A 443654: an Akt kinase inhibitor; structure in first source [MeSH]
(2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine : no description available [CHeBI]
| ID Source | ID |
|---|---|
| PubMed CID | 10172943 |
| CHEMBL ID | 379300 |
| SCHEMBL ID | 570604 |
| CHEBI ID | 91351 |
| MeSH ID | M0489728 |
| Synonym |
|---|
| HY-10425 |
| (2s)-1-(1h-indol-3-yl)-3-{[5-(3-methyl-1h-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine |
| L20 , |
| bdbm15131 |
| indazole-pyridine, 4 |
| 5-{5-[(2s)-2-amino-3-(1h-indol-3-yl)propoxy]pyridin-3-yl}-3-methyl-1h-indazole |
| a-443654 |
| 5-indazolyl pyridine 3 |
| a 443654 |
| (s)-1-(5-(3-methyl-1h-indazol-5-yl)pyridin-3-yloxy)-3-(1h-indol-3-yl)propan-2-amine |
| smr001307829 |
| MLS002232275 |
| DB08073 |
| a-4436554 |
| CHEMBL379300 |
| NCGC00347278-01 |
| CS-0405 |
| SCHEMBL570604 |
| gtpl8204 |
| (2s)-1-(1h-indol-3-yl)-3-[5-(3-methyl-2h-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine |
| 552325-16-3 |
| a443654 |
| DTXSID20436347 |
| AKOS030526845 |
| CHEBI:91351 |
| NCGC00347278-02 |
| (s)-1-(1h-indol-3-yl)-3-[5-(3-methyl-2h-indazol-5-yl)pyridin-3-yl]oxypropan2-amine |
| EX-A7113 |
| Q27074073 |
| F83982 |
| a-654 |
| (2s)-1-(1h-indol-3-yl)-3-[[5-(3-methyl-1h-indazol-5-yl)-3-pyridyl]oxy]propan-2-amine |
| Z2037280935 |
| 1h-indole-3-ethanamine, alpha-[[[5-(3-methyl-1h-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (alphas)- |
| a-443644 |
| Q4UG565ZYH |
| a 443644 |
| Class | Description |
|---|---|
| indoles | Any compound containing an indole skeleton. |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | IC50 | 0.0165 | AID1797359; AID1797514 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 0.0007 | AID1797513; AID290872; AID436502; AID514326 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | Ki | 0.0002 | AID1797345; AID1876208; AID266586; AID514325 |
| RAC-beta serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 0.0152 | AID1797358; AID514328 |
| RAC-gamma serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 0.0510 | AID514330 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID514816 | Inhibition of TBK1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514015 | Inhibition of CLK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435873 | Percentage PLK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435230 | Percentage GSK3-beta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513806 | Inhibition of AURKB at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514809 | Inhibition of STK24 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435739 | Percentage p38-gamma activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514444 | Inhibition of MAPK14 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290875 | AUC in mouse at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID290892 | Selectivity for Akt1 over cKIT | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID290886 | Selectivity for Akt1 over ERK2 | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID435584 | Percentage CaMK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513795 | Inhibition of ABL1 T315I mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514426 | Inhibition of KIT at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435746 | Percentage PRAK activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514057 | Inhibition of FLT3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514483 | Inhibition of PKN1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514486 | Inhibition of PLK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435353 | Percentage HIPK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514785 | Inhibition of RET at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514331 | Inhibition of myristoylated AKT3 M229G mutant expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435366 | Percentage NEK2a activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514054 | Inhibition of FGFR4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514690 | Induction AKT1 Thr308 hyperphosphorylation in insulin-induced rat L6 cells at 10 uM after 20 mins before insulin stimulation by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514039 | Inhibition of EPHA4 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435740 | Percentage PKCzeta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514786 | Inhibition of RET V804L mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514334 | Induction of AKT1 Ser473 phosphorylation expressed in IGF1-stimulated HEK293 cells treated 20 mins before IGF1 stimulation by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435379 | Percentage SmMLCK activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514467 | Inhibition of NTRK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514484 | Inhibition of PLK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514818 | Inhibition of TYRO3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514078 | Inhibition of JAK2 JH1 JH2 domain at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514777 | Inhibition of PRKD1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513794 | Inhibition of ABL1 G250E mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435243 | Percentage MARK3 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514461 | Inhibition of NEK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435543 | Percentage PKCzeta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514065 | Inhibition of GRK7 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514788 | Inhibition of ROCK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435538 | Percentage PDK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514012 | Inhibition of CDK5/p35 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514326 | Inhibition of myristoylated wild type AKT1 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514451 | Inhibition of MATK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514779 | Inhibition of PRKG1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435845 | Percentage CHK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435917 | Percentage PAK6 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435344 | Percentage DYRK1A activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514487 | Inhibition of PRKACA (PKA) at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435861 | Percentage JNK3 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513817 | Inhibition of CAMK2D at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514037 | Inhibition of EPHA2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514821 | Inhibition of PASK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290896 | Half life in mouse at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID436502 | Inhibition of Akt | 2009 | European journal of medicinal chemistry, Oct, Volume: 44, Issue:10 ISSN: 1768-3254 | QSAR study of Akt/protein kinase B (PKB) inhibitors using support vector machine. |
