2-aminoindan profile

2-Aminoindan is a heterocyclic organic compound with a chemical formula of C9H11N. It has been studied for its potential as a building block for the synthesis of various bioactive compounds, including pharmaceuticals and agrochemicals. The compound has been shown to exhibit a range of biological activities, including anticancer, anti-inflammatory, and antibacterial effects. Its synthesis typically involves the reaction of indan with ammonia or an amine derivative under specific reaction conditions. The chemical structure of 2-aminoindan features an indan ring system with an amino group at the 2-position. This unique structural feature contributes to its potential biological activity and makes it a valuable target for further research and development. Research on 2-aminoindan focuses on exploring its synthetic methods, studying its biological activities, and investigating its potential therapeutic applications. '

ID Source	ID
PubMed CID	76310
CHEMBL ID	1188176
SCHEMBL ID	6941
MeSH ID	M0049157

Synonym
AC-19107
BB 0253376
1p810sq3ey ,
einecs 221-021-3
unii-1p810sq3ey
2,3-dihydro-1h-inden-2-ylamine
1h-inden-2-amine, 2,3-dihydro-
SDCCGMLS-0066231.P001
STK501404
2-aminoindan, 97%
2975-41-9
2,3-dihydro-1h-inden-2-amine
2-indanamine
AKOS000321317
2-aminoindan ,
indan-2-amine
2-aminoindane
CHEMBL1188176
2-indanylamine
PS-4613
indane-2-ylamine
AB03106
indan-2-ylamine
rac fenfluramine-d5 hydrochloride
indan-2-yl-amine
2-amino-indane
2-ammo-indane
SCHEMBL6941
xm0 ,
W-106974
j80.606d ,
2-amino-2,3-dihydro-1h-indene
2-ai
(2,3-dihydro-1h-inden-2-yl)amine
STR09579
F0001-0920
DTXSID40183902
2-amineindane
1216927-29-5
2-amino indane
Q4596856
SB36446
EN300-63836
PD048215
mfcd00082597

Excerpt	Reference	Relevance
" In the light of these observations, we have determined MEAI's pharmacokinetic (PK) profile in rats and evaluated in-vitro its pharmacodynamics (PD) profile."	( Pharmacokinetic and pharmacodynamic evaluation of 5-methoxy-2-aminoindane (MEAI): A new binge-mitigating agent. Ben Ari, Y; Gal, O; Golan, E; Shimshoni, JA; Sobol, E, 2018)	0.72
" Lastly, we perform a pharmacokinetic study on mice blood samples, highlighting that the main active metabolite of NM2AI is 2-aminoindane (2AI)."	( Behavioral and Pharmacokinetics Studies of Arfè, R; Bernardi, T; Bilel, S; Boccuto, F; Corli, G; Marchetti, B; Marti, M; Mestria, S; Odoardi, S; Strano-Rossi, S; Tirri, M, 2023)	1.12

Excerpt	Reference	Relevance
" At 10 mg/kg, MEAI displayed low oral bioavailability (25%) and a plasma to brain ratio in the range of 3-5."	( Pharmacokinetic and pharmacodynamic evaluation of 5-methoxy-2-aminoindane (MEAI): A new binge-mitigating agent. Ben Ari, Y; Gal, O; Golan, E; Shimshoni, JA; Sobol, E, 2018)	0.72

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (23.08)	18.7374
1990's	3 (11.54)	18.2507
2000's	1 (3.85)	29.6817
2010's	12 (46.15)	24.3611
2020's	4 (15.38)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.85%)	6.00%
Case Studies	2 (7.69%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (88.46%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzocaine Benzocaine: A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.. dextran sulfate sodium : An organic sodium salt of dextran sulfate. It induces colitis in mice.. benzocaine : A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.	2.1	1	benzoate ester; substituted aniline	allergen; antipruritic drug; sensitiser; topical anaesthetic
amphetamine Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.. 1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.. amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.	2.21	1	primary amine
adtn ADTN: RN given refers to parent cpd without isomeric designation; structure	1.96	1
spiperone Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.. spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.	1.96	1	aromatic ketone; azaspiro compound; organofluorine compound; piperidines; tertiary amino compound	alpha-adrenergic antagonist; antipsychotic agent; dopaminergic antagonist; psychotropic drug; serotonergic antagonist
apomorphine Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.	2.04	1	aporphine alkaloid	alpha-adrenergic drug; antidyskinesia agent; antiparkinson drug; dopamine agonist; emetic; serotonergic drug
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	1.97	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
benzo(f)quinoline [no description available]	1.96	1
1,2,3,4-tetrahydroisoquinoline 1,2,3,4-tetrahydroisoquinoline: RN given refers to cpd with locants as specified	1.97	1	isoquinolines
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.11	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
methamphetamine Methamphetamine: A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.. methamphetamine : A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.	2.52	2	amphetamines; secondary amine	central nervous system stimulant; environmental contaminant; neurotoxin; psychotropic drug; xenobiotic
1-aminotetralin 1-aminotetralin: RN given refers to parent cpd	1.96	1
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.11	1	metal allergen; nickel group element atom; platinum group metal atom
selegiline Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl.	2.49	2	selegiline; terminal acetylenic compound	geroprotector
alkenes [no description available]	2.11	1
2-aminotetralin 2-aminotetralin: RN given refers to parent cpd without isomeric designation; structure	8.06	5	tetralins
cathinone cathinone: alkaloid from khat shrub, Catha edulis; RN given refers to parent cpd without isomeric designation. cathinone : The S stereoisomer of 2-aminopropiophenone.	1.96	1	2-aminopropiophenone; monoamine alkaloid	central nervous system stimulant; psychotropic drug
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	1.96	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
1-aminoindan [no description available]	2.4	2
5,6-methylenedioxy-2-aminoindane 5,6-methylenedioxy-2-aminoindane: structure given in first source	2.1	1	benzodioxoles
beta-lactams 2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.	2.13	1	beta-lactam antibiotic allergen; beta-lactam
rasagiline [no description available]	3.86	3	indanes; secondary amine; terminal acetylenic compound	EC 1.4.3.4 (monoamine oxidase) inhibitor; neuroprotective agent
alpha-synuclein alpha-Synuclein: A synuclein that is a major component of LEWY BODIES and plays a role in SYNUCLEINOPATHIES, neurodegeneration and neuroprotection.	2.11	1

Condition	Relationship Strength	Studies
Binge Alcohol Consumption [description not available]	2.57	2
Chemical Dependence [description not available]	2.1	1
Cyanosis A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule.	2.1	1
Methemoglobinemia The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)	2.1	1
Substance-Related Disorders Disorders related to substance use or abuse.	2.1	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.15	1
Idiopathic Parkinson Disease [description not available]	2.97	1
Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	2.97	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.37	2

2-aminoindan

Cross-References

Synonyms (45)

Research Excerpts

Pharmacokinetics

Bioavailability

Research

Studies (26)

Market Indicators

Research Demand Index: 48.06

Study Types