Page last updated: 2024-12-05

2,4-diacetylphloroglucinol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,4-diacetylphloroglucinol: produced by Pseudomonas aurantiaca [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2,4-diacetylphloroglucinol : A benzenetriol that is phloroglucinol in which two of the ring hydrogens are replaced by acetyl groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID16547
CHEMBL ID276139
CHEBI ID78688
SCHEMBL ID1258932
MeSH IDM0166298

Synonyms (44)

Synonym
2,4-diacetylphloroglucinol
phloroglucinol, diacetyl-
1,1'-(2,4,6-trihydroxy-1,3-phenylene)bisethanone
k-2
ethanone, 1,1'-(2,4,6-trihydroxy-1,3-phenylene)bis-
brn 1881572
ACON1_000673
MEGXM0_000280
1-(3-acetyl-2,4,6-trihydroxy-phenyl)ethanone
smr000440689
MLS000877011
NCGC00169471-01
chebi:78688 ,
2,4-diacetyl phloroglucinol
CHEMBL276139 ,
1-(3-acetyl-2,4,6-trihydroxyphenyl)ethanone
8xv4yyo3wn ,
4-08-00-03374 (beilstein handbook reference)
unii-8xv4yyo3wn
2161-86-6
A815534
HMS2271L07
FT-0609960
1-(3-acetyl-2,4,6-trihydroxyphenyl)ethan-1-one
AKOS022649955
2,4,6-trihydroxy-1,3-diacetylbenzene
1,1'-(2,4,6-trihydroxy-1,3-phenylene)diethanone
5-acetyl-2,4,6-trihydroxyacetophenone
1,5-diacetyl-2,4,6-trihydroxybenzene
diacetylphloroglucinol
SCHEMBL1258932
PIFFQYJYNWXNGE-UHFFFAOYSA-N
DTXSID10175995
mfcd00100483
J-014184
Q4596777
C21896
ipo 15474fs
dapg
bdbm50456593
CS-0065976
HY-118448
1,1-(2,4,6-trihydroxy-1,3-phenylene)bis-ethanone
PD017283

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" In this study, we assessed the hypothesis that the presence of iron-rich vermiculite clay (dominant in suppressive soils) instead of illite (dominant in neighboring conducive soils) translates into higher levels of iron bioavailability and transcription of Pseudomonas DAPG synthetic genes in the tobacco rhizosphere."( Effect of clay mineralogy on iron bioavailability and rhizosphere transcription of 2,4-diacetylphloroglucinol biosynthetic genes in biocontrol Pseudomonas protegens.
Almario, J; Moënne-Loccoz, Y; Muller, D; Prigent-Combaret, C, 2013
)
0.61
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (2 Product(s))

Product Categories

Product CategoryProducts
Vitamins & Supplements2

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Nutrex Hawaii Spirulina Pacifica® Spearmint -- 1000 mg - 180 TabletsNutrex HawaiiVitamins & Supplements K2, Chlorophyll a, Gamma Linolenic Acid, Manganese, K2, Chlorophyll a, Vitamin A, Vitamin B12, Vitamin K, Zeaxanthin2024-11-29 10:47:42
Vitacost Ultra Vitamin K includes Advanced K2 Complex -- 180 SoftgelsVitacost BrandVitamins & Supplements K2, menaquinone-7, menaquinone-4, K2, phytonadione, Vitamin K2024-11-29 10:47:42

Roles (2)

