alpha-synuclein has been researched along with n-pentanoic-acid* in 1 studies
1 other study(ies) available for alpha-synuclein and n-pentanoic-acid
| Article | Year |
|---|---|
Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways.
Parkinson's disease, the second common neurodegenerative disease is clinically characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) with upregulation of neuroinflammatory markers and oxidative stress. Autophagy lysosome pathway (ALP) plays a major role in degradation of damaged organelles and proteins for energy balance and intracellular homeostasis. However, dysfunction of ALP results in impairment of α-synuclein clearance which hastens dopaminergic neurons loss. In this study, we wanted to understand the neuroprotective efficacy of Val in rotenone induced PD rat model. Animals received intraperitoneal injections (2.5 mg/kg) of rotenone daily followed by Val (40 mg/kg, i.p) for four weeks. Valeric acid, a straight chain alkyl carboxylic acid found naturally in Topics: alpha-Synuclein; Animals; Antioxidants; Antiparkinson Agents; Apoptosis; Astrocytes; Autophagy; Corpus Striatum; Dopaminergic Neurons; Male; Oxidative Stress; Parkinson Disease; Pentanoic Acids; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Rotenone; TOR Serine-Threonine Kinases; Uncoupling Agents | 2020 |