Page last updated: 2024-09-27

Antopol Disease

An X-linked dominant multisystem disorder resulting in cardiomyopathy, myopathy and INTELLECTUAL DISABILITY. It is caused by mutation in the gene encoding LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2.

Synonyms(13)

Synonym
Antopol Disease
Glycogen Storage Disease IIb
X-Linked Vacuolar Cardiomyopathy and Myopathy
Glycogen Storage Disease Type IIb
Glycogen Storage Cardiomyopathy
Pseudoglycogenosis 2
Glycogen Storage Disease Type 2B
Glycogen Storage Disease Limited to the Heart
Danon Disease
Pseudoglycogenosis II
Vacuolar Cardiomyopathy and Myopathy, X-linked
Lysosomal Glycogen Storage Disease with Normal Acid Maltase
Lysosomal Glycogen Storage Disease without Acid Maltase Deficiency

Research Excerpts

Overview

ExcerptReference
"Danon disease is a rare X-linked dominant lysosomal glycogen storage disease that can lead to severe ventricular hypertrophy and heart failure."( Fidzianska, A; Kosieradzka, A; Kownacki, L; Krolicki, L; Kuch, M; Piotrowska-Kownacka, D; Walczak, E, 2009)
"Danon disease is a rare entity associated with the clinical triad of mental retardation, skeletal myopathy, and severe hypertrophic cardiomyopathy."( Dara, BS; Fishman, JE; Rusconi, PG, 2011)
"Danon disease is a rare X-linked dominant lysosomal disease due to the primary deficiency of lysosome-associated membrane protein 2 (LAMP2) gene."( Cheng, Z; Fang, Q, 2012)
"Danon disease is an X-linked disorder that leads to fatal cardiomyopathy caused by a deficiency in lysosome-associated membrane protein-2 (LAMP2)."( Au, KW; Butler, AW; Choi, SW; Colman, A; Esteban, MA; Ho, JC; Lai, WH; Lau, YM; Lee, YK; Mok, PY; Ng, KM; Sham, PC; Siu, CW; Tse, HF; Wong, LY, 2016)
"Danon disease is a lethal X-linked genetic syndrome resulting from radical mutations in the LAMP2 gene."( Abraham, NG; Alcalai, R; Arad, M; Hochhauser, E; Petrover, Z; Seidman, CE; Seidman, J; Shainberg, A; Waldman, M; Yadin, D, 2022)
"Danon disease is a rare X-linked genetic disease resulting from LAMP2 mutations leading to defective lysosomal function."( Alcalai, R; Arad, M; Guetta, T; Hochhauser, E; Kornowski, R; Ofek, E; Petrover, Z; Seidman, CE; Seidman, J; Yadin, D, 2023)

Research

Studies (19)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's3 (15.79)18.1394
2010's11 (57.89)28.8240
2020's5 (26.32)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carvedilol0low10
hydroxychloroquine0low10
mianserin0low10
mirtazapine0low10
spironolactone0low10
prednisone0low10
asparagine0low10
threonine0low10
azacitidine0low10
gadolinium0low20
etoposide0low10
glucose, (beta-d)-isomer0low10
angiotensin ii0low10
bortezomib0low10
glycogen0low40
n-acetylneuraminic acid0low10
4-methylumbelliferyl glucoside0low10
hymecromone0low10
sirolimus0low10
ramipril0low10
gadolinium dtpa0low10
alpha-synuclein0low10
tetracycline0low10

