| Assay ID | Title | Year | Journal | Article |
|---|
| AID577516 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 500 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID577335 | Increase of GCase N370S mutant trafficking to lysosomes in human fibroblast cells assessed as colocalization of Gcase with Lamp2 at 1 uM after 5 days by immunofluorescence method | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1408923 | Chaperone activity at beta-galactosidase p.H281Y mutant in Zurich2 fibroblasts derived from GM1-gangliosidosis patient assessed as increase in enzyme activity using 4-methylumbelliferyl beta-D-galactopyranoside as substrate preincubated for 2 days followe | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20
| 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations. |
| AID342972 | Inhibition of basal glycogen degradation in hepatocytes | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID1601617 | Activation of lysosomal beta-glucocerebrosidase N370S mutant in fibroblast cells derived from Gaucher's disease patient at 5 uM using PFB-FDGlu as substrate preincubated for 3 days followed by substrate addition and measured after 1 hr for every 20 mins i | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. |
| AID1408921 | Inhibition of beta-glucosidase derived from human peripheral blood mononuclear cell lysate using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 2 hrs by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20
| 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations. |
| AID270951 | Binding affinity to non-phosphorylated form of rabbit muscle glycogen phosphorylase at 50 mM in absence of phosphate | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID270948 | Inhibition of phosphorylated form of rabbit muscle glycogen phosphorylase | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID613050 | Inhibition of rat intestinal cellobiase assessed as production of p-nitrophenol by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID500310 | Inhibition of GCase assessed as 4-methylumbelliferone release assay after 30 mins by fluorimetry | 2007 | Nature chemical biology, Feb, Volume: 3, Issue:2
| Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. |
| AID620279 | Inhibition of sweet almond beta-glucosidase | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
| Synthesis of new six- and seven-membered 1-N-iminosugars as promising glycosidase inhibitors. |
| AID342800 | Inhibition of human lysosomal alpha-glucosidase at 1000 uM | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID613054 | Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID731610 | Induction of beta glucosidase L444P mutant activity in fibroblasts derived from Gaucher disease patient using 4MUG as substrate relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID577524 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 1 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1321666 | Activation of GCase N370S mutant in human Gaucher disease patient fibroblasts assessed as increase in GCase protein levels at 20 and 50 uM measured after 3 days by immunoblot analysis | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators. |
| AID270952 | Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase in presence of phosphate | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID613046 | Inhibition of rat intestinal maltase assessed as production of D-glucose using maltose as substrate after 10 to 30 mins by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID731607 | Induction of beta glucosidase L444P mutant in mouse brain administered with drinking water measured after 4 weeks relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID613039 | Inhibition of coffee beans alpha-galactosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID342812 | Increase in lysosomal beta-glucosidase N370S mutant activity in human Gaucher GM00372 fibroblast at 10 uM after 4 days | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID342801 | Inhibition of human lysosomal beta-glucosidase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID577514 | Inhibition of alpha-galactosidase | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1125778 | Increase of intracellular activity of beta-glucocerebrosidase in human N370S cells using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate at 50 uM after 4 days relative to control | 2014 | Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8
| Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease. |
| AID1408920 | Inhibition of alpha-galactosidase derived from human peripheral blood mononuclear cell lysate using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate after 2 hrs by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20
| 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations. |
| AID731621 | Induction of beta glucosidase N370S mutant activity in primary skin fibroblast derived from Gaucher disease patient at 30 uM after 5 days relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID613051 | Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID613041 | Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1321660 | Binding affinity to synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) assessed as thermal stabilization measured as increase in melting temperature at pH 5 measured every 10 secs by Sypro Orange-dye based fluorescence therma | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators. |
