Page last updated: 2024-09-27

Channelopathies

A variety of neuromuscular conditions resulting from MUTATIONS in ION CHANNELS manifesting as episodes of EPILEPSY; HEADACHE DISORDERS; and DYSKINESIAS.

Synonyms(1)

Synonym
Channelopathies

Research Excerpts

Overview

ExcerptReference
"Thus, RyR channelopathies are both of interest because they cause significant human diseases and provide model systems that can be studied to elucidate important structure-function relationships of these ion channels."( Betzenhauser, MJ; Marks, AR, 2010)
"Channelopathies are rarely recognized diseases in domestic animals."( Baumgärtner, W; Kiesewetter, IS; Schenk, HC; Tipold, A, 2011)
"Skeletal muscle ion channelopathies are rare genetic diseases mainly characterized by myotonia (muscle stiffness) or periodic paralysis (muscle weakness)."( Altamura, C; Campanale, C; Desaphy, JF; Laghetti, P; Saltarella, I, 2023)
"Skeletal muscle ion channelopathies are rare genetic diseases mainly characterized by myotonia (muscle stiffness) or periodic paralysis (muscle weakness)."( Altamura, C; Campanale, C; Desaphy, JF; Laghetti, P; Saltarella, I, 2023)

Context

ExcerptReference
"Cardiac ion channelopathies have been identified as a cause of death in Sudden Infant Death Syndrome (SIDS) and could be associated with unexplained stillbirths."( Batra, G; Brady, CA; Branco, SQ; Hancock, A; Heazell, AEP; Kerby, A; Petts, G, 2022)

Research

Studies (127)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's15 (11.81)18.1394
2010's76 (59.84)28.8240
2020's36 (28.35)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low40
carbamates0low30
chlorine0low50
lactic acid0low10
4-aminopyridine0low10
homovanillic acid0low10
hydroxyindoleacetic acid0low10
acetazolamide0low40
benzbromarone0low10
caffeine0low10
verapamil0low10
carbamazepine0low10
dichlorphenamide0low20
flecainide0low20
gabapentin0low10
lidocaine0medium21
isoproterenol0low10
isradipine0low10
lamotrigine0low10
metoprolol0low10
mexiletine0low50
apnea0low10
nifedipine0low10
oxidopamine0low10
pilsicainide0low10
pinacidil0low10
propranolol0low10
aldosterone0low10
pilocarpine0low20
glutamine0low10
carbostyril0low10
methionine0low10
phenylalanine0low10
histidine0low10
veratridine0low10
valine0low10
arginine0low10
quinoxalines0low10
xanthenes0low10
pyridostigmine bromide0low10
catechin0low10
kainic acid0low10
alpha-aminopyridine0low10
eosine yellowish-(ys)0low10
metanephrine0low10
carbimazole0low10
glutamic acid0low10
oxcarbazepine0low10
ng-nitroarginine methyl ester0low10
nicorandil0low10
colforsin0low10
fomesafen0low10
epigallocatechin gallate0low10
uk 687980low10
ezogabine0low30
fullerene c600low10
glycerophosphoinositol 4,5-bisphosphate0low10
quinidine0low10
cannabidiol0low20
curcumin0low10
ica-1214310low10
capsaicin0low10
fg 90410low10
barium0low10
rubidium0low10
cysteine0low10
tetrodotoxin0low10
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid0low10
antillatoxin0low10
alpha-synuclein0low10
jaw0low10
a 8034670low20
endothelin-10low10
zetekitoxin ab0low10
wnt-c590low10
lumacaftor, ivacaftor drug combination0low10
nephrin0low10
cyclic gmp0low20
5-methyltetrahydrofolate0low10

Protein Targets (989)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Potassium channel subfamily K member 20246
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE150015
Chain A, Cruzipain2002
thioredoxin reductase240024
RAR-related orphan receptor gamma130013
USP1 protein, partial110011
Microtubule-associated protein tau120012
aldehyde dehydrogenase 1 family, member A1150015
thyroid stimulating hormone receptor120012
estrogen receptor 2 (ER beta)8008
cytochrome P450 family 3 subfamily A polypeptide 4150015
glucocorticoid receptor [Homo sapiens]170017
cytochrome P450 2D6140014
glucocerebrosidase5005
IDH17007
euchromatic histone-lysine N-methyltransferase 2310031
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
cytochrome P450 2D6 isoform 13003
chromobox protein homolog 1170017
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 2160016
mitogen-activated protein kinase 18008
geminin230023
peripheral myelin protein 22120012
survival motor neuron protein isoform d6006
lethal factor (plasmid)7007
lamin isoform A-delta10200020
Rap guanine nucleotide exchange factor 34004
Cellular tumor antigen p539009
Potassium voltage-gated channel subfamily A member 30112
