Page last updated: 2024-09-27

Pantothenate Kinase-Associated Neurodegeneration

A rare autosomal recessive degenerative disorder which usually presents in late childhood or adolescence. Clinical manifestations include progressive MUSCLE SPASTICITY; hyperreflexia; MUSCLE RIGIDITY; DYSTONIA; DYSARTHRIA; and intellectual deterioration which progresses to severe dementia over several years. (From Adams et al., Principles of Neurology, 6th ed, p972; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp972-929)

Synonyms(1)

Synonym
Pantothenate Kinase-Associated Neurodegeneration

Research

Studies (174)

TimeframeStudies, This Condition (%)All Conditions %
pre-199022 (12.64)23.3326
1990's16 (9.20)12.5806
2000's47 (27.01)18.1394
2010's64 (36.78)28.8240
2020's25 (14.37)9.53
DrugIndicatedRelationship StrengthStudiesTrials
5-hydroxytryptophan0low10
choline0low10
citric acid, anhydrous0low10
creatine0low10
lactic acid0low10
glutaric acid0low10
glycine0low20
dihydroxyphenylalanine0low20
thioctic acid0low10
inositol0low20
pyridoxine0low10
thiamine0low10
amantadine0low20
baclofen0low30
carbamazepine0low10
chlorpromazine0low10
deferoxamine0low20
haloperidol0low10
halothane0low10
imipramine0low10
methylphenidate0low10
primaquine0low10
propofol0low20
trifluoperazine0low10
trihexyphenidyl0low10
penicillamine0low10
serine0low10
aspartic acid0low30
cyanides0low10
levodopa0low60
asparagine0low10
tryptophan0low10
isoleucine0low20
arginine0low40
pantothenic acid0medium122
d-alpha tocopherol0low10
manganese0low10
transferrin0low20
phosphopantothenic acid0low40
remifentanil0low10
n-acetylaspartic acid0low20
phosphoramidic acid0low10
coenzyme a0low250
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide0low20
4'-phosphopantetheine0low10
proline0low20
atropine0low10
mevalonic acid0low10
pantetheine0medium41
inositol 3-phosphate0low10
rocuronium0low10
acetyl coenzyme a0low20
cocaine0low20
pantethine0medium31
bilirubin0low10
morphine0low10
dexmedetomidine0low10
lysophosphatidic acid0low10
cysteine0low20
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane0low10
alpha-synuclein0low70
technetium tc 99m exametazime0low10
nad0low10
phosphatidylcholines0low10
calpain0low10
quetiapine fumarate0low10
glycolipids0low30
piperidines0low10
heme0low10
olanzapine0low10
carbidopa0low10
technetium tc 99m bicisate0low10

Protein Targets (768)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Sodium-dependent dopamine transporter 010010
D(2) dopamine receptor09113
D(4) dopamine receptor07111
D(3) dopamine receptor09113
D(2) dopamine receptor011113
N-alpha-acetyltransferase 500022
acetylcholinesterase8008
thioredoxin reductase7007
RAR-related orphan receptor gamma7007
NFKB1 protein, partial6006
GLI family zinc finger 3110011
AR protein130013
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor9009
regulator of G-protein signaling 46006
EWS/FLI fusion protein5005
estrogen nuclear receptor alpha130013
putative alpha-glucosidase1001
euchromatic histone-lysine N-methyltransferase 2170017
thyroid hormone receptor beta isoform 28008
heat shock protein beta-14004
peripheral myelin protein 229009
histone acetyltransferase KAT2A isoform 15005
lamin isoform A-delta10150015
Solute carrier family 22 member 20204
Solute carrier family 22 member 1 0609
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 09112
Spike glycoprotein91212
Glutamate receptor ionotropic, NMDA 2A 08111
Glutamate receptor ionotropic, NMDA 2B08111
Glutamate receptor ionotropic, NMDA 2C08111
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 2D08111
Solute carrier family 22 member 10405
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B08111
Multidrug and toxin extrusion protein 10202
Solute carrier family 22 member 20405
Glutamate receptor ionotropic, NMDA 3A08111
ATP-dependent phosphofructokinase100010
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE8008
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
phosphopantetheinyl transferase110011
GLS protein5005
alpha-galactosidase1001
cytochrome P450 2C19 precursor5005
chromobox protein homolog 15005
flap endonuclease 13003
DNA polymerase iota isoform a (long)6006
muscarinic acetylcholine receptor M19009
lethal factor (plasmid)7007
Cytochrome P450 3A40317
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Carbonic anhydrase 10307