| AID500313 | Restoration of GCase N370S mutant trafficking to lysosomes in human DMN89.15 fibroblast cells assessed as colocalization of Gcase with Lamp1 at 100 uM after 5 days by immunofluorescence method | 2007 | Nature chemical biology, Feb, Volume: 3, Issue:2
| Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. |
| AID617946 | Inhibition of alpha-glucosidase | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes. |
| AID577520 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 100 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID577333 | Binding affinity to recombinant Gcase assessed as change in melting temperature by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID270950 | Inhibition of phosphorylated form of pig liver glycogen phosphorylase | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID617953 | Inhibition of beta-glucosidase | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes. |
| AID1601619 | Activation of lysosomal beta-glucocerebrosidase activity in human healthy fibroblast cells at 5 uM using PFB-FDGlu as substrate preincubated for 3 days followed by substrate addition and measured after 1 hr for every 20 mins in presence of bafilomycin by | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. |
| AID579819 | Activation of beta-glucocerebrosidase in human N370S cells assessed as decrease of residual activity at 0.05 to 100 uM after 3 days | 2011 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 21, Issue:5
| Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease. |
| AID577332 | Increase of GCase trafficking to lysosomes in human fibroblast cells assessed as colocalization of Gcase with Lamp2 at 10 uM after 5 days by immunofluorescence method | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID731611 | Induction of beta glucosidase N370S mutant activity in fibroblast derived from Gaucher disease patient at 10 to 50 uM relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID1412120 | Chaperone activity at GBA N370S mutant in Gaucher disease patient-derived fibroblasts assessed as restoration of enzyme activity at 1 to 10000 nM after 4 days by 4-methylumbelliferyl-beta-D-glucopyranoside substrate based fluorescence assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID270958 | Inhibition of glucagon-stimulated glycogen degradation in hepatocytes | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID577525 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 0.1 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID731595 | Induction of beta glucosidase N370S mutant activity in fibroblasts derived from Gaucher disease type 1 patient at 30 uM relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID1601618 | Activation of lysosomal beta-glucocerebrosidase L444P mutant in fibroblast cells derived from Gaucher's disease patient at 5 uM using PFB-FDGlu as substrate preincubated for 3 days followed by substrate addition and measured after 1 hr for every 20 mins i | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. |
| AID613042 | Inhibition of jack beans alpha-mannosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1884450 | Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate preincubated with enzyme for 10 mins followed by substrate addition by fluorescence spectrophotometry | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease. |
| AID577521 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 50 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID613043 | Inhibition of snail beta-mannosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1119120 | Inhibition of glucocerebrosidase N370S mutant in spleen homogenates of patient with Gaucher disease using resorufin-beta-D-glucopyranoside as substrate after 20 mins fluorescence assay | 2012 | MedChemComm, Jan, Volume: 3, Issue:1
| Non-iminosugar glucocerebrosidase small molecule chaperones. |
| AID1408922 | Inhibition of beta-galactosidase derived from human peripheral blood mononuclear cell lysate using 4-methylumbelliferyl beta-D-galactopyranoside as substrate after 2 hrs by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20
| 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations. |
| AID497872 | Inhibition of wild type Bacteroides thetaiotaomicron beta-mannosidase 2A expressed in Escherichia coli BL21 (DE3) at 37 degC and Ph 5.6 by 2,4-dinitrophenolate release assay | 2008 | Nature chemical biology, May, Volume: 4, Issue:5
| Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. |
| AID342796 | Inhibition of rat intestinal brush border membrane isomaltase at 1000 uM | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID342805 | Inhibition of rabbit muscle amylo-1,6-glucosidase | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID577336 | Increase of GCase trafficking to lysosomes in human fibroblast cells assessed as colocalization of Gcase with Lamp2 at 1 uM after 5 days by immunofluorescence method | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID577519 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 200 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID500311 | Increase in Gcase N370S mutant activity in human DMN89.15 fibroblast cell lysate assessed as 4-methylumbelliferone release after 5 days by fluorimetry | 2007 | Nature chemical biology, Feb, Volume: 3, Issue:2
| Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. |
| AID270949 | Inhibition of phosphorylated form of rat liver glycogen phosphorylase | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID613052 | Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID613047 | Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID342794 | Inhibition of rat intestinal brush border membrane maltase at 1000 uM | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID577518 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 300 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID270947 | Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID342803 | Inhibition of rabbit glycogen phosphorylase B | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID342813 | Increase in lysosomal beta-glucosidase N370S mutant activity in human Gaucher GM00372 fibroblast at 500 uM after 4 days | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID577522 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 25 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID263086 | Inhibition of Agrobacterium sp. beta-glucosidase | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8
| Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols. |
| AID577517 | Binding affinity to recombinant Gcase assessed as change in melting temperature at 400 uM by fluorescence thermal shift technique | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID1601620 | Induction of post-ER GCase activity in fibroblast cells harboring N370S/84GG double mutant derived from Gaucher's disease patient at 25 uM using PFB-FDGlu as substrate preincubated for 3 days followed by substrate addition and measured after 1 hr for ever | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. |
| AID1408919 | Inhibition of alpha-glucosidase derived from human peripheral blood mononuclear cell lysate using 4-methylumbelliferyl alpha-D-glucopyranoside as substrate after 2 hrs by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20
| 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations. |
| AID613031 | Inhibition of rice alpha-glucosidase assessed as production of D-glucose using maltose as substrate at 1000 uM after 10 to 30 mins by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID613045 | Inhibition of Penicillium decumbens alpha-L-rhamnosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID577331 | Increase of GCase N370S mutant trafficking to lysosomes in human fibroblast cells assessed as colocalization of Gcase with Lamp2 at 10 uM after 5 days by immunofluorescence method | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID342973 | Inhibition of glucagon-stimulated glycogen degradation in hepatocytes | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID613044 | Inhibition of bovine epididymis alpha-L-fucosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID577513 | Inhibition of alpha-glucosidase | 2011 | Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. |
| AID500312 | Induction of Gcase N370S mutant distribution in human DMN89.15 fibroblast cells at 100 uM after 5 days by antibody staining based laser scanning confocal microscopy | 2007 | Nature chemical biology, Feb, Volume: 3, Issue:2
| Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. |
| AID342798 | Inhibition of rat intestinal brush border membrane sucrase at 1000 uM | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID613048 | Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID1119122 | Induction of glucocerebrosidase N370S mutant translocation in fibroblasts of patient with Gaucher disease assessed as co-localization of LAMP-1 in lysosomes at 1 uM after 5 days by laser scanning confocal microscopic analysis | 2012 | MedChemComm, Jan, Volume: 3, Issue:1
| Non-iminosugar glucocerebrosidase small molecule chaperones. |
| AID342814 | Inhibition of liver glycogen phosphorylase A | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. |
| AID270957 | Inhibition of glycogen degradation in hepatocytes | 2006 | Journal of medicinal chemistry, Sep-21, Volume: 49, Issue:19
| Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. |
| AID1408924 | Cytotoxicity against human GM02456 fibroblasts after 5 days by MTT assay | 2018 | Bioorganic & medicinal chemistry, 11-01, Volume: 26, Issue:20
| 4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations. |
| AID613049 | Inhibition of almond beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors. |
| AID731609 | Induction of beta glucosidase N370S mutant activity in fibroblast derived from Gaucher disease patient at 10 uM relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID1601621 | Induction of post-ER GCase level in fibroblast cells harboring N370S/84GG double mutant derived from Gaucher's disease patient at 25 uM by immunoblotting analysis | 2019 | Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
| Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. |
| AID1799390 | Btman2A from Article 10.1038/nchembio.81: \\Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.\\ | 2008 | Nature chemical biology, May, Volume: 4, Issue:5
| Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. |
| AID1799775 | Inhibition Assay from Article 10.1074/jbc.M111.280362: \\Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis.\\ | 2011 | The Journal of biological chemistry, Oct-14, Volume: 286, Issue:41
| Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |