Generalized Vulvodynia

Complex pain syndrome with unknown etiology, characterized by constant or intermittent generalized vulva pain (Generalized vulvodynia) or localized burning sensations in the VESTIBULE area when pressure is applied (Vestibulodynia, or Vulvar Vestibulitis Syndrome). Typically, vulvar tissue with vulvodynia appears normal without infection or skin disease. Vulvodynia impacts negatively on a woman's quality of life as it interferes with sexual and daily activities.

Synonym
Generalized Vulvodynia
Vulvodynia
Vestibulodynia

Excerpt	Reference
"Vulvodynia is a genital pain syndrome occurring in 7% to 8% of women."	( Edwards, L, 2015)
"Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset."	( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015)
"Vulvodynia is a poorly understood, prevalent, and serious women's health issue requiring better understanding to improve therapy."	( Bonham, AD; Falsetta, ML; Foster, DC; Phipps, RP, 2017)
"Vulvodynia is a common and debilitating disease, for which treatments are often of limits efficacy."	( Cardaillac, C; Labat, JJ; Levesque, A; Ploteau, S; Riant, T, 2016)
"Vestibulodynia is a form of provoked vulvodynia characterized by profound tenderness, hyperinnervation, and frequently inflammation within well-defined areas of the human vestibule."	( Bhattacherjee, A; Chakrabarty, A; Goestch, M; Leclair, CM; Liao, Z; Mu, Y; Smith, PG, 2017)
"Vulvodynia is a remarkably prevalent chronic pain condition of unknown etiology."	( Benck, CJ; Boo, B; Chatterjea, D; Daughters, R; Dhanwada, J; Fife, BT; Kline, J; Landry, J; Martinov, T; Mengistu, H; Swanson, L; Tonc, E, 2017)
"Vestibulodynia is characterized by perivaginal mechanical hypersensitivity, hyperinnervation, and abundant inflammatory cells expressing renin-angiotensin system proteins."	( Chakrabarty, A; Liao, Z; Mu, Y; Smith, PG, 2018)
"Vulvodynia is common and characterized by vulvar discomfort and pain."	( Harlow, BL; Klann, AM; Parker, SE; Rosenberg, J; Wang, T, 2019)
"Vulvodynia is a remarkably prevalent chronic pain condition of unknown etiology."	( Arriaga-Gomez, E; Boo, B; Chatterjea, D; Emanuel, E; Fife, BT; Joo, S; Kamath, R; Landry, J; Martinov, T; Saldías Montivero, M, 2019)
"Provoked vestibulodynia is the most common subtype of chronic vulvar pain."	( Bergeron, S; Dubois, MF; Dumoulin, C; Khalifé, S; Mayrand, MH; Morin, M; Waddell, G, 2021)
"Vulvodynia is a chronic clinical condition associated with vulvar pain that can impair the sexual, social, and psychological life of women."	( Jo, S; Murthy, SN; Rangappa, S; Repka, MA; Shankar, VK, 2021)
"Provoked vestibulodynia is a vulvar pain condition causing sexual dysfunction, affecting 8% to 10% of women."	( Baxter, ML; Bergeron, S; Corsini-Munt, S; Delisle, I; Rosen, NO; Steben, M; Vaillancourt-Morel, MP, 2021)
"Vulvodynia is chronic vulvar pain or a burning sensation lasting for at least 3 months without a cause."	( Crnković, M; Djaković, I; Lugović-Mihić, L; Magdić-Turković, T; Novak-Hlebar, I; Petričević, T, 2022)

Excerpt	Reference
"Vulvodynia affects 7% of American women, yet clinicians often lack awareness of its presentation."	( Glayzer, EJ; Glayzer, JE; He, Y; Kobak, WH; Li, H; McFarlin, BL; Schlaeger, JM; Takakura, N; Takayama, M; Villegas-Downs, M; Yajima, H, 2023)

