alpha-synuclein and Skin-Diseases

alpha-synuclein has been researched along with Skin-Diseases* in 1 studies

Other Studies

1 other study(ies) available for alpha-synuclein and Skin-Diseases

ArticleYear
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.
    Scientific reports, 2018, 09-24, Volume: 8, Issue:1

    We aimed to characterize in vivo α-synuclein (α-syn) aggregates in skin nerves to ascertain: 1) the optimal marker to identify them; 2) possible differences between synucleinopathies that may justify the clinical variability. We studied multiple skin nerve α-syn deposits in 44 patients with synucleinopathy: 15 idiopathic Parkinson's disease (IPD), 12 dementia with Lewy Bodies (DLB), 5 pure autonomic failure (PAF) and 12 multiple system atrophy (MSA). Ten healthy subjects were used as controls. Antibodies against native α-syn, C-terminal α-syn epitopes such as phosphorylation at serine 129 (p-syn) and to conformation-specific for α-syn mature amyloid fibrils (syn-F1) were used. We found that p-syn showed the highest sensitivity and specificity in disclosing skin α-syn deposits. In MSA abnormal deposits were only found in somatic fibers mainly at distal sites differently from PAF, IPD and DLB displaying α-syn deposits in autonomic fibers mainly at proximal sites. PAF and DLB showed the highest p-syn load with a widespread involvement of autonomic skin nerve fibers.. 1) p-syn in skin nerves was the optimal marker for the in vivo diagnosis of synucleinopathies; 2) the localization and load differences of aggregates may help to identify specific diagnostic traits and support a different pathogenesis among synucleinopathies.

    Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amyloid; Brain; Female; Humans; Lewy Body Disease; Male; Multiple System Atrophy; Nerve Fibers; Parkinson Disease; Protein Aggregation, Pathological; Pure Autonomic Failure; Skin; Skin Diseases

2018