| AID435733 | Percentage NEK6 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514042 | Inhibition of EPHB1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513793 | Inhibition of ABL1 E255K mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435475 | Percentage MKK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435627 | Percentage ROCK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435730 | Percentage MAPKAPK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514440 | Inhibition of MAPK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514438 | Inhibition of MAP4K4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514488 | Inhibition of PRKCA at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514423 | Inhibition of JAK2 JH1 JH2 domain V617F mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514446 | Inhibition of MAPKAPK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514047 | Inhibition of ERBB4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514469 | Inhibition of PAK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514781 | Inhibition of PRKX at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513810 | Inhibition of BRAF at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514056 | Inhibition of FLT1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514460 | Inhibition of NEK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514480 | Inhibition of PHKG2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514472 | Inhibition of PAK6 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290888 | Selectivity for Akt1 over MAPK | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID513819 | Inhibition of CDC42 binding protein alpha at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID1876209 | Cytotoxicity against human HepG2 cells at 1 uM | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2 ISSN: 1520-4804 | Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID514052 | Inhibition of FGFR3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435371 | Percentage p38delta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435460 | Percentage CK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435927 | Percentage PKBalpha activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514433 | Inhibition of MAP2K2 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435954 | Percentage AMPK activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514797 | Inhibition of RPS6KB1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435594 | Percentage CK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514050 | Inhibition of FGFR1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435346 | Percentage EF2K activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514070 | Inhibition of HIPK4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514791 | Inhibition of RPS6KA1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435108 | Percentage IKK-beta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514770 | Inhibition of PKCE at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514456 | Inhibition of MST1R at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514036 | Inhibition of EPHA1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514774 | Inhibition of PRKCN at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514434 | Inhibition of MAP2K6 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513786 | Induction of AKT1 Thr 308 phosphorylation in HEK293 cells at 2.5 uM after 15 mins by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513820 | Inhibition of CDC42 binding protein beta at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514430 | Inhibition of LYN A at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435596 | Percentage CSK activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435736 | Percentage p38delta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514067 | Inhibition of GSK3B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513796 | Inhibition of ABL1 Y253F mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514691 | Induction AKT1 Ser473 hyperphosphorylation in insulin-induced rat L6 cells at 10 uM after 20 mins before insulin stimulation by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514466 | Inhibition of NTRK1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514798 | Inhibition of SGK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435467 | Percentage ERK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435919 | Percentage PIM1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435878 | Percentage PRK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435825 | Percentage PKCalpha activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435711 | Percentage CaMKKbeta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435853 | Percentage GSK3-beta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514455 | Inhibition of MINK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514071 | Inhibition of IGF1R at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514010 | Inhibition of CDK1/cyclin B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290874 | Oral bioavailability in mouse at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID513788 | Induction of AKT1 Thr 308 phosphorylation in HEK293 cells at 2.5 uM after 15 mins at 2.5 uM after 15 mins pretreated with pan-PI3K inhibitor PIK90 10 mins before compound addition by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514458 | Inhibition of MUSK at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514428 | Inhibition of LCK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435109 | Percentage JNK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514061 | Inhibition of FYN at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514449 | Inhibition of MARK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290882 | Selectivity for Akt1 over PKA | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID290889 | Selectivity for Akt1 over CK2 | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID435882 | Percentage RSK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513782 | Induction of flag-tagged wild type AKT1 Thr308 hyperphosphorylation expressed in HEK293 cells at 2.5 uM after 30 mins by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514450 | Inhibition of MARK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435128 | Percentage PKD1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435624 | Percentage PRK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513812 | Inhibition of BRSK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435611 | Percentage MARK3 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514780 | Inhibition of PRKG2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513807 | Inhibition of AURKC at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514792 | Inhibition of RPS6KA2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514035 | Inhibition of EGFR L861Q mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514046 | Inhibition of ERBB2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514485 | Inhibition of PLK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514482 | Inhibition of PIM2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514024 | Inhibition of CSNK1G3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514453 | Inhibition of MET at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514796 | Inhibition of RPS6KA6 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514806 | Inhibition of STK22B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290890 | Selectivity for Akt1 over KDR | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514424 | Inhibition of JAK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514772 | Inhibition of PRKCH at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435735 | Percentage NEK7 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435875 | Percentage PRAK activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513814 | Inhibition of CAMK1D at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514778 | Inhibition of PRKD2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435247 | Percentage MNK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514793 | Inhibition of RPS6KA3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513816 | Inhibition of CAMK2B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514018 | Inhibition of CSK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435921 | Percentage PIM2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435598 | Percentage DYRK3 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435112 | Percentage MAPKAPK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514804 | Inhibition of SRPK1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435362 | Percentage MELK activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID436063 | Percentage Aurora C activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513798 | Inhibition of ACVR1B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514060 | Inhibition of FRK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID436065 | Percentage BRSK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513802 | Inhibition of AKT2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435630 | Percentage RSK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513801 | Inhibition of AKT1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514814 | Inhibition of SYK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290891 | Selectivity for Akt1 over Flt1 | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514468 | Inhibition of NTRK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514784 | Inhibition of RAF1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514072 | Inhibition of IKBKB at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514034 | Inhibition of EGFR L858R mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514470 | Inhibition of PAK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514813 | Inhibition of STK6 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435254 | Percentage p38beta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514051 | Inhibition of FGFR2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID266588 | Antiproliferative activity against human MiaPaCa2 cell line | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 ISSN: 0960-894X | Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase. |
| AID435110 | Percentage Lck activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514819 | Inhibition of YES1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514028 | Inhibition of DCAMKL2 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514073 | Inhibition of INSR at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514795 | Inhibition of RPS6KA5 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435583 | Percentage BRSK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514045 | Inhibition of EPHB4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514776 | Inhibition of PRKCZ at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435815 | Percentage PKBalpha activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435465 | Percentage ERK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID266586 | Inhibition of Akt1 in presence of 10 uM ATP | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 ISSN: 0960-894X | Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase. |
| AID513811 | Inhibition of BRAF V599E mutant at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290893 | Selectivity for Akt1 over SRC | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514773 | Inhibition of PRKCI at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514044 | Inhibition of EPHB3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514425 | Inhibition of KDR at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514068 | Inhibition of HCK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435381 | Percentage SRPK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435305 | Percentage PKA activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435470 | Percentage HIPK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514465 | Inhibition of NEK9 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435616 | Percentage NEK2a activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514069 | Inhibition of HIPK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435457 | Percentage CHK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID436035 | Percentage CaMKKbeta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514041 | Inhibition of EPHA8 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435354 | Percentage HIPK3 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513792 | Inhibition of ABL1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290897 | Toxicity assessed as decrease in MAP in dog