Page last updated: 2024-09-27

Autonomic Failure, Pure

A degenerative disease of the AUTONOMIC NERVOUS SYSTEM that is characterized by idiopathic ORTHOSTATIC HYPOTENSION and a greatly reduced level of CATECHOLAMINES. No other neurological deficits are present.

Synonyms(3)

Synonym
Bradbury-Eggleston Syndrome
Autonomic Failure, Pure
Pure Autonomic Failure

Research Excerpts

Overview

ExcerptReference
"Pure autonomic failure is a rare form of chronic autonomic failure manifesting with neurogenic orthostatic hypotension and evidence of sympathetic noradrenergic denervation unaccompanied by signs of central neurodegeneration."( Cook, GA; Goldstein, DS; Holmes, C; Isonaka, R; Sharabi, Y; Sullivan, P, 2017)

Research

Studies (76)

TimeframeStudies, This Condition (%)All Conditions %
pre-19907 (9.21)23.3326
1990's0 (0.00)12.5806
2000's9 (11.84)18.1394
2010's48 (63.16)28.8240
2020's12 (15.79)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetic acid0low10
3,4-dihydroxyphenylacetic acid0low20
dihydroxyphenylalanine0low10
melatonin0low10
homovanillic acid0low10
clonazepam0low20
clonidine0low20
desipramine0low10
edrophonium0low10
isoproterenol0low10
losartan0medium11
midodrine0medium11
nitroglycerin0low10
thalidomide0low10
tyramine0low10
prednisolone0low10
spironolactone0medium11
aldosterone0medium21
serine0low10
phenylephrine0low20
levodopa0low10
desoxycorticosterone0low10
valine0low10
pyridostigmine bromide0medium21
yohimbine0medium21
pyrazines0low10
ephedrine0low10
methoxyhydroxyphenylglycol0low40
trimethaphan0low20
fludrocortisone0low60
captopril0medium11
fomesafen0low10
atomoxetine hydrochloride0medium31
valsartan0low10
3-iodobenzylguanidine0low20
fluorodeoxyglucose f180low20
3,4-dihydroxyphenylglycol0low40
droxidopa0medium53
yohimbane0low10
5-fluorodopamine0low10
angiotensin ii0medium11
cortisone0low10
bortezomib0low10
eplerenone0medium11
entacapone0medium11
naloxone0low40
naltrexone0low10
methylnaltrexone0low10
alpha-synuclein0low220
pituitrin0low30
glucagon0low20
carbidopa0medium11

