maysin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
maysin : A flavone C-glycoside that is luteolin attached to a disaccharide residue at position 6. It has been isolated from natural product Petrorhagia velutina and Zea mays and exhibits insecticidal and neuroprotective activities. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Petrorhagia | genus | [no description available] | Caryophyllaceae | A plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. The species are diverse in appearance and habitat; most have swollen leaf and stem joints.[MeSH] |
| Zea mays | species | A plant species of the family POACEAE. It is a tall grass grown for its EDIBLE GRAIN, corn, used as food and animal FODDER.[MeSH] | Poaceae | A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 70698181 |
| CHEBI ID | 70206 |
| MeSH ID | M0295117 |
| Synonym |
|---|
| maysin |
| 70255-49-1 |
| 01o8rt377y , |
| unii-01o8rt377y |
| (6r)-2,6-anhydro-1-deoxy-5-o-(6-deoxy-alpha-d-mannopyranosyl)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-chromen-6-yl]-d-xylo-hex-3-ulose |
| CHEBI:70206 , |
| xylo-3-hexulose, 2,6-anhydro-1-deoxy-5-o-(6-deoxy-.alpha.-l-mannopyranosyl)-6-c-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-1-benzopyran-6-yl)- |
| Q27138546 |
| (6r)-2,6-anhydro-1-deoxy-5-o-(6-deoxy-alpha-d-mannopyranosyl)-6-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-chromen-6-yl)-d-xylo-hex-3-ulose |
| 3-hexulose, 2,6-anhydro-1-deoxy-5-o-(6-deoxyhexopyranosyl)-6-c-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-1-benzopyran-6-yl)- |
Maysin is a C-glycosyl flavone. When present in silks, confers natural resistance to the maize earworm (Helicoverpa zea), which is one of the most damaging pests of maize in America.
Maysin pretreatment reduced the cytotoxic effect of H2O2 on SK-N-MC cells. Treatment significantly induced apoptotic cell death, DNA fragmentation, depolarization of MMP, and reduction in Bcl-2 and pro-caspase-3 expression levels.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Maysin pretreatment reduced the cytotoxic effect of H2O2 on SK-N-MC cells, as shown by the increase in cell viability and by reduced LDH release. " | ( Neuroprotective effects of corn silk maysin via inhibition of H2O2-induced apoptotic cell death in SK-N-MC cells. Choi, DJ; Choi, JW; Kim, SL; Park, YI, 2014) | 2.12 |
| "Maysin treatment significantly induced apoptotic cell death, DNA fragmentation, depolarization of MMP, and reduction in Bcl-2 and pro-caspase-3 expression levels." | ( Corn silk maysin induces apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway. Choi, DJ; Choi, JW; Kim, SL; Lee, J; Lee, S; Park, YI; Seo, JY, 2014) | 1.53 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| insecticide | Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. |
| neuroprotective agent | Any compound that can be used for the treatment of neurodegenerative disorders. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| flavone C-glycoside | Any C-glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a flavone skeleton, thus creating a C-C bond. |
| disaccharide derivative | A carbohydrate derivative that is formally obtained from a disaccharide. |
| tetrahydroxyflavone | Any hydroxyflavone carrying four hydroxy substituents. |
| secondary alpha-hydroxy ketone | An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing one hydrogen and one organyl group. Secondary alpha-hydroxy ketones are also known as acyloins, and are formally derived from reductive coupling of two carboxylic acid groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 12 (50.00) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (40.40) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 25 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||