5p Deletion Syndrome

An infantile syndrome characterized by a cat-like cry, failure to thrive, microcephaly, MENTAL RETARDATION, spastic quadriparesis, micro- and retrognathia, glossoptosis, bilateral epicanthus, hypertelorism, and tiny external genitalia. It is caused by a deletion of the short arm of chromosome 5 (5p-).

Synonym
Chromosome 5p Deletion Syndrome
Cat Cry Syndrome
5p- Syndrome
Chromosome 5p- Syndrome
Crying Cat Syndrome
Chromosome 5 Short Arm Deletion Syndrome
Deletion of Short Arm of Chromosome 5 Syndrome
Cri-du-Chat Syndrome
5p Deletion Syndrome
5p Minus Syndrome

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	30 (71.43)	23.3326
1990's	3 (7.14)	12.5806
2000's	0 (0.00)	18.1394
2010's	3 (7.14)	28.8240
2020's	6 (14.29)	9.53

Drug	Relationship Strength	Studies
ammonium hydroxide	low	1
quinacrine	low	5
nitrous oxide	low	1
2-propanol	low	3
thalidomide	low	2
thymidine	low	4
aspartic acid	low	1
bromodeoxyuridine	low	1
galactose	low	1
leucine	low	1
asparagine	low	1
histidine	low	1
threonine	low	1
acridines	low	1
azacitidine	low	1
quinacrine mustard	low	1
fomesafen	low	1
proline	low	1
lenalidomide	low	2
3-methylglutaconic acid	low	1
digoxin	low	1
alpha-synuclein	low	1
acid phosphatase	low	1
jaw	low	1
sodium ethylxanthate	low	1

Protein Targets (320)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	6	0	0	6
GLI family zinc finger 3	5	0	0	5
AR protein	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
retinoid X nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	6	0	0	6
peroxisome proliferator-activated receptor delta	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	3	0	0	3
thyroid hormone receptor beta isoform a	3	0	0	3
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
lamin isoform A-delta10	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Glutamate receptor 2	3	0	0	3
glp-1 receptor, partial	2	0	0	2
TDP1 protein	8	0	0	8
geminin	6	0	0	6
glucocorticoid receptor [Homo sapiens]	5	0	0	5
estrogen-related nuclear receptor alpha	7	0	0	7
thyroid hormone receptor beta isoform 2	5	0	0	5
Chain A, Ferritin light chain	2	0	0	2
thioredoxin reductase	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
Smad3	3	0	0	3
alpha-galactosidase	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
flap endonuclease 1	3	0	0	3
DNA polymerase iota isoform a (long)	2	0	0	2
DNA topoisomerase 2-alpha	0	0	0	1
Acetylcholinesterase	0	2	0	2
Chain A, Beta-lactamase	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Carbonic anhydrase 1	0	0	0	4
Carbonic anhydrase 2	0	0	0	4
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
arylsulfatase A	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	6	0	0	6
Bloom syndrome protein isoform 1	3	0	0	3
cytochrome P450 2C19 precursor	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	3
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	2
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	2
interleukin 8	3	0	0	3
pregnane X receptor	2	0	0	2
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	2	0	0	2
NFKB1 protein, partial	1	0	0	1
PPM1D protein	2	0	0	2
Thrombopoietin	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
progesterone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	5	0	0	5
polyprotein	2	0	0	2
67.9K protein	3	0	0	3
Parkin	1	0	0	1
peroxisome proliferator activated receptor gamma	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
IDH1	5	0	0	5
aryl hydrocarbon receptor	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
chromobox protein homolog 1	4	0	0	4
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
peripheral myelin protein 22	3	0	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
Interferon beta	2	0	0	2
Cellular tumor antigen p53	3	0	0	3
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Adenosine receptor A3	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Nuclear receptor ROR-gamma	3	1	1	5
Spike glycoprotein	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	4	0	0	4
ATP-dependent phosphofructokinase	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Nuclear hormone receptor family member daf-12	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
oxysterols receptor LXR-beta isoform 1	0	0	1	1
survival motor neuron protein isoform d	1	0	0	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	1	0	0	1
PAX8	0	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
STAT3, partial	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
regulator of G-protein signaling 4	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
tumor necrosis factor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Bile salt export pump	0	4	0	4
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	1	3
Cytochrome P450 3A4	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Luciferase	2	0	0	2
USP1 protein, partial	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Adenosine receptor A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
GABA theta subunit	1	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Cereblon isoform 4	0	3	0	3
EWS/FLI fusion protein	2	0	0	2
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	1
Bromodomain-containing protein 4	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	0	1
Breakpoint cluster region protein	0	0	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	1	0	1
Protein cereblon	0	4	2	9
Zinc finger protein Aiolos	0	0	1	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
N	0	1	0	1
dopamine D1 receptor	1	0	0	1
NPYLR7B	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	0	1	1
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Trypanothione reductase	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Aldehyde oxidase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
cytochrome P450 2D6	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research

Studies (42)

Protein Targets (320)

5p Deletion Syndrome

Synonyms(10)

Research

Studies (42)

Drugs Studied (31)

Protein Targets (320)