Gangliosidoses, GM2

A group of recessively inherited diseases characterized by the intralysosomal accumulation of G(M2) GANGLIOSIDE in the neuronal cells. Subtypes include mutations of enzymes in the BETA-N-ACETYLHEXOSAMINIDASES system or G(M2) ACTIVATOR PROTEIN leading to disruption of normal degradation of GANGLIOSIDES, a subclass of ACIDIC GLYCOSPHINGOLIPIDS.

Synonym
Gangliosidoses, GM2

Excerpt	Reference
"GM2 gangliosidoses are a group of pathologies characterized by GM2 ganglioside accumulation into the lysosome due to mutations on the genes encoding for the β-hexosaminidases subunits or the GM2 activator protein."	( Alméciga-Díaz, CJ; Benincore-Flórez, E; Echeverri-Peña, OY; Espejo-Mojica, AJ; Garzón Jaramillo, RG; Leal, AF; Solano-Galarza, D; Suarez, DA, 2020)

Excerpt	Reference
"Three GM2 gangliosidoses have been described: Tay-Sachs disease, Sandhoff disease, and the AB variant."	( Alméciga-Díaz, CJ; Benincore-Flórez, E; Echeverri-Peña, OY; Espejo-Mojica, AJ; Garzón Jaramillo, RG; Leal, AF; Solano-Galarza, D; Suarez, DA, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (2.04)	23.3326
1990's	0 (0.00)	12.5806
2000's	26 (53.06)	18.1394
2010's	12 (24.49)	28.8240
2020's	10 (20.41)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
adenine	low	1	0
choline	low	1	0
methylmalonic acid	low	1	0
creatine	low	2	0
glycine	low	1	0
imidazole	low	1	0
inositol	low	1	0
acetyl-dl-leucine	medium	2	2
amitriptyline	low	1	0
gabapentin	low	2	0
pyrimethamine	medium	3	1
prednisolone	low	1	0
aspartic acid	low	3	0
leucine	low	1	0
histidine	low	1	0
arginine	low	2	0
methylprednisolone	low	1	0
thiazoles	low	1	0
tocopherols	low	1	0
acetylglucosamine	low	1	0
1-deoxynojirimycin	medium	6	2
phenyl acetate	low	2	0
ursodeoxycholic acid	low	1	0
transferrin	low	1	0
tiagabine	low	1	0
n-acetylaspartic acid	low	2	0
fluorodeoxyglucose f18	low	1	0
delta-tocopherol	low	1	0
n-acetylneuraminic acid	low	1	0
thioguanine anhydrous	low	1	0
krn 7000	low	1	0
sphingosine	low	1	0
n-acetylglucosamine thiazoline	low	2	0
ganglioside, gd2	low	3	0
g(m2) ganglioside	low	16	0
alpha-synuclein	low	1	0
glycolipids	low	2	0
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine	low	1	0
g(m3) ganglioside	low	3	0
ganciclovir	low	1	0
trypan blue	low	1	0
filipin	low	1	0