Acetylcholinesterase0101
Pteridine reductase 10101
Potassium voltage-gated channel subfamily A member 10404
Potassium voltage-gated channel subfamily H member 2014015
ATP-dependent phosphofructokinase150015
EWS/FLI fusion protein130014
G9009
Potassium voltage-gated channel subfamily KQT member 30114
Potassium voltage-gated channel subfamily KQT member 20114
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 9009
Muscarinic acetylcholine receptor M20326
Muscarinic acetylcholine receptor M40102
5-hydroxytryptamine receptor 1A0314
Muscarinic acetylcholine receptor M50203
Alpha-2A adrenergic receptor0427
Adenosine receptor A30718
Muscarinic acetylcholine receptor M10337
D(2) dopamine receptor0314
Alpha-2B adrenergic receptor0214
Muscarinic acetylcholine receptor M30214
Cannabinoid receptor 10405
D(1A) dopamine receptor0415
D(4) dopamine receptor0202
D(1B) dopamine receptor0101
Histamine H2 receptor0303
C-X-C chemokine receptor type 20101
Endothelin-1 receptor0314
Adenosine receptor A10101
5-hydroxytryptamine receptor 1B0314
5-hydroxytryptamine receptor 2A0516
5-hydroxytryptamine receptor 2C0819
Adenosine receptor A2a0528
Translocator protein0101
Adenosine receptor A10417
Cholecystokinin receptor type A0213
C-C chemokine receptor type 10101
5-hydroxytryptamine receptor 70213
Cannabinoid receptor 2 0416
Histamine H1 receptor0101
Alpha-1B adrenergic receptor0124
Mu-type opioid receptor0315
D(3) dopamine receptor0404
Delta-type opioid receptor0315
Kappa-type opioid receptor0315
Nociceptin receptor0101
P2Y purinoceptor 20101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60314
P2X purinoceptor 30101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 5 subunit alpha012012
Sodium channel protein type 9 subunit alpha011011
Sodium channel protein type 10 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Transient receptor potential cation channel subfamily V member 10427
Inositol hexakisphosphate kinase 19009
Sodium channel protein type 2 subunit alpha0707
Sigma non-opioid intracellular receptor 10303
Sodium channel protein type 3 subunit alpha0707
P2X purinoceptor 20101
Sodium channel protein type 10 subunit alpha0606
cytochrome P450 2C9, partial9009
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase9009
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0002
Carbonic anhydrase 0202
GALC protein4004
GLI family zinc finger 3140014
nuclear receptor subfamily 1, group I, member 3130013
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha210021
Carbonic anhydrase 0202
Carbonic anhydrase 0202
arylsulfatase A100010
Carbonic anhydrase0202
Bloom syndrome protein isoform 1130013
thyroid hormone receptor beta isoform a9009
nuclear factor erythroid 2-related factor 2 isoform 1130013
muscleblind-like protein 1 isoform 14004
Gamma-aminobutyric acid receptor subunit pi114217
ATP-binding cassette sub-family C member 3015015
Multidrug resistance-associated protein 4015016
Carbonic anhydrase0202
Solute carrier family 22 member 60101
Carbonic anhydrase 1204110
Prolyl endopeptidase0202
Carbonic anhydrase-related protein 110102
Bile salt export pump025025
Glycogen phosphorylase, muscle form0303
Renin0303
Carbonic anhydrase 108119
Carbonic anhydrase 208118
Carbonic anhydrase 20202
Cytochrome P450 1A20505
Carbonic anhydrase 304110
Cathepsin B0101
Cytochrome P450 3A40708
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0202
Polyunsaturated fatty acid 5-lipoxygenase0303
Cytochrome P450 2C80303
Cytochrome P450 2D60606
Cytochrome P450 2A60314
Cytochrome P450 2C9 013013
5-hydroxytryptamine receptor 2A0415
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-1114217
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta114217
Gamma-aminobutyric acid receptor subunit gamma-2114318
Gamma-aminobutyric acid receptor subunit alpha-5114217
Gamma-aminobutyric acid receptor subunit alpha-3114217
Cannabinoid receptor 10303
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60213
Carbonic anhydrase 406111
Carbonic anhydrase 605110
Gamma-aminobutyric acid receptor subunit gamma-1114217
Gamma-aminobutyric acid receptor subunit alpha-2114217
Carbonic anhydrase 5A, mitochondrial0202
Adenosine receptor A11408
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40103
Gamma-aminobutyric acid receptor subunit alpha-4114217
Gamma-aminobutyric acid receptor subunit gamma-3114217