Protein Targets (639)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
dopamine D1 receptor6006
thioredoxin reductase110011
GLS protein100010
Thrombopoietin4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
cytochrome P450 2D6 isoform 14004
cytochrome P450 2C19 precursor3003
ras-related protein Rab-9A3003
histone acetyltransferase KAT2A isoform 17007
lethal factor (plasmid)2002
POU domain, class 2, transcription factor 10003
Spike glycoprotein7007
ATP-dependent phosphofructokinase8008
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10011
Luciferase4004
endonuclease IV4004
RGS121001
phosphopantetheinyl transferase8008
NFKB1 protein, partial4004
TDP1 protein150015
Microtubule-associated protein tau5005
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA12002
thyroid stimulating hormone receptor4004
hypothetical protein, conserved1001
regulator of G-protein signaling 48008
euchromatic histone-lysine N-methyltransferase 2150015
Bloom syndrome protein isoform 15005
lysosomal alpha-glucosidase preproprotein2002
peripheral myelin protein 22 isoform 14004
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
intestinal alkaline phosphatase precursor0101
chromobox protein homolog 17007
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
DNA polymerase beta1001
flap endonuclease 13003
DNA polymerase iota isoform a (long)2002
geminin130013
M-phase phosphoprotein 87007
alkaline phosphatase, germ cell type preproprotein0011
POsterior Segregation0022
muscarinic acetylcholine receptor M1100010
lamin isoform A-delta106006
Prolyl 4-hydroxylase subunit alpha-10101
Sodium-dependent noradrenaline transporter 0336
Zinc finger protein mex-50022
Alpha-1B adrenergic receptor0819
Beta-1 adrenergic receptor0416
Alpha-2B adrenergic receptor0819
Alpha-2C adrenergic receptor0819
Alpha-2A adrenergic receptor0819
Alpha-1D adrenergic receptor0718
Alpha-1A adrenergic receptor09211
Beta-2 adrenergic receptor0202
estrogen nuclear receptor alpha160016
Free fatty acid receptor 30011
Free fatty acid receptor 20112
Tyrosine-protein kinase Lck0112
Tyrosine-protein kinase Fyn0112
Fibrinogen C domain-containing protein 10101
AR protein170017
glucocorticoid receptor [Homo sapiens]140014
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 23003
Sex hormone-binding globulin0033
Corticosteroid-binding globulin0404
Mineralocorticoid receptor 07412
Androgen receptor0405
Mineralocorticoid receptor0303
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G1001
glucocerebrosidase1001
DNA polymerase kappa isoform 15005
Atrial natriuretic peptide receptor 30202
Type-1A angiotensin II receptor 0538
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0505
Type-1 angiotensin II receptor06413
Type-2 angiotensin II receptor0404
Type-2 angiotensin II receptor0404
glp-1 receptor, partial4004
GLI family zinc finger 39009
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 38008
progesterone receptor9009
cytochrome P450 family 3 subfamily A polypeptide 4120012
retinoic acid nuclear receptor alpha variant 19009
estrogen-related nuclear receptor alpha110011
cytochrome P450 2D6100010
peroxisome proliferator-activated receptor delta6006
IDH13003
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
thyroid hormone receptor beta isoform 26006
nuclear factor erythroid 2-related factor 2 isoform 19009
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011011
Bile salt export pump019019
Cellular tumor antigen p536006
Canalicular multispecific organic anion transporter 1011011
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
RAR-related orphan receptor gamma120012
Fumarate hydratase3003
PPM1D protein1001
caspase 7, apoptosis-related cysteine protease2002
EWS/FLI fusion protein6006
retinoid X nuclear receptor alpha7007
farnesoid X nuclear receptor4004
pregnane X nuclear receptor9009
polyprotein3003
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
caspase-32002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
nuclear receptor subfamily 1, group I, member 24004
Histone H2A.x6006
Caspase-71001
caspase-31001
heat shock protein beta-13003
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30101
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120102
Voltage-dependent calcium channel gamma-2 subunit4004
Prothrombin0202
Chymotrypsinogen A0101
Carbonic anhydrase 10102
Carbonic anhydrase 20102
Interferon beta6006
Carbonic anhydrase 30102
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Glutamate receptor 25005
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0102
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70102
26S proteasome regulatory subunit 6B0101
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90102
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130101
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20101
ATPase family AAA domain-containing protein 54004
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Ataxin-26006
Carbonic anhydrase 150102
Histone deacetylase 80101
Histone deacetylase 60101
Carbonic anhydrase 140102
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0102
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
15-lipoxygenase, partial3003
Metallo-beta-lactamase type 20112
transient receptor potential cation channel subfamily V member 11001
Renin0101