Carbonic anhydrase 20307
Neutral amino acid transporter A0303
Neutral amino acid transporter B(0)0303
Carbonic anhydrase-like protein, putative0004
Amino acid transporter0303
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, Ferritin light chain2002
aldehyde dehydrogenase 1 family, member A1100010
arylsulfatase A4004
Bloom syndrome protein isoform 17007
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase 40001
Chain A, 2-oxoglutarate Oxygenase8008
nuclear receptor subfamily 1, group I, member 36006
glucocorticoid receptor [Homo sapiens]9009
retinoid X nuclear receptor alpha3003
pregnane X nuclear receptor6006
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
5-hydroxytryptamine receptor 4012012
Bile salt export pump015015
Muscarinic acetylcholine receptor M2010114
Muscarinic acetylcholine receptor M4011114
Muscarinic acetylcholine receptor M108111
Muscarinic acetylcholine receptor M30619
Muscarinic acetylcholine receptor M40619
Muscarinic acetylcholine receptor M507110
Muscarinic acetylcholine receptor M5012115
Muscarinic acetylcholine receptor M207111
Muscarinic acetylcholine receptor M1011216
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M3011114
Alpha-1D adrenergic receptor011011
5-hydroxytryptamine receptor 2C013013
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor71010
5-hydroxytryptamine receptor 70505
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
Canalicular multispecific organic anion transporter 10909
ATAD5 protein, partial4004
67.9K protein5005
activating transcription factor 65005
D(1A) dopamine receptor6006
cytochrome P450 3A4 isoform 16006
Gamma-aminobutyric acid receptor subunit pi6118
Gamma-aminobutyric acid type B receptor subunit 20213
Gamma-aminobutyric acid type B receptor subunit 20202
Gamma-aminobutyric acid receptor subunit beta-16118
Gamma-aminobutyric acid receptor subunit delta6118
Gamma-aminobutyric acid receptor subunit gamma-26129
Gamma-aminobutyric acid receptor subunit alpha-56118
Gamma-aminobutyric acid receptor subunit alpha-36118
Gamma-aminobutyric acid receptor subunit gamma-16118
Gamma-aminobutyric acid receptor subunit alpha-26118
Gamma-aminobutyric acid receptor subunit alpha-46118
Gamma-aminobutyric acid receptor subunit gamma-36118
Gamma-aminobutyric acid receptor subunit alpha-66118
Gamma-aminobutyric acid receptor subunit alpha-16129
Gamma-aminobutyric acid receptor subunit beta-36118
Gamma-aminobutyric acid receptor subunit beta-26129
GABA theta subunit6118
Gamma-aminobutyric acid receptor subunit epsilon6118
Gamma-aminobutyric acid type B receptor subunit 10213
Gamma-aminobutyric acid type B receptor subunit 10101
TDP1 protein100010
cytochrome P450 family 3 subfamily A polypeptide 49009
Spike glycoprotein0123
Replicase polyprotein 1ab0123
potassium voltage-gated channel subfamily H member 2 isoform d4004
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
Transmembrane protease serine 20123
Cellular tumor antigen p53100010
Procathepsin L0123
Aldo-keto reductase family 1 member B10808
Alpha-2A adrenergic receptor09211
Replicase polyprotein 1a0123
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0123
Alpha-2B adrenergic receptor0808
Alpha-2C adrenergic receptor09110
Sodium-dependent noradrenaline transporter 015015
Sodium-dependent dopamine transporter0808
Histamine H2 receptor0606
5-hydroxytryptamine receptor 2A010010
Sodium-dependent serotonin transporter015015
Sodium-dependent serotonin transporter0708
Histamine H1 receptor010111
5-hydroxytryptamine receptor 2B010010
5-hydroxytryptamine receptor 60808
Sigma non-opioid intracellular receptor 1012012
Angiotensin-converting enzyme 2 0123
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, HADH2 protein7007
Chain B, HADH2 protein7007
Chain A, Cruzipain2002
USP1 protein, partial7007
Microtubule-associated protein tau8008
vitamin D3 receptor isoform VDRA5005
DNA polymerase kappa isoform 18008
caspase-1 isoform alpha precursor1001
Caspase-72002
Inositol monophosphatase 13003
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
Chain A, Beta-lactamase2002
retinoic acid nuclear receptor alpha variant 1100010
estrogen-related nuclear receptor alpha8008
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 15005
geminin110011
Vpr1001
