alpha-synuclein and Sepsis

alpha-synuclein has been researched along with Sepsis* in 2 studies

Other Studies

2 other study(ies) available for alpha-synuclein and Sepsis

Article	Year
Infections or Sepsis Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study. Movement disorders : official journal of the Movement Disorder Society, 2020, Volume: 35, Issue:9 Several studies have proposed a role for infections to induce an inflammatory response triggering Parkinson's disease. This remains controversial and the influence of severe infections on other α-synucleinopathies (Dementia with Lewy Bodies, Parkinson's disease dementia, and Multiple System Atrophy) has not been adequately investigated.. To assess the association between hospitalization-required infections or sepsis and risk of clinically diagnosed α-synucleinopathies.. Using the medical records-linkage system (Rochester Epidemiology Project), we identified all α-synucleinopathy cases of in Olmsted County (1991-2010). Cases were matched by symptom-onset age and sex to controls. We reviewed complete medical records to detect hospital-required infections or sepsis preceding clinical-motor onset of α-synucleinopathies. We used conditional logistic regression to calculate the odds ratio of all α-synucleinopathies, adjusting for medications, coffee, and smoking.. There was no association between infection-related hospitalization (odds ratio: 1.05; 95% confidence interval: 0.78-1.40; P = 0.76) or sepsis (odds ratio: 0.86; 95% confidence interval: 0.40-1.85; P = 0.70) and all α-synucleinopathies in multivariable analyses. We did not identify any associations after stratifying for type of α-synucleinopathy, sex, and age at clinical-motor onset. We analyzed sepsis separately with similar results.. We did not observe any associations between infections leading to hospitalization or sepsis and development of any α-synucleinopathies. © 2020 International Parkinson and Movement Disorder Society. Topics: alpha-Synuclein; Case-Control Studies; Humans; Lewy Body Disease; Minnesota; Sepsis; Synucleinopathies	2020
Science translational medicine, 2019, 09-25, Volume: 11, Issue:511 Variants in the leucine-rich repeat kinase-2 ( Topics: Alleles; alpha-Synuclein; Animals; Brain; Chemotaxis; Encephalitis; Female; Humans; Infections; Inflammation; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Leukocytes; Male; Mice, Inbred C57BL; Mutation; Reactive Oxygen Species; Reoviridae; Salmonella typhimurium; Sepsis; Sex Characteristics; Survival Analysis	2019

Article

Year

Infections or Sepsis Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study.

Movement disorders : official journal of the Movement Disorder Society, 2020, Volume: 35, Issue:9

Several studies have proposed a role for infections to induce an inflammatory response triggering Parkinson's disease. This remains controversial and the influence of severe infections on other α-synucleinopathies (Dementia with Lewy Bodies, Parkinson's disease dementia, and Multiple System Atrophy) has not been adequately investigated.. To assess the association between hospitalization-required infections or sepsis and risk of clinically diagnosed α-synucleinopathies.. Using the medical records-linkage system (Rochester Epidemiology Project), we identified all α-synucleinopathy cases of in Olmsted County (1991-2010). Cases were matched by symptom-onset age and sex to controls. We reviewed complete medical records to detect hospital-required infections or sepsis preceding clinical-motor onset of α-synucleinopathies. We used conditional logistic regression to calculate the odds ratio of all α-synucleinopathies, adjusting for medications, coffee, and smoking.. There was no association between infection-related hospitalization (odds ratio: 1.05; 95% confidence interval: 0.78-1.40; P = 0.76) or sepsis (odds ratio: 0.86; 95% confidence interval: 0.40-1.85; P = 0.70) and all α-synucleinopathies in multivariable analyses. We did not identify any associations after stratifying for type of α-synucleinopathy, sex, and age at clinical-motor onset. We analyzed sepsis separately with similar results.. We did not observe any associations between infections leading to hospitalization or sepsis and development of any α-synucleinopathies. © 2020 International Parkinson and Movement Disorder Society.

Topics: alpha-Synuclein; Case-Control Studies; Humans; Lewy Body Disease; Minnesota; Sepsis; Synucleinopathies

2020

Science translational medicine, 2019, 09-25, Volume: 11, Issue:511

Variants in the leucine-rich repeat kinase-2 (

Topics: Alleles; alpha-Synuclein; Animals; Brain; Chemotaxis; Encephalitis; Female; Humans; Infections; Inflammation; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Leukocytes; Male; Mice, Inbred C57BL; Mutation; Reactive Oxygen Species; Reoviridae; Salmonella typhimurium; Sepsis; Sex Characteristics; Survival Analysis

2019