infused at 0.48 mg/kg/min | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID290884 | Selectivity for Akt1 over PKCdelta | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514020 | Inhibition of CSNK1D at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435813 | Percentage PIM3 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435249 | Percentage MSK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514032 | Inhibition of DYRK4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID1876133 | Antiviral activity against HBV | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2 ISSN: 1520-4804 | Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID514017 | Inhibition of CSF1R at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514478 | Inhibition of PDK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435224 | Percentage DYRK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514441 | Inhibition of MAPK11 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513803 | Inhibition of AKT3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514053 | Inhibition of FGFR3 K650E mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435849 | Percentage DYRK3 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435435 | Percentage CaMK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435127 | Percentage PAK4 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435990 | Percentage SGK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514327 | Inhibition of myristoylated AKT1 M227G mutant expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514442 | Inhibition of MAPK12 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435377 | Percentage S6K1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513805 | Inhibition of AMPK A1/B1/G1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435437 | Percentage PKBbeta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514049 | Inhibition of FES at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514058 | Inhibition of FLT3 D835Y mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435920 | Percentage PIM2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435178 | Percentage PKCalpha activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435975 | Percentage MKK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435337 | Percentage Aurora B activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435216 | Percentage Aurora B activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435817 | Percentage PKBbeta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514013 | Inhibition of CHEK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435610 | Percentage MAPKAPK3 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID429467 | Inhibition of AKT2 at 25 uM by FRET based assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 ISSN: 1464-3405 | Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. |
| AID429466 | Inhibition of AKT2 at 50 uM by FRET based assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16 ISSN: 1464-3405 | Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. |
| AID435369 | Percentage p38alpha activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514040 | Inhibition of EPHA5 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514471 | Inhibition of PAK4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514474 | Inhibition of PDGFRalpha at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435617 | Percentage NEK6 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID290873 | Half life in mouse at 3 mg/kg, iv | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID435752 | Percentage S6K1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514447 | Inhibition of MAPKAPK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513809 | Inhibition of BMX at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514439 | Inhibition of MAP4K5 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514799 | Inhibition of SGK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290894 | Selectivity for Akt1 over Chk1 | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514427 | Inhibition of KIT T670I mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514055 | Inhibition of FGR at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435359 | Percentage JNK3 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435498 | Percentage RSK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514064 | Inhibition of GRK6 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435122 | Percentage NEK7 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435715 | Percentage DYRK1A activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435239 | Percentage JNK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514812 | Inhibition of STK4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435974 | Percentage MELK activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435870 | Percentage p38beta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514807 | Inhibition of STK22D at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513813 | Inhibition of BTK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435132 | Percentage Src activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435609 | Percentage MAPKAPK3 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435187 | Percentage CDK2-cyclinA activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435732 | Percentage MSK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID290887 | Selectivity for Akt1 over GSK3-beta | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514325 | Inhibition of AKT1 | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514043 | Inhibition of EPHB2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514811 | Inhibition of STK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514059 | Inhibition of FLT4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514475 | Inhibition of PDGFRalpha D842V mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435217 | Percentage Aurora C activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514019 | Inhibition of CSNK1A1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514048 | Inhibition of FER at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290899 | Toxicity assessed as prolongation of action potential duration in dog purkinje fibres at 20 uM | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID435712 | Percentage CHK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514459 | Inhibition of MYLK2 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435916 | Percentage PAK6 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514808 | Inhibition of STK23 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514443 | Inhibition of MAPK13 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513815 | Inhibition of CAMK2A at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513787 | Induction of membrane localization of AKT1 in HEK293 cells at 2.5 uM after 15 mins pretreated with pan-PI3K inhibitor PIK90 10 mins before compound addition by anti AKt antibody staining based fluorescence microscopy | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435846 | Percentage CSK activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435222 | Percentage CK1delta activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514022 | Inhibition of CSNK1G1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514038 | Inhibition of EPHA3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514775 | Inhibition of PRKCQ at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514782 | Inhibition of PTK2B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435111 | Percentage Lck activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435301 | Percentage PDK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435961 | Percentage CDK2-cyclinA activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435811 | Percentage PIM1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514805 | Inhibition of SRPK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514817 | Inhibition of TEK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514436 | Inhibition of MAP3K9 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435466 | Percentage ERK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514025 | Inhibition of CSNK2A1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514783 | Inhibition of PTK6 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435755 | Percentage SmMLCK activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435981 | Percentage p38alpha activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435236 | Percentage JNK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435251 | Percentage MST2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514333 | Induction of AKT1 Thr308 phosphorylation expressed in IGF1-stimulated HEK293 cells treated 20 mins before IGF1 stimulation by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435372 | Percentage p38-gamma activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435604 | Percentage IKK-beta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435922 | Percentage PIM3 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435839 | Percentage AMPK activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514802 | Inhibition of SRC N1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435237 | Percentage JNK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514074 | Inhibition of INSRR at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514771 | Inhibition of PKCG at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514464 | Inhibition of NEK7 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514431 | Inhibition of LYN B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514789 | Inhibition of ROCK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514027 | Inhibition of DAPK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514076 | Inhibition of ITK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514800 | Inhibition of SGKL at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435978 | Percentage MST2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514432 | Inhibition of MAP2K1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514490 | Inhibition of PRKCB2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514429 | Inhibition of LTK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513808 | Inhibition of BLK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290883 | Selectivity for Akt1 over PKCgamma | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514473 | Inhibition of PAK7 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514075 | Inhibition of IRAK4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514016 | Inhibition of CLK3 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290885 | Selectivity for Akt1 over CDK2 | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID435964 | Percentage DYRK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514452 | Inhibition of MERTK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514077 | Inhibition of JAK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514457 | Inhibition of MST4 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514023 | Inhibition of CSNK1G2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435872 | Percentage PAK4 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435986 | Percentage PLK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435589 | Percentage CHK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID1876208 | Binding affinity to AKT1 (unknown origin) | 2022 | Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2 ISSN: 1520-4804 | Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. |
| AID436081 | Percentage ERK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514031 | Inhibition of DYRK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514033 | Inhibition of EGFR at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435914 | Percentage PAK5 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513818 | Inhibition of CAMK4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513785 | Induction of membrane localization of AKT1 in HEK293 cells at 2.5 uM after 15 mins by anti AKt antibody staining based fluorescence microscopy | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514011 | Inhibition of CDK2/cyclin A at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514445 | Inhibition of MAPK3 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435960 | Percentage CaMKKalpha activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435477 | Percentage MNK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435634 | Percentage Src activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514790 | Inhibition of ROS1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514029 | Inhibition of DYRK1A at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514435 | Inhibition of MAP3K8 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435229 | Percentage ERK8 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435633 | Percentage SGK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514437 | Inhibition of MAP4K2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514462 | Inhibition of NEK4 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435299 | Percentage PAK5 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514332 | Inhibition of wild type AKT1 expressed in HEK293 cells assessed as reduction of IGF1-induced GSK3-beta Ser9 phosphorylation treated 20 mins before IGF1 stimulation by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514454 | Inhibition of MET M1250T mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435548 | Percentage CaMKKalpha activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID266587 | Oral bioavailability in mouse at 10 mg/kg, po | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 ISSN: 0960-894X | Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase. |