Bile salt export pump0404
Albumin0044
Major prion protein0044
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0404
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0405
Cytochrome P450 2J20404
Potassium voltage-gated channel subfamily H member 2012012
Sodium channel protein type 9 subunit alpha0505
Frizzled-80011
P2X purinoceptor 40101
Proteasome subunit beta type-110001
Fumarate hydratase2002
Thrombopoietin3003
Smad32002
caspase 7, apoptosis-related cysteine protease3003
estrogen receptor 2 (ER beta)3003
progesterone receptor3003
NADPH oxidase 10202
farnesoid X nuclear receptor4004
G3003
cytochrome P450 2D65005
polyprotein2002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
Snq2p0003
caspase-33003
Adenylate cyclase type 1 0303
thyroid stimulating hormone receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x2002
Caspase-71001
cytochrome P450 2D6 isoform 15005
cellular tumor antigen p53 isoform a4004
caspase-31001
histone deacetylase 9 isoform 31001
atrial natriuretic peptide receptor 2 precursor4004
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 14004
nuclear factor erythroid 2-related factor 2 isoform 16006
survival motor neuron protein isoform d2002
M-phase phosphoprotein 84004
Proteasome subunit alpha type-70001
Transient receptor potential cation channel subfamily V member 10202
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Potassium channel subfamily K member 20202
Epidermal growth factor receptor0303
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Albumin0112
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-33003
Cytochrome P450 1A20113
Tyrosine-protein kinase Fyn0202
ATP-dependent translocase ABCB10609
Integrin alpha-IIb3003
5-hydroxytryptamine receptor 1A0516
5-hydroxytryptamine receptor 2C09110
Cys-loop ligand-gated ion channel0101
Calmodulin-10224
Cytochrome P450 2D60314
Polyunsaturated fatty acid lipoxygenase ALOX150404
Angiotensin-converting enzyme0606
5-hydroxytryptamine receptor 2A09110
Alpha-1B adrenergic receptor0909
Sphingomyelin phosphodiesterase0202
D0707
D(3) dopamine receptor0606
5-hydroxytryptamine receptor 1A0707
Alpha-2B adrenergic receptor0808
D(2) dopamine receptor0303
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0608
D(1B) dopamine receptor0305
Adenylate cyclase type 30303
Alpha-2C adrenergic receptor0808
UDP-glucuronosyltransferase 1A40004
Alpha-2A adrenergic receptor0808
Alpha-1D adrenergic receptor0909
D(1B) dopamine receptor0505
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20303
Adenylate cyclase type 40303
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 1B0505
Trypanothione reductase0404
D(4) dopamine receptor0606
5-hydroxytryptamine receptor 2B09110
Histamine H1 receptor0202
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0404
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0306
5-hydroxytryptamine receptor 70404
Mu-type opioid receptor0629
Sodium channel protein type 1 subunit alpha0303
Adenylate cyclase type 80303
Proteasome subunit beta type-100001
Delta-type opioid receptor0416
Kappa-type opioid receptor0416
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0909
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor3104
Gastrin/cholecystokinin type B receptor0202
Proteasome subunit alpha type-60012
Calmodulin 0123
Aldehyde oxidase 10101
Sodium channel protein type 7 subunit alpha0303
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Adenylate cyclase type 60303
Adenylate cyclase type 50303
Aldehyde oxidase0202
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Sodium channel protein type 5 subunit alpha0303
Nuclear receptor subfamily 3 group C member 3 0505
Adenylyl cyclase 7 0303
Proteasome subunit alpha-type 80001
Inositol hexakisphosphate kinase 13003
D0202
Sodium channel protein type 2 subunit alpha0303
Proteasome subunit beta type-70001
Ataxin-25005
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0303
Sodium channel protein type 8 subunit alpha0303
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0303
cytochrome P450 2C9, partial3003
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0203
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0101
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, JmjC domain-containing histone demethylation protein 3A4004