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-6114217
Adenosine receptor A2a0509
5-hydroxytryptamine receptor 2B0202
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0303
Cytochrome P450 2C190505
Delta-type opioid receptor0202
Mu-type opioid receptor0303
Carbonic anhydrase 5A, mitochondrial04110
Carbonic anhydrase0305
Kappa-type opioid receptor0213
Carbonic anhydrase 70419
Carbonic anhydrase0101
D(1A) dopamine receptor1102
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0204
D(2) dopamine receptor0213
Gamma-aminobutyric acid receptor subunit alpha-1114318
Gamma-aminobutyric acid receptor subunit beta-3114217
Gamma-aminobutyric acid receptor subunit beta-2114318
Cholinesterase0404
Carbonic anhydrase 0101
Mu-type opioid receptor0213
Fatty-acid amide hydrolase 10202
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Glutamate receptor ionotropic, NMDA 2B07313
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 905111
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0204
Carbonic anhydrase 30202
Carbonic anhydrase0205
Carbonic anhydrase0205
Carbonic anhydrase 0202
Sigma intracellular receptor 20101
Delta carbonic anhydrase0202
Sigma non-opioid intracellular receptor 10202
Renin0101
Carbonic anhydrase 0204
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130418
GABA theta subunit114217
Canalicular multispecific organic anion transporter 1015015
Carbonic anhydrase 40405
Carbonic anhydrase 150306
Acidic mammalian chitinase0101
Carbonic anhydrase 130307
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon114217
Carbonic anhydrase 0101
Carbonic anhydrase 1404110
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial04110
AR protein220022
nuclear factor erythroid 2-related factor 2 isoform 24004
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0123
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10102
Guanine nucleotide-binding protein G3003
estrogen nuclear receptor alpha210021
thyroid stimulating hormone receptor9009
Voltage-dependent calcium channel gamma-2 subunit8008
Heat shock protein HSP 90-alpha0011
Botulinum neurotoxin type A 0101
Neutrophil cytosol factor 10202
Glutamate receptor 295217
Nitric oxide synthase, endothelial0202
Nitric oxide synthase, brain0203
Nitric oxide synthase, brain 0102
Nitric oxide synthase, inducible0215
Phosphatidylinositol 4-kinase alpha0101
Tyrosine-protein kinase 0011
Phosphatidylinositol 4-kinase type 2-beta0101
Phosphatidylinositol 4-kinase type 2-alpha0101
Phosphatidylinositol 4-kinase beta0101
ATAD5 protein, partial7007
TDP1 protein210021
D(1A) dopamine receptor6006
neuropeptide S receptor isoform A7007
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
phosphopantetheinyl transferase110011
NFKB1 protein, partial4004
GLS protein160016
alpha-galactosidase4004
cytochrome P450 2C19 precursor6006
flap endonuclease 17007
DNA polymerase iota isoform a (long)6006
muscarinic acetylcholine receptor M17007
Nitric oxide synthase, endothelial0103
Nitric oxide synthase, inducible0102
Cationic amino acid transporter 30101
Chain A, Putative fructose-1,6-bisphosphate aldolase7007
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
Luciferase6006
calpain II, partial0101
Skn7p0001
hypoxia-inducible factor 1 alpha subunit5005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
envelope glycoprotein0101
progesterone receptor8008
nonstructural protein 13003
farnesoid X nuclear receptor5005
pregnane X nuclear receptor120012
bromodomain adjacent to zinc finger domain 2B6006
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma110011
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
photoreceptor-specific nuclear receptor0101
aryl hydrocarbon receptor6006
activating transcription factor 65005
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x6006
cytochrome P450 2C9 precursor7007
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
perilipin-50303
vitamin D3 receptor isoform VDRA7007
nuclear receptor corepressor 2 isoform 20101
perilipin-10303
heat shock protein beta-14004
DNA polymerase beta5005
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
serine/threonine-protein kinase PLK12002
peroxisome proliferator-activated receptor gamma isoform 20101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0303
histone acetyltransferase KAT2A isoform 15005
replicative DNA helicase0001
recombinase A0011
streptokinase A precursor0011