Protein Targets (769)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Carbonic anhydrase 120303
Carbonic anhydrase 10304
Carbonic anhydrase 20304
Carbonic anhydrase 90303
glucocerebrosidase2002
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 13003
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0505
Type-2 angiotensin II receptor0202
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Carbonic anhydrase-like protein, putative0001
Amino acid transporter0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Beta-lactamase1001
interleukin 81001
glp-1 receptor, partial4004
pregnane X receptor3003
RAR-related orphan receptor gamma4004
ATAD5 protein, partial3003
Fumarate hydratase3003
NFKB1 protein, partial1001
PPM1D protein2002
TDP1 protein8008
GLI family zinc finger 37007
Thrombopoietin1001
AR protein7007
Smad33003
aldehyde dehydrogenase 1 family, member A14004
estrogen receptor 2 (ER beta)6006
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha8008
farnesoid X nuclear receptor5005
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha8008
polyprotein3003
67.9K protein4004
Parkin1001
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
arylsulfatase A3003
IDH13003
euchromatic histone-lysine N-methyltransferase 23003
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor2002
activating transcription factor 65005
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a1001
chromobox protein homolog 15005
thyroid hormone receptor beta isoform 27007
huntingtin isoform 22002
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 16006
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin7007
peripheral myelin protein 221001
muscarinic acetylcholine receptor M11001
lamin isoform A-delta104004
Interferon beta3003
Cellular tumor antigen p538008
Integrin beta-31001
Integrin alpha-IIb1001
Adenosine receptor A30101
DNA (cytosine-5)-methyltransferase 10101
Adenosine receptor A2a0101
Adenosine receptor A10101
D(1A) dopamine receptor2002
Nuclear receptor ROR-gamma2002
Spike glycoprotein4015
Multidrug and toxin extrusion protein 10303
Histone-lysine N-methyltransferase EHMT20101
ATPase family AAA domain-containing protein 54004
Ataxin-26006
ATP-dependent phosphofructokinase3003
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
caspase 7, apoptosis-related cysteine protease2002
EWS/FLI fusion protein7007
caspase-32002
nuclear receptor subfamily 1, group I, member 21001
Histone H2A.x5005
Caspase-71001
caspase-31001
heat shock protein beta-13003
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30101
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
26S proteasome non-ATPase regulatory subunit 30101
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0808
Prothrombin0102
Chymotrypsinogen A0101
Carbonic anhydrase 30101
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Glutamate receptor 23003
Nuclear factor NF-kappa-B p105 subunit0202
Proteasome subunit beta type-10102
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0101
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70101
26S proteasome regulatory subunit 6B0112
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130101
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20101
Canalicular multispecific organic anion transporter 10708
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150101
Histone deacetylase 80101
Histone deacetylase 60101
Carbonic anhydrase 140101
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, 2-oxoglutarate Oxygenase2002
phosphopantetheinyl transferase2002
Microtubule-associated protein tau1001
bromodomain adjacent to zinc finger domain 2B1001
lysosomal alpha-glucosidase preproprotein2002
D(1A) dopamine receptor2002
mitogen-activated protein kinase 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 13003
short transient receptor potential channel 6 isoform 10011
Toll-like receptor 40101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
5-hydroxytryptamine receptor 40404
Potassium channel subfamily K member 20101
Amyloid-beta precursor protein0101
Beta-2 adrenergic receptor0213
Aldo-keto reductase family 1 member B10505
ATP-dependent translocase ABCB10506
Beta-1 adrenergic receptor0213
Alpha-2A adrenergic receptor0707
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Angiotensin-converting enzyme0303
Beta-3 adrenergic receptor0213
D(2) dopamine receptor0505
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0707
5-hydroxytryptamine receptor 1A0404
D(1A) dopamine receptor0404
UDP-glucuronosyltransferase 1A1 0203
Sodium-dependent noradrenaline transporter 0404
Alpha-1D adrenergic receptor0606
5-hydroxytryptamine receptor 2A0505
5-hydroxytryptamine receptor 2C0505
5-hydroxytryptamine receptor 1B0404
Sodium-dependent serotonin transporter0404
D(3) dopamine receptor0505
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 60405
Potassium channel subfamily K member 100101
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20303
Cytochrome P450 1B10101
Nuclear receptor subfamily 3 group C member 3 0202
hypoxia-inducible factor 1 alpha subunit2002
SMAD family member 23003
SMAD family member 33003
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear factor erythroid 2-related factor 2 isoform 22002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase iota isoform a (long)1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Regulatory protein E20011
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40202
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0128
Cytochrome P450 2C9 0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0129
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0202
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0001
Glycogen phosphorylase, muscle form0101
Asialoglycoprotein receptor 10112
Genome polyprotein 0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M50303
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30303
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Sigma non-opioid intracellular receptor 10101
Angiotensin-converting enzyme 2 0011
Toll-like receptor 90101
Toll-like receptor 70101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, Ferritin light chain1001
acetylcholinesterase2002
thioredoxin reductase1001
GALC protein1001
G1001
alpha-galactosidase1001
cytochrome P450 2C9 precursor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
importin subunit beta-1 isoform 11001
snurportin-11001
caspase-1 isoform alpha precursor1001
Acetylcholinesterase0101
HLA class I histocompatibility antigen, B alpha chain 1001
Aldo-keto reductase family 1 member B10101
Genome polyprotein0101
Amine oxidase [flavin-containing] B0101
Testosterone 17-beta-dehydrogenase 30101
Histamine H2 receptor2104
Caspase-71001
Small conductance calcium-activated potassium channel protein 30101
Cholinesterase0101
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Oleandomycin glycosyltransferase0001
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
5-hydroxytryptamine receptor 3E0101
GLS protein2002
regulator of G-protein signaling 41001
cytochrome P450 2D61001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 1A0325
5-hydroxytryptamine receptor 2C0303
Muscarinic acetylcholine receptor M50101
5-hydroxytryptamine receptor 2A0303
Alpha-1B adrenergic receptor0516
D0202
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0213
Endothelin receptor type B0101
D(4) dopamine receptor0202
Alpha-2C adrenergic receptor0213
Alpha-2A adrenergic receptor0213
Alpha-1D adrenergic receptor0516
5-hydroxytryptamine receptor 3A0202
Endothelin receptor type B0101
Histamine H2 receptor0202
Endothelin-1 receptor0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1D0202
5-hydroxytryptamine receptor 1F0202
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0303
5-hydroxytryptamine receptor 7 0202
5-hydroxytryptamine receptor 70303
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Histamine H1 receptor0303
5-hydroxytryptamine receptor 3A0202
Alpha-1A adrenergic receptor0516
5-hydroxytryptamine receptor 3A0202
Angiotensin-converting enzyme0202
D(2) dopamine receptor0303
Inositol monophosphatase 11001
5-hydroxytryptamine receptor 4 0101
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
5-hydroxytryptamine receptor 3B0202
5-hydroxytryptamine receptor 3B0202
G-protein coupled receptor 0101
Transporter0404
thyroid stimulating hormone receptor1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
Sodium-dependent dopamine transporter0101
TAR DNA-binding protein 431001
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
Glucocorticoid receptor0426
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Angiotensin-converting enzyme 0101
USP1 protein, partial1001
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Nuclear receptor subfamily 1 group I member 20011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Tyrosine-protein kinase ABL10011
Epidermal growth factor receptor0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Protein kinase C beta type0011
Insulin receptor0011
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Cyclin-dependent kinase 20011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Cytochrome P450 2C190202
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Alpha-synuclein1102
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Serine/threonine-protein kinase mTOR0112
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Solute carrier organic anion transporter family member 1B10101
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
thyroid hormone receptor beta isoform a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Vpr1001
Estrogen receptor0213
Progesterone receptor0213
Mineralocorticoid receptor 0203
Androgen receptor0213
Androgen receptor0203
Estrogen receptor beta0112
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Neutrophil collagenase0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Solute carrier family 22 member 80001
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]