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Beta-lactamase0101
Proto-oncogene tyrosine-protein kinase Src0101
3-dehydroquinate dehydratase0011
ATP-citrate synthase 0001
Ribonuclease T0001
Cell death-related nuclease 40001
3-dehydroquinate dehydratase0011
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0203
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20213
Liver carboxylesterase 10001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30213
5-hydroxytryptamine receptor 1D0303
5-hydroxytryptamine receptor 1F0303
5-hydroxytryptamine receptor 60202
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit alpha-30112
5-hydroxytryptamine receptor 5A0202
5-hydroxytryptamine receptor 5B0202
5-hydroxytryptamine receptor 3A0202
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit epsilon0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sodium-dependent dopamine transporter0303
5-hydroxytryptamine receptor 4 0202
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0202
Leukotriene B4 receptor 20101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0505
Choline O-acetyltransferase0101
Histone acetyltransferase p3000101
Histone acetyltransferase KAT2B0101
Histone acetyltransferase KAT50101
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10505
Carbonic anhydrase 40103
Carbonic anhydrase0103
Carbonic anhydrase 150103
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 31001
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
apical membrane antigen 1, AMA14004
nonstructural protein 12002
bromodomain adjacent to zinc finger domain 2B3003
cytochrome P450 2C9 precursor3003
Lysine-specific demethylase 6A0101
Lysine-specific demethylase 4A0202
Lysine-specific demethylase 5C0101
Lysine-specific demethylase 2B0101
Deoxyhypusine hydroxylase0202
Lysine-specific demethylase 2A0101
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Guanine nucleotide-binding protein G2002
Hypoxia-inducible factor 1-alpha0011
Methylcytosine dioxygenase TET20101
Alpha-1B adrenergic receptor 0011
Alpha-1A adrenergic receptor0011
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
endonuclease IV1001
15-lipoxygenase, partial4004
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glutamate receptor 12002
Glutamate receptor 24004
Glutamate receptor 32002
Glutamate receptor 42002
Chain A, Protein (aspartate Aminotransferase)0011
Chain A, Aspartate Aminotransferase0011
Solute carrier family 22 member 60102
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Solute carrier family 22 member 70001
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10404
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
glp-1 receptor, partial2002
glucocerebrosidase2002
peripheral myelin protein 22 isoform 12002
nuclear receptor ROR-gamma isoform 12002
transient receptor potential cation channel subfamily V member 11001
Cocaine esterase0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
UDP-glucuronosyltransferase 1A90103
Voltage-dependent calcium channel gamma-2 subunit2002
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Beta-2 adrenergic receptor0202
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
Beta-1 adrenergic receptor0101
5-hydroxytryptamine receptor 3A0101
Adenosine receptor A10203
Beta-3 adrenergic receptor0101
Histamine H1 receptor0303
C-8 sterol isomerase0202
Delta-type opioid receptor0315
Mu-type opioid receptor0418
5-hydroxytryptamine receptor 2C 0202
Kappa-type opioid receptor0315
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0202
Kappa-type opioid receptor0404
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
5-hydroxytryptamine receptor 2B0101
TAR DNA-binding protein 433003
5-hydroxytryptamine receptor 40101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20202
Sigma non-opioid intracellular receptor 10303
Zinc finger protein 6640101
Vesicular acetylcholine transporter0101
Transporter0202
Cholecystokinin receptor type A0101
Protease 0202
ATPase family AAA domain-containing protein 51001
Transient receptor potential cation channel subfamily V member 40101
Sigma non-opioid intracellular receptor 10303
Transient receptor potential cation channel subfamily V member 20101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
Sodium-dependent noradrenaline transporter0101