Eyes absent homolog 20101
Polymerase acidic protein0112
Estrogen receptor0011
60 kDa chaperonin0303
60 kDa heat shock protein, mitochondrial0303
Alpha-1B adrenergic receptor0819
Tyrosine-protein phosphatase non-receptor type 10101
Mitogen-activated protein kinase 10101
Multidrug resistance-associated protein 1 0416
Alpha-synuclein2114
5-hydroxytryptamine receptor 2B0819
Alpha-1A adrenergic receptor0819
Histamine H2 receptor8019
Cytochrome P450 2J20808
Monocarboxylate transporter 10101
Spike glycoprotein130013
10 kDa heat shock protein, mitochondrial0303
Disintegrin and metalloproteinase domain-containing protein 171102
Eyes absent homolog 30101
Aldo-keto reductase family 1 member C10101
TAR DNA-binding protein 433003
Mitogen-activated protein kinase 140202
Thiosulfate sulfurtransferase0303
Solute carrier family 22 member 60101
60 kDa chaperonin 0303
Estrogen receptor beta0011
Monocarboxylate transporter 20101
10 kDa chaperonin 0303
Rap guanine nucleotide exchange factor 42002
Bile acid receptor0011
Solute carrier family 22 member 120101
Eyes absent homolog 30101
Inosine-5'-monophosphate dehydrogenase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20516
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
M17 leucyl aminopeptidase0101
M1-family alanyl aminopeptidase0101
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
atrial natriuretic peptide receptor 1 precursor1001
nuclear receptor ROR-gamma isoform 17007
DNA polymerase kappa isoform 17007
Cholinesterase0303
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0213
Replicase polyprotein 1ab0314
Amine oxidase [flavin-containing] A0404
Acetylcholinesterase0404
Amine oxidase [flavin-containing] B0505
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10113
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Phosphodiesterase 0101
Guanine deaminase0101
PPM1D protein1001
Acetylcholinesterase0202
L-lactate dehydrogenase A chain0101
Cytochrome P450 1A10101
Cytochrome P450 2C11 0101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Fatty acid-binding protein, liver0101
Alpha-2C adrenergic receptor0225
Cytochrome P450 3A50101
Cytochrome P450 3A70101
Caspase-10011
Peroxisome proliferator-activated receptor gamma0011
N-acylethanolamine-hydrolyzing acid amidase0101
Cytochrome P450 1B10101
Heat sensitive channel TRPV30112
Sigma intracellular receptor 20101
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily M member 80101
Transient receptor potential cation channel subfamily V member 40123
Transient receptor potential cation channel subfamily V member 20123
G-protein coupled receptor 550011
Diacylglycerol lipase-alpha0101
Histamine H3 receptor0101
15-lipoxygenase, partial5005
67.9K protein3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
cytochrome P450 3A4 isoform 1110011
transient receptor potential cation channel subfamily V member 11001
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0202
NADH-ubiquinone oxidoreductase chain 10101
Prostaglandin G/H synthase 10202
Nuclear receptor ROR-gamma3003
Inositol monophosphatase 12002
Corticotropin-releasing factor receptor 20101
acetylcholinesterase7007
Vpr2002
Bile salt export pump0606
Albumin0011
Major prion protein0011
Sodium channel protein type 1 subunit alpha0404
Sodium channel protein type 2 subunit alpha0415
Sodium channel protein type 3 subunit alpha0505
UDP-glucuronosyltransferase 2B70113
Sodium channel protein type 4 subunit alpha08010
Frizzled-80011
P2X purinoceptor 40202
Lactoperoxidase0101
Chain A, serum paraoxonase0101
Poly [ADP-ribose] polymerase tankyrase-20101
Chain A, 2-oxoglutarate Oxygenase5005
peripheral myelin protein 22 isoform 16006
DNA polymerase eta isoform 11001
Prostaglandin G/H synthase 1 0101
Arginase 0202
Pancreatic triacylglycerol lipase0101
Prothrombin0123
Prostaglandin G/H synthase 10112
Aldo-keto reductase family 1 member B10101
Sucrase-isomaltase, intestinal0101
Prostaglandin G/H synthase 20202
Xanthine dehydrogenase/oxidase0101
Melatonin receptor type 1A0011
Melatonin receptor type 1B0011
Death-associated protein kinase 10101
Beta-secretase 10303
Prostaglandin G/H synthase 20101
Dihydroorotate dehydrogenase 0101
glp-1 receptor, partial7007
pregnane X receptor3003
nuclear receptor subfamily 1, group I, member 22002
nuclear receptor subfamily 0 group B member 10101
steroidogenic factor 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor6006
