Tay-Sachs Disease

An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry.

Synonym
Tay-Sachs Disease

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	142 (50.71)	23.3326
1990's	67 (23.93)	12.5806
2000's	34 (12.14)	18.1394
2010's	27 (9.64)	28.8240
2020's	10 (3.57)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
cytosine	low	1	0
diacetyl	low	1	0
dimethyl sulfoxide	low	1	0
formaldehyde	low	2	0
glycine	low	4	0
glycerol	low	1	0
imidazole	low	2	0
taurine	low	1	0
thymine	low	1	0
urea	low	1	0
1-anilino-8-naphthalenesulfonate	low	2	0
chloroquine	low	1	0
flumazenil	low	1	0
lorazepam	low	1	0
potassium chloride	low	1	0
propranolol	low	1	0
serine	low	1	0
aspartic acid	low	3	0
galactose	low	1	0
tyrosine	low	1	0
1,2-dipalmitoylphosphatidylcholine	low	1	0
phenylalanine	low	1	0
chloroform	low	1	0
histidine	low	4	0
arginine	low	4	0
methyl iodide	low	1	0
taurocholic acid	low	2	0
4-phenylenediamine	low	1	0
2-naphthol	low	1	0
thiazoles	low	2	0
phenylglyoxal	low	1	0
pyrithioxin	low	1	0
potassium hydroxide	low	1	0
tocopherols	low	1	0
digoxigenin	low	1	0
fucose	low	1	0
mannose	low	1	0
dithiothreitol	low	1	0
silver	low	1	0
acetylglucosamine	low	12	0
galactosamine	low	1	0
ammonium chloride	low	2	0
1-deoxynojirimycin	medium	9	1
daunorubicin	low	1	0
cetylpyridinium chloride anhydrous	low	6	0
4-methoxyamphetamine	low	3	0
acetylgalactosamine	low	3	0
fomesafen	low	3	0
miglustat	medium	9	1
5-bromo-4-chloro-3-indoxyl phosphate	low	1	0
naphthalimides	low	1	0
naphthol as	low	1	0
leupeptin	low	1	0
4-methylumbelliferyl glucuronide	low	3	0
delta-tocopherol	low	1	0
1-methylhistidine	low	1	0
1-phenyl-2-decanoylamino-3-morpholino-1-propanol	low	1	0
4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside	low	4	0
sulforhodamine 101	low	1	0
celastrol	low	1	0
4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-glucopyranoside	low	11	0
biotin	low	2	0
2-(2-oxolanylmethyl)benzo[de]isoquinoline-1,3-dione	low	1	0
leupeptins	low	2	0
n-acetylneuraminic acid	low	4	0
mannose-6-phosphate	low	2	0
glucosamine	low	4	0
carnosine	low	1	0
n-acetylglucosamine-6-sulfate	low	2	0
keratan sulfate	low	3	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
curcumin	low	1	0
D-fructopyranose	low	2	0
sodium taurodeoxycholate	low	1	0
nadp	low	1	0
lithium	low	1	0
dermatan sulfate	low	1	0
freedom	low	3	0
sodium borohydride	low	1	0
sphingosine	low	2	0
psychosine	low	1	0
hymecromone	low	14	0
genistein	low	1	0
n-acetylglucosamine thiazoline	low	2	0
phosphorus	low	1	0
dolichols	low	1	0
i(3)so3-galactosylceramide	low	1	0
g(m2) ganglioside	low	116	0
g(m1) ganglioside	low	18	0
cystathionine	low	1	0
alpha-synuclein	low	1	0
enerbol	low	2	0
acid phosphatase	low	6	0
nad	low	1	0
oligonucleotides	low	3	0
phosphatidylcholines	low	3	0
calpain	low	1	0
glycolipids	low	16	0
piperidines	low	1	0
chondroitin	low	2	0
globotriaosylceramide	low	1	0
g(m3) ganglioside	low	1	0
chondroitin sulfates	low	2	0
exudates	low	2	0
ganglio-n-triaosylceramide	low	2	0
guanine	low	4	0
cytidylyl-3'-5'-guanosine	low	1	0
eye	low	7	0
concanavalin a	low	4	0

