Adult Neuroaxonal Dystrophy

A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)

Synonym
Neuroaxonal Dystrophies
Seitelberger's Disease
Neuroaxonal Dystrophy, Late Infantile
Neurodegeneration With Brain Iron Accumulation 2A
Neurodegeneration, PLA2G6-Associated
Seitelberger Disease
Infantile Neuroaxonal Dystrophy
NBIA2A
Juvenile Neuroaxonal Dystrophy
Neuroaxonal Dystrophy, Adult
Late Infantile Neuroaxonal Dystrophy
Neuroaxonal Dystrophy, Infantile
Neuroaxonal Dystrophy, Juvenile
Adult Neuroaxonal Dystrophy
NBIA, PLA2G6-Related

Excerpt	Reference
"As the diagnosis of infantile neuroaxonal dystrophy is made by a synopsis of various clinical, neuropathological, neurophysiological, and neuroradiological data, the presence of lactate in the basal ganglia spectra may help to narrow down the diagnosis and can support the decision to perform more invasive diagnostic procedures (such as biopsies of skin, conjunctiva or even of the brain)."	( Bornemann, A; Grodd, W; Krägeloh-Mann, I; Küker, W; Mader, I; Nägele, T; Seeger, U, 2001)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	29 (21.17)	23.3326
1990's	4 (2.92)	12.5806
2000's	18 (13.14)	18.1394
2010's	58 (42.34)	28.8240
2020's	28 (20.44)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	1
choline	low	2
creatine	low	2
lactic acid	low	2
dihydroxyphenylalanine	low	1
inositol	low	1
nitrites	low	1
4-aminobenzoic acid	low	1
palmitic acid	low	1
zopolrestat	low	1
3-methoxytyrosine	low	1
homovanillic acid	low	1
hydroxyindoleacetic acid	low	1
deferiprone	low	4
valproic acid	low	1
flumazenil	low	1
nimodipine	low	1
nitroglycerin	low	1
triclosan	low	1
chloramphenicol	low	1
aspartic acid	low	3
tetrabenazine	low	1
levodopa	low	1
tyrosine	low	1
leucine	low	1
cycloheximide	low	1
valine	low	1
arginine	low	1
pantothenic acid	low	1
quinoxalines	low	1
thiazoles	low	1
2-methylfuran	low	1
methoxyhydroxyphenylglycol	low	1
d-alpha tocopherol	low	7
streptomycin	low	1
manganese	low	1
silver	low	1
cetylpyridinium chloride anhydrous	low	8
glutamic acid	low	1
fomesafen	low	1
n-acetylaspartic acid	low	3
fluorodeoxyglucose f18	low	1
coenzyme a	low	3
cp-166,572	low	1
meropenem	low	1
retinol	low	1
cefoxitin	low	1
thiouracil	low	1
D-fructopyranose	low	1
ferrostatin-1	low	1
vitamin k semiquinone radical	low	1
4-hydroxy-2-nonenal	low	2
cysteine	low	1
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2h-pyran-2-one	low	1
i(3)so3-galactosylceramide	low	1
vitamin u	low	1
alpha-synuclein	low	4
enerbol	low	3
nad	low	1
neuropeptide y	low	1
c-peptide	low	1
glycolipids	low	1
ldn 57444	low	1
amyloid beta-peptides	low	1
levoleucovorin	low	3
folic acid	low	5
ganciclovir	low	1
5-methyltetrahydrofolate	low	4
liproxstatin-1	low	1
eye	low	3
leptin	low	1

Protein Targets (697)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
cellular tumor antigen p53 isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
Nuclear receptor ROR-gamma	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Genome polyprotein	0	0	1	1
USP1 protein, partial	12	0	0	12
AR protein	14	0	0	14
thyroid stimulating hormone receptor	8	0	0	8
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
estrogen nuclear receptor alpha	18	0	0	18
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
Histone H2A.x	4	0	0	4
chromobox protein homolog 1	10	0	0	10
transcriptional regulator ERG isoform 3	3	0	0	3
geminin	17	0	0	17
Polyphenol oxidase 2	0	1	0	3
Cellular tumor antigen p53	11	0	0	11
Thiopurine S-methyltransferase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Cytochrome P450 1B1	0	1	0	1
Dihydropteroate synthase	0	0	1	1
Microtubule-associated protein tau	7	0	0	7
vitamin D3 receptor isoform VDRA	9	0	0	9
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Chain A, Ferritin light chain	8	0	0	8
thioredoxin reductase	14	0	0	14
ATAD5 protein, partial	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
regulator of G-protein signaling 4	7	0	0	7
Parkin	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
Bloom syndrome protein isoform 1	8	0	0	8
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
mitogen-activated protein kinase 1	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
survival motor neuron protein isoform d	5	0	0	5
M-phase phosphoprotein 8	5	0	0	5
lamin isoform A-delta10	9	0	0	9
neuropeptide S receptor isoform A	4	0	0	4
Fatty-acid amide hydrolase 1	0	1	0	1
Amyloid-beta precursor protein	1	2	0	3
Alpha-synuclein	4	1	0	5
D(1A) dopamine receptor	1	0	0	1
Ataxin-2	5	0	0	5
ATP-dependent phosphofructokinase	5	0	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	8	0	0	8
NFKB1 protein, partial	4	0	0	4
GLS protein	10	0	0	10
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
flap endonuclease 1	4	0	0	4
DNA polymerase iota isoform a (long)	10	0	0	10
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	5	0	0	5
Cytochrome P450 3A4	0	1	0	2
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
arylsulfatase A	8	0	0	8
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	1	0	5
Carbonic anhydrase 2	0	1	0	5
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	6
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	1	6
Glutamate receptor ionotropic, NMDA 2B	0	3	1	6
Glutamate receptor ionotropic, NMDA 2C	0	3	1	6
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	3	1	6
Glutamate receptor ionotropic, NMDA 3B	0	3	1	6
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	6
acetylcholinesterase	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	6	0	0	6
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
TDP1 protein	13	0	0	13
GLI family zinc finger 3	7	0	0	7
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	6	0	0	6
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	15	0	0	15
farnesoid X nuclear receptor	7	0	0	7
67.9K protein	4	0	0	4
peroxisome proliferator-activated receptor delta	6	0	0	6
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
caspase-3	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
activating transcription factor 6	6	0	0	6
thyrotropin-releasing hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
thyroid hormone receptor beta isoform 2	7	0	0	7
heat shock protein beta-1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Glutamate receptor 2	6	2	1	9
Caspase-2	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
interleukin 8	3	0	0	3
EWS/FLI fusion protein	6	0	0	6
pregnane X nuclear receptor	6	0	0	6
G	7	0	0	7
cytochrome P450 2D6	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
streptokinase A precursor	0	0	2	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Bile salt export pump	0	11	0	11
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	7	0	0	7
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	7	0	0	7
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
Sorbitol dehydrogenase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	4
glp-1 receptor, partial	6	0	0	6
pregnane X receptor	3	0	0	3
Fumarate hydratase	5	0	0	5
PPM1D protein	2	0	0	2
Smad3	4	0	0	4
polyprotein	5	0	0	5
P53	1	0	0	1
RPL19A	0	0	1	1
IDH1	3	0	0	3
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
cytochrome P450 3A4 isoform 1	3	0	0	3
COUP transcription factor 2 isoform a	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	3	4	0	7
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	4	0	7
Gamma-aminobutyric acid receptor subunit delta	3	4	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	3	4	1	8
Gamma-aminobutyric acid receptor subunit alpha-5	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	3	4	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	3	4	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	3	4	0	7
Spike glycoprotein	3	0	1	4
Eukaryotic initiation factor 4A-I	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	4	1	8
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	3	4	0	7
Gamma-aminobutyric acid receptor subunit beta-2	3	4	1	8
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
TAR DNA-binding protein 43	6	0	0	6
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
GABA theta subunit	3	4	0	7
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	3	4	0	7
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
cytochrome P450 2C9 precursor	2	0	0	2
Lysine-specific demethylase 6A	0	1	0	1
Lysine-specific demethylase 4A	0	1	0	1
Lysine-specific demethylase 5C	0	1	0	1
Histamine H2 receptor	2	0	0	2
Lysine-specific demethylase 2B	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Lysine-specific demethylase 2A	0	1	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
endonuclease IV	5	0	0	5
15-lipoxygenase, partial	3	0	0	3
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
DNA polymerase kappa isoform 1	3	0	0	3
Epidermal growth factor receptor	0	2	0	2
Glutamate receptor 1	1	2	1	4
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Caspase-7	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Bile salt export pump	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	2	4
5-hydroxytryptamine receptor 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
glucocerebrosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Luciferase	3	0	0	3
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
D(1A) dopamine receptor	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peripheral myelin protein 22	7	0	0	7
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Thymidine kinase	0	1	0	1
ClpP	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
hypothetical protein, conserved	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
thyroid stimulating hormone receptor	3	0	0	3
Ubiquitin carboxyl-terminal hydrolase isozyme L1	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L3	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	4
Phospholipase A-2-activating protein	0	1	0	1
dopamine D1 receptor	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Carbonic anhydrase 12	0	0	0	2
Plasma kallikrein	0	0	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Carbonic anhydrase 3	0	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Tyrosinase	0	1	0	1
Carbonic anhydrase 4	0	1	0	3
Carbonic anhydrase 6	0	0	0	2
Adenosine receptor A1	0	0	0	2
Adenosine receptor A2a	0	1	0	3
Carbonic anhydrase 5A, mitochondrial	0	0	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 7	0	0	0	2
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase 9	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 15	0	1	0	3
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	2
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
phosphoglycerate kinase	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	1	2
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Chain A, Beta-lactamase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Adenosine receptor A3	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Bile acid receptor	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Acetylcholinesterase	0	1	0	1
Toll-like receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	1	3
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein 5	0	2	1	3
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Olfactory receptor 51E2	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	3
Protein-arginine deiminase type-4	0	2	0	2
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
PINK1	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Vpr	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Transthyretin	0	1	1	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C21	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Adult Neuroaxonal Dystrophy

Synonyms(15)

Research Excerpts

Overview

Research

Studies (137)

Protein Targets (697)

Adult Neuroaxonal Dystrophy

Synonyms(15)

Research Excerpts

Overview

Research

Studies (137)

Drugs Studied (81)

Protein Targets (697)