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent translocase ABCB1011122
Solute carrier family 2, facilitated glucose transporter member 10011
Adenylate cyclase type 20011
Adenylate cyclase type 80011
ATPase family AAA domain-containing protein 53003
Ataxin-25005
Relaxin receptor 10011
Nuclear receptor subfamily 1 group I member 20011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, Ferritin light chain4004
interleukin 81001
Nrf21001
SMAD family member 23003
SMAD family member 33003
alkaline phosphatase, intestinal0101
thioredoxin glutathione reductase3003
Smad34004
apical membrane antigen 1, AMA11001
caspase 7, apoptosis-related cysteine protease1001
PINK11001
Parkin2002
toll-like receptor 90101
caspase-31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
TPA: protein transporter TIM100101
thyrotropin-releasing hormone receptor1001
lysosomal alpha-glucosidase preproprotein4004
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
polyunsaturated fatty acid lipoxygenase ALOX122002
intestinal alkaline phosphatase precursor0101
potassium voltage-gated channel subfamily H member 2 isoform d7007
huntingtin isoform 22002
importin subunit beta-1 isoform 13003
pyruvate kinase PKM isoform a2002
nuclear factor NF-kappa-B p105 subunit isoform 12002
snurportin-13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 12002
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
alkaline phosphatase, germ cell type preproprotein0101
caspase-1 isoform alpha precursor1001
hypothetical protein SA14220101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Prostaglandin E synthase0202
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Histone deacetylase 30202
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10303
Amyloid-beta precursor protein0203
Integrin beta-33014
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Heme oxygenase 1 0202
Integrin alpha-IIb3014
Glutathione S-transferase P0101
Microtubule-associated protein tau0203
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0101
Tyrosinase0101
Aminopeptidase N0101
Aminopeptidase N0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0505
Heme oxygenase 20202
Alpha-1D adrenergic receptor0415
Voltage-dependent L-type calcium channel subunit alpha-1D0303
Proteasome subunit beta type-50202
17-beta-hydroxysteroid dehydrogenase type 20101
Glycogen synthase kinase-3 beta0101
Caspase-71001
Histone deacetylase 40202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Lactoylglutathione lyase0101
Histone acetyltransferase p3000202
Serine/threonine-protein kinase PAK 10101
Histone deacetylase 10303
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0112
Nuclear factor erythroid 2-related factor 20011
Thioredoxin reductase 1, cytoplasmic0101
Thioredoxin reductase 30101
Sortase A0101
Histone deacetylase 70202
Histone deacetylase 20303
CREB-binding protein0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
NACHT, LRR and PYD domains-containing protein 3 0101
Histone deacetylase 80303
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10011
Chain A, POLYMERASE PA0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Genome polyprotein 0101
Replicase polyprotein 1ab0101
galactokinase1001
POsterior Segregation0011
Telomerase reverse transcriptase0101
Polycomb protein EED0011
NAD kinase0213
Dihydrofolate reductase0001
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
Transthyretin0011
Plasminogen activator inhibitor 10101
Urokinase-type plasminogen activator0101
Heat shock protein HSP 90-beta0101
Neutrophil elastase0202
72 kDa type IV collagenase0101
Hepatocyte growth factor receptor0202
Matrilysin0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Alpha-amylase 1A 0101
Apoptosis regulator Bcl-20202
Glucose-6-phosphate 1-dehydrogenase0101
Fatty acid synthase0101
CPG DNA methylase0101
Lethal factor0101
Phosphoglycerate mutase 10101
Sodium-dependent noradrenaline transporter 0011
DNA (cytosine-5)-methyltransferase 10101
Signal transducer and activator of transcription 1-alpha/beta0011
DNA repair protein RAD52 homolog0202
Fatty acid synthase0202
Matrix metalloproteinase-140101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
Squalene monooxygenase 0101
6-phosphogluconate dehydrogenase, decarboxylating0101
BH3-interacting domain death agonist0101
Lactoperoxidase0001
Bcl-2-like protein 10101