Protein Targets (921)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	10	0	0	10
USP1 protein, partial	6	0	0	6
TDP1 protein	15	0	0	15
vitamin D3 receptor isoform VDRA	9	0	0	9
importin subunit beta-1 isoform 1	5	0	0	5
flap endonuclease 1	8	0	0	8
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	13	0	0	13
DNA polymerase kappa isoform 1	8	0	0	8
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	2	1	3
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
glucocerebrosidase	7	0	0	7
Alpha-mannosidase	0	2	0	2
alpha-galactosidase	5	0	0	5
Trehalase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	4	0	4
Trehalase	0	2	0	2
Lysosomal acid glucosylceramidase	0	4	0	4
Alpha-galactosidase A	0	1	0	1
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Lysosomal alpha-glucosidase	0	4	0	4
Beta-glucosidase A	0	1	0	1
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1B adrenergic receptor	0	4	1	5
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1D adrenergic receptor	0	3	1	4
Beta-glucosidase	0	1	0	1
Protein-lysine 6-oxidase	0	4	0	4
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	2	0	2
Glycogen debranching enzyme	0	1	0	1
Alpha-glucosidase MAL32	0	2	0	2
Alpha-1A adrenergic receptor	0	4	1	5
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	2	0	2
Oxysterols receptor LXR-beta	0	2	0	2
Spike glycoprotein	5	1	1	7
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Oxysterols receptor LXR-alpha	0	2	0	2
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	2	0	2
Lysosomal acid glucosylceramidase	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	2	0	2
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	2	0	2
Putative alpha-glucosidase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	5	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
Beta-hexosaminidase subunit alpha	0	4	0	5
Luciferase	10	0	0	10
RAR-related orphan receptor gamma	17	0	0	17
GLI family zinc finger 3	17	0	0	17
AR protein	17	0	0	17
estrogen receptor 2 (ER beta)	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
progesterone receptor	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
retinoid X nuclear receptor alpha	14	0	0	14
pregnane X nuclear receptor	12	0	0	12
estrogen nuclear receptor alpha	21	0	0	21
peroxisome proliferator-activated receptor delta	11	0	0	11
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	12	0	0	12
thyroid hormone receptor beta isoform 2	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
DNA repair and recombination protein RadA	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Cellular tumor antigen p53	13	0	0	13
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Sulfotransferase 1A1	0	0	0	1
Glutamate receptor 2	11	0	0	11
Cytochrome P450 2A5	0	1	0	1
Sulfotransferase 1E1	0	0	0	1
Sulfotransferase 1A1	0	0	0	1
Sulfotransferase 2A1	0	0	0	1
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	5	2	8
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
mitogen-activated protein kinase 1	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
acetylcholinesterase	8	0	0	8
Microtubule-associated protein tau	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
glucocorticoid receptor [Homo sapiens]	12	0	0	12
estrogen-related nuclear receptor alpha	17	0	0	17
farnesoid X nuclear receptor	7	0	0	7
G	6	0	0	6
cytochrome P450 2D6	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
thyroid stimulating hormone receptor	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
peripheral myelin protein 22	8	0	0	8
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Inositol hexakisphosphate kinase 1	6	0	0	6
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	11	0	0	11
cytochrome P450 2C9, partial	6	0	0	6
Fibrinogen C domain-containing protein 1	0	1	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	4	0	5
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
heat shock protein beta-1	5	0	0	5
tumor susceptibility gene 101 protein	2	0	0	2
lamin isoform A-delta10	13	0	0	13
Bile salt export pump	0	6	0	7
Cyclin-dependent kinase 1	0	2	0	2
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
TAR DNA-binding protein 43	3	0	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	7	0	0	7
NFKB1 protein, partial	2	0	0	2
GLS protein	6	0	0	6
thyroid stimulating hormone receptor	5	0	0	5
cytochrome P450 2C19 precursor	6	0	0	6
chromobox protein homolog 1	8	0	0	8
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	7	0	0	7
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Ferritin light chain	7	0	0	7
arylsulfatase A	6	0	0	6
Bloom syndrome protein isoform 1	6	0	0	6
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	2	0	8
Carbonic anhydrase 2	0	2	0	8
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	3	1	7
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2B	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
Carbonic anhydrase 4	0	0	0	3
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
Proteasome subunit beta type-11	0	1	0	1
Fumarate hydratase	3	0	0	3
PPM1D protein	5	0	0	5
EWS/FLI fusion protein	7	0	0	8
polyprotein	3	0	0	3
survival motor neuron protein isoform d	5	0	0	5
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Cathepsin B	0	3	0	3
