntingtin isoform 21001
Proto-oncogene tyrosine-protein kinase Src0202
Vascular endothelial growth factor receptor 20101
Calmodulin-domain protein kinase 10101
arylsulfatase A2002
muscarinic acetylcholine receptor M11001
Acetylcholinesterase0101
Cholinesterase0202
Cholinesterase0101
Chain A, 2-oxoglutarate Oxygenase2002
STE240001
CAAX prenyl protease0001
histone acetyltransferase KAT2A isoform 13003
streptokinase A precursor0011
Trypsin0001
DNA gyrase subunit A0102
DNA gyrase subunit B0102
DNA gyrase subunit B0102
DNA gyrase subunit A0102
Potassium voltage-gated channel subfamily H member 20101
Solute carrier family 22 member 80101
Beta-lactamase OXA-70001
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Class D beta-lactamase0001
Solute carrier family 15 member 20101
MecA 0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
WRN1001
phosphopantetheinyl transferase1001
Valosin-containing protein0101
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA13003
bromodomain adjacent to zinc finger domain 2B1001
lysosomal alpha-glucosidase preproprotein1001
microphthalmia-associated transcription factor isoform 90101
DNA polymerase beta1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
Rap guanine nucleotide exchange factor 32002
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
phosphoglycerate kinase1001
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
luciferase0001
Fatty acid-binding protein, liver0101
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0303
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
pregnane X receptor1001
Sphingosine kinase 20202
Sphingosine kinase 10101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
Solute carrier organic anion transporter family member 1A40103
Solute carrier organic anion transporter family member 1A50002
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
glucocerebrosidase1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Prothrombin0011
Gamma-aminobutyric acid receptor subunit alpha-10101
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Gamma-aminobutyric acid receptor subunit gamma-10101
Solute carrier organic anion transporter family member 4A10001
Gamma-aminobutyric acid receptor subunit gamma-30101
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 1B30001
Gamma-aminobutyric acid receptor subunit theta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]