Page last updated: 2024-12-11

squamosamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

squamosamide: natural compound from Annoma squamosa; FLZ is the synthetic cyclic analog; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5321487
CHEMBL ID4129283
MeSH IDM0224322

Synonyms (6)

Synonym
squamosamide
benzeneacetamide, 4-hydroxy-alpha-((4-hydroxy-3-methoxyphenyl)methylene)-n-(2-(4-hydroxyphenyl)ethyl)-3,5-dimethoxy-, (e)-
142750-35-4
CHEMBL4129283
(alphae)-4-hydroxy-alpha-[(4-hydroxy-3-methoxyphenyl)methylene]-n-[2-(4-hydroxyphenyl)ethyl]-3,5-dimethoxybenzeneacetamide
DTXSID401107073

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" During ischemia, regional CBF (rCBF) was improved from approximately 30% to over 50% of the baseline and the reperfusion-induced hyperemia was reduced in both FLZ dosage groups."( Neuroprotective effects of compound FLZ in an ischemic model mediated by improving cerebral blood flow and enhancing Hsp27 expression.
Li, M; Liu, GT; Ma, B; Ma, T; Zhang, J, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1494599Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me2018Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9
Anticomplement compounds from Polygonum chinense.
AID1494600Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet2018Bioorganic & medicinal chemistry letters, 05-15, Volume: 28, Issue:9
Anticomplement compounds from Polygonum chinense.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (2.86)18.2507
2000's12 (34.29)29.6817
2010's21 (60.00)24.3611
2020's1 (2.86)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.12

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.12 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index5.71 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.12)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (5.71%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (94.29%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]