alpha-synuclein and 1-2-dielaidoylphosphatidylethanolamine

alpha-synuclein has been researched along with 1-2-dielaidoylphosphatidylethanolamine* in 1 studies

Other Studies

1 other study(ies) available for alpha-synuclein and 1-2-dielaidoylphosphatidylethanolamine

Article	Year
An aminoglycoside antibiotic inhibits both lipid-induced and solution-phase fibrillation of α-synuclein in vitro. Chemical communications (Cambridge, England), 2019, Sep-21, Volume: 55, Issue:74 Parkinson's disease (PD), closely associated with the misfolding and aggregation of the neuronal protein α-synuclein (A-Syn), is a neurodegenerative disorder with no cure to date. Here, we show that the commercially available, inexpensive, aminoglycoside antibiotic kanamycin effectively inhibits both lipid-induced and solution-phase aggregation of A-Syn in vitro, pointing towards the prospective repurposing of kanamycin as a potential anti-PD drug. Topics: alpha-Synuclein; Anti-Bacterial Agents; Cell Line, Tumor; Humans; Kanamycin; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Protein Binding; Protein Conformation; Protein Multimerization; Unilamellar Liposomes	2019

Article

Year

An aminoglycoside antibiotic inhibits both lipid-induced and solution-phase fibrillation of α-synuclein in vitro.

Chemical communications (Cambridge, England), 2019, Sep-21, Volume: 55, Issue:74

Parkinson's disease (PD), closely associated with the misfolding and aggregation of the neuronal protein α-synuclein (A-Syn), is a neurodegenerative disorder with no cure to date. Here, we show that the commercially available, inexpensive, aminoglycoside antibiotic kanamycin effectively inhibits both lipid-induced and solution-phase aggregation of A-Syn in vitro, pointing towards the prospective repurposing of kanamycin as a potential anti-PD drug.

Topics: alpha-Synuclein; Anti-Bacterial Agents; Cell Line, Tumor; Humans; Kanamycin; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Protein Binding; Protein Conformation; Protein Multimerization; Unilamellar Liposomes

2019