Protein Targets (607)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
glucocerebrosidase	2	0	0	2
Alpha-mannosidase	0	1	0	1
alpha-galactosidase	3	0	0	3
Trehalase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
Trehalase	0	2	0	2
Lysosomal acid glucosylceramidase	0	4	0	4
Alpha-galactosidase A	0	1	0	1
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Lysosomal alpha-glucosidase	0	4	0	4
Beta-glucosidase A	0	1	0	1
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Beta-glucosidase	0	1	0	1
Protein-lysine 6-oxidase	0	4	0	4
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	2	0	2
Glycogen debranching enzyme	0	1	0	1
Alpha-glucosidase MAL32	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	2	0	2
Oxysterols receptor LXR-beta	0	1	0	1
Spike glycoprotein	4	0	0	4
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Oxysterols receptor LXR-alpha	0	1	0	1
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	2	0	2
Lysosomal acid glucosylceramidase	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	2	0	2
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	2	0	2
Putative alpha-glucosidase	0	2	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
G	4	0	0	4
cytochrome P450 2D6	3	0	0	3
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
High affinity nerve growth factor receptor	0	2	2	4
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Yes	0	1	0	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	0	1
Cytochrome P450 3A4	0	3	0	4
Mast/stem cell growth factor receptor Kit	0	1	0	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	1	0	1
Tyrosine-protein kinase receptor UFO	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Serine/threonine-protein kinase Nek4	0	1	0	1
Mitogen-activated protein kinase kinase kinase 9	0	1	0	1
Mitogen-activated protein kinase kinase kinase 10	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Receptor-interacting serine/threonine-protein kinase 1	0	1	0	1
Protein-tyrosine kinase 6	0	1	0	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	1	0	1
NT-3 growth factor receptor	0	1	0	1
Mitogen-activated protein kinase kinase kinase 11	0	1	0	1
BDNF/NT-3 growth factors receptor	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Aurora kinase B	0	1	0	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	1	0	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	1	0	1
Eukaryotic translation initiation factor 2-alpha kinase 3	0	1	0	1
Serine/threonine-protein kinase WNK2	0	1	0	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	1	0	1
cytochrome P450 2C9, partial	4	0	0	4
chromobox protein homolog 1	4	0	0	4
geminin	11	0	0	11
Putative glycosyltransferase WbgO	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	5	0	0	5
TDP1 protein	8	0	0	8
AR protein	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
glucocorticoid receptor [Homo sapiens]	7	0	0	7
estrogen-related nuclear receptor alpha	7	0	0	7
pregnane X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
heat shock protein beta-1	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
lamin isoform A-delta10	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Bile salt export pump	0	8	0	8
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	4	0	0	4
Xanthine dehydrogenase/oxidase	0	2	0	2
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	5	0	0	5
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
thioredoxin reductase	4	0	0	4
USP1 protein, partial	3	0	0	3
NFKB1 protein, partial	3	0	0	3
GLS protein	4	0	0	4
arylsulfatase A	4	0	0	4
cytochrome P450 2D6 isoform 1	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	4	0	0	4
Solute carrier family 22 member 1	0	2	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Albumin	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H2 receptor	1	1	0	3
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
cytochrome P450 2C19 precursor	2	0	0	2
flap endonuclease 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
lethal factor (plasmid)	2	0	0	2
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Ferritin light chain	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
Bloom syndrome protein isoform 1	5	0	0	5
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	0	0	3
Carbonic anhydrase 2	0	0	0	3
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	1	5
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	5
acetylcholinesterase	3	0	0	3
GLI family zinc finger 3	6	0	0	6
Histone H2A.x	3	0	0	3
peripheral myelin protein 22	4	0	0	4
Cellular tumor antigen p53	5	0	0	5
thioredoxin glutathione reductase	1	0	0	1
regulator of G-protein signaling 4	3	0	0	3
EWS/FLI fusion protein	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
survival motor neuron protein isoform d	4	0	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
ATAD5 protein, partial	3	0	0	3
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
transcriptional regulator ERG isoform 3	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	3	2	0	5
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	3	2	0	5
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	3	2	0	5
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	3	2	0	5
Sodium- and chloride-dependent GABA transporter 1	0	3	1	6
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit beta-3	3	2	0	5
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	3	2	1	6
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
GABA theta subunit	3	2	0	5
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	3	2	0	5
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Thymidine kinase	0	1	0	1
endonuclease IV	2	0	0	2
ClpP	1	0	0	1
Fumarate hydratase	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
polyprotein	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	3	0	3
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	3	0	0	3
Epoxide hydrolase 1	0	0	0	1
Thromboxane-A synthase	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	0	1	1
Cytochrome P450 1B1	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Serine racemase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
PPM1D protein	1	0	0	1
progesterone receptor	3	0	0	3
nonstructural protein 1	1	0	0	1
IDH1	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	4	2	11
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Sucrase-isomaltase	0	1	0	1
Ceramide glucosyltransferase	0	1	0	1
Beta-galactosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	1	0	1
67.9K protein	3	0	0	3
DNA polymerase kappa isoform 1	1	0	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, Beta-n-acetylhexosaminidase	0	1	0	1
Chain A, N-acetyl-beta-D-glucosaminidase	0	1	0	1
Chain A, ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D	0	0	1	1
Protein O-GlcNAcase	0	1	0	1
Beta-N-acetylhexosaminidase	0	1	0	1
Beta-hexosaminidase subunit alpha	0	2	0	3
Beta-hexosaminidase subunit beta	0	2	0	2
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
luciferase	0	0	0	1
aryl hydrocarbon receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
glp-1 receptor, partial	1	0	0	1
pregnane X receptor	1	0	0	1
SMAD family member 2	1	0	0	1
GALC protein	1	0	0	1
SMAD family member 3	1	0	0	1
Smad3	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
farnesoid X nuclear receptor	2	0	0	2
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
thyroid hormone receptor beta isoform 2	1	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
streptokinase A precursor	0	0	2	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Integrin beta-3	2	0	0	2
Estrogen receptor	0	0	2	2
Integrin alpha-IIb	2	0	0	2
Dihydrofolate reductase	0	2	1	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	2	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, Cruzipain	1	0	0	1
Luciferase	2	0	0	2
acid sphingomyelinase	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
vitamin D3 receptor isoform VDRA	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
DNA polymerase beta	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
PAX8	0	0	0	1
hypothetical protein, conserved	1	0	0	1
activating transcription factor 6	1	0	0	1
hemoglobin subunit beta	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Mitogen-activated protein kinase 3	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Alpha-synuclein	1	0	0	1
Ileal sodium/bile acid cotransporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (49)

Protein Targets (607)

Gangliosidoses, GM2

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (49)

Drugs Studied (50)

Protein Targets (607)