RoleDescription
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
antifungal agentAn antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
diketoneA compound that contains two ketone functionalities.
aromatic ketoneA ketone in which the carbonyl group is attached to an aromatic ring.
methyl ketoneA ketone of formula RC(=O)CH3 (R =/= H).
benzenetriolA triol in which three hydroxy groups are substituted onto a benzene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (19)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glp-1 receptor, partialHomo sapiens (human)Potency7.94330.01846.806014.1254AID624417
ATAD5 protein, partialHomo sapiens (human)Potency12.99000.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency23.26260.000811.382244.6684AID686978; AID686979
TSHR proteinHomo sapiens (human)Potency30.13130.338119.046637.9330AID602292
Smad3Homo sapiens (human)Potency22.38720.00527.809829.0929AID588855
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency10.00000.28189.721235.4813AID2326
IDH1Homo sapiens (human)Potency12.99530.005210.865235.4813AID686970
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency25.92900.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency50.11873.548119.542744.6684AID743266
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency25.11890.425612.059128.1838AID504891
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency6.40920.00798.23321,122.0200AID2546; AID2551
gemininHomo sapiens (human)Potency1.45810.004611.374133.4983AID624297
Alpha-synucleinHomo sapiens (human)Potency15.84890.56239.398525.1189AID652106
Guanine nucleotide-binding protein GHomo sapiens (human)Potency35.48131.995325.532750.1187AID624288
TAR DNA-binding protein 43Homo sapiens (human)Potency35.48131.778316.208135.4813AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
photoreceptor-specific nuclear receptorHomo sapiens (human)IC50 (µMol)3.23800.03742.93408.9620AID624394
transactivating tegument protein VP16 [Human herpesvirus 1]Human alphaherpesvirus 1 (Herpes simplex virus type 1)IC50 (µMol)4.56100.94604.70169.4870AID624395
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
streptokinase A precursorStreptococcus pyogenes M1 GASEC50 (µMol)2.63500.06008.9128130.5170AID1902
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (102)

