Page last updated: 2024-09-27

Claw Toe

A condition characterized by a series of interrelated digital symptoms and joint changes of the lesser digits and METATARSOPHALANGEAL JOINTS of the FOOT. The syndrome can include some or all of the following conditions: hammer toe, claw toe, mallet toe, overlapping fifth toe, curly toe, EXOSTOSIS; HYPEROSTOSIS; interdigital heloma, or contracted toe.

Synonyms(6)

Synonym
Hammertoe Syndrome
Hammer Toe
Hammer Toe Syndrome
Claw Toe
Clawtoe
Mallet Toe

Research

Studies (15)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (6.67)23.3326
1990's0 (0.00)12.5806
2000's6 (40.00)18.1394
2010's7 (46.67)28.8240
2020's1 (6.67)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
nitroglycerin0low10
titanium0low10
trolamine salicylate0low20
ropivacaine0low10
monensin0low10
nitinol0low40

Protein Targets (31)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase1001
RAR-related orphan receptor gamma2002
AR protein1001
estrogen receptor 2 (ER beta)1001
cytochrome P450 family 3 subfamily A polypeptide 41001
retinoic acid nuclear receptor alpha variant 11001
estrogen-related nuclear receptor alpha1001
estrogen nuclear receptor alpha2002
cytochrome P450 2D61001
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
GLS protein1001
TDP1 protein1001
EWS/FLI fusion protein1001
Albumin0011
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Cytochrome P450 2C9 0101
Matrix metalloproteinase-90101
Cytochrome P450 2J20101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
lamin isoform A-delta101001
Potassium channel subfamily K member 30101
Bile salt export pump0101
retinoid X nuclear receptor alpha1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]