Neprilysin0101
Neprilysin0202
Leukotriene A-4 hydrolase0213
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0314
Angiotensin-converting enzyme0405
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 20202
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0202
Angiotensin-converting enzyme0202
Solute carrier family 15 member 10101
Beta-lactamase TEM0101
Mu-type opioid receptor0539
TAR DNA-binding protein 433003
Beta-lactamase 0203
Beta-lactamase 0202
Angiotensin-converting enzyme 2 0101
Beta-lactamase class B VIM-2 0112
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi4105
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-14105
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit delta4105
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-24105
Gamma-aminobutyric acid receptor subunit alpha-54105
Gamma-aminobutyric acid receptor subunit alpha-34105
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-14105
Gamma-aminobutyric acid receptor subunit alpha-24105
Gamma-aminobutyric acid receptor subunit alpha-44105
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit gamma-34105
Gamma-aminobutyric acid receptor subunit alpha-64105
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-14105
Gamma-aminobutyric acid receptor subunit beta-34105
Gamma-aminobutyric acid receptor subunit beta-24105
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
GABA theta subunit4105
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit epsilon4105
Gamma-aminobutyric acid receptor subunit theta0202
Chain A, Ferritin light chain1001
Chain A, Cruzipain2002
acetylcholinesterase2002
Beta-1 adrenergic receptor 0023
arylsulfatase A7007
Alpha-1B adrenergic receptor 0022
cytochrome P450 2C9 precursor1001
Membrane primary amine oxidase 0101
Solute carrier family 22 member 1 0609
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30304
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0639
Alpha-2B adrenergic receptor0617
Alpha-1A adrenergic receptor0224
Alpha-2C adrenergic receptor0628
D0202
D(3) dopamine receptor0303
5-hydroxytryptamine receptor 1A0617
Amine oxidase [flavin-containing] A0102
Alpha-1D adrenergic receptor0426
D(1B) dopamine receptor0202
Amine oxidase [flavin-containing] B0102
5-hydroxytryptamine receptor 1B0516
Adenosine receptor A2b0011
Adenosine receptor A2a0113
Alpha-2B adrenergic receptor0103
D(4) dopamine receptor0202
Delta-type opioid receptor0529
Alpha-1A adrenergic receptor0336
Alpha-1B adrenergic receptor0336
Histamine H2 receptor2115
5-hydroxytryptamine receptor 70202
D(2) dopamine receptor0202
Inositol monophosphatase 12002
Alpha-2C adrenergic receptor0103
Alpha-2A adrenergic receptor0103
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10303
Multidrug and toxin extrusion protein 10404
Nischarin0101
pregnane X receptor2002
aldehyde dehydrogenase 1 family, member A17007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
atrial natriuretic peptide receptor 1 precursor2002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 14004
Glucocorticoid receptor08316
Glycine receptor subunit alpha-10606
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Potassium voltage-gated channel subfamily A member 10011
D(1A) dopamine receptor4004
huntingtin isoform 21001
mitogen-activated protein kinase 13003
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 13003
peripheral myelin protein 223003
Solute carrier family 22 member 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier family 22 member 30202
Albumin0011
Prostaglandin G/H synthase 10202
5-hydroxytryptamine receptor 2C0112
Tryptophan 5-hydroxylase 10101
Cytochrome P450 2C9 0404
5-hydroxytryptamine receptor 2A0112
Sodium-dependent dopamine transporter0202
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60112
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0404
5-hydroxytryptamine receptor 7 0112
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
D(1A) dopamine receptor2002
Cytochrome P450 2J20303
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20202
Sodium channel protein type 5 subunit alpha0101
5-hydroxytryptamine receptor 4 0112
Nuclear receptor subfamily 3 group C member 3 0202
5-hydroxytryptamine receptor 3B0112
Histamine H3 receptor0102
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Transporter0202
Histamine H3 receptor0202
SMAD family member 23003
USP1 protein, partial1001
GALC protein3003
SMAD family member 33003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 12002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
polyunsaturated fatty acid lipoxygenase ALOX121001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Epidermal growth factor receptor0202
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Caspase-71001
Nuclear receptor subfamily 1 group I member 20011
Nuclear receptor subfamily 1 group I member 20011
Cholinesterase0202
Acetylcholinesterase0101
Acetylcholinesterase0303
hypoxia-inducible factor 1 alpha subunit3003
G2002
vitamin D3 receptor isoform VDRA2002
histone deacetylase 9 isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
UDP-glucuronosyltransferase 1A90001
HLA class I histocompatibility antigen, B alpha chain 2002
Catechol O-methyltransferase0101
Catechol O-methyltransferase0101
Adenosine receptor A2a0101
UDP-glucuronosyltransferase 2B150001
