Page last updated: 2024-11-12

lupinifolin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

lupinifolin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10250777
CHEMBL ID559980
MeSH IDM0416409

Synonyms (6)

Synonym
lupinifolin
CHEMBL559980
55890-27-2
bdbm50495310
DTXSID201318262
(8s)-5-hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)-7,8-dihydropyrano[3,2-g]chromen-6-one

Research Excerpts

Treatment

ExcerptReferenceRelevance
"Lupinifolin-treated cells demonstrated no lysis."( Lupinifolin from Albizia myriophylla wood: A study on its antibacterial mechanisms against cariogenic Streptococcus mutans.
Chusri, S; Jaisamut, P; Jarukitsakul, S; Joycharat, N; Limsuwan, S; Moosigapong, K; Voravuthikunchai, SP, 2018
)
2.64
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)47.65000.03403.987110.0000AID1064748; AID1064750
Polyphenol oxidase 2Agaricus bisporusKi20.81500.00063.28838.8900AID1064747; AID1064749
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1064748Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 mins by spectrophotometry2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.
AID1064747Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 mins by Dixon plot analysis2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.
AID1064750Inhibition of mushroom tyrosinase using L-tyrosine as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 mins by spectrophotometry2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.
AID426317Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense.
AID426318Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense.
AID1064749Competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 mins by Dixon plot analysis2014Bioorganic & medicinal chemistry, Feb-01, Volume: 22, Issue:3
Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.
AID426316Cytotoxicity against human KB cells by sulforhodamine B assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense.
AID426315Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 24 hrs by microplate alamar Blue assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (30.77)29.6817
2010's6 (46.15)24.3611
2020's3 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.42 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]