Replicase polyprotein 1ab	0	5	2	7
Replicase polyprotein 1ab	0	5	2	7
Aromatase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	4	0	4
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	2	0	2
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	3	0	0	3
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C9 precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Carbonic anhydrase 4	0	1	0	5
Histamine H2 receptor	6	1	0	8
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
L-ornithine N(5)-monooxygenase	0	1	1	2
Telomerase reverse transcriptase	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L1	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L3	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	2
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase epsilon	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	1
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	0	1	0	1
Heat shock factor protein 1	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Receptor-type tyrosine-protein phosphatase eta	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Regulator of G-protein signaling 17	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 15	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L5	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	4	0	0	4
67.9K protein	4	0	0	4
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
caspase-3	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
activating transcription factor 6	8	0	0	8
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-2	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
interleukin 8	2	0	0	2
Nuclear receptor ROR-gamma	5	0	0	5
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	6	0	6
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	2	0	3
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	2	1	3
Muscarinic acetylcholine receptor M2	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	3	2	6
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	1	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	4
Alpha-2C adrenergic receptor	0	3	2	6
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	1	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	2	0	2
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	2	0	2
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	2	0	2
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Cruzipain	3	0	0	3
Nrf2	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	3	0	0	3
ATAD5 protein, partial	5	0	0	5
alkaline phosphatase, intestinal	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
PINK1	1	0	0	1
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
toll-like receptor 9	0	1	0	1
IDH1	7	0	0	7
TPA: protein transporter TIM10	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
thyroid hormone receptor beta isoform a	6	0	0	6
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
huntingtin isoform 2	3	0	0	3
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
hypothetical protein SA1422	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	6	3	1	10
Prostaglandin E synthase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Histone deacetylase 3	0	1	0	1
Acetylcholinesterase	0	3	0	3
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Integrin beta-3	4	0	0	4
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Cholinesterase	0	2	0	2
Heme oxygenase 1	0	1	0	1
Integrin alpha-IIb	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	6	3	1	10
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	6	3	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	6	3	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	6	3	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	6	3	1	10
Amine oxidase [flavin-containing] A	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Acetylcholinesterase	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	6	3	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	6	3	1	10
Heme oxygenase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	6	3	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	6	3	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	6	3	1	10
Prostaglandin G/H synthase 2	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	2	0	2
Alpha-synuclein	1	1	1	3
Glycogen synthase kinase-3 beta	0	1	0	1
Caspase-7	2	0	0	2
Histone deacetylase 4	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	3	1	10
Gamma-aminobutyric acid receptor subunit beta-3	6	3	1	10
Gamma-aminobutyric acid receptor subunit beta-2	6	3	1	10
Cholinesterase	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	3	0	3
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	2	1	4
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	1	0	1
GABA theta subunit	6	3	1	10
Histone deacetylase 2	0	2	0	2
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	6	3	1	10
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Histone deacetylase 5	0	1	0	1
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Caspase-7	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
caspase-3	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
ATP-dependent translocase ABCB1	0	3	1	5
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	2	0	3
