| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Multiple System Atrophy Syndrome
[description not available] | 0 | 2.5 | 2 | 0 |
Multiple System Atrophy
A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92) | 0 | 2.5 | 2 | 0 |
Atrophy
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes. | 0 | 2.21 | 1 | 0 |
Arterial Obstructive Diseases
[description not available] | 0 | 3 | 1 | 0 |
Allergy, Drug
[description not available] | 0 | 3 | 1 | 0 |
Foreign-Body Reaction
Chronic inflammation and granuloma formation around irritating foreign bodies. | 0 | 3 | 1 | 0 |
Infectious Skin Diseases
[description not available] | 0 | 3 | 1 | 0 |
Abscess
Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection. | 0 | 3 | 1 | 0 |
Arterial Occlusive Diseases
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency. | 0 | 3 | 1 | 0 |
Drug Hypersensitivity
Immunologically mediated adverse reactions to medicinal substances used legally or illegally. | 0 | 3 | 1 | 0 |
Skin Diseases, Infectious
Skin diseases caused by bacteria, fungi, parasites, or viruses. | 0 | 3 | 1 | 0 |
Dementias, Transmissible
[description not available] | 0 | 4.78 | 2 | 1 |
Cognitive Decline
[description not available] | 0 | 4.16 | 3 | 1 |
Acute Confusional Senile Dementia
[description not available] | 0 | 7.23 | 15 | 1 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 0 | 7.23 | 15 | 1 |
Cognitive Dysfunction
Diminished or impaired mental and/or intellectual function. | 0 | 4.16 | 3 | 1 |
Amentia
[description not available] | 0 | 2.1 | 1 | 0 |
Dementia
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. | 0 | 2.1 | 1 | 0 |
Tauopathies
Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration. | 0 | 2.1 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 2.1 | 1 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 2.48 | 2 | 0 |
Hakim Syndrome
[description not available] | 0 | 2.11 | 1 | 0 |
Hydrocephalus, Normal Pressure
A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see GAIT DISORDERS, NEUROLOGIC), progressive intellectual decline, and URINARY INCONTINENCE. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of CSF including SUBARACHNOID HEMORRHAGE, chronic MENINGITIS, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3) | 0 | 2.11 | 1 | 0 |
Amyloid Deposits
[description not available] | 0 | 6.42 | 8 | 2 |
Cognition Disorders
Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment. | 0 | 2.46 | 2 | 0 |
Cortical Lewy Body Disease
[description not available] | 0 | 2.05 | 1 | 0 |
Lewy Body Disease
A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124) | 0 | 2.05 | 1 | 0 |
Disease Exacerbation
[description not available] | 0 | 2.05 | 1 | 0 |
Cardiac Diseases
[description not available] | 0 | 2.07 | 1 | 0 |
Amyloidosis
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits. | 0 | 2.07 | 1 | 0 |
Heart Diseases
Pathological conditions involving the HEART including its structural and functional abnormalities. | 0 | 2.07 | 1 | 0 |
Complications of Diabetes Mellitus
[description not available] | 0 | 2.08 | 1 | 0 |