Compounds > 4'-diethylamino-3-hydroxyflavone
Page last updated: 2024-11-12

4'-diethylamino-3-hydroxyflavone

Description

4'-diethylamino-3-hydroxyflavone: an extrinsic multiple-emission probe; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID12088189
CHEMBL ID3343021
SCHEMBL ID19833677
MeSH IDM0240064

Synonyms (11)

Synonym
146680-78-6
4h-1-benzopyran-4-one, 2-[4-(diethylamino)phenyl]-3-hydroxy-
DTXSID80477337
CHEMBL3343021
SCHEMBL19833677
4'-(diethylamino)-3-hydroxyflavone
2-[4-(diethylamino)phenyl]-3-hydroxychromen-4-one
mfcd30555921
4'-diethylamino-3-hydroxyflavone
2-(4-(diethylamino)phenyl)-3-hydroxy-4h-chromen-4-one
2-[4-(diethylamino)phenyl]-3-hydroxy-4h-chromen-4-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID1166587Agonist activity at mouse MC4 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166599Agonist activity at human PTH receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166601Agonist activity at human NPY5 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166589Agonist activity at human NMU1 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166598Agonist activity at human A3 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166585Agonist activity at mouse MC2 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166582Agonist activity at human MC3 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166586Agonist activity at mouse MC3 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166602Agonist activity at human Glu receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166592Agonist activity at human MCH1 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166595Agonist activity at human D5 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166600Agonist activity at human C5a receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166579Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166583Agonist activity at human MC4 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166597Agonist activity at human A2a receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166590Agonist activity at human 5HT2C receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166594Agonist activity at human D1 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166584Agonist activity at mouse MC1 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166588Agonist activity at mouse MC5 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166593Agonist activity at human M1 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166591Agonist activity at human orexin 2 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166596Agonist activity at human A1 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166580Agonist activity at human MC1 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
AID1166581Agonist activity at human MC2 receptor at 100 uM to 5 mM2014Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's5 (50.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
synephrine
[no description available]		2.110ethanolamines;
phenethylamine alkaloid;
phenols		alpha-adrenergic agonist;
plant metabolite
tert-butylacrylamide
tert-butylacrylamide: structure in first source		2.0510
3-hydroxyflavone
3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.		2.4120flavonols;
monohydroxyflavone
n-isopropylacrylamide
N-isopropylacrylamide: can polymerize with glycidyl acrylate to form reactive water-soluble polymer that can react with the amino groups of enzymes-proteins or other ligands		2.0510
pyrene
pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.		2.0510ortho- and peri-fused polycyclic arenefluorescent probe;
persistent organic pollutant
3,3',4'-trihydroxyflavone
3',4'-dihydroxyflavonol: a neuroprotective agent		2.110hydroxyflavan
4'-hydroxyflavone
4'-hydroxyflavone: structure in first source		2.110
7-methoxyflavone
7-methoxyflavone: an aromatase inhibitor		2.0510ether;
flavonoids
3,4'-dihydroxyflavone
3,4'-dihydroxyflavone: an antioxidant; structure in first source		2.110
rutin
Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.		2.110disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
fisetin
[no description available]		1.98103'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
alpha-synuclein
alpha-Synuclein: A synuclein that is a major component of LEWY BODIES and plays a role in SYNUCLEINOPATHIES, neurodegeneration and neuroprotection.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Idiopathic Parkinson Disease
[description not available]		02.0510
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)		02.0510
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