Processvia Protein(s)Taxonomy
cellular response to starvationAlbuminBos taurus (cattle)
negative regulation of mitochondrial depolarizationAlbuminBos taurus (cattle)
cellular response to calcium ion starvationAlbuminBos taurus (cattle)
calcium ion homeostasisAlpha-synucleinHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIAlpha-synucleinHomo sapiens (human)
microglial cell activationAlpha-synucleinHomo sapiens (human)
positive regulation of receptor recyclingAlpha-synucleinHomo sapiens (human)
positive regulation of neurotransmitter secretionAlpha-synucleinHomo sapiens (human)
negative regulation of protein kinase activityAlpha-synucleinHomo sapiens (human)
fatty acid metabolic processAlpha-synucleinHomo sapiens (human)
neutral lipid metabolic processAlpha-synucleinHomo sapiens (human)
phospholipid metabolic processAlpha-synucleinHomo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
mitochondrial membrane organizationAlpha-synucleinHomo sapiens (human)
adult locomotory behaviorAlpha-synucleinHomo sapiens (human)
response to xenobiotic stimulusAlpha-synucleinHomo sapiens (human)
response to iron(II) ionAlpha-synucleinHomo sapiens (human)
regulation of phospholipase activityAlpha-synucleinHomo sapiens (human)
negative regulation of platelet-derived growth factor receptor signaling pathwayAlpha-synucleinHomo sapiens (human)
regulation of glutamate secretionAlpha-synucleinHomo sapiens (human)
regulation of dopamine secretionAlpha-synucleinHomo sapiens (human)
synaptic vesicle exocytosisAlpha-synucleinHomo sapiens (human)
synaptic vesicle primingAlpha-synucleinHomo sapiens (human)
regulation of transmembrane transporter activityAlpha-synucleinHomo sapiens (human)
negative regulation of microtubule polymerizationAlpha-synucleinHomo sapiens (human)
receptor internalizationAlpha-synucleinHomo sapiens (human)
protein destabilizationAlpha-synucleinHomo sapiens (human)
response to magnesium ionAlpha-synucleinHomo sapiens (human)
negative regulation of transporter activityAlpha-synucleinHomo sapiens (human)
response to lipopolysaccharideAlpha-synucleinHomo sapiens (human)
negative regulation of monooxygenase activityAlpha-synucleinHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationAlpha-synucleinHomo sapiens (human)
response to type II interferonAlpha-synucleinHomo sapiens (human)
cellular response to oxidative stressAlpha-synucleinHomo sapiens (human)
SNARE complex assemblyAlpha-synucleinHomo sapiens (human)
positive regulation of SNARE complex assemblyAlpha-synucleinHomo sapiens (human)
regulation of locomotionAlpha-synucleinHomo sapiens (human)
dopamine biosynthetic processAlpha-synucleinHomo sapiens (human)
mitochondrial ATP synthesis coupled electron transportAlpha-synucleinHomo sapiens (human)
regulation of macrophage activationAlpha-synucleinHomo sapiens (human)
positive regulation of apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
negative regulation of neuron apoptotic processAlpha-synucleinHomo sapiens (human)
positive regulation of endocytosisAlpha-synucleinHomo sapiens (human)
negative regulation of exocytosisAlpha-synucleinHomo sapiens (human)
positive regulation of exocytosisAlpha-synucleinHomo sapiens (human)
regulation of long-term neuronal synaptic plasticityAlpha-synucleinHomo sapiens (human)
synaptic vesicle endocytosisAlpha-synucleinHomo sapiens (human)
synaptic vesicle transportAlpha-synucleinHomo sapiens (human)
positive regulation of inflammatory responseAlpha-synucleinHomo sapiens (human)
regulation of acyl-CoA biosynthetic processAlpha-synucleinHomo sapiens (human)
protein tetramerizationAlpha-synucleinHomo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosolAlpha-synucleinHomo sapiens (human)
neuron apoptotic processAlpha-synucleinHomo sapiens (human)
dopamine uptake involved in synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of dopamine uptake involved in synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of serotonin uptakeAlpha-synucleinHomo sapiens (human)
regulation of norepinephrine uptakeAlpha-synucleinHomo sapiens (human)
negative regulation of norepinephrine uptakeAlpha-synucleinHomo sapiens (human)
excitatory postsynaptic potentialAlpha-synucleinHomo sapiens (human)
long-term synaptic potentiationAlpha-synucleinHomo sapiens (human)
positive regulation of inositol phosphate biosynthetic processAlpha-synucleinHomo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathwayAlpha-synucleinHomo sapiens (human)
response to interleukin-1Alpha-synucleinHomo sapiens (human)
cellular response to copper ionAlpha-synucleinHomo sapiens (human)
cellular response to epinephrine stimulusAlpha-synucleinHomo sapiens (human)
positive regulation of protein serine/threonine kinase activityAlpha-synucleinHomo sapiens (human)
supramolecular fiber organizationAlpha-synucleinHomo sapiens (human)