| AID514787 | Inhibition of RET Y791F mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513800 | Inhibition of ADRBK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435492 | Percentage PKD1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514463 | Inhibition of NEK6 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514014 | Inhibition of CLK1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514489 | Inhibition of PRKCB1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514801 | Inhibition of SRC at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435177 | Percentage PKA activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514803 | Inhibition of SRMS at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514021 | Inhibition of CSNK1E at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514062 | Inhibition of GRK4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435232 | Percentage HIPK3 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514479 | Inhibition of PHKG1 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514329 | Inhibition of myristoylated AKT2 M225G mutant expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514476 | Inhibition of PDGFRalpha T674I mutant at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID290895 | Selectivity for Akt1 over RSK2 | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID514794 | Inhibition of RPS6KA4 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514030 | Inhibition of DYRK1B at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514328 | Inhibition of myristoylated wild type AKT2 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435965 | Percentage EF2K activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514330 | Inhibition of myristoylated wild type AKT3 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513781 | Induction of flag-tagged wild type AKT1 Ser473 hyperphosphorylation expressed in HEK293 cells at 2.5 uM after 30 mins by immunoblotting | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514810 | Inhibition of STK25 at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514477 | Inhibition of PDGFRbeta at 1 uM in presence of 100 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435342 | Percentage CK1delta activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513799 | Inhibition of ADRBK1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514820 | Inhibition of ZAP70 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435612 | Percentage MNK1 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435303 | Percentage PHK activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID513797 | Inhibition of ABL2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID513804 | Inhibition of ALK at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435302 | Percentage PHK activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514026 | Inhibition of CSNK2A2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435134 | Percentage SRPK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514815 | Inhibition of TAOK2 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514491 | Inhibition of PRKCD at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435468 | Percentage ERK8 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID290872 | Inhibition of human Akt1 | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID435259 | Percentage RSK2 activity remaining in the presence of 0.01uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514063 | Inhibition of GRK5 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID435880 | Percentage ROCK2 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID435976 | Percentage MNK1 activity remaining in the presence of 0.1uM inhibitor | 2007 | The Biochemical journal, Dec-15, Volume: 408, Issue:3 ISSN: 1470-8728 | The selectivity of protein kinase inhibitors: a further update. |
| AID514066 | Inhibition of GSK3A at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514448 | Inhibition of MAPKAPK5 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID514481 | Inhibition of PIM1 at 1 uM in presence of 10 uM ATP by Select Screen kinase assay relative to untreated control | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173ISSN: 1872-9096 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347113 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347111 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 ISSN: 2472-5560 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 ISSN: 2211-1247 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347119 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173ISSN: 1872-9096 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | 2022 | The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X | |
| AID1347122 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347118 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347123 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347121 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347124 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347109 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347129 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347125 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347117 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347128 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347112 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347115 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347116 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173ISSN: 1872-9096 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347110 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347114 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347126 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347127 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 ISSN: 1949-2553 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | 2022 | The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X | |