Reverse transcriptase/RNaseH	0	1	0	1
Thrombopoietin	3	0	0	3
D(1A) dopamine receptor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	4	0	4
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Albumin	0	0	2	2
Tryptophan 5-hydroxylase 1	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	1	3
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 2A	0	5	1	6
Histamine H1 receptor	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Cytochrome P450 2J2	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
Transporter	0	2	0	2
Histamine H3 receptor	0	1	0	1
endonuclease IV	3	0	0	3
Cocaine esterase	0	1	0	1
Coagulation factor XII	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Chain A, DigA16	0	0	1	1
Chain A, DigA16	0	0	1	1
PAX8	0	0	0	1
glp-1 receptor, partial	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
regulator of G-protein signaling 4	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Bile salt export pump	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
BRCA1	1	0	0	1
Neuraminidase	0	1	0	1
P53	1	0	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Steroid hormone receptor ERR2	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Estrogen receptor	0	2	1	3
Glucocorticoid receptor	0	0	0	1
Sex hormone-binding globulin	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Androgen receptor	0	1	0	2
Sialidase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Tyrosinase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Cyclin-dependent kinase 4	0	1	0	1
Ornithine decarboxylase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Androgen receptor	0	1	0	1
Protein kinase C alpha type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Cruzipain	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	1	5
Adenosine receptor A2a	0	3	1	4
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	1	0	4
Substance-P receptor	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
Acetylcholinesterase	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Tyrosine-protein kinase CSK	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Aldehyde oxidase	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Estrogen receptor beta	0	2	1	3
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Dipeptidyl peptidase 3	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
Sialidase-2	0	2	0	2
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	1	0	4
Plasma kallikrein	0	1	0	4
Carbonic anhydrase 3	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	0	0	3
Adenosine receptor A1	0	0	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 7	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	3	0	3
Carbonic anhydrase 9	0	2	0	5
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 15	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	0	0	3
GALC protein	3	0	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Genome polyprotein	0	1	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Epoxide hydrolase 1	0	0	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	0	1	1
Cytochrome P450 1B1	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Cathepsin B	0	1	0	1
Prothrombin	0	1	0	1
Plasminogen	0	1	0	1
Cationic trypsin	0	1	0	1
Trypsin	0	1	0	1
Papain	0	1	0	1
Serine protease hepsin	0	1	0	1
Plasminogen	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Cathepsin B	0	1	0	1
Pro-cathepsin H	0	1	0	1
Trypsin-3	0	1	0	1
Calpain-1 catalytic subunit	0	1	0	1
Hepatocyte growth factor activator	0	1	0	1
Transmembrane protease serine 6	0	1	0	1
Cysteine protease	0	1	0	1
Cysteine protease falcipain-3	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Translocator protein	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Sucrase-isomaltase	0	1	0	1
Ceramide glucosyltransferase	0	1	0	1
Beta-galactosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	1	0	1
Chain A, Beta-n-acetylhexosaminidase	0	1	0	1
Chain A, N-acetyl-beta-D-glucosaminidase	0	1	0	1
Chain A, ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D	0	0	1	1
Protein O-GlcNAcase	0	1	0	1
Beta-N-acetylhexosaminidase	0	1	0	1
Beta-hexosaminidase subunit beta	0	2	0	2
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain A, Cholix toxin	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Adenosine receptor A3	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
D(1A) dopamine receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	0	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
streptokinase A precursor	0	0	2	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Estrogen receptor	0	0	2	2
Dihydrofolate reductase	0	2	1	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	2	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/bile acid cotransporter	0	1	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	3
Ileal sodium/bile acid cotransporter	0	2	0	3
G-protein coupled bile acid receptor 1	0	0	2	2
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Solute carrier family 22 member 6	0	1	0	1
ATP-binding cassette sub-family C member 3	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research

Studies (280)

Protein Targets (921)

Tay-Sachs Disease

Synonyms(1)

Research

Studies (280)

Drugs Studied (146)

Protein Targets (921)