Solute carrier family 22 member 30101
Prostaglandin G/H synthase 10101
Cytochrome P450 2C190001
UDP-glucuronosyltransferase 1A30002
D(2) dopamine receptor0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Envelope glycoprotein0011
Sodium-dependent serotonin transporter0101
Multidrug and toxin extrusion protein 20101
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Sodium/myo-inositol cotransporter 20101
Luciferase1001
dopamine D1 receptor1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
DNA polymerase eta isoform 11001
Polyphenol oxidase 20001
Carbonic anhydrase 120002
Plasma kallikrein0002
Tyrosine-protein kinase Lck0101
Carbonic anhydrase 30002
Tyrosinase0101
Carbonic anhydrase 60103
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0002
Carbonic anhydrase 70002
Solute carrier family 15 member 10101
Carbonic anhydrase0002
SLC16A10 protein0002
Carbonic anhydrase 90002
Carbonic anhydrase 0002
Carbonic anhydrase0002
Carbonic anhydrase0002
Carbonic anhydrase 0002
Monocarboxylate transporter 100002
Carbonic anhydrase 130002
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0002
phosphoglycerate kinase1001
Lysophosphatidic acid receptor 60011
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
Lysophosphatidic acid receptor 4 0011
Lysophosphatidic acid receptor 10022
Lysophosphatidic acid receptor 40011
Lysophosphatidic acid receptor 50011
Lysophosphatidic acid receptor 20011
Lysophosphatidic acid receptor 30011
Opioid receptor, delta 1b 0101
Acetylcholinesterase0202
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
Translocator protein0011
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Delta-type opioid receptor0102
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
transcriptional regulator ERG isoform 31001
Rap guanine nucleotide exchange factor 41001
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
5-hydroxytryptamine receptor 3E0101
aryl hydrocarbon receptor2002
lysosomal alpha-glucosidase preproprotein1001
FAD-linked sulfhydryl oxidase ALR0001
5-hydroxytryptamine receptor 3B0101
Glucose-6-phosphate 1-dehydrogenase0101
5-hydroxytryptamine receptor 3A0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Disintegrin and metalloproteinase domain-containing protein 171001
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Type II pantothenate kinase0001
Type III pantothenate kinase0001
Cystathionine gamma-lyase0101
Succinyl-diaminopimelate desuccinylase0101
90-kda heat shock protein beta HSP90 beta, partial0101
heat shock protein HSP 90-alpha isoform 20101
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
Serine hydroxymethyltransferase, mitochondrial0101
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
Phosphoethanolamine N-methyltransferase0101
10 kDa chaperonin 0101
Chloroquine resistance transporter0101
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Prostaglandin G/H synthase 10101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A80001
Pyridoxal kinase0001
Pyruvate kinase PKM0011
Cholinesterase0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Ubiquitin-like modifier activating enzyme 20101
SMAD family member 21001
SUMO1 activating enzyme subunit 10101
SMAD family member 31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
hexokinase0101
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Cholinesterase0101
Aldo-keto reductase family 1 member B10101
Nuclear receptor ROR-gamma1001
Genome polyprotein 0101
NPC intracellular cholesterol transporter 1 precursor1001
DNA repair protein RAD52 homolog isoform a0001
Ubiquitin carboxyl-terminal hydrolase 10101
Lysozyme C-10101
Glycoprotein hormones alpha chain1001
Protein kinase C alpha type0101
Beta-glucuronidase0101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
DNA-dependent protein kinase catalytic subunit0101
Protein kinase C eta type0101
Calcium-dependent protein kinase 40101
WD repeat-containing protein 480101
Emopamil-binding protein-like0101
Protein kinase C theta type0101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
thioredoxin glutathione reductase1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Dihydrofolate reductase0202
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Phospholipase A-2-activating protein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]