Induced myeloid leukemia cell differentiation protein Mcl-10101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Bcl-2-related protein A10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Reverse transcriptase/RNaseH 0101
3-oxoacyl-[acyl-carrier-protein] reductase 0101
MAP kinase-activated protein kinase 50101
Histone acetyltransferase KAT2B0101
Bcl-2-like protein 20101
Bcl2-associated agonist of cell death 0101
Histone acetyltransferase KAT50101
Enoyl-acyl-carrier protein reductase 0202
3-oxoacyl-acyl-carrier protein reductase 0101
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Bcl-2-like protein 100101
Zinc finger protein mex-50011
UDP-glucuronosyltransferase 1A90011
UDP-glucuronosyltransferase 2B110011
UDP-glucuronosyltransferase 2B170011
Potassium voltage-gated channel subfamily KQT member 20011
Potassium voltage-gated channel subfamily KQT member 3 0011
UDP-glucuronosyltransferase 2B40011
UDP-glucuronosyltransferase 2A10011
UDP-glucuronosyltransferase 2A20011
UDP-glucuronosyltransferase 1-60112
UDP-glucuronosyltransferase 1A1 0113
UDP-glucuronosyltransferase 1A40113
UDP-glucuronosyltransferase 1A30011
UDP-glucuronosyltransferase 1A50011
UDP-glucuronosyltransferase 2B10 0112
UDP-glucuronosyltransferase 2B150011
Potassium voltage-gated channel subfamily KQT member 40011
UDP-glucuronosyltransferase 2A30011
UDP-glucuronosyltransferase 2B280011
UDP-glucuronosyltransferase 1A70011
UDP-glucuronosyltransferase 1A100011
UDP-glucuronosyltransferase 1A80011
Potassium voltage-gated channel subfamily KQT member 50012
Potassium voltage-gated channel subfamily KQT member 2 0011
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20202
Chain A, Glutamate Receptor Subunit 20202
Chain B, Glutamate Receptor Subunit 20202
fatty acid synthase0101
M-phase phosphoprotein 86006
Glycoprotein hormones alpha chain1001
Glutamate receptor 11529
Glutamate receptor 31529
Glutamate receptor 41529
Glutamate receptor ionotropic, kainate 10427
Glutamate receptor ionotropic, NMDA 1 06312
Glutamate receptor ionotropic, kainate 20438
Glutamate receptor 10527
Glutamate receptor 20527
Glutamate receptor 30325
Glutamate receptor ionotropic, kainate 30405
Glutamate receptor 40516
Glutamate receptor ionotropic, NMDA 2A 06312
Glutamate receptor ionotropic, NMDA 2C06312
Glutamate receptor ionotropic, kainate 40405
Glutamate receptor ionotropic, NMDA 2D06312
Glutamate receptor ionotropic, kainate 50405
Glutamate receptor ionotropic, NMDA 3B06312
Glutamate receptor ionotropic, NMDA 3A06312
Voltage-dependent L-type calcium channel subunit alpha-1F0707
Potassium voltage-gated channel subfamily A member 50404
Voltage-dependent L-type calcium channel subunit alpha-1D 0707
Voltage-dependent L-type calcium channel subunit alpha-1S0707
Voltage-dependent L-type calcium channel subunit alpha-1C010011
Potassium voltage-gated channel subfamily D member 20303
regulator of G-protein signaling 49009
Voltage-dependent calcium channel subunit alpha-2/delta-10202
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid type B receptor subunit 10011
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor4004
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60124
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10325
Metabotropic glutamate receptor 50124
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20325
Glutamate receptor ionotropic, kainate 30303
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50303
Carbonic anhydrase-like protein, putative0004
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Chain A, HISTIDINE-BINDING PROTEIN0011
Plasma kallikrein0002
Histidine-binding periplasmic protein0011
5-hydroxytryptamine receptor 1D0001
Large neutral amino acids transporter small subunit 10405
Glutaminyl-peptide cyclotransferase0101
ClpP1001
Fumarate hydratase4004
polyprotein4004
Solute carrier family 22 member 80001
endonuclease IV3003
hypothetical protein, conserved2002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 1 subunit alpha0404
Sodium channel protein type 8 subunit alpha0404
NPYLR7B0011
Beta-1 adrenergic receptor 0136
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
serine/threonine-protein kinase mTOR isoform 12002
Beta-2 adrenergic receptor06411
Beta-1 adrenergic receptor0639
Beta-2 adrenergic receptor0416
Polyunsaturated fatty acid lipoxygenase ALOX150202
Beta-3 adrenergic receptor0336
