Striatonigral Atrophy

A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)

Synonym
Striatonigral Atrophy
Striatonigral Degeneration

Excerpt	Reference
"We developed a primate model of striatonigral degeneration (SND), the neuropathology underlying levodopa-unresponsive parkinsonism associated with multiple systemic atrophy (MSA-P), by sequential systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 3-nitropropionic acid (3NP) in a Macaca fascicularis monkey."	( Aubert, I; Bezard, E; Fernagut, PO; Ghorayeb, I; Poewe, W; Tison, F; Wenning, GK, 2000)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	3 (5.77)	12.5806
2000's	32 (61.54)	18.1394
2010's	16 (30.77)	28.8240
2020's	1 (1.92)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	3
3,4-dihydroxyphenylacetic acid	low	1
melatonin	low	1
nitrates	low	1
quinolinic acid	low	4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	low	12
3-nitropropionic acid	low	5
homovanillic acid	low	1
clonidine	low	1
amphetamine	low	1
fipronil	low	1
iofetamine	low	1
mazindol	low	1
oxidopamine	low	10
corticosterone	low	1
apomorphine	low	2
levodopa	low	8
tyrosine	low	1
colchicine	low	1
rotenone	low	1
triphenyltetrazolium	low	1
acetylcysteine	low	1
dronabinol	low	1
dihydro-beta-erythroidine	low	1
5,7-dihydroxytryptamine	low	1
3-iodobenzylguanidine	low	1
(3h)2-carbomethoxy-3-(4-fluorophenyl)tropane	low	3
ym 09151-2	low	1
3-nitrotyrosine	low	1
cocaine	low	3
nadp	low	1
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone	low	1
beta-escin	low	1
lactacystin	low	1
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	2
alpha-synuclein	low	7
calpain inhibitor iii	low	1
calpain	low	1
minocycline	low	1
calpastatin	low	1