Excerpt	Reference
"Although some vulvodynia-afflicted patients derive symptom relief from anticonvulsants, there is, as yet, insufficient evidence to support the recommendation of anticonvulsant pharmacotherapy in the treatment of vulvodynia."	( Leo, RJ, 2013)
"Furthermore, the induced vulvodynia was validated by investigating the potentiation of a flinch response threshold, upon topical application and systemic administration of gabapentin, a commonly used medication for treating neuropathic pain."	( Jo, S; Murthy, SN; Rangappa, S; Repka, MA; Shankar, VK, 2021)
"Improved understanding of vestibulodynia pathophysiology is required to develop appropriately targeted treatments."	( Barry, CM; Brierley, SM; Castro, J; Chegini, F; Haberberger, RV; Harrington, AM; Matusica, D; Spencer, NJ, 2021)
"The etiology of vulvodynia remains unknown, making it difficult to identify or develop effective treatment methods."	( Glayzer, EJ; Glayzer, JE; He, Y; Kobak, WH; Li, H; McFarlin, BL; Schlaeger, JM; Takakura, N; Takayama, M; Villegas-Downs, M; Yajima, H, 2023)
"Eighty-six women with vulvodynia were randomized to (G1) 25 mg amitriptyline, once a day (n=27), (G2) amitriptyline + electrical stimulation therapy (n=29) or (G3) amitriptyline + kinesiotherapy (n=30)."	( Bardin, MG; De Mira, TAA; Giraldo, PC; Lenzi, J; Morin, M; Witkin, SS, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	60 (72.29)	28.8240
2020's	23 (27.71)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	9	1
dalteparin	medium	1	1
thioctic acid	medium	1	1
amitriptyline	medium	10	2
baclofen	low	1	0
bupivacaine	low	1	0
desipramine	medium	2	1
diazepam	medium	1	1
gabapentin	medium	12	3
lidocaine	medium	16	10
nifedipine	medium	1	1
nortriptyline	medium	3	1
palmidrol	medium	2	1
procaine	low	2	0
estriol	medium	4	1
pentylenetetrazole	low	1	0
ethinyl estradiol	low	1	0
dinitrofluorobenzene	low	1	0
medroxyprogesterone acetate	low	2	0
levonorgestrel	low	2	0
s,n,n'-tripropylthiocarbamate	low	1	0
dronabinol	low	1	0
clodronic acid	low	1	0
paclitaxel	low	1	0
desogestrel	low	1	0
imiquimod	low	1	0
venlafaxine hydrochloride	low	1	0
glucose, (beta-d)-isomer	medium	2	1
milnacipran	medium	1	1
6-methoxyflavanone	low	1	0
ropivacaine	low	1	0
eicosapentaenoic acid	medium	1	1
stilbenes	medium	1	1
capsaicin	low	2	0
oxazolone	low	2	0
tamoxifen	medium	1	1
ospemifene	medium	1	1
dinoprostone	low	4	0
naloxone	low	1	0
pd 123319	low	2	0
pregabalin	low	2	0
oxalates	low	1	0
etonogestrel	low	1	0
vasoactive intestinal peptide	low	1	0

