Page last updated: 2024-09-27

Diffuse Neurofibrillary Tangles with Calcification

A form of presenile DEMENTIA characterized by cortical dementia, NEUROFIBRILLARY TANGLES without SENILE PLAQUES, Fahr's type CALCINOSIS, and ATROPHY in frontotemporal or TEMPORAL LOBE.

Synonyms(2)

Synonym
Diffuse Neurofibrillary Tangles with Calcification
Kosaka-Shibayama Disease

Research

Studies (2)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's2 (100.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
risperidone0low10
alpha-synuclein0low10

Protein Targets (96)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, JmjC domain-containing histone demethylation protein 3A1001
acetylcholinesterase1001
thioredoxin reductase1001
TDP1 protein1001
AR protein1001
Smad31001
thyroid stimulating hormone receptor1001
EWS/FLI fusion protein1001
estrogen-related nuclear receptor alpha1001
estrogen nuclear receptor alpha1001
cytochrome P450 2D61001
thyroid stimulating hormone receptor1001
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 31001
nuclear factor erythroid 2-related factor 2 isoform 11001
peripheral myelin protein 221001
survival motor neuron protein isoform d1001
muscarinic acetylcholine receptor M11001
Solute carrier family 22 member 20101
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Voltage-dependent calcium channel gamma-2 subunit1001
Bile salt export pump0101
Albumin0011
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
ATP-dependent translocase ABCB10001
Cytochrome P450 3A40101
5-hydroxytryptamine receptor 1A0123
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0202
Cytochrome P450 2D60101
Muscarinic acetylcholine receptor M10101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
Glutamate receptor 21001
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(4) dopamine receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Glycine receptor subunit alpha-10011
Alpha-1D adrenergic receptor0101
Sodium-dependent dopamine transporter0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 60101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Spike glycoprotein1001
D(2) dopamine receptor0101
D(2) dopamine receptor0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Transporter0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Canalicular multispecific organic anion transporter 10101
Multidrug and toxin extrusion protein 10101
Transporter0101
Histamine H3 receptor0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]