Protein Targets (584)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent serotonin transporter	0	4	0	5
Sodium-dependent dopamine transporter	0	6	0	7
Dihydropteridine reductase	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	2
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	2
Chain A, Ferritin light chain	5	0	0	5
glp-1 receptor, partial	1	0	0	1
thioredoxin reductase	13	0	0	13
TDP1 protein	11	0	0	11
Smad3	2	0	0	2
nonstructural protein 1	3	0	0	3
67.9K protein	2	0	0	2
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
chromobox protein homolog 1	10	0	0	10
DNA polymerase eta isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	5	0	0	5
geminin	13	0	0	13
neuropeptide S receptor isoform A	5	0	0	5
TAR DNA-binding protein 43	4	0	0	4
dopamine D1 receptor	3	0	0	3
GLS protein	7	0	0	7
Thrombopoietin	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
cytochrome P450 2D6 isoform 1	5	0	0	5
cytochrome P450 2C19 precursor	5	0	0	5
ras-related protein Rab-9A	4	0	0	4
histone acetyltransferase KAT2A isoform 1	2	0	0	2
lethal factor (plasmid)	5	0	0	5
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	4	0	0	4
ATP-dependent phosphofructokinase	10	0	0	10
acetylcholinesterase	4	0	0	4
RAR-related orphan receptor gamma	8	0	0	8
GLI family zinc finger 3	7	0	0	7
AR protein	11	0	0	11
progesterone receptor	5	0	0	5
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	2	0	0	2
Bloom syndrome protein isoform 1	9	0	0	9
hemoglobin subunit beta	1	0	0	1
heat shock protein beta-1	5	0	0	5
DNA polymerase iota isoform a (long)	5	0	0	5
muscarinic acetylcholine receptor M1	8	0	0	8
lamin isoform A-delta10	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Cellular tumor antigen p53	7	0	0	7
Delta-aminolevulinic acid dehydratase	0	1	0	1
Glutamate receptor 2	6	1	1	8
Isocitrate lyase 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Isocitrate lyase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
phosphopantetheinyl transferase	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
pyruvate kinase PKM isoform a	1	0	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Tubulin--tyrosine ligase	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	4	0	0	4
endonuclease IV	2	0	0	2
RGS12	1	0	0	1
NFKB1 protein, partial	4	0	0	4
Microtubule-associated protein tau	5	0	0	5
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
thyroid stimulating hormone receptor	6	0	0	6
hypothetical protein, conserved	1	0	0	1
regulator of G-protein signaling 4	9	0	0	9
lysosomal alpha-glucosidase preproprotein	2	0	0	2
peripheral myelin protein 22 isoform 1	3	0	0	3
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	2	0	0	2
flap endonuclease 1	6	0	0	6
M-phase phosphoprotein 8	5	0	0	5
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	1	5
Zinc finger protein mex-5	0	0	1	1
5-hydroxytryptamine receptor 1A	0	6	1	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	3	0	0	3
USP1 protein, partial	4	0	0	4
farnesoid X nuclear receptor	6	0	0	6
arylsulfatase A	7	0	0	7
D(1A) dopamine receptor	2	0	0	2
thyroid hormone receptor beta isoform a	6	0	0	6
thyroid hormone receptor beta isoform 2	7	0	0	7
peripheral myelin protein 22	7	0	0	7
survival motor neuron protein isoform d	4	0	0	4
Histone deacetylase 3	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Ataxin-2	6	0	0	6
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	1	5
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	1	5
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	6	0	6
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	3	1	4
5-hydroxytryptamine receptor 1F	0	3	1	4
5-hydroxytryptamine receptor 2B	0	4	1	5
5-hydroxytryptamine receptor 6	0	2	1	3
5-hydroxytryptamine receptor 7	0	3	1	4
5-hydroxytryptamine receptor 5A	0	2	1	3
5-hydroxytryptamine receptor 5B	0	2	1	3
5-hydroxytryptamine receptor 3A	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
cytochrome P450 2D6	5	0	0	5
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C9 precursor	4	0	0	4
vitamin D3 receptor isoform VDRA	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	7	2	0	9
Solute carrier family 22 member 1	0	5	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Bile salt export pump	0	5	0	5
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Tryptophan 5-hydroxylase 1	0	3	0	3
D(2) dopamine receptor	0	2	2	6
Gamma-aminobutyric acid receptor subunit beta-1	7	2	0	9
Alpha-1B adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	7	2	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	7	2	1	10
D	0	4	0	4
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	7	2	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	7	2	0	9
D(2) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	0	2	2	6
D(4) dopamine receptor	0	2	1	4
D(1B) dopamine receptor	0	2	0	3
Alpha-2C adrenergic receptor	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	7	2	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	7	2	0	9
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	2	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	7	2	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	7	2	0	9
D(4) dopamine receptor	0	2	1	3
D(3) dopamine receptor	0	2	2	5
Alpha-1A adrenergic receptor	0	3	1	4
Histamine H2 receptor	4	0	0	5
5-hydroxytryptamine receptor 7	0	2	0	2
D(2) dopamine receptor	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-3	7	2	0	9
Gamma-aminobutyric acid receptor subunit beta-2	7	2	1	10
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	1	0	1
GABA theta subunit	7	2	0	9
Canalicular multispecific organic anion transporter 1	0	5	0	5
D	0	2	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Sigma non-opioid intracellular receptor 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit epsilon	7	2	0	9
Chain A, Beta-lactamase	2	0	0	2
Calpain-9	0	1	0	1
Calpain-1 catalytic subunit	0	1	0	1
Cathepsin D	0	1	0	1
Calpain-1 catalytic subunit	0	2	0	2
Procathepsin L	0	1	0	1
Cathepsin B	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Pro-cathepsin H	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Calpain-2 catalytic subunit	0	1	0	1
Calpain-1 catalytic subunit	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Falcipain 2B	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	4	0	4
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	2	1	3
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A2a	0	0	1	3
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Mu-type opioid receptor	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Multidrug and toxin extrusion protein 1	0	1	0	1
Nischarin	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Liver carboxylesterase 1	0	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Sodium-dependent serotonin transporter	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Glutamate receptor ionotropic, NMDA 1	0	2	0	4
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	2	0	4
Glutamate receptor ionotropic, NMDA 2B	0	2	0	4
Glutamate receptor ionotropic, NMDA 2C	0	2	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Sodium-dependent dopamine transporter	0	4	0	4
Glutamate receptor ionotropic, NMDA 2D	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	4
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	4	0	4
interleukin 8	2	0	0	2
PAX8	0	0	0	1
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	3	0	0	3
PPM1D protein	2	0	0	2
pregnane X nuclear receptor	6	0	0	6
polyprotein	3	0	0	3
glucocerebrosidase	2	0	0	2
activating transcription factor 6	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Interferon beta	6	0	0	6
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	3
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	2
Cytochrome P450 3A4	0	1	0	1
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
GALC protein	1	0	0	1
G	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Solute carrier family 22 member 2	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Androgen receptor	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
Solute carrier family 22 member 2	0	2	0	2
cytochrome P450 2C9, partial	5	0	0	5
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	1	1	1	3
Glutamate receptor 3	1	1	1	3
Glutamate receptor 4	1	1	1	3
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 1	0	2	1	4
Glycine receptor subunit alpha-1	0	0	1	1
Cannabinoid receptor 2	0	2	1	4
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
Proteasome subunit beta type-11	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
EWS/FLI fusion protein	4	0	0	4
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Polyphenol oxidase 2	0	0	0	2
Carbonic anhydrase 12	0	0	0	2
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	1	0	3
Carbonic anhydrase 2	0	1	0	3
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Carbonic anhydrase 3	0	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Tyrosinase	0	1	0	1
Carbonic anhydrase 4	0	1	0	3
Carbonic anhydrase 6	0	0	0	2
Adenosine receptor A1	0	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 7	0	0	0	2
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase 9	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 15	0	1	0	3
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
phosphoglycerate kinase	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Albumin	0	0	1	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
Sodium/iodide cotransporter	0	1	0	1
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
DNA repair protein RAD52 homolog	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Advanced glycosylation end product-specific receptor	0	0	1	1
Beta-lactamase	0	1	0	1
Advanced glycosylation end product-specific receptor	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Taste receptor type 2 member 14	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Treatment

Research

Studies (52)

Protein Targets (584)

Striatonigral Atrophy

Synonyms(2)

Research Excerpts

Treatment

Research

Studies (52)

Drugs Studied (45)

Protein Targets (584)