Protein Targets (663)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
acid sphingomyelinase	1	0	0	1
Nrf2	1	0	0	1
glp-1 receptor, partial	2	0	0	2
TDP1 protein	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
geminin	18	0	0	18
Glucocorticoid receptor	0	6	1	8
ATP-dependent translocase ABCB1	0	5	1	9
Androgen receptor	0	3	2	6
Guanine nucleotide-binding protein G	2	0	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
thioredoxin reductase	8	0	0	8
USP1 protein, partial	9	0	0	9
NFKB1 protein, partial	5	0	0	5
GLS protein	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
cytochrome P450 2D6	7	0	0	7
arylsulfatase A	5	0	0	5
cytochrome P450 2D6 isoform 1	6	0	0	6
D(1A) dopamine receptor	7	0	0	7
chromobox protein homolog 1	7	0	0	7
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
muscarinic acetylcholine receptor M1	8	0	0	8
Solute carrier family 22 member 1	0	3	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	16
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	8	0	8
Bile salt export pump	0	22	0	22
Albumin	0	0	2	2
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	8	0	8
Muscarinic acetylcholine receptor M2	0	6	0	7
Muscarinic acetylcholine receptor M4	0	6	0	7
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	3
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	6	0	7
Alpha-2A adrenergic receptor	0	7	0	7
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	6	0	7
Angiotensin-converting enzyme	0	6	0	6
D(2) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	5	0	5
Alpha-2B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 1A	0	9	1	10
Muscarinic acetylcholine receptor M3	0	6	0	7
D(1A) dopamine receptor	0	6	0	6
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	3
Sodium-dependent noradrenaline transporter	0	14	1	15
Histamine H2 receptor	0	10	0	10
Alpha-1D adrenergic receptor	0	8	0	8
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 2C	0	8	0	8
5-hydroxytryptamine receptor 1B	0	8	0	8
5-hydroxytryptamine receptor 1D	0	3	0	3
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 6	0	3	0	3
Histamine H1 receptor	0	3	0	3
Sodium-dependent serotonin transporter	0	15	0	15
5-hydroxytryptamine receptor 7	0	3	0	3
5-hydroxytryptamine receptor 5A	0	3	0	3
5-hydroxytryptamine receptor 5B	0	3	0	3
Histamine H1 receptor	0	4	0	4
D(3) dopamine receptor	0	6	1	7
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 3A	0	3	0	3
5-hydroxytryptamine receptor 2B	0	6	0	6
Alpha-1A adrenergic receptor	0	9	0	9
Histamine H2 receptor	5	3	0	11
D(1A) dopamine receptor	4	0	0	4
5-hydroxytryptamine receptor 6	0	6	0	6
5-hydroxytryptamine receptor 7	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	12	0	12
Potassium voltage-gated channel subfamily H member 2	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
5-hydroxytryptamine receptor 4	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Canalicular multispecific organic anion transporter 1	0	14	0	14
Sodium channel protein type 2 subunit alpha	0	2	0	2
Ataxin-2	9	0	0	9
Sigma non-opioid intracellular receptor 1	0	5	0	5
5-hydroxytryptamine receptor 3B	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
phosphopantetheinyl transferase	6	0	0	6
ATAD5 protein, partial	7	0	0	7
GLI family zinc finger 3	13	0	0	13
AR protein	20	0	0	20
regulator of G-protein signaling 4	8	0	0	8
67.9K protein	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
activating transcription factor 6	5	0	0	5
Bloom syndrome protein isoform 1	6	0	0	6
cytochrome P450 3A4 isoform 1	9	0	0	9
histone acetyltransferase KAT2A isoform 1	5	0	0	5
lamin isoform A-delta10	14	0	0	14
Gamma-aminobutyric acid receptor subunit pi	9	4	1	14
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	9	4	1	14
Gamma-aminobutyric acid receptor subunit delta	9	4	1	14
Gamma-aminobutyric acid receptor subunit gamma-2	9	4	3	16
Gamma-aminobutyric acid receptor subunit alpha-5	9	4	1	14
Gamma-aminobutyric acid receptor subunit alpha-3	9	4	1	14
Gamma-aminobutyric acid receptor subunit gamma-1	9	4	1	14
Gamma-aminobutyric acid receptor subunit alpha-2	9	4	1	14
Gamma-aminobutyric acid receptor subunit alpha-4	9	4	1	14
Gamma-aminobutyric acid receptor subunit gamma-3	9	4	1	14
Gamma-aminobutyric acid receptor subunit alpha-6	9	4	1	14
Gamma-aminobutyric acid receptor subunit alpha-1	9	4	3	16
Gamma-aminobutyric acid receptor subunit beta-3	9	4	1	14
Gamma-aminobutyric acid receptor subunit beta-2	9	4	3	16
GABA theta subunit	9	4	1	14
Gamma-aminobutyric acid receptor subunit epsilon	9	4	1	14
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
ATP-dependent phosphofructokinase	7	0	0	7
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Potassium channel subfamily K member 9	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
15-lipoxygenase, partial	1	0	0	1
RAR-related orphan receptor gamma	13	0	0	13
Microtubule-associated protein tau	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
estrogen-related nuclear receptor alpha	12	0	0	12
pregnane X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	21	0	0	21
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	8	0	0	8
peroxisome proliferator activated receptor gamma	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
thyroid hormone receptor beta isoform 2	16	0	0	16
mitogen-activated protein kinase 1	5	0	0	5
DNA polymerase iota isoform a (long)	4	0	0	4
nuclear receptor ROR-gamma isoform 1	5	0	0	5
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	3
Lysine-specific histone demethylase 1A	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Cytochrome P450 1A2	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Glutamate receptor 2	11	0	1	12
Cannabinoid receptor 1	0	4	1	6
Acetylcholinesterase	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Cannabinoid receptor 2	0	4	1	6
Nuclear receptor ROR-gamma	6	0	0	6
