Piriformis Muscle Syndrome

A chronic PELVIC PAIN characterized by pain deep in the buttock that may radiate to posterior aspects of the leg. It is caused by the piriformis muscle compressing or irritating the SCIATIC NERVE due to trauma, hypertrophy, inflammation or anatomic variations.

Synonym
Piriformis Muscle Syndrome
Piriformis syndrome

Excerpt	Reference
"Piriformis syndrome is a rare neuromuscular disorder that occurs when the piriformis muscle compresses or irritates the sciatic nerve."	( Denk, CC; Gundogmus, B; Ozisik, PA; Taskiran, OO; Toru, M, 2014)
"Piriformis syndrome is the compression or the irritation of the sciatic nerve by the adjacent piriformis muscle in the buttock leading to symptoms that include buttock pain, leg pain, and altered neurology in the sciatic nerve distribution."	( Brick, MJ; Knudsen, JS; Mei-Dan, O, 2016)
"Piriformis syndrome is described as a neuromuscular condition which occurs when the sciatic nerve is compressed and/or irritated by the piriformis muscle."	( Black, AC; Blackwell, TA; Reynolds, Z; Swetenburg, J; Williams, SE, 2020)

Excerpt	Reference
"The treatment of piriformis syndrome includes injections into the piriformis muscle around the sciatic nerve."	( Denk, CC; Gundogmus, B; Ozisik, PA; Taskiran, OO; Toru, M, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	14 (93.33)	28.8240
2020's	1 (6.67)	9.53

Drug	Relationship Strength	Studies	Trials
bupivacaine	low	1	0
glyphosate	low	1	0
lidocaine	medium	3	2
cloxacillin	low	1	0
mannitol	medium	1	1
methylprednisolone	medium	2	1
pyrroles	low	1	0
betamethasone	medium	1	1
vancomycin	low	1	0
floxacillin	low	1	0
triamcinolone	low	1	0
amikacin	low	1	0
atorvastatin	low	1	0
meropenem	low	1	0
rifampin	low	1	0

Protein Targets (239)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen nuclear receptor alpha	8	0	0	8
peripheral myelin protein 22	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
lamin isoform A-delta10	4	0	0	4
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Bile salt export pump	0	8	0	8
Canalicular multispecific organic anion transporter 1	0	6	0	6
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
RAR-related orphan receptor gamma	3	0	0	3
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	5	0	0	5
AR protein	8	0	0	8
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
retinoid X nuclear receptor alpha	4	0	0	4
estrogen-related nuclear receptor alpha	6	0	0	6
pregnane X nuclear receptor	5	0	0	5
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
caspase-3	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
Caspase-7	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
geminin	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Cellular tumor antigen p53	2	0	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Insulin receptor	0	1	0	1
Glutamate receptor 2	2	0	0	2
Dipeptidyl peptidase 4	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase 2	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Histone deacetylase 6	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	3	0	5
pregnane X receptor	1	0	0	1
progesterone receptor	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
IDH1	4	0	0	4
aryl hydrocarbon receptor	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	6	0	6
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
ORF73	0	0	1	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Beta-lactamase	0	1	0	1
Bile salt export pump	0	4	0	4
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Beta-lactamase TEM	0	1	0	2
Solute carrier family 15 member 2	0	1	0	1
Efflux transporter	0	1	0	1
Beta-lactamase	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase class B VIM-2	0	0	1	3
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Beta-lactamase	1	0	0	1
thioredoxin reductase	2	0	0	2
GLS protein	1	0	0	1
TDP1 protein	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
chromobox protein homolog 1	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
flap endonuclease 1	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Sodium channel protein type 4 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
GABA theta subunit	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
USP1 protein, partial	2	0	0	2
activating transcription factor 6	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Beta-lactamase	0	0	0	1
G	2	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
lethal factor (plasmid)	1	0	0	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
cytochrome P450 2C9, partial	2	0	0	2
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
PPM1D protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	2	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
interleukin 8	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Albumin	0	0	2	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Histamine H2 receptor	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
glp-1 receptor, partial	1	0	0	1
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	1	0	0	1
arylsulfatase A	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
heat shock protein beta-1	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (15)

Protein Targets (239)

Piriformis Muscle Syndrome

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (15)

Drugs Studied (19)

Protein Targets (239)