alpha-synuclein and Attention-Deficit-Disorder-with-Hyperactivity

Studies have strongly suggested a disturbed regulation of dopaminergic neurotransmission in attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease (PD). A genetic and phenotypic overlap between both disorders is discussed. A well-studied risk gene for PD is the gene coding for α-synuclein (SNCA). α-Synuclein, a protein located primarily in the presynaptic vesicles, has been suggested to play a role in the modulation of dopamine transporter (DAT) function. DAT is the target of psychostimulants for the treatment of ADHD and plays a key role in regulating the dopamine concentrations in the synaptic cleft. In our sample consisting of German families with children affected by ADHD, we tested for association of allelic variants of two functionally relevant polymorphisms of the α-synuclein gene (NACP-Rep1: 156 families, 232 children; rs356219: 195 families, 284 children) with ADHD. Transmission disequilibrium test analysis revealed no over-transmission for NACP-Rep1 (OR 1, p

Topics: Alleles; alpha-Synuclein; Attention Deficit Disorder with Hyperactivity; Child; Dinucleotide Repeats; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Pilot Projects; Polymorphism, Single Nucleotide

Topics: alpha-Synuclein; Attention Deficit Disorder with Hyperactivity; Biogenic Amines; Diagnosis, Differential; Dystonia; Homozygote; Humans; Intellectual Disability; Molecular Chaperones; Parkinsonian Disorders; Phenylketonurias; Protein Aggregation, Pathological; Proteostasis; Repressor Proteins