alpha-synuclein has been researched along with adrenic-acid* in 1 studies
1 other study(ies) available for alpha-synuclein and adrenic-acid
| Article | Year |
|---|---|
Changes in the cellular fatty acid profile drive the proteasomal degradation of α-synuclein and enhance neuronal survival.
Parkinson's disease is biochemically characterized by the deposition of aberrant aggregated α-synuclein in the affected neurons. The aggregation properties of α-synuclein greatly depend on its affinity to bind cellular membranes via a dynamic interaction with specific lipid moieties. In particular, α-synuclein can interact with arachidonic acid (AA), a polyunsaturated fatty acid, in a manner that promotes the formation of α-helix enriched assemblies. In a cellular context, AA is released from membrane phospholipids by phospholipase A Topics: alpha-Synuclein; Arachidonic Acid; Cell Survival; Cells, Cultured; Fatty Acids; Fatty Acids, Unsaturated; Humans; Neuroblastoma; Neurons; Phospholipase A2 Inhibitors; Phospholipases A2; Proteasome Endopeptidase Complex; Proteolysis | 2020 |