negative regulation of mitochondrial electron transport, NADH to ubiquinoneAlpha-synucleinHomo sapiens (human)
positive regulation of glutathione peroxidase activityAlpha-synucleinHomo sapiens (human)
positive regulation of hydrogen peroxide catabolic processAlpha-synucleinHomo sapiens (human)
regulation of synaptic vesicle recyclingAlpha-synucleinHomo sapiens (human)
regulation of reactive oxygen species biosynthetic processAlpha-synucleinHomo sapiens (human)
positive regulation of protein localization to cell peripheryAlpha-synucleinHomo sapiens (human)
negative regulation of chaperone-mediated autophagyAlpha-synucleinHomo sapiens (human)
regulation of presynapse assemblyAlpha-synucleinHomo sapiens (human)
amyloid fibril formationAlpha-synucleinHomo sapiens (human)
synapse organizationAlpha-synucleinHomo sapiens (human)
chemical synaptic transmissionAlpha-synucleinHomo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
negative regulation of protein phosphorylationTAR DNA-binding protein 43Homo sapiens (human)
mRNA processingTAR DNA-binding protein 43Homo sapiens (human)
RNA splicingTAR DNA-binding protein 43Homo sapiens (human)
negative regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
regulation of protein stabilityTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of insulin secretionTAR DNA-binding protein 43Homo sapiens (human)
response to endoplasmic reticulum stressTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of protein import into nucleusTAR DNA-binding protein 43Homo sapiens (human)
regulation of circadian rhythmTAR DNA-binding protein 43Homo sapiens (human)
regulation of apoptotic processTAR DNA-binding protein 43Homo sapiens (human)
negative regulation by host of viral transcriptionTAR DNA-binding protein 43Homo sapiens (human)
rhythmic processTAR DNA-binding protein 43Homo sapiens (human)
regulation of cell cycleTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA destabilizationTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA stabilizationTAR DNA-binding protein 43Homo sapiens (human)
nuclear inner membrane organizationTAR DNA-binding protein 43Homo sapiens (human)
amyloid fibril formationTAR DNA-binding protein 43Homo sapiens (human)
regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Processvia Protein(s)Taxonomy
oxygen bindingAlbuminBos taurus (cattle)
DNA bindingAlbuminBos taurus (cattle)
fatty acid bindingAlbuminBos taurus (cattle)
protein bindingAlbuminBos taurus (cattle)
toxic substance bindingAlbuminBos taurus (cattle)
pyridoxal phosphate bindingAlbuminBos taurus (cattle)
metal ion bindingAlbuminBos taurus (cattle)
enterobactin bindingAlbuminBos taurus (cattle)
fatty acid bindingAlpha-synucleinHomo sapiens (human)
phospholipase D inhibitor activityAlpha-synucleinHomo sapiens (human)
SNARE bindingAlpha-synucleinHomo sapiens (human)
magnesium ion bindingAlpha-synucleinHomo sapiens (human)
transcription cis-regulatory region bindingAlpha-synucleinHomo sapiens (human)
actin bindingAlpha-synucleinHomo sapiens (human)
protein kinase inhibitor activityAlpha-synucleinHomo sapiens (human)
copper ion bindingAlpha-synucleinHomo sapiens (human)
calcium ion bindingAlpha-synucleinHomo sapiens (human)
protein bindingAlpha-synucleinHomo sapiens (human)
phospholipid bindingAlpha-synucleinHomo sapiens (human)
ferrous iron bindingAlpha-synucleinHomo sapiens (human)
zinc ion bindingAlpha-synucleinHomo sapiens (human)
lipid bindingAlpha-synucleinHomo sapiens (human)
oxidoreductase activityAlpha-synucleinHomo sapiens (human)
kinesin bindingAlpha-synucleinHomo sapiens (human)
Hsp70 protein bindingAlpha-synucleinHomo sapiens (human)
histone bindingAlpha-synucleinHomo sapiens (human)
identical protein bindingAlpha-synucleinHomo sapiens (human)
alpha-tubulin bindingAlpha-synucleinHomo sapiens (human)
cysteine-type endopeptidase inhibitor activity involved in apoptotic processAlpha-synucleinHomo sapiens (human)
tau protein bindingAlpha-synucleinHomo sapiens (human)
phosphoprotein bindingAlpha-synucleinHomo sapiens (human)
molecular adaptor activityAlpha-synucleinHomo sapiens (human)
dynein complex bindingAlpha-synucleinHomo sapiens (human)
cuprous ion bindingAlpha-synucleinHomo sapiens (human)
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
double-stranded DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
RNA bindingTAR DNA-binding protein 43Homo sapiens (human)
mRNA 3'-UTR bindingTAR DNA-binding protein 43Homo sapiens (human)
protein bindingTAR DNA-binding protein 43Homo sapiens (human)
lipid bindingTAR DNA-binding protein 43Homo sapiens (human)
identical protein bindingTAR DNA-binding protein 43Homo sapiens (human)
pre-mRNA intronic bindingTAR DNA-binding protein 43Homo sapiens (human)
molecular condensate scaffold activityTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (29)

