diphenoquinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Diphenoquinone is a quinone derivative that can be synthesized through various methods, including the oxidation of phenols. It exhibits notable biological activity, serving as a potent antioxidant and demonstrating antibacterial properties. Research into diphenoquinone focuses on its potential applications in areas such as medicine, agriculture, and materials science. This compound's unique chemical structure and biological activity make it a subject of ongoing scientific investigation.'

Cross-References

ID Source	ID
PubMed CID	10310
SCHEMBL ID	2751602
MeSH ID	M0041169

Synonyms (18)

Synonym
4-07-00-02472 (beilstein handbook reference)
[bi-2,5-cyclohexadien-1-ylidene]-4,4'-dione
2,5-cyclohexadien-1-one, 4-(4-oxo-2,5-cyclohexadien-1-ylidene)-
brn 2043852
(bi-2,5-cyclohexadien-1-ylidene)-4,4'-dione
4,4'-biphenyldione
diphenoquinone
4,4'-diphenoquinone
4-(4-oxocyclohexa-2,5-dien-1-ylidene)cyclohexa-2,5-dien-1-one
494-72-4
AKOS006273970
4-(4-oxocyclohexa-2,5-dien-1-ylidene)cyclohexa-2,5-dien-1-one;ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
A828719
SCHEMBL2751602
4,4'-diphenoquinone(dq)
DTXSID00197787
diphenochinon
[1,1'-bi(cyclohexylidene)]-2,2',5,5'-tetraene-4,4'-dione

Research Excerpts

Overview

Diphenoquinones are a poorly explored class of compounds. A wide variety can be synthesized, isolated, crystallized, and fully characterized.

Excerpt	Reference	Relevance
"Diphenoquinones are a poorly explored class of compounds, but a wide variety can be synthesized, isolated, crystallized, and fully characterized."	( Diphenoquinones Redux. Chen, L; Iftimie, R; Maris, T; Morency, M; Néron, S; Rochefort, D; Wuest, JD, 2022)	2.89

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (12.50)	18.7374
1990's	1 (12.50)	18.2507
2000's	2 (25.00)	29.6817
2010's	3 (37.50)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.24 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.85 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.24)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
probucol Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).. probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.	7.96	4	dithioketal; polyphenol	anti-inflammatory drug; anticholesteremic drug; antilipemic drug; antioxidant; cardiovascular drug
bisphenol a 4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.	2.03	1	bisphenol	endocrine disruptor; environmental contaminant; xenobiotic; xenoestrogen
spirorenone spirorenone: structure given in first source	2.13	1
alpha-synuclein alpha-Synuclein: A synuclein that is a major component of LEWY BODIES and plays a role in SYNUCLEINOPATHIES, neurodegeneration and neuroprotection.	2.07	1
calpain Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.	2.46	2

Condition	Relationship Strength	Studies
Atherogenesis [description not available]	2.77	3
Atheroma [description not available]	2.13	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.13	1
Elevated Cholesterol [description not available]	2.13	1
Aortic Diseases Pathological processes involving any part of the AORTA.	2.13	1
Hypercholesterolemia A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.	2.13	1
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	2.77	3
Apoplexy [description not available]	2.03	1
Anoxia, Brain [description not available]	2.03	1
Injury, Ischemia-Reperfusion [description not available]	2.03	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.03	1
Stroke A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)	2.03	1

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