| AID1345789 | Human phosphorylase kinase catalytic subunit gamma 1 (Phosphorylase kinase (PHK) family) | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID1345374 | Human AKT serine/threonine kinase 1 (Akt (Protein kinase B)) | 2005 | Molecular cancer therapeutics, Jun, Volume: 4, Issue:6 ISSN: 1535-7163 | Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. |
| AID1345311 | Human CDC42 binding protein kinase beta (GEK subfamily) | 2009 | Nature chemical biology, Jul, Volume: 5, Issue:7 ISSN: 1552-4469 | Inhibitor hijacking of Akt activation. |
| AID1345349 | Human AKT serine/threonine kinase 2 (Akt (Protein kinase B)) | 2005 | Molecular cancer therapeutics, Jun, Volume: 4, Issue:6 ISSN: 1535-7163 | Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. |
| AID1345907 | Human AKT serine/threonine kinase 3 (Akt (Protein kinase B)) | 2005 | Molecular cancer therapeutics, Jun, Volume: 4, Issue:6 ISSN: 1535-7163 | Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. |
| AID1797513 | Akt Kinase Assay from Article 10.1021/jm0701019: \\Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension.\\ | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID1797358 | PKB In Vitro Enzyme Assay from Article 10.1016/j.jmb.2007.01.004: \\A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.\\ | 2007 | Journal of molecular biology, Mar-30, Volume: 367, Issue:3 ISSN: 0022-2836 | A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. |
| AID1797514 | PKA/PKC Kinase Assay from Article 10.1021/jm0701019: \\Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension.\\ | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13 ISSN: 0022-2623 | Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. |
| AID1797359 | PKA In Vitro Enzyme Assay from Article 10.1016/j.jmb.2007.01.004: \\A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.\\ | 2007 | Journal of molecular biology, Mar-30, Volume: 367, Issue:3 ISSN: 0022-2836 | A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. |
| AID1797345 | Akt Kinase Assay from Article 10.1016/j.bmcl.2006.04.046: \\Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.\\ | 2006 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14 ISSN: 0960-894X | Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347414 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Secondary screen by immunofluorescence | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347412 | qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347415 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: tertiary screen by RT-qPCR | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 ISSN: 1554-8937 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (39.53) | 29.6817 |
| 2010's | 18 (41.86) | 24.3611 |
| 2020's | 8 (18.60) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 43 (100.00%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2019 Novel Coronavirus Disease | 0 | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 | |
| Adenosis of Breast | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Age-Related Memory Disorders | 0 | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Alcohol Drinking | 0 | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Angelman Syndrome | 0 | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Anoxemia | 0 | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Astrocytoma, Grade IV | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| ATLL | 0 | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| B-Cell Chronic Lymphocytic Leukemia | 0 | 2009 | 2010 | 14.5 | low | 0 | 0 | 0 | 2 | 0 | 0 | |
| Benign Neoplasms | 0 | 2005 | 2006 | 18.5 | low | 0 | 0 | 0 | 2 | 0 | 0 | |
| Blood Pressure, Low | 0 | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Breast Cancer | 0 | 2010 | 2017 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 | |
| Breast Neoplasms | 0 | 2010 | 2017 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 | |
| Cancer of Pancreas | 0 | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Cancer of Prostate | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Congenital Zika Syndrome | 0 | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Disease Exacerbation | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Disease Models, Animal | 0 | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Fibrocystic Breast Disease | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Glioblastoma | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Happy Puppet Syndrome | 0 | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Hyperglycemia | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Hyperglycemia, Postprandial | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Hypotension | 0 | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Hypoxia | 0 | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Idiopathic Parkinson Disease | 0 | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 | |
| Inflammation | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Innate Inflammatory Response | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Leukemia-Lymphoma, Adult T-Cell | 0 | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Leukemia, Lymphocytic, Chronic, B-Cell | 0 | 2009 | 2010 | 14.5 | low | 0 | 0 | 0 | 2 | 0 | 0 | |
| Memory Disorders | 0 | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Metastase | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Neoplasm Metastasis | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Neoplasms | 0 | 2005 | 2006 | 18.5 | low | 0 | 0 | 0 | 2 | 0 | 0 | |
| Pancreatic Neoplasms | 0 | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Parkinson Disease | 0 | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 | |
| Prostatic Neoplasms | 0 | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Sensitivity and Specificity | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Viral Diseases | 0 | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 | |
| Virus Diseases | 0 | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 | |
| Zika Virus Infection | 0 | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Article | Year |
|---|---|
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5 | 2019 |
| Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. Journal of medicinal chemistry, , Jun-28, Volume: 50, Issue:13 | 2007 |
| Article | Year |
|---|---|
| An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo. Cancer biology & therapy, , Apr-01, Volume: 9, Issue:7 | 2010 |
| Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Molecular cancer therapeutics, , Volume: 4, Issue:6 | 2005 |