Inositol hexakisphosphate kinase 12002
Alpha-ketoglutarate-dependent dioxygenase FTO0101
cytochrome P450 2C9, partial2002
67.9K protein2002
Estrogen receptor0527
Progesterone receptor0629
Androgen receptor0527
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Estrogen receptor beta0426
aryl hydrocarbon receptor4004
ClpP3003
ATAD5 protein, partial2002
Solute carrier family 22 member 80001
NPYLR7B0011
activating transcription factor 62002
beta-2 adrenergic receptor1001
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
Bile salt export pump0101
Beta-2 adrenergic receptor0236
Beta-1 adrenergic receptor0224
Beta-2 adrenergic receptor0213
Polyunsaturated fatty acid lipoxygenase ALOX150202
Beta-3 adrenergic receptor0123
D(2) dopamine receptor0404
Beta-2 adrenergic receptor0011
D(1A) dopamine receptor0203
D(4) dopamine receptor0101
Beta-adrenergic receptor kinase 10011
Beta-3 adrenergic receptor0011
Beta-3 adrenergic receptor0112
Vasopressin V1a receptor0011
Beta-1 adrenergic receptor0112
Glutamate receptor ionotropic, NMDA 1 0012
D(3) dopamine receptor0101
Taste receptor type 2 member 380011
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310011
Taste receptor type 2 member 450011
Taste receptor type 2 member 460011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600011
Oxytocin receptor0011
Glutamate receptor ionotropic, NMDA 2A 0012
Glutamate receptor ionotropic, NMDA 2B0012
Glutamate receptor ionotropic, NMDA 2C0012
Beta-2 adrenergic receptor 0112
Glutamate receptor ionotropic, NMDA 2D0012
Taste receptor type 2 member 420011
Beta-2 adrenergic receptor0123
Glutamate receptor ionotropic, NMDA 3B0012
Taste receptor type 2 member 160011
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 100011
Taste receptor type 2 member 90011
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40011
Taste receptor type 2 member 30011
Taste receptor type 2 member 10011
Glutamate receptor ionotropic, NMDA 3A0012
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
pyruvate kinase1001
importin subunit beta-1 isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
snurportin-12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
Polyphenol oxidase 20002
Plasma kallikrein0001
Tyrosinase0101
Adenosine receptor A10001
Carbonic anhydrase0001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10202
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 130001
phosphoglycerate kinase1001
ATP-dependent translocase ABCB10102
Thromboxane A2 receptor 0103
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Type-1 angiotensin II receptor0213
Squalene synthase0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Platelet glycoprotein VI0124
Solute carrier organic anion transporter family member 1B30202
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Type-1 angiotensin II receptor0112
Solute carrier organic anion transporter family member 1B10202
interleukin 81001
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 1A20101
Cytochrome P450 2C11 0101
Cytochrome P450 2D60506
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor0538
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma1001
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Mu-type opioid receptor05412
Delta-type opioid receptor05412
Kappa-type opioid receptor0517
Kappa-type opioid receptor05413
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Histidine decarboxylase0022
Adenosine receptor A10101
Delta-type opioid receptor0437
Kappa-type opioid receptor0315
Kappa-type opioid receptor0336
Mu-type opioid receptor0316
Sigma non-opioid intracellular receptor 10101
Sigma non-opioid intracellular receptor 10101
UDP-glucuronosyltransferase 1A80002
Sigma non-opioid intracellular receptor 10101
5-hydroxytryptamine receptor 3E0101
5-hydroxytryptamine receptor 3B0101
UDP-glucuronosyltransferase 1A1 0001
Nociceptin receptor0101
5-hydroxytryptamine receptor 3A0112
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Alpha-1B adrenergic receptor0101
luciferase0001
Fatty acid-binding protein, liver0101
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Chain A, Beta-lactamase1001
alpha-galactosidase1001
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Neutral amino acid transporter A0101
Cholinesterase0101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
Smad31001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Vpr1001
Cytochrome P450 2C190101
Cereblon isoform 40202
Prostaglandin G/H synthase 20101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
guanine nucleotide-binding protein subunit alpha-150112
lethal(3)malignant brain tumor-like protein 1 isoform I1001
D(3) dopamine receptor isoform e1001
trace amine-associated receptor 10112
Phenylethanolamine N-methyltransferase0101
Dopamine beta-hydroxylase 0001
Beta-secretase 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Chain A, Arginase 10101
Leukotriene B4 receptor 20011
potassium voltage-gated channel subfamily H member 2 isoform d1001
Estrogen receptor beta0101
DNA topoisomerase 10101
Alpha-2A adrenergic receptor0101
Estrogen receptor0101
M-phase inducer phosphatase 10101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60202
Lysosomal alpha-glucosidase0101
Lysosomal alpha-glucosidase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]