Spike glycoprotein	6	0	1	7
D(2) dopamine receptor	0	0	1	1
Inositol monophosphatase 1	4	0	0	4
Potassium voltage-gated channel subfamily A member 1	0	2	0	2
Corticotropin-releasing factor receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	2	2	5
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Thrombopoietin	3	0	0	3
huntingtin isoform 2	2	0	0	2
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Albumin	0	0	2	3
Prostaglandin G/H synthase 1	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Alpha-1B adrenergic receptor	0	7	0	7
Sodium-dependent dopamine transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
Solute carrier family 22 member 1	0	2	0	2
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
Transporter	0	2	0	2
glucocorticoid receptor [Homo sapiens]	14	0	0	14
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
Sex hormone-binding globulin	0	0	5	5
Cellular tumor antigen p53	13	0	0	13
Gamma-aminobutyric acid	0	1	1	2
G	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	3	6
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
cytochrome P450 2C9, partial	5	0	0	5
interleukin 8	3	0	0	3
acetylcholinesterase	4	0	0	4
pregnane X receptor	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
farnesoid X nuclear receptor	7	0	0	7
caspase-3	3	0	0	3
aryl hydrocarbon receptor	6	0	0	6
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	4	0	0	4
lethal factor (plasmid)	3	0	0	3
Chain A, Cruzipain	2	0	0	2
thyroid stimulating hormone receptor	8	0	0	8
retinoid X nuclear receptor alpha	9	0	0	9
thyroid stimulating hormone receptor	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
vitamin D3 receptor isoform VDRA	5	0	0	5
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Cytochrome P450 3A4	0	3	1	4
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	1	0	1	2
Glutamate receptor 3	1	0	1	2
Glutamate receptor 4	1	0	1	2
Cannabinoid receptor 1	0	2	1	3
Glycine receptor subunit alpha-1	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
Aromatase	0	1	0	1
Tissue factor	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Oxoeicosanoid receptor 1	0	1	0	1
Estrogen receptor	0	7	3	11
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Androgen receptor	0	7	0	7
UDP-glucuronosyltransferase 2B7	0	1	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Alpha-synuclein	3	1	0	4
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
Luciferase	5	0	0	5
Fumarate hydratase	3	0	0	3
PPM1D protein	2	0	0	2
polyprotein	3	0	0	3
IDH1	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
lysosomal alpha-glucosidase preproprotein	1	0	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Vpr	1	0	0	1
Cytochrome P450 2B1	0	1	0	1
Adenosine receptor A3	0	6	0	6
Cytochrome P450 2B6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
Adenosine receptor A2a	0	7	0	7
Mu-type opioid receptor	0	6	1	8
Kappa-type opioid receptor	0	6	2	9
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Estrogen receptor beta	0	4	3	7
Multidrug and toxin extrusion protein 1	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
thioredoxin glutathione reductase	1	0	0	1
EWS/FLI fusion protein	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Chain A, Ferritin light chain	2	0	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
transcriptional regulator ERG isoform 3	4	0	0	4
neuropeptide S receptor isoform A	2	0	0	2
Histone deacetylase 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
DNA polymerase beta	3	0	0	3
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
Chain A, Beta-lactamase	8	0	0	8
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
Histone H2A.x	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Progesterone receptor	0	3	2	5
flap endonuclease 1	3	0	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
PINK1	1	0	0	1
nonstructural protein 1	2	0	0	2
Parkin	2	0	0	2
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	0	1	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
POU domain, class 2, transcription factor 1	0	0	0	1
Histidine decarboxylase	0	0	1	1
D(3) dopamine receptor	0	1	0	1
Adenosine receptor A1	0	5	0	5
Delta-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	2	4
Kappa-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	2	2	4
Kappa-type opioid receptor	0	1	2	3
Delta-type opioid receptor	0	6	1	8
Kappa-type opioid receptor	0	2	1	3
Mu-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Smad3	1	0	0	1
hypothetical protein, conserved	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bile salt export pump	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Integrin beta-3	3	1	0	4
Integrin alpha-IIb	3	0	0	3
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Thromboxane-A synthase	0	2	0	2
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
dopamine D1 receptor	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Genome polyprotein	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Tyrosine-protein kinase Fyn	0	2	0	2
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	4	0	4
Serum paraoxonase/arylesterase 1	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Tyrosinase	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Chain A, CES1 protein	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
interferon gamma precursor	0	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Procathepsin L	0	0	1	1
Beta-1 adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
D(4) dopamine receptor	0	2	0	2
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Cholinesterase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

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Studies (83)

Protein Targets (663)

Generalized Vulvodynia

Synonyms(3)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (83)

Drugs Studied (55)

Protein Targets (663)