Page last updated: 2024-11-13

maysin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

maysin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

maysin : A flavone C-glycoside that is luteolin attached to a disaccharide residue at position 6. It has been isolated from natural product Petrorhagia velutina and Zea mays and exhibits insecticidal and neuroprotective activities. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Flora	Rank	Flora Definition	Family	Family Definition
Petrorhagia	genus	[no description available]	Caryophyllaceae	A plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. The species are diverse in appearance and habitat; most have swollen leaf and stem joints.[MeSH]
Zea mays	species	A plant species of the family POACEAE. It is a tall grass grown for its EDIBLE GRAIN, corn, used as food and animal FODDER.[MeSH]	Poaceae	A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.[MeSH]

Cross-References

ID Source	ID
PubMed CID	70698181
CHEBI ID	70206
MeSH ID	M0295117

Synonyms (10)

Synonym
maysin
70255-49-1
01o8rt377y ,
unii-01o8rt377y
(6r)-2,6-anhydro-1-deoxy-5-o-(6-deoxy-alpha-d-mannopyranosyl)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-chromen-6-yl]-d-xylo-hex-3-ulose
CHEBI:70206 ,
xylo-3-hexulose, 2,6-anhydro-1-deoxy-5-o-(6-deoxy-.alpha.-l-mannopyranosyl)-6-c-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-1-benzopyran-6-yl)-
Q27138546
(6r)-2,6-anhydro-1-deoxy-5-o-(6-deoxy-alpha-d-mannopyranosyl)-6-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-chromen-6-yl)-d-xylo-hex-3-ulose
3-hexulose, 2,6-anhydro-1-deoxy-5-o-(6-deoxyhexopyranosyl)-6-c-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-1-benzopyran-6-yl)-

Research Excerpts

Overview

Maysin is a C-glycosyl flavone. When present in silks, confers natural resistance to the maize earworm (Helicoverpa zea), which is one of the most damaging pests of maize in America.

Excerpt	Reference	Relevance
"Maysin is a major flavonoid of CS."	( Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages. Chung, MJ; Kim, SL; Lee, J; Lee, S; Park, YI, 2014)	1.41
"Maysin is a C-glycosyl flavone that, when present in silks, confers natural resistance to the maize earworm (Helicoverpa zea), which is one of the most damaging pests of maize in America."	( Identification and Characterization of Maize salmon silks Genes Involved in Insecticidal Maysin Biosynthesis. Casas, MI; Casati, P; Engelmeier, J; Falcone-Ferreyra, ML; Grotewold, E; Jiang, N; Mejía-Guerra, MK; Rodríguez, E; Wilson, T, 2016)	1.38
"Maysin is a naturally occurring C-glycosyl flavone found in maize (Zea mays L.) silk tissue that confers resistance to corn earworm (Helicoverpa zea, Boddie). "	( Quantitative trait loci for maysin synthesis in maize (Zea mays L.) lines selected for high silk maysin content. Houchins, KE; McMullen, MD; Meyer, JD; Rector, BG; Snook, ME; Widstrom, NW, 2007)	2.08

Treatment

Maysin pretreatment reduced the cytotoxic effect of H2O2 on SK-N-MC cells. Treatment significantly induced apoptotic cell death, DNA fragmentation, depolarization of MMP, and reduction in Bcl-2 and pro-caspase-3 expression levels.

Excerpt	Reference	Relevance
"Maysin pretreatment reduced the cytotoxic effect of H2O2 on SK-N-MC cells, as shown by the increase in cell viability and by reduced LDH release. "	( Neuroprotective effects of corn silk maysin via inhibition of H2O2-induced apoptotic cell death in SK-N-MC cells. Choi, DJ; Choi, JW; Kim, SL; Park, YI, 2014)	2.12
"Maysin treatment significantly induced apoptotic cell death, DNA fragmentation, depolarization of MMP, and reduction in Bcl-2 and pro-caspase-3 expression levels."	( Corn silk maysin induces apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway. Choi, DJ; Choi, JW; Kim, SL; Lee, J; Lee, S; Park, YI; Seo, JY, 2014)	1.53

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
insecticide	Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.
neuroprotective agent	Any compound that can be used for the treatment of neurodegenerative disorders.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

Class	Description
flavone C-glycoside	Any C-glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a flavone skeleton, thus creating a C-C bond.
disaccharide derivative	A carbohydrate derivative that is formally obtained from a disaccharide.
tetrahydroxyflavone	Any hydroxyflavone carrying four hydroxy substituents.
secondary alpha-hydroxy ketone	An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing one hydrogen and one organyl group. Secondary alpha-hydroxy ketones are also known as acyloins, and are formally derived from reductive coupling of two carboxylic acid groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (24)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.17)	18.2507
2000's	9 (37.50)	29.6817
2010's	12 (50.00)	24.3611
2020's	2 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	40.40 (24.57)
Research Supply Index	3.26 (2.92)
Research Growth Index	5.42 (4.65)
Search Engine Demand Index	56.46 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (40.40)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2.17	1	pyrrole; secondary amine
benzoxazoles 1,3-benzoxazole : A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.. benzoxazole : Compounds based on a fused 1,2- or 1,3-oxazole and benzene bicyclic ring skeleton.	2.17	1	1,3-benzoxazoles; mancude organic heterobicyclic parent
flavone flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.	7.44	2	flavones	metabolite; nematicide
6-methoxybenzoxazolinone 6-methoxybenzoxazolinone: plant derivative which stimulates reproduction in Microtus montanus. 6-methoxy-2-benzoxazolinone : A 2-benzoxazolinone that is substituted by a methoxy group at position 6.	2.17	1	aromatic ether; benzoxazole	antibacterial agent; anticonvulsant; antifungal agent; muscle relaxant; plant metabolite
decamethrin decamethrin: pyrethroid insecticide; RN given refers to cpd without isomeric designation; structure	2.01	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organobromine compound	agrochemical; antifeedant; calcium channel agonist; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; pyrethroid ester insecticide
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	4.59	24	D-glucopyranose	epitope; mouse metabolite
homoorientin homoorientin: isolated from Swertia japonica; structure given in first source	2.13	1	flavone C-glycoside; tetrahydroxyflavone	antineoplastic agent; radical scavenger
buclizine luteolinidin: structure in first source	2.07	1	5-hydroxyanthocyanidin
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	2.72	3	cinnamate ester; tannin	food component; plant metabolite
luteolin [no description available]	2.5	2	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
alpha-synuclein alpha-Synuclein: A synuclein that is a major component of LEWY BODIES and plays a role in SYNUCLEINOPATHIES, neurodegeneration and neuroprotection.	2.25	1
UDP-rhamnose UDP-rhamnose : A UDP-sugar in which the sugar component is rhamnose.	2.13	1	UDP-sugar
pyrethrins [no description available]	2.01	1

Condition	Relationship Strength	Studies
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.15	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	7.15	1
Weight Gain Increase in BODY WEIGHT over existing weight.	2.15	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.55	2
Anasarca [description not available]	2.15	1
Innate Inflammatory Response [description not available]	2.15	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.15	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.15	1
Diabetes Mellitus, Adult-Onset [description not available]	2.21	1
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.21	1
Cancer of Prostate [description not available]	2.1	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.1	1
Protein Aggregation, Pathological A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.	2.11	1
Amyloid Deposits [description not available]	2.15	1
Acute Confusional Senile Dementia [description not available]	2.15	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.15	1

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