Beta-1 adrenergic receptor05310
Beta-2 adrenergic receptor0011
Alpha-2B adrenergic receptor0213
Alpha-2C adrenergic receptor0213
Alpha-2A adrenergic receptor0213
Beta-adrenergic receptor kinase 10011
Alpha-1D adrenergic receptor0023
Beta-3 adrenergic receptor0011
Beta-3 adrenergic receptor0314
Vasopressin V1a receptor0011
Beta-1 adrenergic receptor0314
Alpha-1A adrenergic receptor0135
Beta-2 adrenergic receptor0202
Taste receptor type 2 member 380011
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310011
Taste receptor type 2 member 450011
Taste receptor type 2 member 460011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600011
Oxytocin receptor0011
Beta-2 adrenergic receptor 0112
Taste receptor type 2 member 420011
Beta-2 adrenergic receptor0147
Taste receptor type 2 member 160011
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 100011
Taste receptor type 2 member 90011
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40011
Taste receptor type 2 member 30011
Taste receptor type 2 member 10011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Chymotrypsinogen A0101
Chain A, Glutamate receptor 20011
Chain A, Glutamate receptor 20011
Chain C, Glutamate receptor 20011
Glutamate receptor ionotropic, kainate 40101
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10202
Potassium voltage-gated channel subfamily KQT member 10202
Sigma non-opioid intracellular receptor 10101
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 180101
Multidrug and toxin extrusion protein 10202
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
5-hydroxytryptamine receptor 1A0528
Sodium channel protein type 7 subunit alpha0303
Sodium channel protein type 11 subunit alpha0303
Collagenase 30101
Thrombopoietin1001
tumor necrosis factor1001
atrial natriuretic peptide receptor 2 precursor1001
eyes absent homolog 2 isoform a1001
Voltage-dependent L-type calcium channel subunit alpha-1C0505
5-hydroxytryptamine receptor 40606
Phospholipase A2, membrane associated0001
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Thromboxane-A synthase 0101
Platelet-activating factor receptor0001
Indoleamine 2,3-dioxygenase 10101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
C-C chemokine receptor type 20202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
C-terminal-binding protein 11001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Leukotriene B4 receptor 10001
Myosin light chain kinase, smooth muscle0101
Transient receptor potential cation channel subfamily A member 10011
Potassium channel subfamily K member 2 0101
Indoleamine 2,3-dioxygenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Leukotriene B4 receptor 20001
polyadenylate-binding protein 10101
bcl-2-related protein A10101
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glyceraldehyde-3-phosphate dehydrogenase0101
Sodium-dependent dopamine transporter0101
Transporter0101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0001
Large neutral amino acids transporter small subunit 1 0101
Monocarboxylate transporter 100001
Phospholipase A-2-activating protein0101
Muscarinic acetylcholine receptor M10203
Muscarinic acetylcholine receptor M30203
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor DM10101
Cytochrome P450 2A130112
ATP-binding cassette sub-family C member 90011
Solute carrier family 22 member 1 0506
Albumin0022
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1B0404
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0404
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 70303
Nuclear receptor subfamily 2 group E member 10022
Solute carrier organic anion transporter family member 1A40101
Histidine-rich protein PFHRP-II0101
ATP-dependent translocase ABCB10202
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
ATP-dependent translocase ABCB10203
Solute carrier family 22 member 10203
Cytochrome P450 2D40101
Multidrug resistance protein 1a0001
Solute carrier family 22 member 20202
Chain A, Arginase 10101
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Catechol O-methyltransferase0101
Chloroquine resistance transporter0101
Solute carrier organic anion transporter family member 1B10202
Bifunctional purine biosynthesis protein ATIC0101
tyrosine-protein kinase Yes1001
Protein-serine O-palmitoleoyltransferase porcupine0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]