Processvia Protein(s)Taxonomy
extracellular regionAlbuminBos taurus (cattle)
extracellular spaceAlbuminBos taurus (cattle)
protein-containing complexAlbuminBos taurus (cattle)
platelet alpha granule membraneAlpha-synucleinHomo sapiens (human)
extracellular regionAlpha-synucleinHomo sapiens (human)
extracellular spaceAlpha-synucleinHomo sapiens (human)
nucleusAlpha-synucleinHomo sapiens (human)
cytoplasmAlpha-synucleinHomo sapiens (human)
mitochondrionAlpha-synucleinHomo sapiens (human)
lysosomeAlpha-synucleinHomo sapiens (human)
cytosolAlpha-synucleinHomo sapiens (human)
plasma membraneAlpha-synucleinHomo sapiens (human)
cell cortexAlpha-synucleinHomo sapiens (human)
actin cytoskeletonAlpha-synucleinHomo sapiens (human)
membraneAlpha-synucleinHomo sapiens (human)
inclusion bodyAlpha-synucleinHomo sapiens (human)
axonAlpha-synucleinHomo sapiens (human)
growth coneAlpha-synucleinHomo sapiens (human)
synaptic vesicle membraneAlpha-synucleinHomo sapiens (human)
perinuclear region of cytoplasmAlpha-synucleinHomo sapiens (human)
postsynapseAlpha-synucleinHomo sapiens (human)
supramolecular fiberAlpha-synucleinHomo sapiens (human)
protein-containing complexAlpha-synucleinHomo sapiens (human)
cytoplasmAlpha-synucleinHomo sapiens (human)
axon terminusAlpha-synucleinHomo sapiens (human)
neuronal cell bodyAlpha-synucleinHomo sapiens (human)
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
intracellular non-membrane-bounded organelleTAR DNA-binding protein 43Homo sapiens (human)
nucleusTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
perichromatin fibrilsTAR DNA-binding protein 43Homo sapiens (human)
mitochondrionTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmic stress granuleTAR DNA-binding protein 43Homo sapiens (human)
nuclear speckTAR DNA-binding protein 43Homo sapiens (human)
interchromatin granuleTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
chromatinTAR DNA-binding protein 43Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID1378049Antiglycation activity in bovine serum albumin assessed as inhibition of advanced glycated end product formation in presence of D-glucose by spectrofluorimetric analysis2017Journal of natural products, 07-28, Volume: 80, Issue:7
Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.
AID284264Antibacterial activity against methicillin-resistant Staphylococcus aureus at 20 ug/mL2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID284270Antimalarial activity against Plasmodium falciparum W22007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID80601Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 2*10e-5 M concentration.1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Analogues of natural phloroglucinols as antagonists against both thromboxane A2 and leukotriene D4.
AID284268Antifungal activity against Cryptococcus neoformans at 20 ug/mL2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID1378052Antiglycation activity in human serum albumin assessed as inhibition of fructosamine formation by measuring amadori products after 10 to 15 mins by NBT assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.
AID648688Growth inhibition of human PANC1 cells at 10 uM after 48 hrs by WST-8 assay2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
One pot synthesis and anticancer activity of dimeric phloroglucinols.
AID648689Growth inhibition of human Calu1 cells at 10 uM after 48 hrs by WST-8 assay2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
One pot synthesis and anticancer activity of dimeric phloroglucinols.
AID648691Growth inhibition of human HCT116 cells at 10 uM after 48 hrs by WST-8 assay2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
One pot synthesis and anticancer activity of dimeric phloroglucinols.
AID1378055Antiglycation activity in bovine serum albumin assessed as inhibition of advanced glycated end product formation in presence of D-glucose and 5-hydroxyferulic acid by spectrofluorimetric analysis2017Journal of natural products, 07-28, Volume: 80, Issue:7
Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.
AID648687Growth inhibition of human ACHN cells at 10 uM after 48 hrs by WST-8 assay2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
One pot synthesis and anticancer activity of dimeric phloroglucinols.
AID80614Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 2*10e-5 M concentration.1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Analogues of natural phloroglucinols as antagonists against both thromboxane A2 and leukotriene D4.
AID1378053Antiglycation activity in human serum albumin assessed as inhibition of fructosamine formation by measuring amadori products after 10 to 15 mins in presence of 5-hydroxyferulic acid by NBT assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.
AID284257Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by Alamar blue assay2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID284259Cytotoxicity against Vero cells by neutral red assay2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID284269Antimalarial activity against Plasmodium falciparum D62007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID1378050Inhibition of glucose auto-oxidation after 30 mins in presence of deoxyribose by benzoate hydroxylation assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.
AID284273Antimicrobial activity against Mycobacterium intracellular2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID284261Cytotoxicity against LLC-PK1 cells by neutral red assay2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID251500Percent viability of Raji cells at concentration of 1000 mol ratio / 20 ng/mL TPA2005Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.
AID1378051Antiglycation activity in bovine serum albumin assessed as inhibition of MGO-mediated protein modification after 5 days by PAGE analysis2017Journal of natural products, 07-28, Volume: 80, Issue:7
Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.
AID284274Antifungal activity against Aspergillus fumigatus2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID648690Growth inhibition of human NCI-H460 cells at 10 uM after 48 hrs by WST-8 assay2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
One pot synthesis and anticancer activity of dimeric phloroglucinols.
AID284266Antifungal activity against Candida albicans at 20 ug/mL2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (171)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's13 (7.60)18.2507
2000's78 (45.61)29.6817
2010's61 (35.67)24.3611
2020's19 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.94 (24.57)
Research Supply Index5.16 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (1.72%)6.00%
Case Studies1 (0.57%)4.05%
Observational0 (0.00%)0.25%
Other170 (97.70%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]